Inhibition of postoperative pain by continuous low-dose intravenous infusion of lidocaine.

Abstract:

:Intravenous lidocaine has been reported previously to inhibit postoperative pain when given either as single injections or as short infusions in amounts usually causing adverse reactions. To determine the efficacy of a continuous low-dose (2 mg/kg) intravenous infusion of lidocaine, postoperative pain (visual analogue pain scale) and the requirements for postoperative analgesics were measured in a double-blind randomized trial in 20 patients after cholecystectomy. Lidocaine infusion was started 30 min before the operation and continued for 24 hr after surgery (n = 10). Saline was infused in a comparable group of ten patients. The lidocaine-treated patients had significantly lower pain scores during the first day after surgery (P less than 0.001) and required significantly less meperidine during the first (P less than 0.02) and second postoperative days (P less than 0.01). No adverse reactions to lidocaine were observed. Whole blood levels of lidocaine ranged between 1 and 2 micrograms/ml. The results suggest that low-dose continuous infusions of lidocaine decrease the severity of postoperative pain and are devoid of side effects.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Cassuto J,Wallin G,Högström S,Faxén A,Rimbäck G

subject

Has Abstract

pub_date

1985-10-01 00:00:00

pages

971-4

issue

10

eissn

0003-2999

issn

1526-7598

journal_volume

64

pub_type

临床试验,杂志文章,随机对照试验
  • Anesthetic management of a patient with an allergy to propylene glycol and parabens.

    abstract::Multiple pharmaceutical products contain excipients, or additive chemicals, to improve stability, bioavailability, antimicrobial activity, or palatability. Two of the most common excipients are propylene glycol and parabens. We report the successful anesthetic management of a patient with idiosyncratic reactions to pr...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e3181cde5a5

    authors: Farber MK,Angelo TE,Castells M,Tsen LC

    更新日期:2010-03-01 00:00:00

  • Anesthetic concerns for robot-assisted laparoscopy in an infant.

    abstract::A 2-mo-old infant with biliary atresia was scheduled for laparoscopic Kasai with robot assistance. Before surgery, a practice trial maneuvering the cumbersome robotic equipment was performed to ensure rapid access to the patient in case of emergency. IV access, tracheal intubation, and arterial line placement followed...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ANE.0000137394.99683.66

    authors: Mariano ER,Furukawa L,Woo RK,Albanese CT,Brock-Utne JG

    更新日期:2004-12-01 00:00:00

  • Effect of hydroxyzine on morphine analgesia for the treatment of postoperative pain.

    abstract::In a double-blind, single-dose study hydroxyzine combined with morphine was administered intramuscularly to postoperative patients to determine the efficacy of this combination in the relief of postoperative pain, and to compare its effect to that produced by morphine alone. Eighty-two patients received morphine (5 or...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Hupert C,Yacoub M,Turgeon LR

    更新日期:1980-09-01 00:00:00

  • The division of the sciatic nerve in the popliteal fossa: anatomical implications for popliteal nerve blockade.

    abstract:UNLABELLED:The sciatic nerve (SN) originates from the L4-S3 roots in the form of two nerve trunks: the tibial nerve (TN) and the common peroneal nerve (CPN). The TN and CPN are encompassed by a single epineural sheath and eventually separate (divide) in the popliteal fossa. This division of the SN occurs at a variable ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200101000-00041

    authors: Vloka JD,Hadzić A,April E,Thys DM

    更新日期:2001-01-01 00:00:00

  • The Effect of the No Pain Labor & Delivery-Global Health Initiative on Cesarean Delivery and Neonatal Outcomes in China: An Interrupted Time-Series Analysis.

    abstract:BACKGROUND:The proportion of live births by cesarean delivery (CD) in China is significant, with some, particularly rural, provinces reporting up to 62.5%. The No Pain Labor & Delivery-Global Health Initiative (NPLD-GHI) was established to improve obstetric and neonatal outcomes in China, including through a reduction ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000004805

    authors: Drzymalski DM,Guo JC,Qi XQ,Tsen LC,Sun Y,Ouanes JP,Xia Y,Gao WD,Ruthazer R,Hu F,Hu LQ

    更新日期:2020-04-22 00:00:00

  • A characterization of motion affecting pulse oximetry in 350 patients.

    abstract::As part of an oximetry research effort in which plethysmographic data were collected from moving patients, a wide variety of patient motion affecting pulse oximetry was observed and characterized by the clinical incidence, type, severity and duration of patient motion. 350 patients were observed for movement in clinic...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Tobin RM,Pologe JA,Batchelder PB

    更新日期:2002-01-01 00:00:00

  • The effect of cisatracurium and rocuronium on lung function in anesthetized children.

    abstract:BACKGROUND:Neuromuscular blocking drugs have been implicated in intraoperative bronchoconstrictive episodes. We examined the effects of clinically relevant doses of cisatracurium and rocuronium on the lung mechanics of pediatric subjects. We hypothesized that cisatracurium and rocuronium would have bronchoconstrictive ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0b013e3182a6d191

    authors: Yang CI,Fine GF,Jooste EH,Mutich R,Walczak SA,Motoyama EK

    更新日期:2013-12-01 00:00:00

  • Influence of volume on the spread of local anesthetic-methylene blue solution after injection for intercostal block.

    abstract::The purpose of this study was to evaluate the influence of the volume of methylene blue-local anesthetic on the spread of the injectate along the costal pleura. Twenty patients undergoing elective thoracotomy were studied. Twelve patients received intercostal nerve injection with 10 mL of 0.5% bupivacaine with methyle...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199209000-00013

    authors: Moorthy SS,Dierdorf SF,Yaw PB

    更新日期:1992-09-01 00:00:00

  • Hemodynamic effects of rapid vancomycin infusion in critically ill patients.

    abstract::The rapid infusion of vancomycin produces histamine release resulting in rash ("red-man's" syndrome) and hypotension. Because this phenomenon has been described primarily in healthy subjects, we prospectively studied the rapid infusion of vancomycin in 16 critically ill patients after open heart surgery in an attempt ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1213/00000539-199010000-00013

    authors: Stier GR,McGory RW,Spotnitz WD,Schwenzer KJ

    更新日期:1990-10-01 00:00:00

  • The effect of isoflurane or spinal anesthesia on indocyanine green disappearance rate in the elderly.

    abstract::This study was designed to measure the disappearance rate of indocyanine green (ICG) as an indicator of hepatic blood flow in elderly patients undergoing internal fixation of fractured neck of femur. All patients were aged 60-90 yr and were randomized to receive either spinal (n = 10) or isoflurane (n = 10) anesthesia...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/00000539-199404000-00016

    authors: Darling JR,Murray JM,Hainsworth AM,Trinick TR

    更新日期:1994-04-01 00:00:00

  • Neuraxial Anesthesia Reduces Lymphatic Flow: Proof-of-Concept in First In-Human Study.

    abstract::Dilation of lymphatic vessels may contribute to iatrogenic dissemination of cancer cells during surgery. We sought to determine whether neuraxial anesthesia reduces regional lymphatic flow. Using nuclear lymphoscintigraphy, 5 participants receiving spinal anesthesia for brachytherapy had lower extremity lymph flow at ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1213/ANE.0000000000001562

    authors: Hiller JG,Ismail HM,Hofman MS,Narayan K,Ramdave S,Riedel BJ

    更新日期:2016-11-01 00:00:00

  • Hydroxyethyl Starch 130/0.4 and Its Impact on Perioperative Outcome: A Propensity Score Matched Controlled Observation Study.

    abstract:BACKGROUND:Adverse effects of hydroxyethyl starches (HESs) have been verified in patients suffering from sepsis or kidney disease, but not in surgical patients at large. The investigation aimed to determine whether the use of HES 130/0.4 was associated with the incidence of acute postinterventional adverse events compa...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000002778

    authors: Pagel JI,Rehm M,Kammerer T,Hulde N,Speck E,Briegel J,Reinholz F,Crispin A,Hofmann-Kiefer KF

    更新日期:2018-06-01 00:00:00

  • Suppression of noxious-induced c-fos expression in the rat lumbar spinal cord by isoflurane alone or combined with fentanyl.

    abstract:BACKGROUND:Although our understanding of nociceptive processing during anesthesia has increased greatly over the last decade, many patients still experience hyperalgesia and acute pain postoperatively. The noxious-induced withdrawal reflex (NIWR) model is specifically designed and validated to quantitatively study the ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e3181678831

    authors: Sommers MG,Nguyen NK,Veening JG,Vissers KC,Ritskes-Hoitinga M,van Egmond J

    更新日期:2008-04-01 00:00:00

  • Conjugated estrogen reduces transfusion and coagulation factor requirements in orthotopic liver transplantation.

    abstract:UNLABELLED:We conducted a prospective, randomized study to determine the efficacy of conjugated estrogen in reducing blood product transfusion during orthotopic liver transplantation (OLT). Patients undergoing OLT were included in the study. Only those having a reaction time of more than 30 mm or 15 min (19 -28 mm) on ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199806000-00008

    authors: Frenette L,Cox J,McArdle P,Eckhoff D,Bynon S

    更新日期:1998-06-01 00:00:00

  • A review of intrathecal and epidural analgesia after spinal surgery in children.

    abstract::In view of the overall experience regarding regional anesthetic techniques to control postoperative pain in infants and children, it is feasible that a similar efficacy and safety profile can be obtained when using such techniques after major orthopedic procedures such as anterior or posterior spinal fusion. I reviewe...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/01.ane.0000107938.80562.75

    authors: Tobias JD

    更新日期:2004-04-01 00:00:00

  • Gastric tubes and airway management in patients at risk of aspiration: history, current concepts, and proposal of an algorithm.

    abstract::Rapid sequence induction and intubation (RSII) and awake tracheal intubation are commonly used anesthetic techniques in patients at risk of pulmonary aspiration of gastric or esophageal contents. Some of these patients may have a gastric tube (GT) placed preoperatively. Currently, there are no guidelines regarding whi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0b013e3182917f11

    authors: Salem MR,Khorasani A,Saatee S,Crystal GJ,El-Orbany M

    更新日期:2014-03-01 00:00:00

  • Nitrous oxide attenuates pressor but augments norepinephrine response to laryngoscopy and endotracheal intubation.

    abstract:UNLABELLED:Nitrous oxide (N(2)O) exerts a sympathomimetic action. We investigated whether N(2)O modifies the cardiovascular responses to tracheal intubation during general anesthesia. One-hundred healthy patients were assigned randomly to receive one of four concentrations (0%, 25%, 50%, or 75%; n = 25 each) of N(2)O i...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/01.ane.0000058842.05373.e3

    authors: Yoo KY,Jeong ST,Ha IH,Lee J

    更新日期:2003-05-01 00:00:00

  • The effect of fentanyl on arginine vasopressin and cortisol secretion during anesthesia.

    abstract::The effects of nitrous oxide-oxygen plus small doses of fentanyl with (N = 7) and without (N = 15) naloxone and the effects of nitrous oxide-oxygen plus halothane (N = 13) on plasma concentration of arginine vasopressin (AVP) and cortisol were studied in normal patients before and during gynecologic laparotomies. Pati...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Lehtinen AM,Fyhrquist F,Kivalo I

    更新日期:1984-01-01 00:00:00

  • Comparative myocardial depression of sevoflurane, isoflurane, and halothane in cultured neonatal rat ventricular myocytes.

    abstract:UNLABELLED:In this study, we compared the direct myocardial depressant effects of sevoflurane, isoflurane, and halothane and determined whether an L-type Ca2+ channel agonist, Bay K 8644, could attenuate the myocardial depression induced by these anesthetics in cultured neonatal rat ventricular myocytes. Ventricular my...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199811000-00013

    authors: Kanaya N,Kawana S,Tsuchida H,Miyamoto A,Ohshika H,Namiki A

    更新日期:1998-11-01 00:00:00

  • Is dexamethasone associated with recurrence of ovarian cancer?

    abstract:BACKGROUND:Basic science studies suggest that perioperative immune impairment may augment the risk of cancer recurrence after otherwise potentially curative surgery. Despite its immunosuppressant properties, dexamethasone is commonly given to oncologic patients in an effort to reduce postoperative nausea and vomiting. ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e3182a5d656

    authors: De Oliveira GS Jr,McCarthy R,Turan A,Schink JC,Fitzgerald PC,Sessler DI

    更新日期:2014-06-01 00:00:00

  • Total Joint Replacement Perioperative Surgical Home Program: 2-Year Follow-Up.

    abstract:BACKGROUND:Previously, our group successfully established one of the nation's first Perioperative Surgical Homes (PSHs) aimed at coordinating services to patients undergoing primary total hip arthroplasty (THA) and primary total knee arthroplasty (TKA). As we now focus on extending the PSH to other service lines within...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000001308

    authors: Cyriac J,Garson L,Schwarzkopf R,Ahn K,Rinehart J,Vakharia S,Cannesson M,Kain Z

    更新日期:2016-07-01 00:00:00

  • The hyperglycemic response to major noncardiac surgery and the added effect of steroid administration in patients with and without diabetes.

    abstract:BACKGROUND:The pattern and magnitude of the hyperglycemic response to surgical stress, the added effect of low-dose steroids, and whether these differ in diabetics and nondiabetics remain unclear. We therefore tested 2 hypotheses: (1) that diabetics show a greater increase from preoperative to intraoperative glucose co...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0b013e318288416d

    authors: Abdelmalak BB,Bonilla AM,Yang D,Chowdary HT,Gottlieb A,Lyden SP,Sessler DI

    更新日期:2013-05-01 00:00:00

  • Perioperative liver graft function: the role of oxygen transport and utilization.

    abstract::To assess the evolution of satisfactory neohepatic graft function or failure, hemodynamic variables, along with data for oxygen delivery and utilization, were analyzed retrospectively in 99 patients undergoing orthotopic liver transplantation. Caval cross-clamping without venovenous bypass initiated a series of hemody...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199303000-00022

    authors: Steltzer H,Hiesmayr M,Tüchy G,Zimpfer M

    更新日期:1993-03-01 00:00:00

  • Difficult tracheal intubation is more common in obese than in lean patients.

    abstract:UNLABELLED:Whether tracheal intubation is more difficult in obese patients is debatable. We compared the incidence of difficult tracheal intubation in obese and lean patients by using a recently validated objective scale, the intubation difficulty scale (IDS). We studied 134 lean (body mass index, <30 kg/m2) and 129 ob...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000072547.75928.b0

    authors: Juvin P,Lavaut E,Dupont H,Lefevre P,Demetriou M,Dumoulin JL,Desmonts JM

    更新日期:2003-08-01 00:00:00

  • Carbon Dioxide Absorption During Inhalation Anesthesia: A Modern Practice.

    abstract::CO2 absorbents were introduced into anesthesia practice in 1924 and are essential when using a circle system to minimize waste by reducing fresh gas flow to allow exhaled anesthetic agents to be rebreathed. For many years, absorbent formulations consisted of calcium hydroxide combined with strong bases like sodium and...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000005137

    authors: Feldman JM,Hendrickx J,Kennedy RR

    更新日期:2020-09-14 00:00:00

  • Conservative treatment of tracheal injuries.

    abstract::Tracheal injuries, independent of their origin, may be life-threatening. Surgical repair is regarded as the treatment of choice but has not been compared with other approaches. We hypothesized that defects bridgeable by an artificial airway may enable conservative treatment. We report on five patients with tracheal in...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ANE.0000140780.14175.5A

    authors: Beiderlinden M,Adamzik M,Peters J

    更新日期:2005-01-01 00:00:00

  • The effect of sevoflurane and isoflurane anesthesia on interictal spike activity among patients with refractory epilepsy.

    abstract:UNLABELLED:The electrophysiologic effects of sevoflurane are not well characterized in humans. Among patients with refractory epilepsy, this study compared 1) electroencephalographic (EEG) interictal spike activity during wakefulness and sevoflurane anesthesia, and 2) electrocorticographically (ECoG) recorded intericta...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Watts AD,Herrick IA,McLachlan RS,Craen RA,Gelb AW

    更新日期:1999-11-01 00:00:00

  • Case report: neurological complications associated with epidural analgesia in children: a report of 4 cases of ambiguous etiologies.

    abstract::The safety and utility of pediatric epidural analgesia is well established, but the risk of permanent neurological injury is unknown and largely must be extrapolated from adult literature. In this article we present a series of 4 cases of longterm or permanent neurologic complications associated with epidural analgesi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e31826918b6

    authors: Meyer MJ,Krane EJ,Goldschneider KR,Klein NJ

    更新日期:2012-12-01 00:00:00

  • Presenting research information to children: a tale of two methods.

    abstract:BACKGROUND:Research information for children is often presented in a manner that is difficult to understand. We designed this study, therefore, to examine the effect of improved readability and processability of written study information on children's understanding. METHODS:One-hundred-ninety children aged 7-17 yr who...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/01.ane.0000270326.44507.11

    authors: Tait AR,Voepel-Lewis T,Malviya S

    更新日期:2007-08-01 00:00:00

  • Anatomical landmarks for femoral nerve block: a comparison of four needle insertion sites.

    abstract:UNLABELLED:The site for needle insertion in femoral nerve block varies significantly among various descriptions of the technique. To determine the site with the highest likelihood of needle-femoral nerve contact, femoral nerve block was simulated in a human cadaver model (17 femoral triangles from 9 adult cadavers). Fo...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199912000-00028

    authors: Vloka JD,Hadzić A,Drobnik L,Ernest A,Reiss W,Thys DM

    更新日期:1999-12-01 00:00:00