Effect of hydroxyzine on morphine analgesia for the treatment of postoperative pain.

Abstract:

:In a double-blind, single-dose study hydroxyzine combined with morphine was administered intramuscularly to postoperative patients to determine the efficacy of this combination in the relief of postoperative pain, and to compare its effect to that produced by morphine alone. Eighty-two patients received morphine (5 or 10 mg) with or without hydroxyzine (100 mg). Analgesia was measured by a method quantifying the subjective responses of patients when questioned about pain. Analgesia obtained when 10 mg of morphine was combined with 100 mg of hydroxyzine was significantly superior to that obtained with morphine alone. Drowsiness was significantly more frequent when 10 mg of morphine was combined with 100 mg of hydroxyzine than with morphine alone.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Hupert C,Yacoub M,Turgeon LR

subject

Has Abstract

pub_date

1980-09-01 00:00:00

pages

690-6

issue

9

eissn

0003-2999

issn

1526-7598

journal_volume

59

pub_type

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