Solubility of I-653, sevoflurane, isoflurane, and halothane in plastics and rubber composing a conventional anesthetic circuit.

Abstract:

:This study defines some characteristics of a standard anesthetic circuit that may impede anesthetic induction and recovery with I-653, sevoflurane, isoflurane, and halothane. Partition coefficients for anesthetic circuit components (masks, bellows, bags, airways, and circuit tubes) consistently ranked halothane greater than isoflurane greater than sevoflurane greater than I-653, suggesting a reverse order of washin and washout rates for an anesthetic circuit constructed from similar components. Consistent with this prediction, the concentrations of I-653 increased and decreased more rapidly than those of the other agents at any flow rate during washin (0.5, 1, or 2 L/min gas inflow rates) or washout (1, 3, or 5 L/min) in a conventional anesthetic circuit. The rates of change in I-653 concentration closely approximated the maximal possible theoretical rates. Our results suggest that absorption of I-653 by circuit components or soda lime should not hinder induction of or recovery from anesthesia.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Targ AG,Yasuda N,Eger EI 2nd

subject

Has Abstract

pub_date

1989-08-01 00:00:00

pages

218-25

issue

2

eissn

0003-2999

issn

1526-7598

journal_volume

69

pub_type

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