Target-Controlled Infusions: Paths to Approval.

abstract：BACKGROUND:Recent randomized controlled trials have shown no benefit for transfusion to a hemoglobin >10 g/dL compared with lower hemoglobin thresholds in the perioperative period, even among older adults. Nevertheless, physicians may choose to transfuse older adults more liberally than younger adults. It is unclear wh...

journal_title：Anesthesia and analgesia

authors： Brown CH 4th,Savage WJ,Masear CG,Walston JD,Tian J,Colantuoni E,Hogue CW,Frank SM

更新日期：2014-06-01 00:00:00

abstract：:Lung dysfunction after cardiopulmonary bypass and lung transplantation results from oxidant-mediated cellular damage. Previously, we observed the shedding of angiotensin-converting enzyme (ACE) from the endothelial cell surface to be a more sensitive and earlier marker of oxidative lung endothelial injury than lung we...

journal_title：Anesthesia and analgesia

authors： Balyasnikova IV,Visintine DJ,Gunnerson HB,Paisansathan C,Baughman VL,Minshall RD,Danilov SM

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Cannabinoid agonists induce norepinephrine release in central, spinal, and peripheral sites. Previous studies suggest an interaction between the cannabinoid and adrenergic systems on antinociception. In this study, we sought to verify whether the CB1 and CB2 cannabinoid receptor agonists anandamide and N-pal...

journal_title：Anesthesia and analgesia

authors： Romero TR,Resende LC,Guzzo LS,Duarte ID

更新日期：2013-02-01 00:00:00

abstract：:Spine surgery has been growing rapidly as a neurosurgical operation, with an increase of 220% over a 15-year period. Intraoperative blood transfusion is a major outcome determinant of spine procedures. Various approaches, including pharmacologic and nonpharmacologic therapies, have been tested to decrease both intraop...

journal_title：Anesthesia and analgesia

authors： Willner D,Spennati V,Stohl S,Tosti G,Aloisio S,Bilotta F

更新日期：2016-11-01 00:00:00

abstract：:The aim of this study was to determine the need for supplemental oxygen during recovery from general anesthesia for ambulatory surgery in healthy women without obesity or respiratory disease. Arterial oxygen saturation by pulse oximetry (SpO2) was monitored throughout the first postoperative hour in 164 patients. The ...

journal_title：Anesthesia and analgesia

authors： Murray RS,Raemer DB,Morris RW

更新日期：1988-10-01 00:00:00

abstract：:To evaluate the effects of succinylcholine on cardiac arrhythmias and serum levels of potassium and catecholamines, dogs with hypoxia alone and with hypoxia and hypercarbia were studied during anesthesia with halothane or enflurane. After the injection of succinylcholine (0.3 mg/kg), cardiac arrhythmias occurred in al...

journal_title：Anesthesia and analgesia

authors： Leiman BC,Katz J,Butler BD

更新日期：1987-12-01 00:00:00

abstract：:Computer-based measuring of the level of sedation and hypnosis is difficult and has proven to be challenging. The electroencephalogram (EEG) has been proposed as a potential method. Response entropy (RE) and state entropy (SE) are multifactor, dimensionless parameters of a new technology of EEG monitoring, and we inve...

journal_title：Anesthesia and analgesia

authors： Litscher G

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Intraoperative hypoglycemia can result in devastating neurologic injury if not promptly diagnosed and treated. Few studies have defined risk factors for intraoperative hypoglycemia. The authors sought to characterize children with intraoperative hypoglycemia and determine independent risk factors in a multic...

journal_title：Anesthesia and analgesia

authors： Riegger LQ,Leis AM,Golmirzaie KH,Malviya S

更新日期：2020-06-25 00:00:00

abstract：UNLABELLED:Pressure infusion devices are often used to administer fluids in the operating room, but they may rarely be associated with serious venous air embolism. We studied the performance of the Level 1 and the Ranger Pressure Infusor in the laboratory. The Ranger delivered less air and delivered fluid faster than t...

journal_title：Anesthesia and analgesia

authors： Eaton MP,Dhillon AK

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Increasing evidence links postoperative cognitive dysfunction (POCD) to surgery and anesthesia. POCD is recognized as an important neuropsychological adverse outcome in surgical patients, particularly the elderly. This prospective cohort study aimed to investigate whether POCD is associated with impaired int...

journal_title：Anesthesia and analgesia

authors： Goettel N,Burkhart CS,Rossi A,Cabella BC,Berres M,Monsch AU,Czosnyka M,Steiner LA

更新日期：2017-03-01 00:00:00

abstract：UNLABELLED:The purpose of this study was to investigate whether propofol protects rat hepatocyte suspensions against an oxidant attack by a free radical generator 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH). Rat hepatocyte suspensions (2 x 10(6) cells/mL) were prepared using Seglen's collagenase perfusion tec...

journal_title：Anesthesia and analgesia

authors： Navapurkar VU,Skepper JN,Jones JG,Menon DK

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Impaired cerebral blood flow (CBF) autoregulation during cardiopulmonary bypass (CPB) is associated with stroke and other adverse outcomes. Large and small arterial stenosis is prevalent in patients undergoing cardiac surgery. We hypothesize that large and/or small vessel cerebral arterial disease is associa...

journal_title：Anesthesia and analgesia

authors： Nomura Y,Faegle R,Hori D,Al-Qamari A,Nemeth AJ,Gottesman R,Yenokyan G,Brown C,Hogue CW

更新日期：2018-12-01 00:00:00

abstract：:To determine the safety, efficacy, and dose response of epidurally administered morphine for analgesia after cesarean delivery, 40 healthy women who underwent cesarean delivery with epidural anesthesia were randomly assigned to receive one of four regimens for relief of postoperative pain: intramuscular administration...

journal_title：Anesthesia and analgesia

authors： Rosen MA,Hughes SC,Shnider SM,Abboud TK,Norton M,Dailey PA,Curtis JD

更新日期：1983-07-01 00:00:00

abstract：:While a large number of studies has examined the efficacy of opioid-sparing analgesics in adult surgical populations, fewer studies are available to guide postoperative pain treatment in pediatric patients. We systematically reviewed available publications on the use of systemic nonopioid agents for postoperative anal...

journal_title：Anesthesia and analgesia

authors： Zhu A,Benzon HA,Anderson TA

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:In this randomized study, we compared intrathecal (i.t.) morphine with or without clonidine and i.v. postoperative patient-controlled analgesia (PCA) morphine for analgesia after radical retropubic prostatectomy. METHODS:Fifty patients were randomly divided into three groups. They were allocated to receive ...

journal_title：Anesthesia and analgesia

authors： Andrieu G,Roth B,Ousmane L,Castaner M,Petillot P,Vallet B,Villers A,Lebuffe G

更新日期：2009-06-01 00:00:00

abstract：:Hemispheric synchronization is currently promoted as a treatment for preoperative anxiety and for reduction of intraoperative anesthetic and analgesic consumption. We designed this study to examine the effect of Hemisync sounds on anesthetic hypnotic depth. After obtaining informed consent, we randomized subjects unde...

journal_title：Anesthesia and analgesia

authors： Dabu-Bondoc S,Drummond-Lewis J,Gaal D,McGinn M,Caldwell-Andrews AA,Kain ZN

更新日期：2003-09-01 00:00:00

abstract：IMPLICATIONS:The performance of regional blockade on a patient with a preexisting neurologic condition or a history of neurologic complications after regional anesthesia is controversial. We present a case of recurring brachial plexus neuropathy in a diabetic patient after two shoulder procedures performed 4 mo apart. ...

journal_title：Anesthesia and analgesia

authors： Horlocker TT,O'Driscoll SW,Dinapoli RP

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Anesthesiologists may contribute to postoperative infections by means of the transmission of blood and pathogens to the patient and the environment in the operating room (OR). Our primary aims were to determine whether contamination of the IV hub, the anesthesia work area, and the patient could be reduced af...

journal_title：Anesthesia and analgesia

authors： Birnbach DJ,Rosen LF,Fitzpatrick M,Carling P,Arheart KL,Munoz-Price LS

更新日期：2015-11-01 00:00:00

abstract：:Epidural catheter placement offers flexibility in block management. However, during epidural catheter insertion, complications such as paresthesia and venous and subarachnoid cannulation may occur, and suboptimal catheter placement can affect the quality of anesthesia. We performed this prospective, randomized, double...

journal_title：Anesthesia and analgesia

authors： Cesur M,Alici HA,Erdem AF,Silbir F,Yuksek MS

更新日期：2005-11-01 00:00:00

abstract：:Acute fatty liver of pregnancy (AFLP) is a late gestational complication with biochemical similarities to the inherited disorders of mitochondrial fatty acid oxidation and clinical similarities to fulminant hepatic failure. The following case illustrates our perioperative management of this rarely encountered disorder...

journal_title：Anesthesia and analgesia

authors： Holzman RS,Riley LE,Aron E,Fetherston J

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Local anesthetics cause reversible block of pain and robustly inhibit TWIK-related K channel (TREK-1) currents. Before local anesthesia onset, injection of local anesthetics can cause unwanted transient pain. TREK-1 is an anesthetic-sensitive potassium channel that when inhibited produces pain. A disordered ...

journal_title：Anesthesia and analgesia

authors： Pavel MA,Chung HW,Petersen EN,Hansen SB

更新日期：2019-10-01 00:00:00

abstract：:The dose-dependent effects of nitrous oxide on thymidine and methionine syntheses were investigated in pregnant rats. Female Sprague-Dawley rats were exposed on day 9 of gestation to 0.75%, 7.5%, or 75% nitrous oxide for 24 h. Immediately and 72 h after exposure, a deoxyuridine-suppression test was performed on matern...

journal_title：Anesthesia and analgesia

authors： Baden JM,Rice SA,Serra M,Kelley M,Mazze R

更新日期：1983-08-01 00:00:00

abstract：BACKGROUND:In this study, we hypothesized that leg positioning and distal tourniquet application, when compared with neutral positioning of the leg, alters the efficacy of sciatic nerve block performed by the double-stimulation technique. METHODS:Ninety randomized, consecutive, ASA physical status I to III patients un...

journal_title：Anesthesia and analgesia

authors： Sertoz N,Deniz MN,Ayanoglu HO

更新日期：2011-12-01 00:00:00

abstract：:The hemodynamic effects of an induction dose of propofol, 2.5 mg/kg, or etomidate, 0.3 mg/kg, were studied in eight dogs. In addition, cardiodynamic changes were measured using a left ventricular catheter and needle force probes. Propofol was associated with significant decreases in systolic (19.9%) and diastolic (25....

journal_title：Anesthesia and analgesia

authors： Brüssel T,Theissen JL,Vigfusson G,Lunkenheimer PP,Van Aken H,Lawin P

更新日期：1989-07-01 00:00:00

abstract：UNLABELLED:Although isoflurane can reduce ischemic neuronal injury after short postischemic recovery intervals, this neuroprotective efficacy is not sustained. Neuronal apoptosis can contribute to the gradual increase in infarct size after ischemia. This suggests that isoflurane, although capable of reducing early neur...

journal_title：Anesthesia and analgesia

authors： Kawaguchi M,Drummond JC,Cole DJ,Kelly PJ,Spurlock MP,Patel PM

更新日期：2004-03-01 00:00:00

abstract：:Colloids and crystalloids are usually administered as treatment for hypovolemia in severely injured patients. However, dilution of clotting factors and platelets together with impaired fibrinogen polymerization are associated with fluid therapy and may aggravate hemorrhage, thus worsening final outcome of these patien...

journal_title：Anesthesia and analgesia

authors： Fries D,Innerhofer P,Reif C,Streif W,Klingler A,Schobersberger W,Velik-Salchner C,Friesenecker B

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Transversus abdominis plane (TAP) block and local anesthetic wound infiltration provide analgesia after cesarean delivery. Studies comparing the 2 techniques are scarce, with conflicting results. This double-blind, randomized controlled trial aimed to compare bilateral ultrasound-guided TAP block with single...

journal_title：Anesthesia and analgesia

authors： Tawfik MM,Mohamed YM,Elbadrawi RE,Abdelkhalek M,Mogahed MM,Ezz HM

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:The clinical utility of focused transthoracic echocardiography (TTE) is increasingly recognized in perioperative medicine. However its use is limited among anesthesiologists because of a lack of training. The most efficient training methods have not been determined. We hypothesized that simulation-based TTE ...

journal_title：Anesthesia and analgesia

authors： Neelankavil J,Howard-Quijano K,Hsieh TC,Ramsingh D,Scovotti JC,Chua JH,Ho JK,Mahajan A

更新日期：2012-11-01 00:00:00

abstract：:The dynamics of IV drug delivery resulting from drug infusions connected to main-line crystalloid carriers can be complex and depend on infusion set dead-volume, drug flow rate, and carrier flow rate. While the concept of dead-volume is intuitive, a lack of appreciation of the interaction with the carrier and drug flo...

journal_title：Anesthesia and analgesia

authors： Lovich MA,Doles J,Peterfreund RA

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Recently, there has been significant focus on the effects of anesthesia on the developing brain. Concern is heightened in children <3 years of age requiring lengthy and/or multiple anesthetics. Hypospadias correction is common in otherwise healthy children and may require both lengthy and repeated anesthetic...

journal_title：Anesthesia and analgesia

authors： Adler AC,Chandrakantan A,Sawires Y,Lee AD,Hart M,Koh CJ,Janzen NK,Austin PF,Andropoulos DB

更新日期：2019-12-09 00:00:00