Analysis of 1478 Cases of Hypospadias Repair: The Incidence of Requiring Repeated Anesthetic Exposure as Well as Exploration of the Involvement of Trainees on Case Duration.

Abstract:

BACKGROUND:Recently, there has been significant focus on the effects of anesthesia on the developing brain. Concern is heightened in children <3 years of age requiring lengthy and/or multiple anesthetics. Hypospadias correction is common in otherwise healthy children and may require both lengthy and repeated anesthetics. At academic centers, many of these cases are performed with the assistance of anesthesia and surgical trainees. We sought to identify both the incidence of these children undergoing additional anesthetics before age 3 as well as to understand the effect of trainees on duration of surgery and anesthesia and thus anesthetic exposure (AE), specifically focusing on those cases >3 hours. METHODS:We analyzed all cases of hypospadias repair from December 2011 through December 2018 at Texas Children's Hospital. In all, 1326 patients undergoing isolated hypospadias repair were analyzed for anesthesia time, surgical time, provider types involved, AE, caudal block, and additional AE related/unrelated to hypospadias. RESULTS:For the primary aim, a total of 1573 anesthetics were performed in children <3 years of age, including 1241 hypospadias repairs of which 1104 (89%) were completed with <3 hours of AE. For patients with <3 hours of AE, 86.1% had a single surgical intervention for hypospadias. Of patients <3 years of age, 17.3% required additional nonrelated surgeries. There was no difference in anesthesia time in cases performed solely by anesthesia attendings versus those performed with trainees/assistance (16.8 vs 16.8 minutes; P = .98). With regard to surgery, cases performed with surgical trainees were of longer duration than those performed solely by surgical attendings (83.5 vs 98.3 minutes; P < .001). Performance of surgery solely by attending surgeon resulted in a reduced total AE in minimal alveolar concentration (MAC) hours when compared to procedures done with trainees (1.92 vs 2.18; P < .001). Finally, comparison of patients undergoing initial correction of hypospadias with subsequent revisions revealed a longer time (117.7 vs 132.2 minutes; P < .001) and AE during the primary stage. CONCLUSIONS:The majority of children with hypospadias were repaired within a single AE. In general, most children did not require repeated AE before age 3. While presence of nonattending surgeons was associated with an increase in AE, this might at least partially be due to differences in case complexity. Moreover, the increase is likely not clinically significant. While it is critical to maintain a training environment, attempts to minimize AE are crucial. This information facilitates parental consent, particularly with regard to anesthesia duration and the need for additional anesthetics in hypospadias and nonhypospadias surgeries.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Adler AC,Chandrakantan A,Sawires Y,Lee AD,Hart M,Koh CJ,Janzen NK,Austin PF,Andropoulos DB

doi

10.1213/ANE.0000000000004596

subject

Has Abstract

pub_date

2019-12-09 00:00:00

eissn

0003-2999

issn

1526-7598

pub_type

杂志文章
  • Control of intraoperative hypertension with isoflurane in patients with coronary artery disease: effects on regional myocardial blood flow and metabolism.

    abstract::The effect of isoflurane on regional myocardial metabolism and blood flow, when used as an adjunct to fentanyl-nitrous oxide anesthesia, to control intraoperative hypertension was investigated. Twenty-two patients with two- or three-vessel coronary artery disease with an ejection fraction greater than 0.5 and on beta-...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-198902000-00006

    authors: Sahlman L,Milocco I,Appelgren L,William-Olsson G,Ricksten SE

    更新日期:1989-02-01 00:00:00

  • Intraoperative Red Blood Cell Transfusion in Infant Heart Transplant Patients Is Not Associated with Worsened Outcomes.

    abstract:BACKGROUND:Red blood cell (RBC) transfusion is common during infant cardiac surgery. A previous report of pediatric heart transplant recipients showed that increased RBC transfusion volume was independently associated with increased length of intensive care unit stay. It is unclear whether transfusion to infants as a s...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000001241

    authors: Carter HF,Lau C,Juma D,Wells B,Applegate RL 2nd

    更新日期:2016-05-01 00:00:00

  • The protective effects of volatile anesthestics against the bronchoconstriction induced by an allergic reaction in sensitized rabbit pups.

    abstract:BACKGROUND:Volatile inhaled anesthetics exert a differential protective effect against bronchospasm development after cholinergic stimulation. However, their ability to inhibit the adverse respiratory consequences of an anaphylactic reaction after exposure to an allergen has not been characterized. We therefore compare...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e31828e5ccf

    authors: Lele E,Petak F,Carnesecchi S,Virag K,Argiroffo CB,Habre W

    更新日期:2013-06-01 00:00:00

  • Supplemental oxygen after ambulatory surgical procedures.

    abstract::The aim of this study was to determine the need for supplemental oxygen during recovery from general anesthesia for ambulatory surgery in healthy women without obesity or respiratory disease. Arterial oxygen saturation by pulse oximetry (SpO2) was monitored throughout the first postoperative hour in 164 patients. The ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Murray RS,Raemer DB,Morris RW

    更新日期:1988-10-01 00:00:00

  • The Analgesic Effect of Ultrasound-Guided Quadratus Lumborum Block After Cesarean Delivery: A Randomized Clinical Trial.

    abstract:BACKGROUND:Landmark and ultrasound-guided transversus abdominis plane blocks have demonstrated an opioid-sparing effect postoperatively after cesarean delivery. The more posterior quadratus lumborum (QL) might provide superior local anesthetic spread to the thoracolumbar fascia and paravertebral space. The aim of our s...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000002648

    authors: Krohg A,Ullensvang K,Rosseland LA,Langesæter E,Sauter AR

    更新日期:2018-02-01 00:00:00

  • Hemodynamic effects of rapid vancomycin infusion in critically ill patients.

    abstract::The rapid infusion of vancomycin produces histamine release resulting in rash ("red-man's" syndrome) and hypotension. Because this phenomenon has been described primarily in healthy subjects, we prospectively studied the rapid infusion of vancomycin in 16 critically ill patients after open heart surgery in an attempt ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1213/00000539-199010000-00013

    authors: Stier GR,McGory RW,Spotnitz WD,Schwenzer KJ

    更新日期:1990-10-01 00:00:00

  • Central venous access: the effects of approach, position, and head rotation on internal jugular vein cross-sectional area.

    abstract:UNLABELLED:We investigated the effects of approach (lateral versus anterior), position (supine versus Trendelenburg), and head rotation (0 degrees, 20 degrees, and maximum) during central venous catheterization on the area of the right internal jugular vein. Twenty-four patients were placed in supine position, followed...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200212000-00010

    authors: Suarez T,Baerwald JP,Kraus C

    更新日期:2002-12-01 00:00:00

  • Gene Transfer of Glutamic Acid Decarboxylase 67 by Herpes Simplex Virus Vectors Suppresses Neuropathic Pain Induced by Human Immunodeficiency Virus gp120 Combined with ddC in Rats.

    abstract:BACKGROUND:Human immunodeficiency virus (HIV)-related painful sensory neuropathies primarily consist of the HIV infection-related distal sensory polyneuropathy and antiretroviral toxic neuropathies. Pharmacotherapy provides only partial relief of pain in patients with HIV/acquired immune deficiency syndrome because lit...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000000729

    authors: Kanao M,Kanda H,Huang W,Liu S,Yi H,Candiotti KA,Lubarsky DA,Levitt RC,Hao S

    更新日期:2015-06-01 00:00:00

  • Neuromuscular pharmacology of TAAC3, a new nondepolarizing muscle relaxant with rapid onset and ultrashort duration of action.

    abstract:UNLABELLED:We selected bis [N-(3,4-diacetoxybenzyl) tropanium-3alpha-yl] glutarate dibromide (TAAC3) from many new tropinyl diester derivatives to evaluate its neuromuscular blocking (NMB) and autonomic side effects on anesthetized rats, rabbits, guinea pigs, cats, pigs, dogs, and monkeys. NMB potency, onset, recovery ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200204000-00020

    authors: Gyermek L,Lee C,Cho YM,Nguyen N,Tsai SK

    更新日期:2002-04-01 00:00:00

  • The effects of plasma and brain magnesium concentrations on lidocaine-induced seizures in the rat.

    abstract::Lidocaine and MgSO4 are often coadministered to patients with pregnancy-induced hypertension. This study examined whether MgSO4 alters the lidocaine-seizure threshold in the rat and, if so, whether systemic MgSO4 administration is as effective as intracerebroventricular MgSO4 infusion. In Experiment 1, rats were admin...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199612000-00016

    authors: Kim YJ,McFarlane C,Warner DS,Baker MT,Choi WW,Dexter F

    更新日期:1996-12-01 00:00:00

  • The incidence of complex regional pain syndrome after fasciectomy for Dupuytren's contracture: a prospective observational study of four anesthetic techniques.

    abstract::The development of complex regional pain syndrome (CRPS) is not an uncommon complication after Dupuytren's surgery. Despite increasing research interest, little is known regarding which patients are at increased risk for developing CRPS and what is the optimal perioperative treatment strategy for preventing the occurr...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,收录出版

    doi:10.1213/01.ane.0000194879.85643.ff

    authors: Reuben SS,Pristas R,Dixon D,Faruqi S,Madabhushi L,Wenner S

    更新日期:2006-02-01 00:00:00

  • Altered response to formalin by L5 spinal nerve ligation in rats: a behavioral and molecular study.

    abstract:BACKGROUND:The status of neuropathic pain alters the responsiveness to formalin injection in rats. However, the mechanism by which this alteration occurs is unknown. METHODS:We used immunocytochemistry to examine the expression of brain-derived neurotrophic factor (BDNF) and calcitonin gene-related peptide (CGRP) in t...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000258762.22607.15

    authors: Kaku R,Yokoyama M,Kobayashi H,Matsuoka Y,Sato T,Mizobuchi S,Itano Y,Morita K

    更新日期:2007-04-01 00:00:00

  • Intrathecal morphine reduces infarct size in a rat model of ischemia-reperfusion injury.

    abstract:UNLABELLED:Systemically-administered morphine reduces infarct size in rat models of myocardial ischemia-reperfusion. We sought to determine whether much smaller doses of spinally-administered morphine offer a similar cardioprotective benefit. Barbiturate-anesthetized, open-chested, Wistar rats with chronic indwelling t...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000105878.96434.05

    authors: Groban L,Vernon JC,Butterworth J

    更新日期:2004-04-01 00:00:00

  • Spinal and cortical evoked potential studies in the ketamine-anesthetized rabbit: fentanyl exerts component-specific, naloxone-reversible changes dependent on stimulus intensity.

    abstract::This study examined the changes in spinal and cortical evoked potentials (EPs) produced by fentanyl in the rabbit. The reversibility of these effects by naloxone and the effects of varying stimulus intensity also were examined. Eleven ketamine-anesthetized rabbits underwent analysis of spinal and cortical EPs produced...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199402000-00014

    authors: Lee VC

    更新日期:1994-02-01 00:00:00

  • Ryanodine Receptor to Mitochondrial Reactive Oxygen Species Pathway Plays an Important Role in Chronic Human Immunodeficiency Virus gp120MN-Induced Neuropathic Pain in Rats.

    abstract:BACKGROUND:Chronic pain is one of the most common complaints in patients with human immunodeficiency virus (HIV)-associated sensory neuropathy. Ryanodine receptor (RyR) and mitochondrial oxidative stress are involved in neuropathic pain induced by nerve injury. Here, we investigated the role of RyR and mitochondrial su...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000003916

    authors: Godai K,Takahashi K,Kashiwagi Y,Liu CH,Yi H,Liu S,Dong C,Lubarsky DA,Hao S

    更新日期:2019-07-01 00:00:00

  • Capnographic Parameters in Ventilated Patients: Correspondence with Airway and Lung Tissue Mechanics.

    abstract:BACKGROUND:Although the mechanical status of the lungs affects the shape of the capnogram, the relations between the capnographic parameters and those reflecting the airway and lung tissue mechanics have not been established in mechanically ventilated patients. We, therefore, set out to characterize how the mechanical ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000001185

    authors: Csorba Z,Petak F,Nevery K,Tolnai J,Balogh AL,Rarosi F,Fodor GH,Babik B

    更新日期:2016-05-01 00:00:00

  • Response time of the Narkotest anesthetic gas monitor.

    abstract::Response time (RT) of the Narkotest anesthetic gas monitor was measured for 7 inhalation anesthetics, using a 5 L/min fresh gas flow (FGF). Time to 63 percent of maximum response (RT63) and to 95 percent of maximum response (RT95) was directly related to rubber/gas and oil/gas partition coefficients. RT95 ranged from ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-197705000-00016

    authors: Velazquez JL,Feingold A,Walther P

    更新日期:1977-05-01 00:00:00

  • Oral clonidine premedication enhances the quality of postoperative analgesia by intrathecal morphine.

    abstract::Since clonidine potentiates the analgesia by morphine, the current study was performed to investigate whether oral clonidine premedication would enhance the postoperative analgesia by intrathecal morphine. Twenty-six patients, aged 37-60 yr, schedule for abdominal total hysterectomy under spinal anesthesia, were studi...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199606000-00016

    authors: Goyagi T,Nishikawa T

    更新日期:1996-06-01 00:00:00

  • Pediatric Regional Anesthesia Network (PRAN): a multi-institutional study of the use and incidence of complications of pediatric regional anesthesia.

    abstract:BACKGROUND:Regional anesthesia is increasingly used in pediatric patients to provide postoperative analgesia and to supplement intraoperative anesthesia. The Pediatric Regional Anesthesia Network was formed to obtain highly audited data on practice patterns and complications and to facilitate collaborative research in ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,多中心研究

    doi:10.1213/ANE.0b013e31825d9f4b

    authors: Polaner DM,Taenzer AH,Walker BJ,Bosenberg A,Krane EJ,Suresh S,Wolf C,Martin LD

    更新日期:2012-12-01 00:00:00

  • Errors and omissions in anesthesia: a pilot study using a pilot's checklist.

    abstract::There are recent concerns that anesthesiologists are becoming less skilled in providing general anesthesia for Cesarean delivery. We considered whether a verbal checklist would help in the preparation for this event. We created a list of items to be checked when preparing to administer general anesthesia for a Cesarea...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ANE.0000156567.24800.0B

    authors: Hart EM,Owen H

    更新日期:2005-07-01 00:00:00

  • The pain visual analog scale: is it linear or nonlinear?

    abstract:UNLABELLED:The visual analog scale (VAS) is a tool widely used to measure pain, yet controversy surrounds whether the VAS score is ratio or ordinal data. We studied 52 postoperative patients and measured their pain intensity using the VAS. We then asked them to consider different amounts of pain (conceptually twice as ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000539-199912000-00038

    authors: Myles PS,Troedel S,Boquest M,Reeves M

    更新日期:1999-12-01 00:00:00

  • A comparison of the INVOS 4100 and the NIRO 300 near-infrared spectrophotometers.

    abstract:UNLABELLED:We determined whether two different devices for measuring near-infrared spectroscopy (NIRS)---the INVOS 4100 and the NIRO 300---produce similar cerebral oxygenation data during the CO(2) challenge test. Nineteen patients anesthetized with sevoflurane, 67% nitrous oxide in oxygen, and fentanyl were studied. A...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200203000-00020

    authors: Yoshitani K,Kawaguchi M,Tatsumi K,Kitaguchi K,Furuya H

    更新日期:2002-03-01 00:00:00

  • Somatosensory evoked potential quantification of ulnar nerve blockade.

    abstract::We investigated the appropriateness of the somatosensory evoked potentials (SSEPs) as an objective monitor of sensory blockade of the ulnar nerve by comparing the effects of saline and lidocaine infiltration of the ulnar nerve at the elbow, with and without epinephrine. The four treatments were administered in random ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Benzon HT,Toleikis JR,Shanks C,Ramseur A,Sloan T

    更新日期:1986-08-01 00:00:00

  • Venodilation contributes to propofol-mediated hypotension in humans.

    abstract::The present investigation explored the possibility that the commonly observed hypotension that occurs during induction of anesthesia with propofol might be related to its ability to produce venodilation. Thirty-six ASA I and II patients who received no premedication were studied. The first 20 patients were divided int...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/00000539-199206000-00017

    authors: Muzi M,Berens RA,Kampine JP,Ebert TJ

    更新日期:1992-06-01 00:00:00

  • Effects of augmenting cardiac contractility, preload, and heart rate on cardiac output during enflurane anesthesia.

    abstract::Changes in cardiac output in response to augmenting cardiac contractility, preload, and heart rate during enflurane anesthesia were examined in 12 open-chested dogs. Cardiac contractility was assessed by the slope of the end-systolic pressure-volume relation (Emax). Dobutamine (3, 6, and 9 micrograms.kg-1.min-1) was a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199111000-00014

    authors: Sato M,Hoka S,Arimura H,Ono K,Yoshitake J

    更新日期:1991-11-01 00:00:00

  • Propofol and thiopental in a 1:1 volume mixture is chemically stable.

    abstract:UNLABELLED:Propofol and thiopental have been used clinically in combination for induction of anesthesia. Studies suggest that this mixture has synergistic activity, recovery characteristics similar to propofol alone, and bactericidal effects on multiple organisms. It may therefore be both clinically useful and cost-eff...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199802000-00038

    authors: Lazar ER,Jolly DT,Tam YK,Hrazdil J,Tawfik SR,Clanachan AS

    更新日期:1998-02-01 00:00:00

  • Intravenous droperidol causes a reduction in the bispectral index in propofol-sedated patients during spinal anesthesia.

    abstract:UNLABELLED:We investigated the effect of IV droperidol on the bispectral index (BIS) in conscious and propofol-sedated patients during spinal anesthesia. Thirty minutes after the induction of spinal anesthesia, 20 patients were given 2 mg of droperidol IV without administration of other sedatives (conscious group). Ano...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/01.ane.0000048517.98692.53

    authors: Nakayama M,Kanaya N,Ichinose H,Yamamoto S,Namiki A

    更新日期:2003-03-01 00:00:00

  • The pulmonary absorption-excretion volume effect.

    abstract::An in-vitro experiment demonstrated the concentration effect of N2O (3% versus 75%) during elimination and during uptake. Other pulmonary absorption-excretion phenomena also occur simultaneously, as paired events during uptake and then during elimination:diffusion hyperoxia and diffusion anoxia; alveolar concentration...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-197601000-00013

    authors: Rackow H,Salanitre E

    更新日期:1976-01-01 00:00:00

  • The use of metoprolol and glycopyrrolate to prevent hypotensive/bradycardic events during shoulder arthroscopy in the sitting position under interscalene block.

    abstract:UNLABELLED:Sudden profound hypotensive and/or bradycardic events (HBE) have been reported in >20% of patients undergoing shoulder arthroscopy in the sitting position under interscalene block anesthesia. Retrospective studies suggest that the administration of beta-blockers is safe and may decrease the incidence of thes...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199812000-00020

    authors: Liguori GA,Kahn RL,Gordon J,Gordon MA,Urban MK

    更新日期:1998-12-01 00:00:00

  • A comparison of the antinociceptive and behavioral effects of intrathecally administered opiates, alpha-2-adrenergic agonists, and local anesthetics in mice and rats.

    abstract::This study was undertaken to compare the antinociceptive and behavioral effects of intrathecally administered opiates, alpha-2-adrenergic agonists, and local anesthetics injected by lumbar puncture in the mouse and rat. Antinociception was determined by observing the response to a clamp applied to the tail (Haffner te...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Ossipov MH,Suarez LJ,Spaulding TC

    更新日期:1988-07-01 00:00:00