Intravenous droperidol causes a reduction in the bispectral index in propofol-sedated patients during spinal anesthesia.

Abstract:

UNLABELLED:We investigated the effect of IV droperidol on the bispectral index (BIS) in conscious and propofol-sedated patients during spinal anesthesia. Thirty minutes after the induction of spinal anesthesia, 20 patients were given 2 mg of droperidol IV without administration of other sedatives (conscious group). Another group of patients were sedated with a propofol infusion to maintain BIS at 60 +/- 5 and were administered IV saline (placebo group; n = 20), droperidol 1 mg (dro-1 group; n = 20), or droperidol 2 mg (dro-2 group; n = 20) in a randomized order and in a double-blinded fashion. Although BIS remained the same in the conscious and placebo groups, it significantly decreased after administration of droperidol in the dro-1 and dro-2 groups. The decrease in BIS was significantly larger in the dro-2 group than in the dro-1 group. These results suggest that an antiemetic dose of droperidol enhances the hypnotic effect of propofol in a dose-dependent manner during spinal anesthesia. IMPLICATIONS:An antiemetic dose of IV droperidol causes a decrease in the bispectral index in patients sedated with propofol during spinal anesthesia. We conclude that droperidol may enhance the hypnotic effect of propofol.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Nakayama M,Kanaya N,Ichinose H,Yamamoto S,Namiki A

doi

10.1213/01.ane.0000048517.98692.53

subject

Has Abstract

pub_date

2003-03-01 00:00:00

pages

765-8, table of contents

issue

3

eissn

0003-2999

issn

1526-7598

journal_volume

96

pub_type

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