Epidural morphine for the relief of postoperative pain after cesarean delivery.

Abstract:

:To determine the safety, efficacy, and dose response of epidurally administered morphine for analgesia after cesarean delivery, 40 healthy women who underwent cesarean delivery with epidural anesthesia were randomly assigned to receive one of four regimens for relief of postoperative pain: intramuscular administration of morphine, 7.5 mg (N = 10); or epidural administration of morphine, 2 mg (N = 10), 5 mg (N = 10), or 7.5 mg (N = 10). Evaluations were made of intensity and relief of pain, time to administration of additional analgesic medications, changes in vital signs and blood-gas tensions, and adverse effects. Intramuscular administration of 7.5 mg of morphine effectively relieved pain for only a short time. When morphine was administered epidurally, 2 mg proved ineffective whereas both 5 mg and 7.5 mg provided substantial pain relief for approximately 24 h. There were no significant changes in vital signs or blood-gas tensions. Side effects included pruritus and nausea, which occurred frequently but were usually mild and easily treated. We concluded that either 5 mg or 7.5 mg of morphine epidurally administered was effective and safe in providing prolonged analgesia after cesarean delivery.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Rosen MA,Hughes SC,Shnider SM,Abboud TK,Norton M,Dailey PA,Curtis JD

subject

Has Abstract

pub_date

1983-07-01 00:00:00

pages

666-72

issue

7

eissn

0003-2999

issn

1526-7598

journal_volume

62

pub_type

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