Population pharmacokinetics of dexmedetomidine in infants after open heart surgery.

abstract：:Animal studies suggest that increased circulating estrogen and progesterone, and activation of the endorphin system cause prenancy-induced antinociceptive effects. Human studies have provided inconsistent results and have often lacked a nonpregnant control group. In this study, we compared sensitivity to experimental ...

journal_title：Anesthesia and analgesia

authors： Carvalho B,Angst MS,Fuller AJ,Lin E,Mathusamy AD,Riley ET

更新日期：2006-11-01 00:00:00

abstract：:Dr. Paul Janssen was the founder of Janssen Pharmaceutica and the developer of over 80 pharmaceutical compounds that proved useful in human, botanical, and veterinary medicine. He and his coworkers synthesized the fentanyl family of drugs, many other potent analgesics, droperidol, etomidate, and numerous other importa...

journal_title：Anesthesia and analgesia

authors： Stanley TH,Egan TD,Van Aken H

更新日期：2008-02-01 00:00:00

abstract：IMPLICATIONS:Complications of IV mannitol administration resulting in compartment syndrome may warrant surgical intervention. Compartment syndrome is difficult to diagnose in the anesthetized patient. Infusing mannitol in an observed IV site permits discontinuation of mannitol before complications ensue. Early recognit...

journal_title：Anesthesia and analgesia

authors： Edwards JJ,Samuels D,Fu ES

更新日期：2003-01-01 00:00:00

abstract：:Tramadol analgesia results from a monoaminergic effect by tramadol itself and an opioid effect of its metabolite (+)-M1 formed by O-demethylation of tramadol by CYP2D6. In this study we sought to determine the impact of (+)-M1 on the analgesic effect of tramadol evaluated by experimental pain models. The effect of an ...

journal_title：Anesthesia and analgesia

authors： Enggaard TP,Poulsen L,Arendt-Nielsen L,Brøsen K,Ossig J,Sindrup SH

更新日期：2006-01-01 00:00:00

abstract：:It is not known how sevoflurane affects the cardiac conduction system. We compared the effects of halothane, isoflurance, and sevoflurane on specialized atrioventricular (AV) conduction times in eight pentobarbital-anesthetized dogs. AV conduction times with three inhaled anesthetics at end-tidal concentrations of 1 a...

journal_title：Anesthesia and analgesia

authors： Nakaigawa Y,Akazawa S,Shimizu R,Ishii R,Yamato R

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND:A predictive model that can identify patients who are at an increased risk for prolonged postanesthesia care unit (PACU) stay could help optimize resource utilization and case sequencing. Although previous studies identified some predictors, there is not a model that only utilizes various patients demographi...

journal_title：Anesthesia and analgesia

authors： Gabriel RA,Waterman RS,Kim J,Ohno-Machado L

更新日期：2017-05-01 00:00:00

abstract：UNLABELLED:We examined the reliability of an airway evaluation test to assess the occipitoatlantoaxial (OAA) extension capacity described by Bellhouse et al. (Bellhouse test) in 20 adult volunteers with normal cervical spines. Each subject sat upright with the head in the neutral position and was then asked to extend t...

journal_title：Anesthesia and analgesia

authors： Urakami Y,Takenaka I,Nakamura M,Fukuyama H,Aoyama K,Kadoya T

更新日期：2002-11-01 00:00:00

abstract：:The effects of anesthetics on intracranial pressure (ICP) may be different in preterm neonates than in adults because the neonate's cranial sutures are not yet fused. The authors monitored changes in anterior fontanel pressure (AFP), a noninvasive indicator of ICP, during anesthesia in 44 preterm neonates without neur...

journal_title：Anesthesia and analgesia

authors： Friesen RH,Thieme RE,Honda AT,Morrison JE Jr

更新日期：1987-05-01 00:00:00

abstract：UNLABELLED:The purpose of our study was to investigate the effects of sodium nitroprusside-induced hypotension on splanchnic perfusion and hepatocellular integrity. Thirty patients undergoing radical prostatectomy were allocated randomly to a sodium nitroprusside (SNP) or control group (control). Regional pco2 was meas...

journal_title：Anesthesia and analgesia

authors： Suttner SW,Boldt J,Schmidt CC,Piper SN,Schuster P,Kumle B

更新日期：1999-12-01 00:00:00

abstract：:We measured the pharmacokinetics of hydromorphone in normal volunteers given three doses of the drug (10, 20, and 40 micrograms/kg) as intravenous 45-s injections on different days. Concentrations of hydromorphone in plasma from serial blood samples were measured by a high-performance liquid chromatography method spec...

journal_title：Anesthesia and analgesia

authors： Hill HF,Coda BA,Tanaka A,Schaffer R

更新日期：1991-03-01 00:00:00

abstract：:Calciphylaxis is a small-vessel disease associated with renal failure. Here, we report the management of a 43-yr-old man with calciphylaxis who received left lower leg amputation with prostaglandin E(1) (PGE(1)) under monitoring by laser Doppler blood flowmetry in the left second and third fingers. Anesthesia was indu...

journal_title：Anesthesia and analgesia

authors： Horishita T,Minami K,Ogata J,Sata T

更新日期：2004-08-01 00:00:00

abstract：:Only 1 in about 110 sex acts results in a conception and 1 in 270 in a live birth. Of all conceptions, 40% result in live births, 5% in stillbirths, and 55% never develop. 1/3 of all known conceptions ends in abortion, spontaneous or induced. It appears that the population problem depends on a small fraction of the...

journal_title：Anesthesia and analgesia

authors： Berelson B

更新日期：1971-07-01 00:00:00

abstract：BACKGROUND:The American Society of Anesthesiologists has announced that perioperative normothermia is a "Quality Incentive in Anesthesiology." We examined whether we could meet this quality incentive in a simple population: patients undergoing anesthesia for electroconvulsive therapy (ECT). METHODS:We compared infrare...

journal_title：Anesthesia and analgesia

authors： Modell JH,Gravenstein N,Morey TE

更新日期：2008-11-01 00:00:00

abstract：UNLABELLED:The purpose of this study was to investigate whether propofol protects rat hepatocyte suspensions against an oxidant attack by a free radical generator 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH). Rat hepatocyte suspensions (2 x 10(6) cells/mL) were prepared using Seglen's collagenase perfusion tec...

journal_title：Anesthesia and analgesia

authors： Navapurkar VU,Skepper JN,Jones JG,Menon DK

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Obstructive sleep apnea (OSA) is a commonly encountered comorbid condition in patients undergoing surgery and is associated with a greater risk of postoperative adverse events. Our objective in this review was to investigate the effectiveness of continuous positive airway pressure (CPAP) in reducing the risk...

journal_title：Anesthesia and analgesia

authors： Nagappa M,Mokhlesi B,Wong J,Wong DT,Kaw R,Chung F

更新日期：2015-05-01 00:00:00

abstract：:The cold pressor test is often used to assess vasoconstrictive responses because it simulates the vasoconstrictive challenges commonly encountered in the clinical setting. With IRB approval, 12 healthy volunteers, aged 25--50 yr, underwent baseline plethysmographic monitoring on the finger and ear. The contralateral h...

journal_title：Anesthesia and analgesia

authors： Awad AA,Ghobashy MA,Ouda W,Stout RG,Silverman DG,Shelley KH

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:N-methyl-D-aspartate receptor (NMDARs)-dependent central sensitization plays an important role in cancer pain. Binding of NMDAR subunit 2B (NR2B) by postsynaptic density protein-95 (PSD-95) can couple NMDAR activity to intracellular enzymes, such as neuronal nitric oxide synthase (nNOS), facilitate downstrea...

journal_title：Anesthesia and analgesia

authors： Liu Y,Cui X,Sun YE,Yang X,Ni K,Zhou Y,Ma Z,Gu X

更新日期：2014-06-01 00:00:00

abstract：UNLABELLED:Obese surgical patients are typically considered to be more likely than lean patients to possess high-volume and low-pH (HVLP) gastric contents after a standard preoperative fast, based on a study of a population predominately consisting of patients receiving intramuscular preoperative sedation. We revisited...

journal_title：Anesthesia and analgesia

authors： Harter RL,Kelly WB,Kramer MG,Perez CE,Dzwonczyk RR

更新日期：1998-01-01 00:00:00

abstract：:Alfentanil causes cardiac stimulation or depression in intact animals and in clinical practice; there is no information concerning its direct effects on the heart. Therefore, we studied the effects of alfentanil on isolated cardiac tissues from young adult rabbits. The right atrium with sinoatrial node (SA node) was b...

journal_title：Anesthesia and analgesia

authors： Zhang CC,Su JY,Calkins D

更新日期：1990-09-01 00:00:00

abstract：:We investigated the usefulness of peripheral flow index (PFI) measurement using a standard pulse oximetry digit probe for early prediction of successful regional blocks. Sixty-six patients scheduled for limb surgery underwent either axillary or sciatic block using a nerve stimulator technique with mepivacaine 1.5%. PF...

journal_title：Anesthesia and analgesia

authors： Galvin EM,Niehof S,Verbrugge SJ,Maissan I,Jahn A,Klein J,van Bommel J

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Vital sign monitors and ventilator/anesthesia workstations are equipped with multiple alarms to improve patient safety. A high number of false alarms can lead to a "crying wolf" phenomenon with consecutively ignored critical situations. Systematic data on alarm patterns and density in the perioperative phase...

journal_title：Anesthesia and analgesia

authors： Schmid F,Goepfert MS,Kuhnt D,Eichhorn V,Diedrichs S,Reichenspurner H,Goetz AE,Reuter DA

更新日期：2011-01-01 00:00:00

abstract：:In in vitro pharmacological experiments, determination of effective concentration values for various anesthetics depends on understanding the exact concentration of the drugs dissolved in physiological solutions. Actual anesthetic concentration may differ from expectations because of drug adsorption, absorption or oth...

journal_title：Anesthesia and analgesia

authors： Suzuki T,Uchida I,Mashimo T

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:Performing key actions efficiently during crises can determine clinical outcomes, yet even expert clinicians omit key actions. Simulation-based studies of crises show that correct performance of key actions dramatically increases when emergency manuals (EMs) are used. Despite widespread dissemination of EMs,...

journal_title：Anesthesia and analgesia

authors： Goldhaber-Fiebert SN,Bereknyei Merrell S,Agarwala AV,De La Cruz MM,Cooper JB,Howard SK,Asch SM,Gaba DM

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:We determined the sensitivity of motor responses evoked by stimulating catheters in determining catheter-nerve contact using ultrasonography as reference. METHODS:Femoral nerves were contacted using stimulating catheters under ultrasonography scanning in 25 patients. The output current was increased from it...

journal_title：Anesthesia and analgesia

authors： Altermatt FR,Corvetto MA,Venegas C,Echevarría G,Bravo P,De la Cuadra JC,Irribarra LA

更新日期：2011-11-01 00:00:00

abstract：:Adrenomedullin is a potent vasodilatory peptide. Plasma adrenomedullin (AM) concentrations increase during and after cardiopulmonary bypass (CPB). However, the cause of this increase and its site of production have not been identified. We investigated the role of the hepatosplanchnic and cerebral circulations in the i...

journal_title：Anesthesia and analgesia

authors： Yoshikawa D,Kawahara F,Okano N,Hiraoka H,Kadoi Y,Fujita N,Morita T,Goto F

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:Unicondylar knee arthroplasty (UKA) is a commonly performed procedure with significant expected postoperative pain. Peripheral nerve blocks are 1 analgesic option, but some approaches may decrease quadriceps motor strength and interfere with early ambulation. In this study, we compared the analgesia provided...

journal_title：Anesthesia and analgesia

authors： Henshaw DS,Jaffe JD,Reynolds JW,Dobson S,Russell GB,Weller RS

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Various different interventions can be used to reduce surgical blood loss; however, there is no "gold standard" for accurately measuring the volume of perioperative blood loss, and this makes it difficult to assess the efficacy of these interventions. METHODS:We used data from a previous multicenter double-...

journal_title：Anesthesia and analgesia

authors： Lopez-Picado A,Albinarrate A,Barrachina B

更新日期：2017-07-01 00:00:00

abstract：:The aim of this study was to determine the need for supplemental oxygen during recovery from general anesthesia for ambulatory surgery in healthy women without obesity or respiratory disease. Arterial oxygen saturation by pulse oximetry (SpO2) was monitored throughout the first postoperative hour in 164 patients. The ...

journal_title：Anesthesia and analgesia

authors： Murray RS,Raemer DB,Morris RW

更新日期：1988-10-01 00:00:00

abstract：UNLABELLED:Sameridine is a new compound with local anesthetic and analgesic properties when injected intrathecally. We studied the anesthetic and analgesic efficacy of three doses of isobaric sameridine (15, 20, and 23 mg) compared with 100 mg of hyperbaric lidocaine for spinal anesthesia in 140 healthy male patients u...

journal_title：Anesthesia and analgesia

authors： Mulroy MF,Greengrass R,Ganapathy S,Chan V,Heierson A

更新日期：1999-04-01 00:00:00

abstract：UNLABELLED:We examined the effects of two perioperative pain management techniques on recovery after laparotomy, as assessed by body weight (BW) and food consumption (FC). All rats received a preoperative intrathecal mixture of morphine plus bupivacaine combined with one of two treatments: (a) injection of slow-release...

journal_title：Anesthesia and analgesia

authors： Shavit Y,Fish G,Wolf G,Mayburd E,Meerson Y,Yirmiya R,Beilin B

更新日期：2005-10-01 00:00:00