Experimental heat pain for detecting pregnancy-induced analgesia in humans.

Abstract:

:Animal studies suggest that increased circulating estrogen and progesterone, and activation of the endorphin system cause prenancy-induced antinociceptive effects. Human studies have provided inconsistent results and have often lacked a nonpregnant control group. In this study, we compared sensitivity to experimental heat and cold pain in pregnant and nonpregnant women. Nineteen healthy nonpregnant female volunteers and 20 pregnant women at term were enrolled. Pain threshold and tolerance were examined using experimental heat-induced pain and cold pressor pain models. Subjects were evaluated pre- and 1-2 days post-delivery (pregnant), or on consecutive days (nonpregnant). Heat pain tolerance was significantly increased in the pregnant women during pre and postdelivery when compared with nonpregnant controls (50.0 +/- 1.0 vs 49.0 +/- 1.2 and 50.1 +/- 0.7 vs 49.2 +/- 1.2 degrees C; mean +/- sd). However, pain induced by the cold pressor test was endured for a similar amount of time by both study groups. Pregnancy-induced analgesic effects at term can be detected in a model of experimental heat pain. These effects persist during the first 24-48 h after delivery. Experimental heat pain is a suitable modality for further characterizing the phenomenon of pregnancy-induced analgesia in humans.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Carvalho B,Angst MS,Fuller AJ,Lin E,Mathusamy AD,Riley ET

doi

10.1213/01.ane.0000239224.48719.28

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

1283-7

issue

5

eissn

0003-2999

issn

1526-7598

pii

103/5/1283

journal_volume

103

pub_type

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