Vasodilation from sufentanil in humans.

Abstract:

:Sufentanil is a potent opioid that occasionally has been associated with hypotension. The mechanism behind this hypotension is unclear. We hypothesized that sufentanil had a direct effect on vascular smooth muscle to cause vasodilation. Sufentanil was infused into the brachial artery of 10 young, healthy volunteers at rates of 0.083, 0.167, 0.333, and 0.833 microg/min. Forearm blood flow was measured in both the experimental and control arms with venous occlusion plethysmography. The forearm blood flow in the infused arm increased in a dose-dependent fashion from 3.2 to 5.2 mL/min per 100 mL of tissue whereas simultaneous measurements in the control (non-infused) arm did not increase. Heart rate and mean arterial blood pressure were unchanged during the infusions. Furthermore, respiratory rate did not change at any infusion level and sedation did not occur. Thus, the data support that significant systemic "spillover" of sufentanil did not occur. We conclude that sufentanil has a direct, vasodilatory effect on human vascular tissue that is likely independent of a neurogenic or systemic mechanism.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Ebert TJ,Ficke DJ,Arain SR,Holtz MN,Shankar H

doi

10.1213/01.ANE.0000184119.85400.0E

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

1677-80

issue

6

eissn

0003-2999

issn

1526-7598

pii

101/6/1677

journal_volume

101

pub_type

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