The effects of paracetamol and parecoxib on kidney function in elderly patients undergoing orthopedic surgery.

Abstract:

:The common adverse effects of traditional nonsteroidal antiinflammatory drugs on renal function include reductions in renal blood flow, glomerular filtration rate, and sodium and potassium excretion, mainly via inhibition of renal cyclooxygenase. We designed the present study to determine the effects of IV paracetamol or parecoxib on renal function in elderly patients undergoing orthopedic surgery. Seventy-five patients (76 +/- 8 yr, mean +/- sd) undergoing hip replacement or surgery of the femoral shaft completed this randomized and placebo-controlled study. After their arrival in the postanesthesia care unit, patients received an initial dose of the study medication, paracetamol 1000 mg IV (n = 25), parecoxib 40 mg IV (n = 25), or saline IV (n = 25); subsequent doses were administered for the next 3 days. Opioids were provided as rescue medication. Blood and urine samples were collected before and after surgery, and markers of renal function were determined. During the first 2 h after the initial dose of parecoxib, creatinine clearance was slightly diminished (125 +/- 83 to 86 +/- 45 mL/min, P < 0.05), whereas no significant decrease of creatinine clearance was observed in the placebo and paracetamol groups. After all treatments, sodium and potassium excretion as well as urine albumin and alpha-1-microglobulin were transiently increased (group differences: not signicifant). In conclusion, glomerular and tubular functions were transiently affected in all patients after orthopedic surgery; however, the differences between the treatment groups were small and not clinically relevant. Further studies are warranted to determine adverse renal effects of longer-lasting therapy with these drugs, especially in patients with renal impairment or concomitant diseases.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Koppert W,Frötsch K,Huzurudin N,Böswald W,Griessinger N,Weisbach V,Schmieder RE,Schüttler J

doi

10.1213/01.ane.0000244324.87947.29

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

1170-6

issue

5

eissn

0003-2999

issn

1526-7598

pii

103/5/1170

journal_volume

103

pub_type

杂志文章,随机对照试验
  • Prevalence and characteristics of pain induced by percutaneous liver biopsy.

    abstract:UNLABELLED:Percutaneous needle liver biopsy is an important procedure for the diagnosis and evaluation of liver disease and is frequently associated with pain. In this prospective study, we investigated the prevalence and characteristics of this pain syndrome. Fifty-four subjects, who underwent liver biopsy under ultra...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1213/01.ane.0000060453.74744.17

    authors: Eisenberg E,Konopniki M,Veitsman E,Kramskay R,Gaitini D,Baruch Y

    更新日期:2003-05-01 00:00:00

  • Propofol anesthesia for children undergoing magnetic resonance imaging: a comparison with isoflurane, nitrous oxide, and a laryngeal mask airway.

    abstract:BACKGROUND:Both propofol infusions with oxygen delivered through nasal cannula and isoflurane/N2O (nitrous oxide) delivered via a laryngeal mask airway (LMA) are used to provide anesthesia for children undergoing magnetic resonance imaging scans. We compared the incidence of adverse events and perioperative physiologic...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0000000000000504

    authors: Heard C,Harutunians M,Houck J,Joshi P,Johnson K,Lerman J

    更新日期:2015-01-01 00:00:00

  • A comparison between meperidine, clonidine and urapidil in the treatment of postanesthetic shivering.

    abstract:UNLABELLED:Postanesthetic shivering can be treated with many types of drugs. We compared the effects of meperidine, clonidine, and urapidil on postanesthetic shivering. Sixty patients shivering during recovery from general anesthesia were treated in a randomized, double-blinded fashion with 25 mg meperidine IV, 0.15 mg...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-200101000-00051

    authors: Schwarzkopf KR,Hoff H,Hartmann M,Fritz HG

    更新日期:2001-01-01 00:00:00

  • Dolasetron for preventing postanesthetic shivering.

    abstract:UNLABELLED:We designed this study to assess the efficacy of dolasetron compared with clonidine and placebo in prophylaxis of postanesthetic shivering. We included 90 patients undergoing elective abdominal or urologic surgery. The patients were randomly assigned to one three groups (each group n = 30) using a double-bli...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验,收录出版

    doi:10.1097/00000539-200201000-00020

    authors: Piper SN,Röhm KD,Maleck WH,Fent MT,Suttner SW,Boldt J

    更新日期:2002-01-01 00:00:00

  • The effect of fentanyl on arginine vasopressin and cortisol secretion during anesthesia.

    abstract::The effects of nitrous oxide-oxygen plus small doses of fentanyl with (N = 7) and without (N = 15) naloxone and the effects of nitrous oxide-oxygen plus halothane (N = 13) on plasma concentration of arginine vasopressin (AVP) and cortisol were studied in normal patients before and during gynecologic laparotomies. Pati...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Lehtinen AM,Fyhrquist F,Kivalo I

    更新日期:1984-01-01 00:00:00

  • A New Approach to Pathogen Containment in the Operating Room: Sheathing the Laryngoscope After Intubation.

    abstract:BACKGROUND:Anesthesiologists may contribute to postoperative infections by means of the transmission of blood and pathogens to the patient and the environment in the operating room (OR). Our primary aims were to determine whether contamination of the IV hub, the anesthesia work area, and the patient could be reduced af...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0000000000000854

    authors: Birnbach DJ,Rosen LF,Fitzpatrick M,Carling P,Arheart KL,Munoz-Price LS

    更新日期:2015-11-01 00:00:00

  • The influences of maternal albumin concentrations on the placental transfer of propofol in human dually perfused cotyledon in vitro.

    abstract:IMPLICATIONS:These results indicate that fetal exposure to propofol can vary considerably depending on maternal plasma albumin concentration. A fractional change in the maternal protein binding of propofol can result in a relatively large difference in fetal exposure. ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200205000-00048

    authors: He YL,Seno H,Sasaki K,Tashiro C

    更新日期:2002-05-01 00:00:00

  • Preincisional dextromethorphan treatment decreases postoperative pain and opioid requirement after laparoscopic cholecystectomy.

    abstract:UNLABELLED:In the present study, we examined whether preincisional treatment with dextromethorphan (DM) provides preemptive analgesia. Ninety patients scheduled for laparoscopic cholecystectomy were included. Patients receiving chlorpheniramine maleate (CPM) 20 mg via an IM injection 30 min before skin incision were de...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199906000-00025

    authors: Wu CT,Yu JC,Yeh CC,Liu ST,Li CY,Ho ST,Wong CS

    更新日期:1999-06-01 00:00:00

  • Arterial carbon dioxide markedly increases during diagnostic laparoscopy in portal hypertensive children.

    abstract:UNLABELLED:Several factors are responsible for hypercarbia during laparoscopic procedures. This study was undertaken because we observed a sudden increase in PaCO(2) in children with portal hypertension (PHT), which was unusual in healthy children undergoing laparoscopic procedures. Fifty-seven children underwent lapar...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000539-200211000-00022

    authors: Bozkurt P,Kaya G,Yeker Y,Sarimurat N,Yesildag E,Tekant G,Emir H,Senyuz OF

    更新日期:2002-11-01 00:00:00

  • A Perioperative Evaluation of Respiratory Mechanics Using the Forced Oscillation Technique.

    abstract:BACKGROUND:The forced oscillation technique is a new approach for assessing perioperative respiratory function. METHODS:This study enrolled 40 patients undergoing general anesthesia: 20 for ≥2 hours and 20 for <2 hours. Respiratory parameters were measured the day before and after surgery using forced oscillation duri...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000000720

    authors: Kuzukawa Y,Nakahira J,Sawai T,Minami T

    更新日期:2015-11-01 00:00:00

  • Evolution of the French public's knowledge and attitudes regarding postoperative pain, cancer pain, and their treatments: two national surveys over a six-year period.

    abstract:UNLABELLED:Pain management has become a notable feature of public health policy and mass media communication in France over the past few years. To assess the evolution of the knowledge and attitudes of the French population with respect to pain management and morphine use, telephone surveys using similar questionnaires...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199909000-00023

    authors: Larue F,Fontaine A,Brasseur L

    更新日期:1999-09-01 00:00:00

  • A Novel Approach for the Control of Inflammatory Pain: Prostaglandin E2 Complexation by Randomly Methylated β-Cyclodextrins.

    abstract:BACKGROUND:Inhibitors of cyclooxygenase, which block the formation of prostaglandin (PG) E2, are the standard treatment of inflammatory pain. These drugs, however, have serious gastrointestinal, renal, and cardiovascular side effects that limit their clinical use. Cyclodextrins are neutral glucose oligomers that form a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000001674

    authors: Sauer RS,Rittner HL,Roewer N,Sohajda T,Shityakov S,Brack A,Broscheit JA

    更新日期:2017-02-01 00:00:00

  • Adenosine-induced flow arrest to facilitate intracranial aneurysm clip ligation does not worsen neurologic outcome.

    abstract:BACKGROUND:When temporary arterial occlusion of the parent artery is difficult for anatomical reasons, or when inadvertent aneurysmal rupture occurs during surgical dissection, adenosine administration can be used to produce flow arrest and brief, profound systemic hypotension that can facilitate intracranial aneurysm ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e3182a6d31b

    authors: Bebawy JF,Zeeni C,Sharma S,Kim ES,DeWood MS,Hemmer LB,Ramaiah VK,Bendok BR,Koht A,Gupta DK

    更新日期:2013-11-01 00:00:00

  • Effect of halothane and isoflurane on in situ diameter responses of small mesenteric veins to acute graded hypercapnia.

    abstract::The purpose of the present study was to quantify the inhibitory effect of inhaled halothane and isoflurane on acute hypercapnia-induced responses of capacitance-regulating veins and related cardiovascular variables in response to sequential 40-s periods of 5%, 10%, 15%, and 20% inspired CO2 (FICO2). Measurements were ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199602000-00024

    authors: Stekiel TA,Stekiel WJ,Tominaga M,Stadnicka A,Bosnjak ZJ,Kampine JP

    更新日期:1996-02-01 00:00:00

  • Designing meaningful industry metrics for clinical productivity for anesthesiology departments.

    abstract:IMPLICATIONS:Clinical productivity measurements that account for differences in clinical settings and concurrencies provided more precise comparisons between two anesthesiology groups. The data show that different concurrencies confound the current industry standard, "per full-time equivalent" measurements, whereas "pe...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200108000-00014

    authors: Abouleish AE,Prough DS,Zornow MH,Lockhart A,Abate JJ,Hughes J

    更新日期:2001-08-01 00:00:00

  • Modification of suction-induced hemolysis during cell salvage.

    abstract:BACKGROUND:The efficiency of red blood cell collection during cell salvage is dictated by multiple variables, including suction pressure. In this study, we attempted to determine the influence of suction pressure on the efficiency of cell salvage and to identify methods for minimizing the impact of suction on salvaged ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000255208.96685.2e

    authors: Waters JH,Williams B,Yazer MH,Kameneva MV

    更新日期:2007-03-01 00:00:00

  • Comparative maternal, fetal, and neonatal effects of chloroprocaine with and without epinephrine for epidural anesthesia in obstetrics.

    abstract::The effects of epidural chloroprocaine with and without 1:200,000 epinephrine during labor and delivery on uterine activity, progress of labor, fetal heart rate, maternal blood pressure, newborn Apgar scores, neonatal acid-base status, and the Neurologic and Adaptive Capacity Scoring System (NACS) were compared in 28 ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Abboud TK,DerSarkissian L,Terrasi J,Murakawa K,Zhu J,Longhitano M

    更新日期:1987-01-01 00:00:00

  • The frequency and magnitude of cerebrospinal fluid pulsations influence intrathecal drug distribution: key factors for interpatient variability.

    abstract:BACKGROUND:Intrathecal drug delivery is an efficient method to administer therapeutic molecules to the central nervous system. However, even with identical drug dosage and administration mode, the extent of drug distribution in vivo is highly variable and difficult to control. Different cerebrospinal fluid (CSF) pulsat...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e3182536211

    authors: Hsu Y,Hettiarachchi HD,Zhu DC,Linninger AA

    更新日期:2012-08-01 00:00:00

  • Pressure-heart rate relationship in intact and after stepwise elimination of three major baroreflex loops in dogs.

    abstract::Systemic arterial blood pressure (BP)-heart rate (HR) relationship (the pressor test) is often used as an index of baroreflex. We evaluated this index by simultaneously comparing BP-HR, right carotid sinus pressure (CSP)-nerve action potentials (NAP), and NAP-HR relationship in dogs anesthetized with pentobarbital. BP...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199611000-00012

    authors: Behnia R,Koushanpour E,Sinclair DM

    更新日期:1996-11-01 00:00:00

  • Sufentanil pharmacokinetics in pediatric cardiovascular patients.

    abstract::The pharmacokinetics of sufentanil were studied in 28 pediatric patients undergoing cardiovascular procedures. Patients were divided into four groups on the basis of age: neonates (0-1 month, n = 9), infants (1-24 months, n = 7), children (2-12 yr, n = 7), and adolescents (12-18 yr, n = 5). Sufentanil 10-15 micrograms...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Greeley WJ,de Bruijn NP,Davis DP

    更新日期:1987-11-01 00:00:00

  • Variable rate infusion of alfentanil as a supplement to nitrous oxide anesthesia for general surgery.

    abstract::In this study we attempted to define the minimal dosage of alfentanil (AF) needed in combination with nitrous oxide to provide satisfactory anesthetic conditions for lower abdominal gynecologic surgery. General anesthesia was induced in 12 women with AF (150 micrograms X kg-1) and 66% N2O in O2. An infusion of AF was ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Ausems ME,Hug CC Jr,de Lange S

    更新日期:1983-11-01 00:00:00

  • Society for Obstetric Anesthesia and Perinatology: Consensus Statement and Recommendations for Enhanced Recovery After Cesarean.

    abstract::The purpose of this article is to provide a summary of the Enhanced Recovery After Cesarean delivery (ERAC) protocol written by a Society for Obstetric Anesthesia and Perinatology (SOAP) committee and approved by the SOAP Board of Directors in May 2019. The goal of the consensus statement is to provide both practical ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000005257

    authors: Bollag L,Lim G,Sultan P,Habib AS,Landau R,Zakowski M,Tiouririne M,Bhambhani S,Carvalho B

    更新日期:2020-11-03 00:00:00

  • Oxygen metabolism during liver transplantation: the effect of dichloroacetate.

    abstract:UNLABELLED:Dichloroacetate (DCA) stimulates pyruvate dehydrogenase (PDH), accelerating recovery of the postischemic heart. Because DCA also stimulates hepatic PDH, it may facilitate graft recovery during liver transplantation (OLT). Hepatic removal and replacement during OLT produce major changes in O2 consumption (VO2...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199710000-00007

    authors: Shangraw RE,Robinson ST

    更新日期:1997-10-01 00:00:00

  • Bisulfite-containing propofol: is it a cost-effective alternative to Diprivan for induction of anesthesia?

    abstract:UNLABELLED:Propofol (Diprivan(TM); AstraZeneca, Wilmington, DE) is a commonly used drug for the induction of general anesthesia in the ambulatory setting. With the availability of a new bisulfite-containing generic formulation of propofol, questions have arisen regarding its cost effectiveness and safety compared with ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-200010000-00019

    authors: Shao X,Li H,White PF,Klein KW,Kulstad C,Owens A

    更新日期:2000-10-01 00:00:00

  • Changes in anterior fontanel pressure in preterm neonates receiving isoflurane, halothane, fentanyl, or ketamine.

    abstract::The effects of anesthetics on intracranial pressure (ICP) may be different in preterm neonates than in adults because the neonate's cranial sutures are not yet fused. The authors monitored changes in anterior fontanel pressure (AFP), a noninvasive indicator of ICP, during anesthesia in 44 preterm neonates without neur...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-198705000-00011

    authors: Friesen RH,Thieme RE,Honda AT,Morrison JE Jr

    更新日期:1987-05-01 00:00:00

  • Ropivacaine continuous wound infusion versus epidural morphine for postoperative analgesia after cesarean delivery: a randomized controlled trial.

    abstract:BACKGROUND:The infusion of local anesthetic in the surgical wound is helpful in the multimodal management of postoperative pain. We hypothesized that local anesthetic wound infusion after cesarean delivery would provide better pain control than epidural morphine analgesia. METHODS:Healthy, term women scheduled for ele...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0b013e3182368e87

    authors: O'Neill P,Duarte F,Ribeiro I,Centeno MJ,Moreira J

    更新日期:2012-01-01 00:00:00

  • Biotransformation of sevoflurane in dogs and rats.

    abstract::Sevoflurane, 3% and 4% in oxygen was administered to four dogs for 3 hours. Sevoflurane was metabolized to inorganic fluoride and hexafluoroisopropanol. Serum fluoride concentrations reached peak values during 2 to 3 hours into anesthesia and averaged 18.5 micrometer/L (n = 2) and 20.0 +/- 4.8 (mean +/- SD) micrometer...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Martis L,Lynch S,Napoli MD,Woods EF

    更新日期:1981-04-01 00:00:00

  • Controversies in the Postoperative Management of the Critically Ill Heart Transplant Patient.

    abstract::Heart transplant recipients are susceptible to a number of complications in the immediate postoperative period. Despite advances in surgical techniques, mechanical circulatory support (MCS), and immunosuppression, evidence supporting optimal management strategies of the critically ill transplant patient is lacking on ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0000000000004220

    authors: Shen T,Huh MH,Czer LS,Vaidya A,Esmailian F,Kobashigawa JA,Nurok M

    更新日期:2019-10-01 00:00:00

  • Brain sodium, potassium, and osmolality: effects on anesthetic requirement.

    abstract::We determined the effects of hyperkalemia, hypernatremia, hyperosmolality and hypo-osmolality on halothane requirement (MAC) in dogs. Hyperkalemia did not change cerebrospinal fluid potassium or MAC. Hypernatremia proportionately increased cerebrospinal fluid sodium and osmolality. MAC concomitantly increased 43%. Ser...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-197807000-00007

    authors: Tanifuji Y,Eger EI 2nd

    更新日期:1978-07-01 00:00:00

  • Synergy between pairs of competitive antagonists at adult human muscle acetylcholine receptors.

    abstract:BACKGROUND:Synergistic neuromuscular blocking effects have been observed clinically with certain pairs of nicotinic acetylcholine receptor (nAChR) competitive antagonists. The mechanism for synergy has not been elucidated. We tested the hypothesis that synergy arises from a differential selectivity of antagonists for t...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e31817b4469

    authors: Liu M,Dilger JP

    更新日期:2008-08-01 00:00:00