Brain sodium, potassium, and osmolality: effects on anesthetic requirement.

Abstract:

:We determined the effects of hyperkalemia, hypernatremia, hyperosmolality and hypo-osmolality on halothane requirement (MAC) in dogs. Hyperkalemia did not change cerebrospinal fluid potassium or MAC. Hypernatremia proportionately increased cerebrospinal fluid sodium and osmolality. MAC concomitantly increased 43%. Serum hyperosmolality achieved by administration of 12 and 25% dextrose increased cerebrospinal fluid osmolality without appreciably altering cerebrospinal fluid sodium or MAC. Infusion of 5% dextraose produced hypo-osmolality of blood and cerebrospinal fluid. Cerebrospinal fluid sodium was diluted and MAC was reduced by 24%.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Tanifuji Y,Eger EI 2nd

doi

10.1213/00000539-197807000-00007

subject

Has Abstract

pub_date

1978-07-01 00:00:00

pages

404-10

issue

4

eissn

0003-2999

issn

1526-7598

journal_volume

57

pub_type

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