The effects of perioperative pain management techniques on food consumption and body weight after laparotomy in rats.

Abstract:

UNLABELLED:We examined the effects of two perioperative pain management techniques on recovery after laparotomy, as assessed by body weight (BW) and food consumption (FC). All rats received a preoperative intrathecal mixture of morphine plus bupivacaine combined with one of two treatments: (a) injection of slow-release morphine at the end of the surgery or (b) an antiinflammatory drug, interleukin-1 receptor antagonist (IL-1ra), combined with the preoperative mixture. Laparotomy significantly decreased FC and BW. Both analgesic treatments resulted in a faster recovery of FC and BW. This beneficial effect was more pronounced in the group receiving preoperative analgesics combined with IL-1ra. IMPLICATIONS:Effective perioperative pain management can improve postoperative recovery. We studied the effects of two preoperative pain management techniques on recovery after laparotomy in rats. Both analgesic treatments resulted in a faster recovery, especially preoperative analgesics combined with interleukin-1 receptor antagonist.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Shavit Y,Fish G,Wolf G,Mayburd E,Meerson Y,Yirmiya R,Beilin B

doi

10.1213/01.ane.0000167771.98680.a7

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

1112-6, table of contents

issue

4

eissn

0003-2999

issn

1526-7598

pii

101/4/1112

journal_volume

101

pub_type

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