Multiple-dose evaluation of intravenous hydromorphone pharmacokinetics in normal human subjects.

abstract：BACKGROUND:Pain in sickle cell disease (SCD) is characterized by episodes of acute pain, primarily responsible for acute health care utilization, and persistent chronic pain. Pain severity and frequency vary significantly among patients with SCD. In this study, we investigated the possible contribution of monoamine gen...

journal_title：Anesthesia and analgesia

authors： Jhun E,He Y,Yao Y,Molokie RE,Wilkie DJ,Wang ZJ

更新日期：2014-11-01 00:00:00

abstract：:We investigated the appropriateness of the somatosensory evoked potentials (SSEPs) as an objective monitor of sensory blockade of the ulnar nerve by comparing the effects of saline and lidocaine infiltration of the ulnar nerve at the elbow, with and without epinephrine. The four treatments were administered in random ...

journal_title：Anesthesia and analgesia

authors： Benzon HT,Toleikis JR,Shanks C,Ramseur A,Sloan T

更新日期：1986-08-01 00:00:00

abstract：BACKGROUND:To prevent reflex-induced bronchoconstriction in patients with asthma, local anesthetics are commonly administered by aerosol or IV as adjunct medication. Lidocaine attenuates responsiveness to a neurally active stimulus that increases tone, but there is scant information about the effect of lidocaine on bas...

journal_title：Anesthesia and analgesia

authors： Chang HY,Togias A,Brown RH

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Many of the complications of mechanical ventilation are related to inappropriate endotracheal tube (ETT) cuff pressure. The aim of the current study was to evaluate the effectiveness of automatic cuff pressure closed-loop control in patients under prolonged intubation, where presence of carbon dioxide (CO2) ...

journal_title：Anesthesia and analgesia

authors： Efrati S,Bolotin G,Levi L,Zaaroor M,Guralnik L,Weksler N,Levinger U,Soroksky A,Denman WT,Gurman GM

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Cerebral cholinergic transmission plays a key role in cognitive function, and anticholinergic drugs administered during the perioperative phase are a hypothetical cause of postoperative cognitive dysfunction (POCD). We hypothesized that a perioperative increase in serum anticholinergic activity (SAA) is asso...

journal_title：Anesthesia and analgesia

authors： Rossi A,Burkhart C,Dell-Kuster S,Pollock BG,Strebel SP,Monsch AU,Kern C,Steiner LA

更新日期：2014-10-01 00:00:00

abstract：:We previously reported that in rats with closed head trauma (CHT), intravenous (IV) administration of 0.25 mL/g of 5% dextrose solution (D5W) increased blood glucose (G), decreased blood sodium (Na), caused no change in blood osmolality (Osm), increased brain edema (BE), and worsened neurological severity score (NSS) ...

journal_title：Anesthesia and analgesia

authors： Gurevich B,Talmor D,Artru AA,Katcko L,Geva D,Gurman G,Shapira Y

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND:Lidocaine is used clinically for tactile allodynia associated with diabetes-induced neuropathy. Although the analgesic effect of lidocaine through suppression of microglial activation has been implicated in the development of injury-induced neuropathic pain, its mechanism of action in diabetes-induced tactil...

journal_title：Anesthesia and analgesia

authors： Suzuki N,Hasegawa-Moriyama M,Takahashi Y,Kamikubo Y,Sakurai T,Inada E

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Patients with bone marrow failure and severe thrombocytopenia are frequently given prophylactic platelet transfusion before interventions. The clinical effects of such transfusions, however, are poorly defined. We performed a prospective observational study on patients with bone marrow failure scheduled for ...

journal_title：Anesthesia and analgesia

authors： Kander T,Tanaka KA,Norström E,Persson J,Schött U

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Statins have been shown to possess antiinflammatory and immunomodulatory effects. In this study, we sought to determine if preoperative statin therapy is associated with a reduced frequency of postoperative acute respiratory distress syndrome (ARDS) in surgical populations at increased risk of developing ARD...

journal_title：Anesthesia and analgesia

authors： Yadav H,Lingineni RK,Slivinski EJ,Stockler KA,Subramanian A,Oderich GS,Wigle DA,Carter RE,Kor DJ

更新日期：2014-10-01 00:00:00

abstract：:The hemodynamic effects of high-dose hydromorphone hydrochloride (H), 1.25 mg/kg, were investigated in 10 patients with normal ventricular function undergoing coronary artery bypass graft (CABG) surgery. One patient with unstable angina was excluded from the study because of hypotension and facial flushing after a 6-m...

journal_title：Anesthesia and analgesia

authors： Welti RS,Moldenhauer CC,Hug CC Jr,Kaplan JA,Holbrook GW

更新日期：1984-01-01 00:00:00

abstract：:We hypothesized that intrathecal fentanyl infusion would provide excellent analgesia, require lower doses than necessary for the epidural or intravenous route of administration, and reduce the incidence and/or severity of side effects. Accordingly, we studied 12 patients during 48 h after thoracotomy (three pneumonect...

journal_title：Anesthesia and analgesia

authors： Guinard JP,Chiolero R,Mavrocordatos P,Carpenter RL

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:The vitalHEAT vH(2) (Dynatherm Medical, Inc., Fremont, California) system transfers heat through a single extremity using a combination of conductive heat (circulating warm water within soft fluid pads) with mild vacuum, which improves both vasodilation and contact between the heating element and the skin su...

journal_title：Anesthesia and analgesia

authors： Ruetzler K,Kovaci B,Güloglu E,Kabon B,Fleischmann E,Kurz A,Mascha E,Dietz D,Remzi F,Sessler DI

更新日期：2011-03-01 00:00:00

abstract：:Invasive cardiac output (CO) monitoring, traditionally performed with transpulmonary thermodilution techniques, is usually reserved for high-risk patients because of the inherent risks of these methods. In contrast, transesophageal Doppler (TED) technology offers a safe, quick, and less invasive method for routine mea...

journal_title：Anesthesia and analgesia

authors： Schober P,Loer SA,Schwarte LA

更新日期：2009-08-01 00:00:00

abstract：:The effect of enflurane anesthesia on bronchomotor tone was studied in 15 dogs, using isolated tracheal segments in situ. In six animals, the changes of tracheal tension in response to changing enflurane concentration were continuously measured while keeping tidal volume, respiratory frequency, and end-tidal PCO2 cons...

journal_title：Anesthesia and analgesia

authors： Kochi T,Hagiya M,Mizuguchi T

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:Drug-induced sleep endoscopy (DISE) uses sedative-hypnotics to induce moderate obstruction in sleep apnea patients, thereby facilitating anatomic assessment of obstructive physiology. Implementation of DISE with propofol requires a dosing strategy that reliably and efficiently produces obstruction while mini...

journal_title：Anesthesia and analgesia

authors： Atkins JH,Mandel JE,Rosanova G

更新日期：2014-10-01 00:00:00

abstract：:The pharmacokinetics of sufentanil were studied in 28 pediatric patients undergoing cardiovascular procedures. Patients were divided into four groups on the basis of age: neonates (0-1 month, n = 9), infants (1-24 months, n = 7), children (2-12 yr, n = 7), and adolescents (12-18 yr, n = 5). Sufentanil 10-15 micrograms...

journal_title：Anesthesia and analgesia

authors： Greeley WJ,de Bruijn NP,Davis DP

更新日期：1987-11-01 00:00:00

abstract：:The performance of five of the most commonly used halothane vaporizers and three enflurane vaporizers was tested under conditions encountered in low-flow and closed-circuit anesthesia. Anesthetic gas concentrations were measured continuously with a mass spectrometer connected to a circle system. The results indicated ...

journal_title：Anesthesia and analgesia

authors： Lin CY

更新日期：1980-05-01 00:00:00

abstract：UNLABELLED:The calcium channel blocker nifedipine has analgesic properties that are enhanced by nicotine. Although it is not known how this analgesic state might affect the awareness of anginal pain and impending myocardial infraction, recent studies have shown an increased mortality associated with the use of large do...

journal_title：Anesthesia and analgesia

authors： Hunt TE,Wu WH,Zbuzek VK

更新日期：1998-11-01 00:00:00

abstract：UNLABELLED:We tested the ability of electroconvulsive treatment (ECT) to block thermal hyperalgesia and mechanical allodynia in rats with peripheral neuropathy. Repeated ECT (six times daily) significantly reduced thermal hyperalgesia 48 h after the end of the final treatment but had no significant effects on mechanica...

journal_title：Anesthesia and analgesia

authors： Shibata M,Wakisaka S,Inoue T,Shimizu T,Yoshiya I

更新日期：1998-03-01 00:00:00

abstract：:This study was designed to evaluate effects of enalaprilat, an angiotensin-converting enzyme inhibitor, on hemodynamic and hormonal responses during surgery at endotracheal intubation, incision, and limb-tourniquet inflation. Thirty patients undergoing limb procedures with general anesthesia (N2O/narcotic technique) a...

journal_title：Anesthesia and analgesia

authors： Heropoulos M,Schieren H,Seltzer JL,Bartkowski RR,Lessin J,Torjman M,Moody C,Goldberg ME

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:Previous studies show that the potent, prototypical sigma(1)-receptor agonist 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) prevents cell death after oxygen-glucose deprivation (OGD) in primary cortical neuronal cultures. We tested the hypothesis that PPBP protects neurons by a mechanism involving activation ...

journal_title：Anesthesia and analgesia

authors： Yang S,Alkayed NJ,Hurn PD,Kirsch JR

更新日期：2009-03-01 00:00:00

abstract：IMPLICATIONS:Chronic hiccups may be a serious therapeutic problem. Pharmacological treatment with increasing dosages of baclofen, carbamazepine, or gabapentin is not always successful. In this paper, the use of general anesthesia with positive-pressure ventilation and muscle relaxation for the termination of chronic hi...

journal_title：Anesthesia and analgesia

authors： Lierz P,Felleiter P

更新日期：2002-08-01 00:00:00

abstract：UNLABELLED:We evaluated, by using a before-and-after study, the influence of leukoreduction by filtration on postoperative infections and adverse outcomes in patients undergoing elective major aortic surgery. From January 1995 to October 2000, all patients who underwent elective abdominal aortic surgery were included i...

journal_title：Anesthesia and analgesia

authors： Baron JF,Gourdin M,Bertrand M,Mercadier A,Delort J,Kieffer E,Coriat P

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Hypercapnia with hyperventilation shortens the time between turning off the vaporizer (1 MAC) and when patients open their eyes after isoflurane anesthesia by 62%. METHODS:In the present study we tested whether a proportional shortening occurs with sevoflurane and desflurane. RESULTS:Consistent with a prop...

journal_title：Anesthesia and analgesia

authors： Sakata DJ,Gopalakrishnan NA,Orr JA,White JL,Westenskow DR

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:It has been shown that the combination of electroencephalogram (EEG) and auditory evoked potentials (AEP) allows a good separation of consciousness from unconsciousness. In the present study, we sought a combined EEG/AEP indicator that allows both separation of consciousness from unconsciousness and discrimi...

journal_title：Anesthesia and analgesia

authors： Horn B,Pilge S,Kochs EF,Stockmanns G,Hock A,Schneider G

更新日期：2009-05-01 00:00:00

abstract：UNLABELLED:Subarachnoid lidocaine has been the anesthetic of choice for outpatient spinal anesthesia. However, its use is associated with transient neurologic symptoms (TNS). Preservative-free formulations of 2-chloroprocaine are now available and may compare favorably with lidocaine for spinal anesthesia. In this doub...

journal_title：Anesthesia and analgesia

authors： Kouri ME,Kopacz DJ

更新日期：2004-01-01 00:00:00

abstract：UNLABELLED:The objective of this study was to evaluate prognostic models for quality assurance purposes in predicting automatically detected intraoperative cardiovascular events (CVE) in 58458 patients undergoing noncardiac surgery. To this end, we assessed the performance of two established models for risk assessment ...

journal_title：Anesthesia and analgesia

authors： Röhrig R,Junger A,Hartmann B,Klasen J,Quinzio L,Jost A,Benson M,Hempelmann G

更新日期：2004-03-01 00:00:00

abstract：UNLABELLED:We investigated the effect of epidural local anesthetic blockade on urinary substance P levels in five patients suffering from painful flare-ups of interstitial cystitis. Urine was collected in 24-h intervals commencing at the onset of an epidural bolus of 0.25% bupivacaine followed by maintenance epidural i...

journal_title：Anesthesia and analgesia

authors： Sukiennik A,Carr DB,Bonney I,Marchand JE,Wurm H,Sant GR

更新日期：2004-03-01 00:00:00

abstract：:Cardioprotection by anesthetic preconditioning (APC) can be abolished by nitric oxide (NO*) synthase inhibitors or by reactive oxygen species (ROS) scavengers. We previously reported attenuated mitochondrial electron transport (ET) and increased ROS generation during preconditioning sevoflurane exposure as part of the...

journal_title：Anesthesia and analgesia

authors： Riess ML,Kevin LG,McCormick J,Jiang MT,Rhodes SS,Stowe DF

更新日期：2005-01-01 00:00:00

abstract：UNLABELLED:We performed this study to compare the correlation of bispectral index (BIS) values with different sevoflurane concentrations between normal children and those with quadriplegic cerebral palsy with mental retardation (CPMR). Twenty children with CPMR (Group I) and 21 normal children (Group II) between 2 and ...

journal_title：Anesthesia and analgesia

authors： Choudhry DK,Brenn BR

更新日期：2002-12-01 00:00:00