Lidocaine attenuates the development of diabetic-induced tactile allodynia by inhibiting microglial activation.

Abstract:

BACKGROUND:Lidocaine is used clinically for tactile allodynia associated with diabetes-induced neuropathy. Although the analgesic effect of lidocaine through suppression of microglial activation has been implicated in the development of injury-induced neuropathic pain, its mechanism of action in diabetes-induced tactile allodynia has not yet been completely elucidated. METHODS:To evaluate the effects of lidocaine on microglial response in diabetic neuropathy, streptozotocin (STZ)-injected mice received a continuous infusion of lidocaine (vehicle, 2, or 10%) from day 14 to day 21 after STZ injection. On day 21, microglial accumulation and p38 mitogen-activated protein kinase activation in the dorsal horn were evaluated. In vitro, the effects of lidocaine on cell viability, chemotactic response to monocyte chemotactic protein-1, and induction of proinflammatory mediators were examined in interferon (IFN)-γ-stimulated primary microglial cells. RESULTS:Continuous systemic administration of lidocaine in the early progression of tactile allodynia produced long-lasting analgesic effects in STZ-treated mice. Lidocaine significantly reduced accumulation and p38 phosphorylation of microglial cells in the dorsal horn. In vitro, lidocaine down-regulated IFN-γ-induced gene induction of inducible oxide synthase and interleukin-1β. Pretreatment with lidocaine significantly reduced chemotactic response to monocyte chemotactic protein-1 of IFN-γ-activated microglial cells. CONCLUSION:Lidocaine alleviates STZ-induced tactile allodynia, possibly by modulating the p38 pathway in spinal microglial cells. Inhibiting microglial activation by lidocaine treatment early in the course of diabetes-induced neuropathy represents a potential therapeutic strategy for tactile allodynia.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Suzuki N,Hasegawa-Moriyama M,Takahashi Y,Kamikubo Y,Sakurai T,Inada E

doi

10.1213/ANE.0b013e31822827a2

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

941-6

issue

4

eissn

0003-2999

issn

1526-7598

pii

ANE.0b013e31822827a2

journal_volume

113

pub_type

杂志文章
  • An estimation of right- and left-sided central venous catheter insertion depth using measurement of surface landmarks along the course of central veins.

    abstract:BACKGROUND:In this study we sought to determine whether the topographical measurement along the course of the central veins can estimate the approximate insertion depths of central venous catheters (CVC). METHODS:Two hundred central venous catheterizations were performed via the right and left internal jugular vein (I...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e31820902bf

    authors: Kim MC,Kim KS,Choi YK,Kim DS,Kwon MI,Sung JK,Moon JY,Kang JM

    更新日期:2011-06-01 00:00:00

  • Comparison of the effects of halothane, isoflurane, and sevoflurane on atrioventricular conduction times in pentobarbital-anesthetized dogs.

    abstract::It is not known how sevoflurane affects the cardiac conduction system. We compared the effects of halothane, isoflurance, and sevoflurane on specialized atrioventricular (AV) conduction times in eight pentobarbital-anesthetized dogs. AV conduction times with three inhaled anesthetics at end-tidal concentrations of 1 a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199508000-00007

    authors: Nakaigawa Y,Akazawa S,Shimizu R,Ishii R,Yamato R

    更新日期:1995-08-01 00:00:00

  • The Effect of Intrathecal Morphine Dose on Outcomes After Elective Cesarean Delivery: A Meta-Analysis.

    abstract:BACKGROUND:The intrathecal morphine dose achieving optimal analgesia for cesarean delivery while minimizing side effects has not yet been deduced. In this meta-analysis, our objective was to determine whether low- or high-dose intrathecal morphine provides acceptable duration and intensity of analgesia with fewer side ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,meta分析,评审

    doi:10.1213/ANE.0000000000001255

    authors: Sultan P,Halpern SH,Pushpanathan E,Patel S,Carvalho B

    更新日期:2016-07-01 00:00:00

  • Nitrous oxide inactivates methionine synthetase in human liver.

    abstract::Activity of methionine synthetase was measured in liver biopsies of seven patients who had received 50% to 70% nitrous oxide supplemented by a combination of a narcotic and/or barbiturate with or without a volatile anesthetic, and from seven patients who were anesthetized without nitrous oxide (control group). Methion...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Koblin DD,Waskell L,Watson JE,Stokstad EL,Eger EI 2nd

    更新日期:1982-02-01 00:00:00

  • Maternal sepsis mortality and morbidity during hospitalization for delivery: temporal trends and independent associations for severe sepsis.

    abstract:BACKGROUND:Sepsis is currently the leading cause of direct maternal death in the United Kingdom. In this study, we aimed to determine frequency, temporal trends, and independent associations for severe sepsis during hospitalization for delivery in the United States. METHODS:Data were obtained from the Nationwide Inpat...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e3182a009c3

    authors: Bauer ME,Bateman BT,Bauer ST,Shanks AM,Mhyre JM

    更新日期:2013-10-01 00:00:00

  • The effects of systemic lidocaine on airway tone and pulmonary function in asthmatic subjects.

    abstract:BACKGROUND:To prevent reflex-induced bronchoconstriction in patients with asthma, local anesthetics are commonly administered by aerosol or IV as adjunct medication. Lidocaine attenuates responsiveness to a neurally active stimulus that increases tone, but there is scant information about the effect of lidocaine on bas...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000260638.57139.87

    authors: Chang HY,Togias A,Brown RH

    更新日期:2007-05-01 00:00:00

  • Cryoanalgesia: effect on postherniorrhaphy pain.

    abstract:UNLABELLED:Cryoanalgesia versus sham treatment was applied to the ilioinguinal and iliohypogastric nerves after mesh repair of an inguinal hernia under local anesthesia in 48 male patients in a prospective, randomized, and observer- and patient-blinded trial. Pain was scored daily during rest, while coughing, and durin...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199810000-00028

    authors: Callesen T,Bech K,Thorup J,Andersen J,Nielsen R,Roikjaer O,Kehlet H

    更新日期:1998-10-01 00:00:00

  • Hemodynamic and cardiodynamic effects of propofol and etomidate: negative inotropic properties of propofol.

    abstract::The hemodynamic effects of an induction dose of propofol, 2.5 mg/kg, or etomidate, 0.3 mg/kg, were studied in eight dogs. In addition, cardiodynamic changes were measured using a left ventricular catheter and needle force probes. Propofol was associated with significant decreases in systolic (19.9%) and diastolic (25....

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Brüssel T,Theissen JL,Vigfusson G,Lunkenheimer PP,Van Aken H,Lawin P

    更新日期:1989-07-01 00:00:00

  • Closed-loop coadministration of propofol and remifentanil guided by bispectral index: a randomized multicenter study.

    abstract:BACKGROUND:We have developed a proportional-integral-derivative controller allowing the closed-loop coadministration of propofol and remifentanil, guided by a Bispectral Index (BIS) monitor, during induction and maintenance of general anesthesia. The controller was compared with manual target-controlled infusion. METH...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1213/ANE.0b013e318205680b

    authors: Liu N,Chazot T,Hamada S,Landais A,Boichut N,Dussaussoy C,Trillat B,Beydon L,Samain E,Sessler DI,Fischler M

    更新日期:2011-03-01 00:00:00

  • Carbon monoxide production from degradation of desflurane, enflurane, isoflurane, halothane, and sevoflurane by soda lime and Baralyme.

    abstract::Anecdotal reports suggest that soda lime and Baralyme brand absorbent can degrade inhaled anesthetics to carbon monoxide (CO). We examined the factors that govern CO production and found that these include: 1) The anesthetic used: for a given minimum alveolar anesthetic concentration (MAC)-multiple, the magnitude of C...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199506000-00021

    authors: Fang ZX,Eger EI 2nd,Laster MJ,Chortkoff BS,Kandel L,Ionescu P

    更新日期:1995-06-01 00:00:00

  • Rates of Perioperative Respiratory Adverse Events Among Caucasian and African American Children Undergoing General Anesthesia.

    abstract:BACKGROUND:Perioperative respiratory adverse events (PRAEs) account for the major cause of morbidity and mortality in children undergoing general anesthesia. In our institutional clinical practice, we suspected that African American children experienced untoward respiratory events more frequently than other racial grou...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000003430

    authors: Tariq S,Syed M,Martin T,Zhang X,Schmitz M

    更新日期:2018-07-01 00:00:00

  • The effects of maternal position during induction of combined spinal-epidural anesthesia for cesarean delivery.

    abstract:UNLABELLED:Combined spinal-epidural anesthesia (CSE) is a popular technique for cesarean delivery. Regional blocks in obstetrics are often performed with the parturient in the sitting position because the midline may be recognized more easily than in the lateral decubitus position. When conventional spinal anesthesia i...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199809000-00023

    authors: Yun EM,Marx GF,Santos AC

    更新日期:1998-09-01 00:00:00

  • Acute toxicity of ropivacaine compared with that of bupivacaine.

    abstract::The acute central nervous and cardiovascular effects of the local anesthetics ropivacaine and bupivacaine were compared in 12 volunteers in a randomized double-blind manner with use of intravenous infusions at a rate of 10 mg/min up to a maximal dose of 150 mg. The volunteers were all healthy men. They were familiariz...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Scott DB,Lee A,Fagan D,Bowler GM,Bloomfield P,Lundh R

    更新日期:1989-11-01 00:00:00

  • Comparison of regional ophthalmic anesthesia produced by pH-adjusted 0.75% and 0.5% bupivacaine and 1% and 1.5% etidocaine, all with hyaluronidase.

    abstract::Two concentrations of etidocaine (1 and 1.5%) and of pH-adjusted bupivacaine (0.5 and 0.75%, pH 6.8), all fortified with hyaluronidase, were compared as local anesthetics in regional ophthalmic surgery for cataract extraction. The series comprised 160 patients assigned randomly to four groups (n = 40). Each patient re...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/00000539-199307000-00026

    authors: Sarvela PJ

    更新日期:1993-07-01 00:00:00

  • The effect of music on the neurohormonal stress response to surgery under general anesthesia.

    abstract:UNLABELLED:Several pharmacological interventions reduce perioperative stress hormone release during surgery under general anesthesia. Listening to music and therapeutic suggestions were also studied, but mostly in awake patients, and these have a positive effect on postoperative recovery and the need for analgesia. In ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/01.ane.0000096182.70239.23

    authors: Migneault B,Girard F,Albert C,Chouinard P,Boudreault D,Provencher D,Todorov A,Ruel M,Girard DC

    更新日期:2004-02-01 00:00:00

  • The Efficacy of Eslicarbazepine Acetate in Models of Trigeminal, Neuropathic, and Visceral Pain: The Involvement of 5-HT1B/1D Serotonergic and CB1/CB2 Cannabinoid Receptors.

    abstract:BACKGROUND:Many clinical pain states that are difficult to treat share a common feature of sensitization of nociceptive pathways. Drugs that could normalize hyperexcitable neural activity (e.g., antiepileptic drugs) may be useful in relieving these pain states. Eslicarbazepine acetate (ESL) is a novel antiepileptic dru...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000000953

    authors: Tomić MA,Pecikoza UB,Micov AM,Stepanović-Petrović RM

    更新日期:2015-12-01 00:00:00

  • The safety of immediate extubation after abdominal aortic surgery: a prospective, randomized trial.

    abstract:UNLABELLED:We performed this study to assess the safety of immediate extubation after elective abdominal aortic aneurysm surgery. Consecutive patients were prospectively randomized into two groups after surgery: Group 1 (n = 29) immediate extubation; and Group 2 (n = 21) delayed (at least 4 h) extubation. All patients ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-200112000-00044

    authors: Cohen J,Loewinger J,Hutin K,Sulkes J,Zelikovski A,Singer P

    更新日期:2001-12-01 00:00:00

  • Propofol versus propofol-ketamine sedation for retrobulbar nerve block: comparison of sedation quality, intraocular pressure changes, and recovery profiles.

    abstract:UNLABELLED:We compared sedation quality, intraocular pressure (IOP) changes, and recovery profiles in patients who received propofol or propofol-ketamine sedation during placement of the retrobulbar nerve block (RBB). Seventy elderly patients undergoing cataract extraction according to a prospective, randomized, double...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199908000-00013

    authors: Frey K,Sukhani R,Pawlowski J,Pappas AL,Mikat-Stevens M,Slogoff S

    更新日期:1999-08-01 00:00:00

  • The anesthetic mechanism of urethane: the effects on neurotransmitter-gated ion channels.

    abstract:UNLABELLED:Urethane is widely used as an anesthetic for animal studies because of its minimal effects on cardiovascular and respiratory systems and maintenance of spinal reflexes. Despite its usefulness in animal research, there are no reports concerning its molecular actions. We designed this study to determine whethe...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200202000-00015

    authors: Hara K,Harris RA

    更新日期:2002-02-01 00:00:00

  • A comparison of observational and objective measures to differentiate depth of sedation in children from birth to 18 years of age.

    abstract::Several observational and objective methods are available to assess sedation depth; however, data regarding their accuracy in differentiating deep sedation are limited. In this study we compared 3 sedation tools in children from birth to 18 yr of age and determined their relative value in detecting deep levels of seda...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ANE.0000184045.01780.73

    authors: Malviya S,Voepel-Lewis T,Tait AR

    更新日期:2006-02-01 00:00:00

  • Technical communication: new teaching model for practicing ultrasound-guided regional anesthesia techniques: no perishable food products!

    abstract:BACKGROUND:There is a pronounced learning curve for the technique of ultrasound-guided regional anesthesia. Practicing with a simulator model has been shown to speed the acquisition of these skills for various ultrasound-guided procedures. However, commercial models for ultrasound-guided regional anesthesia may be too ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e3181cc558b

    authors: Liu Y,Glass NL,Power RW

    更新日期:2010-04-01 00:00:00

  • The carbon dioxide absorption capacity of Amsorb is half that of soda lime.

    abstract:UNLABELLED:A new CO(2) absorbent, Amsorb (A), which does not contain monovalent bases, is ideal because it does not degrade volatile anesthetics to either Compound A (from sevoflurane) or carbon monoxide (from desflurane, enflurane, or isoflurane). The CO(2) absorption capacity of A, however, has not been investigated ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200107000-00044

    authors: Higuchi H,Adachi Y,Arimura S,Kanno M,Satoh T

    更新日期:2001-07-01 00:00:00

  • Comparison of resuscitation of sheep and dogs after bupivacaine-induced cardiovascular collapse.

    abstract::This study evaluated interspecies sensitivity and ability to resuscitate pentobarbital anesthetized sheep and dogs after cardiovascular toxic doses of bupivacaine. Every minute, 3 mg/kg of bupivacaine was injected into the right atrium over the course of 10 sec until cardiovascular collapse occurred. While the bupivac...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Kasten GW,Martin ST

    更新日期:1986-10-01 00:00:00

  • Small-dose ketamine reduces the pain of propofol injection.

    abstract:BACKGROUND:I.v. injection of propofol during anesthetic induction induces pain. Ketamine has been shown to reduce injection pain. In this study, we established the optimal dose of ketamine to prevent the pain of injection with propofol. METHODS:Two hundred forty patients presenting for elective surgery were randomly a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/01.ane.0000243334.83816.53

    authors: Koo SW,Cho SJ,Kim YK,Ham KD,Hwang JH

    更新日期:2006-12-01 00:00:00

  • Brain edema, hemorrhagic necrosis volume, and neurological status with rapid infusion of 0.45% saline or 5% dextrose in 0.9% saline after closed head trauma in rats.

    abstract::We previously reported that in rats with closed head trauma (CHT), intravenous (IV) administration of 0.25 mL/g of 5% dextrose solution (D5W) increased blood glucose (G), decreased blood sodium (Na), caused no change in blood osmolality (Osm), increased brain edema (BE), and worsened neurological severity score (NSS) ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199703000-00016

    authors: Gurevich B,Talmor D,Artru AA,Katcko L,Geva D,Gurman G,Shapira Y

    更新日期:1997-03-01 00:00:00

  • Pressure support ventilation decreases inspiratory work of breathing during general anesthesia and spontaneous ventilation.

    abstract::Spontaneous ventilation may offer advantages over controlled mechanical ventilation (CMV), but increase in work of breathing may diminish its usefulness. During general anesthesia, respiratory depression and increased work of breathing often preclude spontaneous ventilation, and patients then receive CMV. We compared ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199208000-00003

    authors: Christie JM,Smith RA

    更新日期:1992-08-01 00:00:00

  • Continuous femoral nerve analgesia after unilateral total knee arthroplasty: stimulating versus nonstimulating catheters.

    abstract:BACKGROUND:Continuous femoral analgesia provides extended pain relief and improved functional recovery for total knee arthroplasty (TKA). Stimulating catheters may allow more accurate placement of catheters. METHODS:We performed a randomized prospective study to investigate the use of stimulating catheters versus nons...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/01.ane.0000244476.38588.c9

    authors: Hayek SM,Ritchey RM,Sessler D,Helfand R,Samuel S,Xu M,Beven M,Bourdakos D,Barsoum W,Brooks P

    更新日期:2006-12-01 00:00:00

  • Leg warming minimizes core hypothermia during abdominal surgery.

    abstract::The efficacy of leg skin warming in preventing hypothermia and shivering was evaluated in two separate prospective, randomized trials in patients undergoing abdominal surgery. In the first trial, 22 patients were randomized to receive no hypothermia prevention (control group) or active warming with an electric warming...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/00000539-199311000-00021

    authors: Camus Y,Delva E,Just B,Lienhart A

    更新日期:1993-11-01 00:00:00

  • Effect of halothane on cardiac output and regional flow in the fetal lamb in utero.

    abstract::We studied the effect of halothane on the fetal cardiovascular system of six lambs in utero by measuring fetal heart rate and femoral arterial blood pressure and by injecting labeled microspheres during a control period and again after 60 and 90 min of halothane anesthesia administered to six pregnant ewes at an inspi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Biehl DR,Tweed WA,Cote J,Wade JG,Sitar D

    更新日期:1983-05-01 00:00:00

  • Supplemental oxygen does not reduce myocardial ischemia in premedicated patients with critical coronary artery disease.

    abstract::This randomized, prospective clinical study investigated the effects of supplemental inspired oxygen on arterial hemoglobin desaturation and myocardial ischemia in premedicated patients who have critical coronary artery stenosis, identified predictors for these adverse events, and examined the temporal relationship be...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/00000539-199305000-00006

    authors: Kavanagh BP,Cheng DC,Sandler AN,Chung F,Lawson S,Ong D

    更新日期:1993-05-01 00:00:00