Nitrous oxide inactivates methionine synthetase in human liver.

Abstract:

:Activity of methionine synthetase was measured in liver biopsies of seven patients who had received 50% to 70% nitrous oxide supplemented by a combination of a narcotic and/or barbiturate with or without a volatile anesthetic, and from seven patients who were anesthetized without nitrous oxide (control group). Methionine synthetase activity (+/- SE) averaged 219 +/- 28 nmol of methionine per hour per gran of liver in patients given nitrous oxide, and 414 +/- 29 in control patients. Inactivation of methionine synthetase progressively increased as the product of the concentration of nitrous oxide and the exposure time increased. These results in humans are similar to those in animals and suggest that inactivation of methionine synthetase may play a role in the development of the pathologic effects seen in patients and medical personnel after exposure to nitrous oxide.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Koblin DD,Waskell L,Watson JE,Stokstad EL,Eger EI 2nd

subject

Has Abstract

pub_date

1982-02-01 00:00:00

pages

75-8

issue

2

eissn

0003-2999

issn

1526-7598

journal_volume

61

pub_type

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