Abstract：
:Initial, but not subsequent, inhalation of 8% desflurane produces transient sympathetic stimulation. We hypothesized that initial but not subsequent increases should produce pupil dilation, and that N2O, fentanyl, and clonidine, but not esmolol, should blunt the response. In 10 volunteers, we maintained anesthesia with 4% end-tidal desflurane in oxygen for 32 min, then increased the concentration to 8% for 10 min. In nine of the volunteers, we twice repeated the increase to 8%, separating each increase by a 32-min period at 4%. On separate days, five volunteers received 4%-8% desflurane in 60% N2O; five received fentanyl 1.5 micrograms/kg or 4.5 micrograms/kg intravenously 5 min before 4%-8% desflurane; four received clonidine 4.3 micrograms/kg, orally, 90 min before 4% to 8%; and four received esmolol 0.75 mg/kg, intravenously, 1.5 min before 4%-8%. Without other drugs present, 4%-8% desflurane transiently increased pupil diameter to 5.4 +/- 0.5 mm (mean +/- SD), with subsequent 4%-8% increases producing attenuated responses (2.9 +/- 1.5 and 3.2 +/- 1.8 mm). N2O produced a higher peak (6.2 +/- 0.7 mm). Fentanyl 1.5 micrograms/kg and 4.5 micrograms/kg decreased peak diameter (2.3 +/- 0.9 and 1.6 +/- 0.3 mm), as did clonidine (2.3 +/- 1.7 mm) but not esmolol. We conclude that, concurrent with sympathetic stimulation, an initial rapid increase in desflurane concentration transiently increases pupil diameter, whereas repeated increases produce attenuated responses. N2O augments, fentanyl and clonidine attenuate, and esmolol does not affect the response.
journal_name
Anesth Analgjournal_title
Anesthesia and analgesiaauthors
Daniel M,Larson MD,Eger EI 2nd,Noorani M,Weiskopf RBdoi
10.1097/00000539-199508000-00028subject
Has Abstractpub_date
1995-08-01 00:00:00pages
372-8issue
2eissn
0003-2999issn
1526-7598journal_volume
81pub_type
杂志文章abstract：INTRODUCTION:The infraclavicular approach to the brachial plexus provides suitable anesthesia and also lends itself well to stabilizing and securing a catheter for a continuous infusion. We describe an approach for continuous infusions using an infraclavicular approach in children. METHODS:Twenty-five patients aged 8 ...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章
doi：10.1213/01.ane.0000289633.81407.65
更新日期：2008-01-01 00:00:00
abstract：UNLABELLED:The effect of opioid administration on the bispectral index (BIS) during general anesthesia is controversial. Several investigators have reported BIS to be insensitive to opioid addition, whereas others have found a hypnotic response. We designed this study to examine the effect of remifentanil on BIS during...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章
doi：10.1097/00000539-200206000-00028
更新日期：2002-06-01 00:00:00
abstract：:The traditional tests that have been used for the past 30 yr to determine plasma cholinesterase phenotype--measurement of esterase activity with a variety of substrates, dibucaine inhibition, fluoride inhibition, and Ro2-0683 inhibition--are inadequate for identifying some variants of this enzyme and leave many cases ...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章,评审
doi：10.1213/00000539-199377020-00027
更新日期：1993-08-01 00:00:00
abstract：UNLABELLED:Clinical pathways are being introduced by hospitals to reduce costs and control unnecessary variation in care. We studied 766 inpatients to measure the impact of a perioperative clinical pathway for patients undergoing knee replacement surgery on hospital costs. One hundred twenty patients underwent knee rep...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1097/00000539-199805000-00012
更新日期：1998-05-01 00:00:00
abstract：UNLABELLED:In this retrospective cohort study, we compared adverse cardiac outcomes after noncardiac surgery among patients with prior percutaneous transluminal coronary angioplasty (PTCA), patients with nonrevascularized coronary artery disease (CAD), and normal controls. Inpatient hospital discharge abstracts from al...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1097/00000539-199909000-00003
更新日期：1999-09-01 00:00:00
abstract：:To evaluate the effect of propranolol on anesthetic requirement, changes in minimum alveolar concentration (MAC) of halothane accompanying acute (2 and 10 mg/kg IV) and chronic (200 mg/day orally for 10 days) propranolol administration were determined in dogs. MAC did not change significantly in either case. Beta-adre...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/00000539-197605000-00022
更新日期：1976-05-01 00:00:00
abstract：:This study was designed to evaluate effects of enalaprilat, an angiotensin-converting enzyme inhibitor, on hemodynamic and hormonal responses during surgery at endotracheal intubation, incision, and limb-tourniquet inflation. Thirty patients undergoing limb procedures with general anesthesia (N2O/narcotic technique) a...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00000539-199503000-00027
更新日期：1995-03-01 00:00:00
abstract：UNLABELLED:Our aim in this study, performed using a closed cranial window preparation, was to investigate the effect of systemic pretreatment with dexmedetomidine on cerebrovascular response to isoflurane or sevoflurane. After instrumentation under pentobarbital anesthesia, 48 dogs were assigned to one of two groups: t...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1097/00000539-199908000-00023
更新日期：1999-08-01 00:00:00
abstract：UNLABELLED:We conducted a randomized, controlled, cross-over cadaver study to test the hypothesis that the efficacy of seal for ventilation and airway protection, anatomic position, and airway patency with the flexible laryngeal mask airway (FLMA) are altered by the application of a Boyle Davis (B-D) gag. We also deter...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00000539-199907000-00032
更新日期：1999-07-01 00:00:00
abstract：BACKGROUND:Atelectasis occurs regularly after induction of general anesthesia, persists postoperatively, and may contribute to significant postoperative morbidity and additional health care costs. Laparoscopic surgery has been reported to be associated with an increased incidence of postoperative atelectasis. It has be...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章,随机对照试验
doi：10.1213/ANE.0b013e3181ba7945
更新日期：2009-11-01 00:00:00
abstract：BACKGROUND:Paravertebral analgesia is useful for breast surgery. Patient controlled analgesia by IV or epidural routes is well established for delivering postoperative analgesia. Our objective was to apply patient control to paravertebral analgesia and evaluate the efficacy and tolerability of two distinct dosing regim...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章,随机对照试验
doi：10.1213/ane.0b013e31817b7f01
更新日期：2008-08-01 00:00:00
abstract：:Fentanyl pharmacokinetics was compared in two groups of adult patients, one group (n = 5) aged less than 50 years, and one group (n = 4) aged greater than 60 years. Despite equivalent doses of fentanyl (10 microgram/kg IV), serum drug concentrations were significantly higher in the older patient group. This was reflec...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：
更新日期：1982-12-01 00:00:00
abstract：:Previous studies have shown that the anesthetic potency of organic compounds increases as a given halogen is replaced with successively larger halogens. These studies often are limited in the accuracy of determination of potency, rarely correlate potency with physical properties, and usually fail to include ether comp...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
abstract：UNLABELLED:Atrial fibrillation is a common complication of coronary artery bypass graft (CABG) surgery that is associated with adverse patient outcomes. We evaluated whether preexisting abnormalities of cardiac structure or function detected with transesophageal echocardiography (TEE) are prevalent in patients later de...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章
doi：10.1097/00000539-200107000-00004
更新日期：2001-07-01 00:00:00
abstract：BACKGROUND:General anesthesia-induced atelectasis is common, and persistent postoperative atelectasis is associated with pulmonary complications. We aimed to evaluate the preventive effects of a high-flow nasal cannula (HFNC) on postoperative atelectasis and respiratory complications in infants and small children. MET...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/ANE.0000000000005285
更新日期：2020-11-10 00:00:00
abstract：UNLABELLED:We constructed a single-dose response curve for succinylcholine in 30 obese adolescents during thiopental-fentanyl anesthesia administration by using 100 microg/kg, 150 microg/kg, or 250 microg/kg IV. The maximal response (percent depression of neuromuscular function) of the adductor pollicis to supramaximal...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1097/00000539-200003000-00015
更新日期：2000-03-01 00:00:00
abstract：:A newly developed transtracheal Doppler (TTD) computer for cardiac output determination was studied in nine patients after open heart surgery (coronary artery bypass grafting, n = 4; mitral valve replacement, n = 5). The measurements were compared with those simultaneously obtained by thermodilation. Doppler signals w...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章
doi：10.1213/00000539-199206000-00004
更新日期：1992-06-01 00:00:00
abstract：:Bispectral Index Scale (BIS)-guided closed-loop delivery of anesthetics has been extensively studied. We performed a meta-analysis of all the randomized clinical trials comparing efficacy and performance between BIS-guided closed-loop delivery and manually controlled administration of total IV anesthesia. Scopus, PubM...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章,meta分析,评审
doi：10.1213/ANE.0000000000001394
更新日期：2017-02-01 00:00:00
abstract：:A series of 50 combat-injured patients given crash intubation for rapid induction of anesthesia is presented. The technic consisted of injection of 3 mg of d-tubocurarine and 0.4 mg of atropine IV, preoxygenation by face mask for 3 minutes, and then injection of sodium thiopental or ketamine, followed immediately by 6...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:The decrease of cardiac index observed during portal triad clamping (PTC) with and without pneumoperitoneum has been studied only with right heart catheterization. To better understand this decrease of cardiac index, we investigated the balance between the adequacy of preload and the ability of the heart to pump again...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/01.ANE.0000144592.20499.12
更新日期：2005-03-01 00:00:00
abstract：:Patient-reported outcomes (PROs) are measures of health status that come directly from the patient. PROs are an underutilized tool in the perioperative setting. Enhanced recovery pathways (ERPs) have primarily focused on traditional measures of health care quality such as complications and hospital length of stay. The...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章,评审
doi：10.1213/ANE.0000000000002758
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND:Hyperkalemia poses serious hazards to patients undergoing orthotopic liver transplantation (OLT), and its predictors have not been thoroughly examined. METHODS:We retrospectively studied 1124 consecutive adult patients who underwent OLT. Hyperkalemia was defined as serum K+ > or =5.5 mmol/L. A total of 47 r...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/01.ane.0000271914.54261.17
更新日期：2007-09-01 00:00:00
abstract：UNLABELLED:Nitric oxide (NO) may play an important role in central and peripheral nociceptive processes. However, its contribution to peripheral antinociception is still not clear. In the present study, we investigated the effect of peripherally administered FK409, a spontaneous NO releaser, and its interaction with pe...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1097/00000539-199802000-00028
更新日期：1998-02-01 00:00:00
abstract：BACKGROUND:Incomplete reversal with a recommended 5-g dose of idarucizumab has been reported in patients with excessively high dabigatran concentrations. A timely detection of reversal failure after idarucizumab using whole blood (WB) coagulation testing is clinically useful. The aims of this study were to determine re...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/ANE.0000000000004419
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Hypoxemia, as measured by pulse oximetry (SpO2), is common in postanesthesia care unit (PACU) patients. The temporal distribution of desaturation has managerial implications because treatment may necessitate the presence of an anesthesiologist. METHODS:We retrieved SpO2 values recorded electronically every ...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/ANE.0000000000000410
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:Goal-directed fluid therapy (GDFT) is associated with improved outcomes after surgery. The esophageal Doppler monitor (EDM) is widely used, but has several limitations. The NICOM, a completely noninvasive cardiac output monitor (Cheetah Medical), may be appropriate for guiding GDFT. No prospective studies ha...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/ANE.0000000000000182
更新日期：2014-05-01 00:00:00
abstract：BACKGROUND:Implementation of initiatives to increase anesthesia group productivity depends not just on anesthesia groups, but on operating room (OR) nursing administration. OR nursing directors may encourage organizational change based on the needs of their hospitals and nurses. These changes may differ from those that...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/ane.0b013e31818874a8
更新日期：2008-12-01 00:00:00
abstract：BACKGROUND:We have shown previously that either echocardiographic indices of diastolic dysfunction or increased preoperative brain natriuretic peptide (BNP) predict postoperative atrial fibrillation (POAF). Because these 2 predictors of POAF have not been evaluated together, our goal was to further elucidate their conc...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/ANE.0000000000001471
更新日期：2017-04-01 00:00:00
abstract：:The renal effects of pulsatile (pulse pressure 18.0 +/- 1.5 mm Hg [mean +/- SEM]) or nonpulsatile perfusion (mean pulse pressure 1.9 +/- 0.4 mm Hg) during either alpha-stat (mean PaCO2 41.2 +/- 0.9 mm Hg measured at 37 degrees C) or pH-stat (mean PaCO2 60.6 +/- 1.7 mm Hg measured at 37 degrees C) pH management of hypo...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/00000539-199211000-00007
更新日期：1992-11-01 00:00:00
abstract：BACKGROUND:Musculoskeletal deformities in mucopolysaccharidoses (MPSs) patients pose unique challenges when patients present for surgery, especially nonspinal surgery. MPS patients have developed postsurgical neurological deficits after nonspinal surgery. While the incidence of neurological deficits after nonspinal sur...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/ANE.0000000000004215
更新日期：2020-06-01 00:00:00
