Effect of isoproterenol and propranolol on halothane MAD in dogs.


:To evaluate the effect of propranolol on anesthetic requirement, changes in minimum alveolar concentration (MAC) of halothane accompanying acute (2 and 10 mg/kg IV) and chronic (200 mg/day orally for 10 days) propranolol administration were determined in dogs. MAC did not change significantly in either case. Beta-adrenergic blockade was achieved with the 2 mg/kg propranolol dose, as indicated by abolition of the pulse rate increase in response to isoproterenol infusion. Isoproterenol itself did not alter MAC. Mean arterial pressure (MAP) and heart rate (HR) at any given level of alveolar halothane were the same before and after chronic propranolol administration. Acute IV administration of propranolol, especially at the 10 mg/kg dose, reduced MAP and increased HR only transiently.


Anesth Analg


Anesthesia and analgesia


Tanifuji Y,Eger EI II




Has Abstract


1976-05-01 00:00:00












  • Neostigmine decreases bupivacaine use by patient-controlled epidural analgesia during labor: a randomized controlled study.

    abstract:BACKGROUND:Intrathecal neostigmine not only produces analgesia but also severe nausea. In contrast, epidural neostigmine enhances opioid and local anesthetic analgesia without causing nausea. Previous studies examined only single epidural neostigmine bolus administration and did not assess the efficacy of continuous ep...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Ross VH,Pan PH,Owen MD,Seid MH,Harris L,Clyne B,Voltaire M,Eisenach JC

    更新日期:2009-08-01 00:00:00

  • Decision Support for the Capacity Management of Bronchoscopy Devices: Optimizing the Cost-Efficient Mix of Reusable and Single-Use Devices Through Mathematical Modeling.

    abstract:BACKGROUND:Increasing costs of material resources challenge hospitals to stay profitable. Particularly in anesthesia departments and intensive care units, bronchoscopes are used for various indications. Inefficient management of single- and multiple-use systems can influence the hospitals' material costs substantially....

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Edenharter GM,Gartner D,Pförringer D

    更新日期:2017-06-01 00:00:00

  • Variation in Patient-Reported Advance Care Preferences in the Preoperative Setting.

    abstract:BACKGROUND:High-quality shared decision-making for patients undergoing elective surgical procedures includes eliciting patient goals and treatment preferences. This is particularly important, should complications occur and life-sustaining therapies be considered. Our objective was to determine the preoperative care pre...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Udelsman BV,Govea N,Cooper Z,Chang DC,Bader A,Meyer MJ

    更新日期:2021-01-01 00:00:00

  • Pathogenic Link Between Postextubation Pneumonia and Ventilator-Associated Pneumonia: An Experimental Study.

    abstract:BACKGROUND:The presence of an endotracheal tube is the main cause for developing ventilator-associated pneumonia (VAP), but pneumonia can still develop in hospitalized patients after endotracheal tube removal (postextubation pneumonia [PEP]). We hypothesized that short-term intubation (24 hours) can play a role in the ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Rezoagli E,Zanella A,Cressoni M,De Marchi L,Kolobow T,Berra L

    更新日期:2017-04-01 00:00:00

  • Auditory event-related potentials, bispectral index, and entropy for the discrimination of different levels of sedation in intensive care unit patients.

    abstract:BACKGROUND:Sedation protocols, including the use of sedation scales and regular sedation stops, help to reduce the length of mechanical ventilation and intensive care unit stay. Because clinical assessment of depth of sedation is labor-intensive, performed only intermittently, and interferes with sedation and sleep, pr...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Haenggi M,Ypparila-Wolters H,Buerki S,Schlauri R,Korhonen I,Takala J,Jakob SM

    更新日期:2009-09-01 00:00:00

  • An Observational Study of the Pharmacokinetics of Surgeon-Performed Intercostal Nerve Blockade With Liposomal Bupivacaine for Posterior-Lateral Thoracotomy Analgesia.

    abstract:BACKGROUND:Intercostal nerve blocks with liposomal bupivacaine are commonly used for thoracic surgery pain management. However, dose scheduling is difficult because the pharmacokinetics of a single-dose intercostal injection of liposomal bupivacaine has never been investigated. The primary aim of this study was to asse...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Manson WC,Blank RS,Martin LW,Alpert SB,Dobrzanski TP,Schneider EB,Ratcliffe SJ,Durieux ME

    更新日期:2020-12-01 00:00:00

  • Culture-Negative and Culture-Positive Sepsis: A Comparison of Characteristics and Outcomes.

    abstract:BACKGROUND:The primary objective of this study was to compare the characteristics of culture-positive and culture-negative status in septic patients. We also determined whether culture status is associated with mortality and whether unique variables are associated with mortality in culture-positive and culture-negative...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Sigakis MJG,Jewell E,Maile MD,Cinti SK,Bateman BT,Engoren M

    更新日期:2019-11-01 00:00:00

  • The effects of isoflurane and desflurane on cognitive function in humans.

    abstract:BACKGROUND:The etiology of postoperative cognitive decline (POCD) remains to be determined. Anesthetic isoflurane, but not desflurane, may induce neurotoxicity. However, the functional consequences of these effects have not been assessed. We therefore performed a pilot study to determine the effects of isoflurane and d...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Zhang B,Tian M,Zhen Y,Yue Y,Sherman J,Zheng H,Li S,Tanzi RE,Marcantonio ER,Xie Z

    更新日期:2012-02-01 00:00:00

  • A Methyltransferase Inhibitor (Decitabine) Alleviates Intergenerational Effects of Paternal Neonatal Exposure to Anesthesia With Sevoflurane.

    abstract:BACKGROUND:Neonatal exposure to sevoflurane induces neurobehavioral and neuroendocrine abnormalities in exposed male rats (generation F0) and neurobehavioral, but not neuroendocrine, abnormalities in their male, but not female, offspring (generation F1). These effects of sevoflurane are accompanied by a hypermethylated...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Xu N,Lei L,Lin Y,Ju LS,Morey TE,Gravenstein N,Yang J,Martynyuk AE

    更新日期:2020-10-01 00:00:00

  • Perioperative management of the multiorgan donor.

    abstract::Organ transplantation is a multidisciplinary specialty that has seen remarkable advances in the past two decades, in the tireless pursuit of providing life-saving therapy for patients suffering from end-stage organ failure. As the scientific basis and clinical practice of organ transplantation continues to evolve, it ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Robertson KM,Cook DR

    更新日期:1990-05-01 00:00:00

  • Pharmacologic basis of responses to midazolam in the isolated, cross-perfused, canine right atrium.

    abstract::The effects of midazolam on atrial rate and contractile force in the isolated canine atrium perfused with donor blood were investigated. When midazolam in a dose range of 100-1000 micrograms was injected directly into the sinus node artery of the isolated atrium, biphasic (negative followed by positive) chronotropic a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Saegusa K,Furukawa Y,Ogiwara Y,Takeda M,Chiba S

    更新日期:1987-08-01 00:00:00

  • The addition of bupivacaine to intrathecal sufentanil for labor analgesia.

    abstract::We designed a prospective, randomized, double-blind study to evaluate the efficacy of the combination of intrathecal sufentanil with a low dose of local anesthetic in an attempt to prolong analgesia in labor. Fifty-two patients received one of the following intrathecal study solutions: 2.5 mg of bupivacaine; 10 microg...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Campbell DC,Camann WR,Datta S

    更新日期:1995-08-01 00:00:00

  • Posterior tibial nerve sensory blockade duration prolonged by adding dexmedetomidine to ropivacaine.

    abstract:BACKGROUND:Dexmedetomidine, an α(2)-receptor agonist, prolongs analgesia when used in neuraxial and IV blocks. We evaluated the effect of dexmedetomidine added to ropivacaine for tibial nerve block on the duration of the sensory blockade. METHODS:For this prospective, randomized, controlled, double-blind, crossover tr...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Rancourt MP,Albert NT,Côté M,Létourneau DR,Bernard PM

    更新日期:2012-10-01 00:00:00

  • Intercostal nerve block: a roentgenographic anatomic study of technique and absorption in humans.

    abstract::Roentgenograms of iothalamate meglumine 60% (Conray) injected bilaterally into the intercostal grooves of the ninth or tenth ribs in 30 surgical patients showed extensive spread of the contrast central and peripherally from the site of injection within 30 seconds, with almost complete absorption within 10 minutes 30 s...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Moore DC,Bush WH,Scurlock JE

    更新日期:1980-11-01 00:00:00

  • Lecture practices in United States anesthesiology residencies.

    abstract::We obtained data on lecture practices from 100 of the 110 university-affiliated anesthesiology residency programs certified in the United States in 1988. Of these residency programs, 36% had a majority of their lectures before the operating room schedule began, 57% had no lectures at all in this early time slot, and 7...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Landers DF,Becker GL,Newland MC,Peters KR

    更新日期:1992-01-01 00:00:00

  • The coherent frequency in the electroencephalogram as an objective measure of cognitive function during propofol sedation.

    abstract::Ten volunteers were studied during six stages of propofol sedation, namely awake (no propofol), light sedation (small dose of propofol), deep sedation (large dose), deep sedation with stimulation of the ulnar nerve, then light sedation again (small dose), and awake (recovery). Light and deep sedation were defined in t...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Andrade J,Sapsford DJ,Jeevaratnum D,Pickworth AJ,Jones JG

    更新日期:1996-12-01 00:00:00

  • Trends in the Prevalence of Intraoperative Adverse Events at Two Academic Hospitals After Implementation of a Mandatory Reporting System.

    abstract:BACKGROUND:Anesthesia information management systems (AIMSs) have been effectively used to improve quality in anesthesia care, and have enabled the development of mandatory quality assurance (QA) reporting systems for adverse events (AEs). While this approach has been shown to increase event reporting over time, the lo...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,多中心研究


    authors: Wanderer JP,Gratch DM,Jacques PS,Rodriquez LI,Epstein RH

    更新日期:2018-01-01 00:00:00

  • Cerebrovascular cytokine responses during coronary artery bypass surgery: specific production of interleukin-8 and its attenuation by hypothermic cardiopulmonary bypass.

    abstract:UNLABELLED:Brain dysfunction after cardiopulmonary bypass (CPB) is common, and it has been hypothesized that this injury might be due partly to activation of inflammatory processes in the brain. We measured juguloarterial gradients for interleukin-1beta, interleukin-6, and interleukin-8 (IL-8) as indices of local proin...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Nandate K,Vuylsteke A,Crosbie AE,Messahel S,Oduro-Dominah A,Menon DK

    更新日期:1999-10-01 00:00:00

  • Digital skin blood flow as an indicator for intravascular injection of epinephrine-containing simulated epidural test dose in sevoflurane-anesthetized adults.

    abstract:UNLABELLED:I designed this study to determine the efficacy of heart rate (HR), systolic blood pressure (SBP), and digital skin blood flow (DSBF) in detecting intravascular injection after a simulated epidural test dose containing 15 mug of epinephrine in sevoflurane-anesthetized adults. In addition, the testing thresho...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Mowafi HA

    更新日期:2005-08-01 00:00:00

  • Butorphanol and morphine: a double-blind comparison of their parenteral analgesic activity.

    abstract::The analgesic effects of butorphanol tartrate and morphine sulfate were compared in 127 patients judged to have moderate to severe pain following major operations. The study was double-blind, and the drugs were given IM at several dosage levels. Scores for pain intensity and relief, as well as pain-intensity differenc...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Tavakoli M,Corssen G,Caruso FS

    更新日期:1976-05-01 00:00:00

  • Brain edema, hemorrhagic necrosis volume, and neurological status with rapid infusion of 0.45% saline or 5% dextrose in 0.9% saline after closed head trauma in rats.

    abstract::We previously reported that in rats with closed head trauma (CHT), intravenous (IV) administration of 0.25 mL/g of 5% dextrose solution (D5W) increased blood glucose (G), decreased blood sodium (Na), caused no change in blood osmolality (Osm), increased brain edema (BE), and worsened neurological severity score (NSS) ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Gurevich B,Talmor D,Artru AA,Katcko L,Geva D,Gurman G,Shapira Y

    更新日期:1997-03-01 00:00:00

  • Fentanyl-air-oxygen anesthesia for ligation of patent ductus arteriosus in preterm infants.

    abstract::In 10 premature infants (1123 +/- 263 g), fentanyl citrate (30 to 50 microgram/kg) was used in conjunction with pancuronium (0.1 mg/kg) as the sole anesthetic for transthoracic ligation of patent ductus arteriosus. Ventilation was controlled with air and oxygen in concentrations sufficient to maintain transcutaneous P...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Robinson S,Gregory GA

    更新日期:1981-05-01 00:00:00

  • Intrathecal anesthesia: ropivacaine versus bupivacaine.

    abstract::We compared intrathecal ropivacaine to bupivacaine in patients scheduled for transurethral resection of bladder or prostate. Doses of ropivacaine and bupivacaine were chosen according to a 3:2 ratio found to be equipotent in orthopedic surgery. One hundred patients were randomly assigned to blindly receive either 10 m...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Malinovsky JM,Charles F,Kick O,Lepage JY,Malinge M,Cozian A,Bouchot O,Pinaud M

    更新日期:2000-12-01 00:00:00

  • Urodynamic studies after intrathecal fentanyl and buprenorphine in the dog.

    abstract::Cystometrograms (CMG) and urethral pressure profiles (UPP) were used in six anesthetized dogs to study the urodynamic effects of intrathecal (IT) injections of fentanyl and buprenorphine. The CMG and UPP were examined for each of the two drugs in all dogs (four experiments per animal). The measurements were performed ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Drenger B,Magora F

    更新日期:1989-09-01 00:00:00

  • Effects of Intraoperative Opioid Use on Recurrence-Free and Overall Survival in Patients With Esophageal Adenocarcinoma and Squamous Cell Carcinoma.

    abstract:BACKGROUND:Perioperative opioid use is associated with poor survival in patients with esophageal squamous cell carcinoma. The most common histological type of esophageal cancer in western countries is adenocarcinoma. The objective of this study was to evaluate the association between intraoperative opioid consumption a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Du KN,Feng L,Newhouse A,Mehta J,Lasala J,Mena GE,Hofstetter WL,Cata JP

    更新日期:2018-07-01 00:00:00

  • Anesthetic Management for Percutaneous Minimally Invasive Fetoscopic Surgery of Spina Bifida Aperta: A Retrospective, Descriptive Report of Clinical Experience.

    abstract::Minimally invasive fetoscopic surgery for spina bifida aperta is a new therapeutic approach to preserve neurologic function by protecting exposed neural tissue. The anesthetic management is of paramount importance for the success of the procedure. Therefore, our protocol was developed with particular attention to safe...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Arens C,Koch C,Veit M,Greenberg RS,Lichtenstern C,Weigand MA,Khaleeva A,Schuerg R,Kohl T

    更新日期:2017-07-01 00:00:00

  • Energy dose and other variables possibly affecting ventricular defibrillation during cardiac surgery.

    abstract::Previous studies have suggested that shocks of 5-10 J are required for direct ventricular defibrillation during open heart surgery. However, the efficacy of shocks of less than 5 J, the effects of thermal, biochemical, and temporal factors, and the influence of disease process on defibrillation have not been fully inv...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Lake CL,Sellers TD,Nolan SP,Crosby IK,Wellons HA Jr,Crampton RS

    更新日期:1984-08-01 00:00:00

  • The inhibitory effects of local anesthetics on primary sensory nerve and parasympathetic nerve in rabbit eye.

    abstract::Primary sensory nerves transmit information to both the periphery and central nervous systems, and they mediate neurogenic inflammation by release of neurotransmitters, such as tachykinins, in the periphery. Because the effect of local anesthetics on neurogenic inflammation is a subject of controversy, we investigated...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Takakura K,Mizogami M,Morishima S,Muramatsu I

    更新日期:2006-09-01 00:00:00

  • Assessment of Tricuspid Annular Motion by Speckle Tracking in Anesthetized Patients Using Transesophageal Echocardiography.

    abstract:BACKGROUND:The perioperative assessment of right ventricular (RV) function remains a challenge. Tricuspid annular plane systolic excursion (TAPSE) using M-mode is a widely used measure of RV function. However, accurate alignment of the ultrasound beam with the direction of annular movement can be difficult with transes...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Shen T,Picard MH,Hua L,Burns SM,Andrawes MN

    更新日期:2018-01-01 00:00:00

  • Intrabiliary pressure changes produced by narcotic drugs and inhalation anesthetics in guinea pigs.

    abstract::The effects of narcotic agents and two inhalation anesthetics on intrabiliary pressure (IBP) were measured before and after morphine (0.2 mg/kg), meperidine (2 mg/kg), fentanyl (0.002 mg/kg), or pentazocine (1 mg/kg) given intramuscularly to guinea pigs, and after halothane (0.5, 1.0, 1.5, or 2.0 MAC) or enflurane (sa...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Arguelles JE,Franatovic Y,Romo-Salas F,Aldrete JA

    更新日期:1979-03-01 00:00:00