The in vivo effects of general and epidural anesthesia on human immune function.

Abstract:

UNLABELLED:Impaired in vivo immunity is often observed after major surgery and is multifactorial. We conducted a randomized clinical study to determine the independent effects of general anesthesia (GA) and of lumbar epidural anesthesia (LEA) on human immune function in the absence of surgical trauma. Nineteen healthy volunteers were randomized to receive GA with thiopental and isoflurane, LEA with lidocaine, or no anesthesia (Control). Serial blood samples were tested for antibody responses to antigen inoculation, neutrophil and mononuclear cell antibody-dependent cell cytotoxicity (ADCC), natural killer cell cytotoxicity, and neutrophil phagocytic activity. Antibody responses were similar in the three groups. Mononuclear cell ADCC increased in the LEA group at the end of the anesthetic (P < 0.05 at effector/target [E/T] ratios of 10:1, 25:1, and 50:1). Natural killer cell cytotoxicity increased at the end of the anesthetic in both the LEA group (P < 0.05 at all E/T ratios) and the GA group (P < 0.05 at an E/T ratio of 5:1 and 10:1). No significant changes were observed for neutrophil ADCC or phagocytosis. General or epidural anesthesia alone, in the absence of surgery, seems to have only transient and minor effects on human immune function. IMPLICATIONS:General or epidural anesthesia alone, in the absence of surgery, seems to have only transient and minor effects on human immune function.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Procopio MA,Rassias AJ,DeLeo JA,Pahl J,Hildebrandt L,Yeager MP

doi

10.1097/00000539-200108000-00044

subject

Has Abstract

pub_date

2001-08-01 00:00:00

pages

460-5, 4th contents page

issue

2

eissn

0003-2999

issn

1526-7598

journal_volume

93

pub_type

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