Does preoperative anxiety influence gastric fluid volume and acidity?


:Preoperative anxiety may increase gastric fluid acidity and volume. To pursue this possibility we evaluated the relationship between peroral premedication, preoperative anxiety, and gastric content in 246 consecutive patients presenting for elective gynecologic surgery. All patients fasted overnight and received either flunitrazepam 1 mg, oxazepam 25 mg, or placebo with 20 mL of water on the morning of surgery in a randomized, double-blind fashion. The patients assessed relief of anxiety using a four-graded scale (excellent, good, fair, poor). Both flunitrazepam and oxazepam decreased anxiety (P less than 0.01) compared with placebo. However, no correlations between type of premedication or level of anxiety and gastric contents were found. The proportion of patients with gastric fluid volume greater than 25 mL and pH less than 2.5 was not significantly different in any of the groups studied. These results suggest that neither peroral benzodiazepine premedication nor preoperative anxiety have a clinically important impact on gastric content in patients presenting for elective gynecologic surgery.


Anesth Analg


Anesthesia and analgesia


Haavik PE,Søreide E,Hofstad B,Steen PA




Has Abstract


1992-07-01 00:00:00












  • The effects of dobutamine and phenylephrine on atrioventricular conduction during combined use of halothane and thoracic epidural lidocaine.

    abstract::The purpose of this study was to measure cardiac sympathetic nerve activity (CSNA) and atrioventricular (AV) conduction and to test the effects of dobutamine (DOB) and phenylephrine (PHE) on AV conduction during combined use of halothane and thoracic epidural lidocaine. Cats were anesthetized with 1 % halothane and an...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Nishikawa K,Yabe M,Mori T,Terai T,Yukioka H,Fujimori M

    更新日期:1996-03-01 00:00:00

  • The local peripheral antihyperalgesic effect of levetiracetam and its mechanism of action in an inflammatory pain model.

    abstract:BACKGROUND:We have recently shown that levetiracetam, administered systemically, exerts an antihyperalgesic effect in a rat inflammatory pain model. In this study, we examined whether levetiracetam has local peripheral antihyperalgesic/anti-edematous effects in the same model of localized inflammation and whether opioi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Stepanović-Petrović RM,Micov AM,Tomić MA,Ugrešić ND

    更新日期:2012-12-01 00:00:00

  • Reliability of the transient hyperemic response test in detecting changes in cerebral autoregulation induced by the graded variations in end-tidal carbon dioxide.

    abstract:UNLABELLED:The transient hyperemic response (THR) in the middle cerebral artery (MCA) after the release of brief compression of the ipsilateral common carotid artery has been used to study cerebral autoregulation. We conducted the present study to evaluate the reliability of THR to detect changes in cerebral autoregula...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Mahajan RP,Cavill G,Simpson EJ

    更新日期:1998-10-01 00:00:00

  • Rates of Perioperative Respiratory Adverse Events Among Caucasian and African American Children Undergoing General Anesthesia.

    abstract:BACKGROUND:Perioperative respiratory adverse events (PRAEs) account for the major cause of morbidity and mortality in children undergoing general anesthesia. In our institutional clinical practice, we suspected that African American children experienced untoward respiratory events more frequently than other racial grou...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Tariq S,Syed M,Martin T,Zhang X,Schmitz M

    更新日期:2018-07-01 00:00:00

  • Cost analysis of target-controlled infusion-based anesthesia compared with standard anesthesia regimens.

    abstract:UNLABELLED:With the development of new computer-assisted target-controlled infusion (TCI) systems and the availability of short-acting anesthetics, total IV anesthesia (TIVA) has become increasingly popular. The aim of this study was to compare costs of TCI-based anesthesia with two standard anesthesia regimens. Sixty ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验,收录出版


    authors: Suttner S,Boldt J,Schmidt C,Piper S,Kumle B

    更新日期:1999-01-01 00:00:00

  • Macroscopic postmortem findings in 235 surgical intensive care patients with sepsis.

    abstract:BACKGROUND:Although detailed analyses of the postmortem findings of various critically ill patient groups have been published, no such study has been performed in patients with sepsis. In this retrospective cohort study, we reviewed macroscopic postmortem examinations of surgical intensive care unit (ICU) patients who ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Torgersen C,Moser P,Luckner G,Mayr V,Jochberger S,Hasibeder WR,Dünser MW

    更新日期:2009-06-01 00:00:00

  • Hyperglycemia impairs isoflurane-induced adenosine triphosphate-sensitive potassium channel activation in vascular smooth muscle cells.

    abstract:BACKGROUND:Isoflurane activates vascular adenosine triphosphate sensitive potassium (K(ATP)) channels, and may induce vasodilation. In the present study, we investigated whether hyperglycemia modifies isoflurane activation of vascular K(ATP) channel. METHODS:We used a cell-attached patch-clamp configuration to test th...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Kawano T,Tanaka K,Mawatari K,Oshita S,Takahashi A,Nakaya Y

    更新日期:2008-03-01 00:00:00

  • Mice tolerant to nitrous oxide are not tolerant to barbiturates.

    abstract::Mice continuously exposed to 50% nitrous oxide for 2 weeks or more become tolerant to nitrous oxide, as measured by an 8% to 19% increase in their nitrous oxide ED50 (the dose required to abolish the righting reflex in 50% of the animals). Control mice tolerant to nitrous oxide were given intraperitoneal injections of...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Koblin DD,Deady JE,Nelson NT,Eger EI 2nd,Bainton CR

    更新日期:1981-03-01 00:00:00

  • Nocebo-induced hyperalgesia during local anesthetic injection.

    abstract::Common practice during local anesthetic injection is to warn the patient using words such as: "You will feel a big bee sting; this is the worst part." Our hypothesis was that using gentler words for administration of the local anesthetic improves pain perception and patient comfort. One hundred forty healthy women at ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Varelmann D,Pancaro C,Cappiello EC,Camann WR

    更新日期:2010-03-01 00:00:00

  • Interaction between mivacurium and succinylcholine.

    abstract::We investigated the interaction between mivacurium and succinylcholine when mivacurium was administered during the early recovery from succinylcholine block. We studied 40 adult patients during propofol-alfentanil-N2O-O2 anesthesia. Neuromuscular function was monitored using an electromyographic method (Relaxograph, D...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Erkola O,Rautoma P,Meretoja OA

    更新日期:1995-03-01 00:00:00

  • Transdiscal lumbar sympathetic block: a new technique for a chemical sympathectomy.

    abstract:UNLABELLED:Genitofemoral neuritis, which occurs when the neurolytic solution spreads into the psoas muscle, is the most common complication after neurolytic lumbar sympathetic block. We developed a transdiscal approach for neurolytic lumbar sympathetic block to reduce the danger of genitofemoral neuritis by making a sy...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Ohno K,Oshita S

    更新日期:1997-12-01 00:00:00

  • Evolution of the French public's knowledge and attitudes regarding postoperative pain, cancer pain, and their treatments: two national surveys over a six-year period.

    abstract:UNLABELLED:Pain management has become a notable feature of public health policy and mass media communication in France over the past few years. To assess the evolution of the knowledge and attitudes of the French population with respect to pain management and morphine use, telephone surveys using similar questionnaires...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Larue F,Fontaine A,Brasseur L

    更新日期:1999-09-01 00:00:00

  • A Retrospective Analysis of Clinical Research Misconduct Using FDA-Issued Warning Letters and Clinical Investigator Inspection List From 2010 to 2014.

    abstract:BACKGROUND:The US Food and Drug Administration (FDA) conducts inspections of clinical investigation sites as a component of clinical trial regulation. The FDA describes the results of these inspections in the Clinical Investigator Inspection List (CLIIL). More serious violations are followed up in FDA warning letters i...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Romano CA,Nair S,Delphin ES

    更新日期:2018-03-01 00:00:00

  • Carbon monoxide production from degradation of desflurane, enflurane, isoflurane, halothane, and sevoflurane by soda lime and Baralyme.

    abstract::Anecdotal reports suggest that soda lime and Baralyme brand absorbent can degrade inhaled anesthetics to carbon monoxide (CO). We examined the factors that govern CO production and found that these include: 1) The anesthetic used: for a given minimum alveolar anesthetic concentration (MAC)-multiple, the magnitude of C...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Fang ZX,Eger EI 2nd,Laster MJ,Chortkoff BS,Kandel L,Ionescu P

    更新日期:1995-06-01 00:00:00

  • Transient neurologic syndrome in one thousand forty-five patients after 3% lidocaine spinal anesthesia.

    abstract:UNLABELLED:Recent reports have discussed the potential risk of transient radicular irritation (TRI) after spinal anesthesia with lidocaine. Because we have not encountered such neurologic sequelae with the high incidence reported, we prospectively examined the incidence of TRI after spinal anesthesia with lidocaine. On...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Morisaki H,Masuda J,Kaneko S,Matsushima M,Takeda J

    更新日期:1998-05-01 00:00:00

  • Labor epidural analgesia and maternal fever.

    abstract::Women in labor who receive epidural analgesia are more likely to experience hyperthermia and overt clinical fever. The gradual development of modest hyperthermia observed in laboring women with epidural analgesia is not seen in those electing other forms of analgesia or unmedicated labor. Clinical fever is also far mo...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Segal S

    更新日期:2010-12-01 00:00:00

  • Epidural anesthesia for cesarean section in diabetic parturients: maternal and neonatal acid-base status and bupivacaine concentration.

    abstract::Acid-base status and blood levels of bupivacaine were determined in 16 diabetic parturients and their infants after epidural anesthesia for cesarean section. The newborn infants were divided into two groups based on umbilical artery pH at birth. Group A consisted of 10 infants who had a pH of less than 7.2 and group B...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Datta S,Brown WU Jr,Ostheimer GW,Weiss JB,Alper MH

    更新日期:1981-08-01 00:00:00

  • Effect of naloxone infusion on analgesia and respiratory depression after epidural fentanyl.

    abstract::The efficacy of two dosage regimens of intravenous naloxone were compared to avoid nonrespiratory side effects and respiratory depression and yet to preserve analgesia (maximum tolerance to periostial pressure over the tibia) after administration of 200 micrograms epidural fentanyl. Three groups of eight patients were...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Gueneron JP,Ecoffey Cl,Carli P,Benhamou D,Gross JB

    更新日期:1988-01-01 00:00:00

  • Prothrombin Complex Concentrates for Bleeding in the Perioperative Setting.

    abstract::Prothrombin complex concentrates (PCCs) contain vitamin K-dependent clotting factors (II, VII, IX, and X) and are marketed as 3 or 4 factor-PCC formulations depending on the concentrations of factor VII. PCCs rapidly restore deficient coagulation factor concentrations to achieve hemostasis, but like with all procoagul...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Ghadimi K,Levy JH,Welsby IJ

    更新日期:2016-05-01 00:00:00

  • Case report: a thrombus in the venous reservoir while using bivalirudin in a patient with heparin-induced thrombocytopenia undergoing heart transplantation.

    abstract::Direct thrombin inhibitors are heparin alternatives for anticoagulation during cardiopulmonary bypass in patients with heparin-induced thrombocytopenia. We report a case of a large thrombus forming in the venous reservoir while using bivalirudin. We suggest that blood stasis associated with the full venous reservoir m...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Wong JK,Tian Y,Shuttleworth P,Caffarelli AD,Reitz BA,Mora-Mangano CT

    更新日期:2010-09-01 00:00:00

  • Enhancement of fentanyl analgesia by clonidine plus verapamil in rats.

    abstract::An investigation was made of the analgesic effects of the subcutaneous coadministration of fentanyl, an opioid mu-agonist (15 micrograms/kg), clonidine, an alpha 2-agonist (100 micrograms/kg), and verapamil, a calcium channel blocker (10 mg/kg) in rats. Nociceptive sensitivity was assessed with hot-plate and tail-flic...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Horváth G,Benedek G,Szikszay M

    更新日期:1990-03-01 00:00:00

  • Myocardial metabolism and hemodynamic responses with isoflurane anesthesia for coronary arterial surgery.

    abstract::Isoflurane-oxygen was given for induction and maintenance of anesthesia to ten patients having coronary artery bypass grafts. All had preserved ventricular function without hypertension or other cardiac lesions; treatment with beta-blocking drugs was maintained until the operation in all patients. Cardiac output, arte...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Moffitt EA,Barker RA,Glenn JJ,Imrie DD,DelCampo C,Landymore RW,Kinley CE,Murphy DA

    更新日期:1986-01-01 00:00:00

  • The Cognitive Science of Learning: Concepts and Strategies for the Educator and Learner.

    abstract::Education is the fundamental process used to develop and maintain the professional skills of physicians. Medical students, residents, and fellows are expected to learn considerable amounts of information as they progress toward board certification. Established practitioners must continue to learn in an effort to remai...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Weidman J,Baker K

    更新日期:2015-12-01 00:00:00

  • Propofol and thiopental in a 1:1 volume mixture is chemically stable.

    abstract:UNLABELLED:Propofol and thiopental have been used clinically in combination for induction of anesthesia. Studies suggest that this mixture has synergistic activity, recovery characteristics similar to propofol alone, and bactericidal effects on multiple organisms. It may therefore be both clinically useful and cost-eff...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Lazar ER,Jolly DT,Tam YK,Hrazdil J,Tawfik SR,Clanachan AS

    更新日期:1998-02-01 00:00:00

  • The effects of tramadol and morphine on immune responses and pain after surgery in cancer patients.

    abstract:UNLABELLED:There has been growing interest in determining the possible immune consequences of opioid administration for the management of postoperative pain. We studied the effects of morphine and tramadol on pain and immune function during the postoperative period in 30 patients undergoing abdominal surgery for uterin...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Sacerdote P,Bianchi M,Gaspani L,Manfredi B,Maucione A,Terno G,Ammatuna M,Panerai AE

    更新日期:2000-06-01 00:00:00

  • Lateral approach to the sciatic nerve in the popliteal fossa.

    abstract:UNLABELLED:We describe a modification of the sciatic nerve (SN) block in the popliteal fossa through the lateral approach. After a brief anatomic study using previously reported landmarks, we propose a new needle orientation associated with a double injection technique after identification of the tibial and the common ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Zetlaoui PJ,Bouaziz H

    更新日期:1998-07-01 00:00:00

  • Train-of-four and tetanic fade are not always a prejunctional phenomenon as evaluated by toxins having highly specific pre- and postjunctional actions.

    abstract:BACKGROUND:Nerve-stimulated fade in muscle is generally accepted as a prejunctional phenomenon mediated by block of prejunctional acetylcholine receptors (AChRs) at the nerve terminal, whereas decrease of twitch tension is considered a postjunctional effect due to block of muscle AChRs. Using ligands with specific pre-...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Nagashima M,Yasuhara S,Martyn JA

    更新日期:2013-05-01 00:00:00

  • The influence of propofol on vomiting induced by apomorphine.

    abstract::It has been proposed that propofol has antiemetic effects even in nonsedative doses. The aim of this study was to investigate whether propofol influences vomiting induced by the dopamine agonist apomorphine. Ten healthy male volunteers received apomorphine infusion (1 mg/min) until vomiting was induced on four differe...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hvarfner A,Hammas B,Thörn SE,Wattwil M

    更新日期:1995-05-01 00:00:00

  • Beta-adrenergic blockers and vasovagal episodes during shoulder surgery in the sitting position under interscalene block.

    abstract:UNLABELLED:Shoulder surgery is often performed with patients in the sitting position under interscalene block anesthesia. Vasovagal episodes, characterized by a sudden decrease in heart rate and/or blood pressure, have a reported incidence of 17%-24% in this setting. We performed a retrospective study to determine whet...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Kahn RL,Hargett MJ

    更新日期:1999-02-01 00:00:00

  • A secure method of nasotracheal tube fixation using an infant feeding tube.

    abstract::A well secured endotracheal tube is very essential for the safe conduct of anesthesia. In maxillofacial surgeries, providing secure fixation of the nasotracheal tube has always been a problem. We have used an infant feeding tube that goes around the nasal septum for the fixation of the nasal endotracheal tube. This me...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Bhat VR,Venkateshwaran G

    更新日期:2004-11-01 00:00:00