Comparison of resuscitation of sheep and dogs after bupivacaine-induced cardiovascular collapse.

Abstract:

:This study evaluated interspecies sensitivity and ability to resuscitate pentobarbital anesthetized sheep and dogs after cardiovascular toxic doses of bupivacaine. Every minute, 3 mg/kg of bupivacaine was injected into the right atrium over the course of 10 sec until cardiovascular collapse occurred. While the bupivacaine was given, the animals were made apneic for 90 sec and then ventilated with 100% oxygen. After the bupivacaine administration, cardiovascular collapse occurred in the form of electromechanical dissociation progressing to asystole in dogs, whereas in sheep the predominant rhythm was ventricular fibrillation leading to asystole. Resuscitation was performed using open chest heart massage, bretylium for treatment of ventricular tachycardia and fibrillation, and epinephrine with atropine for treatment of electromechanical dissociation or asystole. The initial dose of bupivacaine used to cause cardiovascular collapse was 3.5 +/- 1.2 mg/kg in sheep and 24.6 +/- 8.5 mg/kg in dogs (P less than 0.01). All sheep and dogs were resuscitated from the first cardiovascular collapse. The resuscitation time was 2.1 +/- 1.0 min in dogs and 36.9 +/- 15.4 min in sheep (P less than 0.01). All dogs could be resuscitated after two additional cardiovascular collapses induced by bupivacaine, but no sheep could be resuscitated after a second cardiovascular collapse. Concentrations of bupivacaine in cardiac tissue and serum levels of bupivacaine after the last resuscitation attempt were significantly greater in the dogs than in the sheep. We conclude that sheep are more sensitive to bupivacaine than dogs, but that even sheep can be resuscitated after cardiovascular collapse produced by bupivacaine.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Kasten GW,Martin ST

subject

Has Abstract

pub_date

1986-10-01 00:00:00

pages

1029-32

issue

10

eissn

0003-2999

issn

1526-7598

journal_volume

65

pub_type

杂志文章
  • Brief report: The sensitivity of motor responses for detecting catheter-nerve contact during ultrasound-guided femoral nerve blocks with stimulating catheters.

    abstract:BACKGROUND:We determined the sensitivity of motor responses evoked by stimulating catheters in determining catheter-nerve contact using ultrasonography as reference. METHODS:Femoral nerves were contacted using stimulating catheters under ultrasonography scanning in 25 patients. The output current was increased from it...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e31822c9887

    authors: Altermatt FR,Corvetto MA,Venegas C,Echevarría G,Bravo P,De la Cuadra JC,Irribarra LA

    更新日期:2011-11-01 00:00:00

  • Management of an unusual complication during placement of a pulmonary artery catheter.

    abstract::We describe an unusual complication during flotation of a pulmonary artery catheter through a preexisting percutaneous introducer sheath. A malfunctioning pulmonary artery catheter, which was placed through an introducer sheath in the right internal jugular vein, was removed. Attempts at repositioning a second pulmona...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ANE.0000133244.59867.6F

    authors: Bhatia P,Saied NN,Comunale ME

    更新日期:2004-09-01 00:00:00

  • Reflex responses to sodium nitroprusside and their control by cryptenamine.

    abstract::In chloralose-anesthetized dogs the hypotensive and reflex cardiovascular responses to infusions of sodium nitroprusside were studied before and during halothane and enflurane, and before after divided doses of cryptenamine. The latter drug, a mixture of hypotensive veratrum alkaloids, lowers blood pressure reflexly b...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Flacke JW,Flacke WE,Cant JW

    更新日期:1980-12-01 00:00:00

  • Antinociceptive potentiation and attenuation of tolerance by intrathecal co-infusion of magnesium sulfate and morphine in rats.

    abstract:UNLABELLED:N-methyl-D-aspartate (NMDA) antagonists, such as MK801, delay the development of morphine tolerance. Magnesium, a noncompetitive NMDA antagonist, reduces postoperative morphine requirements. The present study was designed to evaluate the effects of intrathecal co-administration of magnesium sulfate with morp...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199804000-00028

    authors: McCarthy RJ,Kroin JS,Tuman KJ,Penn RD,Ivankovich AD

    更新日期:1998-04-01 00:00:00

  • Avoiding transfusions in children undergoing cardiac surgery: a meta-analysis of randomized trials of aprotinin.

    abstract::Aprotinin, a potent antifibrinolytic drug, reduces the proportion of adults who receive blood transfusions during cardiac surgery, although the effect in children remains unclear. We performed a systematic review of the literature to identify all English language, randomized controlled trials of aprotinin involving ch...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,meta分析

    doi:10.1213/01.ane.0000194954.64293.61

    authors: Arnold DM,Fergusson DA,Chan AK,Cook RJ,Fraser GA,Lim W,Blajchman MA,Cook DJ

    更新日期:2006-03-01 00:00:00

  • Sevoflurane inhibited beta-adrenoceptor-G protein bindings in myocardial membrane in rats.

    abstract::The effects of sevoflurane on the beta-adrenoceptor (beta AR) system, consisting of the receptor, stimulatory guanosine triphosphate (GTP) binding protein (Gs), and adenylate cyclase (AC), were studied in rat myocardial membrane. Cyclic adenosine monophosphate (cAMP) production rate was measured as cAMP generation sti...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199409000-00011

    authors: Sanuki M,Yuge O,Kawamoto M,Fujii K,Azuma T

    更新日期:1994-09-01 00:00:00

  • Neostigmine and 4-aminopyridine antagonism of lincomycin-pancuronium neuromuscular blockade in man.

    abstract::Seven anesthetized patients were studied to determine the interaction between pancuronium and lincomycin and the ability of neostigmine and 4-aminopyridine to antagonize the block. Lincomycin 600 mg given IV alone did not decrease twitch tension. An 8 to 10% decrease in twitch tension occurred when lincomycin was give...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-197805000-00007

    authors: Booij LH,Miller RD,Crul JF

    更新日期:1978-05-01 00:00:00

  • The effects of perioperative ketorolac infusion on postoperative pain and endocrine-metabolic response.

    abstract::We designed a randomized, double-blind study to assess the analgesic efficacy and safety of perioperative ketorolac infusion in 95 patients undergoing cholecystectomy. The ketorolac group (n = 48) received premedication, combined with ketorolac 30 mg intramuscularly (IM), followed by a ketorolac continuous infusion (2...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/00000539-199403000-00017

    authors: Varrassi G,Panella L,Piroli A,Marinangeli F,Varrassi S,Wolman I,Niv D

    更新日期:1994-03-01 00:00:00

  • Production of endothelin-1 and reduced blood flow in the rat kidney during lung-injurious mechanical ventilation.

    abstract:INTRODUCTION:The mechanisms by which mechanical ventilation (MV) can injure remote organs, such as the kidney, remain poorly understood. We hypothesized that upregulation of systemic inflammation, as reflected by plasma interleukin-6 (IL-6) levels, in response to a lung-injurious ventilatory strategy, ultimately result...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e31818067a2

    authors: Kuiper JW,Versteilen AM,Niessen HW,Vaschetto RR,Sipkema P,Heijnen CJ,Groeneveld AB,Plötz FB

    更新日期:2008-10-01 00:00:00

  • Hemodynamic responses to physostigmine in patients with a drug overdose.

    abstract::Hemodynamic responses to physostigmine were evaluated in eight patients with coma due to overdose with mainly anticholinergic drugs (AC) and in five patients with coma due to overdose with nonanticholinergic drugs (NAC). After correction of hypovolemia, but before administration of physostigmine, AC patients had signi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Nilsson E,Meretoja OA,Neuvonen P

    更新日期:1983-10-01 00:00:00

  • Halothane enhances pulmonary artery endothelial eicosanoid release.

    abstract::To determine whether anesthetics alter endothelial eicosanoid release, cultured bovine pulmonary artery endothelial cells were studied during constant flow and pressure perfusion at two oxygen tensions (hypoxia, 50 +/- 2 mm Hg; normoxia, 144 +/- 5 mm Hg; mean +/- SEM) with and without 1% halothane. Endothelialized mic...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199212000-00022

    authors: Barnes SD,Martin LD,Wetzel RC

    更新日期:1992-12-01 00:00:00

  • Intrathecal anesthesia: ropivacaine versus bupivacaine.

    abstract::We compared intrathecal ropivacaine to bupivacaine in patients scheduled for transurethral resection of bladder or prostate. Doses of ropivacaine and bupivacaine were chosen according to a 3:2 ratio found to be equipotent in orthopedic surgery. One hundred patients were randomly assigned to blindly receive either 10 m...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-200012000-00030

    authors: Malinovsky JM,Charles F,Kick O,Lepage JY,Malinge M,Cozian A,Bouchot O,Pinaud M

    更新日期:2000-12-01 00:00:00

  • Intravenous lidocaine as a suppressant of coughing during tracheal intubation in elderly patients.

    abstract::The effects of intravenously administered lidocaine on cough suppression in elderly patients over the age of 60 yr during tracheal intubation under general anesthesia were evaluated in two studies. In the first study, 100 patients received a placebo of either 0.5, 1.0, 1.5, or 2.0 mg/kg lidocaine intravenously 1 min b...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/00000539-199308000-00016

    authors: Yukioka H,Hayashi M,Terai T,Fujimori M

    更新日期:1993-08-01 00:00:00

  • Catheter-associated masses in patients receiving intrathecal analgesic therapy.

    abstract:UNLABELLED:A cohort of seven patients receiving intrathecal analgesic drug therapy for chronic intractable pain underwent radiocontrast myelography and computed tomography (CT) scanning to screen for catheter-associated intrathecal masses. Three of seven patients examined had intraspinal masses associated with the tip ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200301000-00039

    authors: McMillan MR,Doud T,Nugent W

    更新日期:2003-01-01 00:00:00

  • Candida albicans versus non-albicans intensive care unit-acquired bloodstream infections: differences in risk factors and outcome.

    abstract:OBJECTIVE:In this study we sought to identify differences in risk factors and outcome of critically ill patients with Candida albicans and non-albicans candidemia. METHODS:Nonimmunosuppressed, nonneutropenic patients with candidemia diagnosed after intensive care unit (ICU) admission were included in a prospective obs...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e3181607262

    authors: Dimopoulos G,Ntziora F,Rachiotis G,Armaganidis A,Falagas ME

    更新日期:2008-02-01 00:00:00

  • Malignant hyperthermia associated with enflurane anesthesia: a case report.

    abstract::Malignant hyperthermia syndrome associated with various anesthetic agents has been well documented, but none has been reported with enflurane (Ethrane). This particular case is the first involving exposure for the second time to enflurane anesthesia after a six-month interval in which malignant hyperthermia resulted. ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-197501000-00009

    authors: Pan TH,Wollack AR,DeMarco JA

    更新日期:1975-01-01 00:00:00

  • The effect of intravenous administration of dexamethasone on postoperative pain, nausea, and vomiting after intrathecal injection of meperidine.

    abstract:BACKGROUND:Different drugs have been used to enhance postoperative neuraxial opioid analgesia and reduce adverse effects. METHODS:We randomized 60 patients into 2 groups to receive either 2 mL saline or 0.1 mg/kg dexamethasone IV before the administration of intrathecal anesthesia (15 mg and meperidine 15 mg). After s...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/01.ane.0000257926.07491.55

    authors: Movafegh A,Soroush AR,Navi A,Sadeghi M,Esfehani F,Akbarian-Tefaghi N

    更新日期:2007-04-01 00:00:00

  • Isoflurane and halothane produce similar alterations in aortic distensibility and characteristic aortic impedance.

    abstract::The effects of volatile anesthetics on arterial mechanical properties in vivo are incompletely understood. The present investigation tested the hypothesis that isoflurane and halothane cause differential actions on the mechanical characteristics of the aorta in barbiturate-anesthetized dogs instrumented for measuremen...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199612000-00006

    authors: Hettrick DA,Pagel PS,Warltier DC

    更新日期:1996-12-01 00:00:00

  • Tactical decision making for selective expansion of operating room resources incorporating financial criteria and uncertainty in subspecialties' future workloads.

    abstract::We considered the allocation of operating room (OR) time at facilities where the strategic decision had been made to increase the number of ORs. Allocation occurs in two stages: a long-term tactical stage followed by short-term operational stage. Tactical decisions, approximately 1 yr in advance, determine what specia...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ANE.0000149898.45044.3D

    authors: Dexter F,Ledolter J,Wachtel RE

    更新日期:2005-05-01 00:00:00

  • Do new anesthesia ventilators deliver small tidal volumes accurately during volume-controlled ventilation?

    abstract:BACKGROUND:During mechanical ventilation of infants and neonates, small changes in tidal volume may lead to hypo- or hyperventilation, barotrauma, or volutrauma. Partly because breathing circuit compliance and fresh gas flow affect tidal volume delivery by traditional anesthesia ventilators in volume-controlled ventila...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e31816a68c6

    authors: Bachiller PR,McDonough JM,Feldman JM

    更新日期:2008-05-01 00:00:00

  • Maternal sepsis mortality and morbidity during hospitalization for delivery: temporal trends and independent associations for severe sepsis.

    abstract:BACKGROUND:Sepsis is currently the leading cause of direct maternal death in the United Kingdom. In this study, we aimed to determine frequency, temporal trends, and independent associations for severe sepsis during hospitalization for delivery in the United States. METHODS:Data were obtained from the Nationwide Inpat...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e3182a009c3

    authors: Bauer ME,Bateman BT,Bauer ST,Shanks AM,Mhyre JM

    更新日期:2013-10-01 00:00:00

  • Serotonergic activity in man as a function of pain, pain mechanisms, and depression.

    abstract::Lumbar cerebrospinal fluid levels of 5-hydroxyindoleacetic acid, which are used as indicators of central nervous system serotonergic neuronal activity, were significantly higher in 67 patients with chronic pain and in 32 patients with acute pain (23.6 +/- 3.3 and 23.1 +/- 3.8, respectively) than in 30 patients (8.8 +/...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Ghia JN,Mueller RA,Duncan GH,Scott DS,Mao W

    更新日期:1981-12-01 00:00:00

  • Transnasal placement of biplane transesophageal echocardiography probe intraoperatively in an adolescent with congenital heart disease.

    abstract:UNLABELLED:Intraoperative transesophageal echocardiography (TEE) is frequently used in children with congenital heart disease (CHD). Although transnasal TEE is being used in various settings in the adult population, there are no descriptions of its use intraoperatively in patients with CHD. This report describes the su...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000086729.89284.45

    authors: Aronson LA

    更新日期:2003-12-01 00:00:00

  • The Amsterdam Preoperative Anxiety and Information Scale (APAIS)

    abstract::The purpose of the present study was to assess patients' anxiety level and information requirement in the preoperative phase. During routine preoperative screening, 320 patients were asked to assess their anxiety and information requirement on a six-item questionnaire, the Amsterdam Preoperative Anxiety and Informatio...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199603000-00002

    authors: Moerman N,van Dam FS,Muller MJ,Oosting H

    更新日期:1996-03-01 00:00:00

  • Prothrombin Complex Concentrates for Bleeding in the Perioperative Setting.

    abstract::Prothrombin complex concentrates (PCCs) contain vitamin K-dependent clotting factors (II, VII, IX, and X) and are marketed as 3 or 4 factor-PCC formulations depending on the concentrations of factor VII. PCCs rapidly restore deficient coagulation factor concentrations to achieve hemostasis, but like with all procoagul...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0000000000001188

    authors: Ghadimi K,Levy JH,Welsby IJ

    更新日期:2016-05-01 00:00:00

  • The effects of femoral nerve blockade in conjunction with epidural analgesia after total knee arthroplasty.

    abstract::Either epidural analgesia or femoral nerve blockade improves analgesia and rehabilitation after total knee arthroplasty. No study has evaluated the combination of femoral nerve blockade and epidural analgesia. In this prospective, randomized, blinded study we investigated combining femoral nerve blockade with epidural...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/01.ANE.0000159150.79908.21

    authors: YaDeau JT,Cahill JB,Zawadsky MW,Sharrock NE,Bottner F,Morelli CM,Kahn RL,Sculco TP

    更新日期:2005-09-01 00:00:00

  • Immobilizing doses of halothane, isoflurane or propofol, do not preferentially depress noxious heat-evoked responses of rat lumbar dorsal horn neurons with ascending projections.

    abstract:BACKGROUND:The spinal cord is an important site where volatile anesthetics decrease sensation and produce immobility. Beyond this knowledge, our understanding of a site of anesthetic action is limited. Previous evidence suggests that dorsal horn neurons with ascending projections may be more susceptible to depression b...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e318163f8f3

    authors: Barter LS,Mark LO,Jinks SL,Carstens EE,Antognini JF

    更新日期:2008-03-01 00:00:00

  • Continuous infusion epidural analgesia in labor: the effect of adding sufentanil to 0.125% bupivacaine.

    abstract::The purpose of this study was to determine if the addition of sufentanil would improve the quality of analgesia obtained with 0.125% epidural bupivacaine infusions given to women in active labor. Forty healthy laboring women were randomly assigned to two equal groups. Group 1 had epidural analgesia instituted with the...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Phillips G

    更新日期:1988-05-01 00:00:00

  • Ocular microtremor during general anesthesia: results of a multicenter trial using automated signal analysis.

    abstract::Ocular microtremor (OMT) is a fine physiologic tremor of the eye related to neuronal activity in the reticular formation of the brainstem. The frequency of OMT is suppressed by propofol and sevoflurane and predicts the response to command at emergence from anesthesia. Previous studies have relied on post hoc computer ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,多中心研究

    doi:10.1213/01.ANE.0000133145.98702.C0

    authors: Heaney M,Kevin LG,Manara AR,Clayton TJ,Timmons SD,Angel JJ,Smith KR,Ibata B,Bolger C,Cunningham AJ

    更新日期:2004-09-01 00:00:00

  • Cyclic adenosine monophosphate response element-binding protein phosphorylation and neuroprotection by 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP).

    abstract:BACKGROUND:Previous studies show that the potent, prototypical sigma(1)-receptor agonist 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) prevents cell death after oxygen-glucose deprivation (OGD) in primary cortical neuronal cultures. We tested the hypothesis that PPBP protects neurons by a mechanism involving activation ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e318192442c

    authors: Yang S,Alkayed NJ,Hurn PD,Kirsch JR

    更新日期:2009-03-01 00:00:00