The Efficacy of Eslicarbazepine Acetate in Models of Trigeminal, Neuropathic, and Visceral Pain: The Involvement of 5-HT1B/1D Serotonergic and CB1/CB2 Cannabinoid Receptors.

abstract：BACKGROUND:Propofol-evoked injection site pain is not observed with fospropofol. We hypothesized that unlike propofol, fospropofol does not activate the irritant receptor, transient receptor potential 1 (TRPA1). METHODS:We tested the hypothesis using electrophysiology and behavioral studies. RESULTS:Our data demonstr...

journal_title：Anesthesia and analgesia

authors： Patwardhan A,Edelmayer R,Annabi E,Price T,Malan P,Dussor G

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:The electroencephalogram (EEG) measures cerebral activity and, because of its use as an intraoperative monitor, the Accreditation Council for Graduate Medical Education requires EEG monitoring experience during anesthesiology residency. To improve the anesthesiology residents' education at the University of ...

journal_title：Anesthesia and analgesia

authors： Fahy BG,Chau DF,Owen MB

更新日期：2008-01-01 00:00:00

abstract：UNLABELLED:Chronic ingestion of small doses of ethanol protects the myocardium from ischemic damage. It was demonstrated that short-term administration of ethanol (SAE) enhances the recovery of stunned myocardium in acutely instrumented, anesthetized dogs. It is unclear whether this beneficial effect of SAE also occurs...

journal_title：Anesthesia and analgesia

authors： Weber TP,Hartlage MA,Rolf N,Booke M,Berendes E,Van Aken H,Meissner A

更新日期：2003-03-01 00:00:00

abstract：UNLABELLED:Nitric oxide (NO) may play an important role in central and peripheral nociceptive processes. However, its contribution to peripheral antinociception is still not clear. In the present study, we investigated the effect of peripherally administered FK409, a spontaneous NO releaser, and its interaction with pe...

journal_title：Anesthesia and analgesia

authors： Nozaki-Taguchi N,Yamamoto T

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Preoperative risk stratification is a critical element in assessing the risks and benefits of surgery. Prior work has demonstrated that intra-abdominal general surgery patients can be classified based on their comorbidities and risk factors using latent class analysis (LCA), a model-based clustering techniqu...

journal_title：Anesthesia and analgesia

authors： Kim M,Wall MM,Li G

更新日期：2018-03-01 00:00:00

abstract：:The decrease of cardiac index observed during portal triad clamping (PTC) with and without pneumoperitoneum has been studied only with right heart catheterization. To better understand this decrease of cardiac index, we investigated the balance between the adequacy of preload and the ability of the heart to pump again...

journal_title：Anesthesia and analgesia

authors： Decailliot F,Streich B,Heurtematte Y,Duvaldestin P,Cherqui D,Stéphan F

更新日期：2005-03-01 00:00:00

abstract：:The purpose of this study was to determine whether injection rate affects the spread of hypobaric spinal anesthesia. Hypobaric spinal anesthesia was performed on 20 patients for total hip arthroplasty. Dural puncture was performed with a 22-gauge Whitacre needle. All patients received 10 mg of hypobaric tetracaine wit...

journal_title：Anesthesia and analgesia

authors： Atchison SR,Wedel DJ,Wilson PR

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND:In this prospective study, we compared the relationship between propofol concentrations and bispectral index (BIS) in children versus young adults anesthetized with target-controlled infusion (TCI) of propofol. METHODS:Forty-five prepubertal subjects (children) and 45 postpubertal subjects (adults) were stu...

journal_title：Anesthesia and analgesia

authors： Rigouzzo A,Girault L,Louvet N,Servin F,De-Smet T,Piat V,Seeman R,Murat I,Constant I

更新日期：2008-04-01 00:00:00

abstract：UNLABELLED:The sciatic nerve (SN) originates from the L4-S3 roots in the form of two nerve trunks: the tibial nerve (TN) and the common peroneal nerve (CPN). The TN and CPN are encompassed by a single epineural sheath and eventually separate (divide) in the popliteal fossa. This division of the SN occurs at a variable ...

journal_title：Anesthesia and analgesia

authors： Vloka JD,Hadzić A,April E,Thys DM

更新日期：2001-01-01 00:00:00

abstract：UNLABELLED:Supraclavicular nerve blocks are effective but may be complicated by pneumothorax. We hypothesized that, to avoid this complication, the depths of the brachial plexus and the lung could be estimated to guide needle placement. In 17 patients undergoing surgical relief of thoracic outlet syndrome, we designate...

journal_title：Anesthesia and analgesia

authors： Cornish PB,Greenfield LJ,O'Reilly M,Allan L

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to identify optimal target propofol and remifentanil concentrations to avoid a gag reflex in response to insertion of an upper gastrointestinal endoscope. METHODS:Patients presenting for endoscopy received target-controlled infusions (TCI) of both propofol and remifentanil for ...

journal_title：Anesthesia and analgesia

authors： Borrat X,Valencia JF,Magrans R,Gimenez-Mila M,Mellado R,Sendino O,Perez M,Nunez M,Jospin M,Jensen EW,Troconiz I,Gambus PL

更新日期：2015-07-01 00:00:00

abstract：UNLABELLED:We evaluated in a qualitative systematic review the effect of N-methyl-D-aspartate (NMDA) receptor antagonists on reducing postoperative pain and analgesic consumption beyond the clinical duration of action of the target drug (preventive analgesia). Randomized trials examining the use of an NMDA antagonist i...

journal_title：Anesthesia and analgesia

authors： McCartney CJ,Sinha A,Katz J

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Although local anesthetics (LAs) are generally accepted as being safe, incidental neuronal damage has been reported for all LAs in humans. Therefore, in this study, we compared the dose corresponding to 50% cell lethality (LD50) of articaine, lidocaine, mepivacaine, bupivacaine, prilocaine, and ropivacaine i...

journal_title：Anesthesia and analgesia

authors： Malet A,Faure MO,Deletage N,Pereira B,Haas J,Lambert G

更新日期：2015-03-01 00:00:00

abstract：:A newly developed transtracheal Doppler (TTD) computer for cardiac output determination was studied in nine patients after open heart surgery (coronary artery bypass grafting, n = 4; mitral valve replacement, n = 5). The measurements were compared with those simultaneously obtained by thermodilation. Doppler signals w...

journal_title：Anesthesia and analgesia

authors： Hausen B,Schäfers HJ,Rohde R,Haverich A

更新日期：1992-06-01 00:00:00

abstract：:A new single injection procedure, the fascia iliaca compartment block, is described for blocking the femoral, lateral cutaneous, and obturator nerves. The technique consists of injecting a local anesthetic immediately behind the fascia iliaca at the union of the lateral with the two medial thirds of the inguinal ligam...

journal_title：Anesthesia and analgesia

authors： Dalens B,Vanneuville G,Tanguy A

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND:We tested the hypothesis that hypothyroidism, as defined by thyroid-stimulating hormone (TSH) concentration, is associated with a severity-weighted composite of mortality and major cardiovascular and infectious complications after noncardiac surgery. METHODS:In this retrospective cohort study, we evaluated ...

journal_title：Anesthesia and analgesia

authors： Komatsu R,You J,Mascha EJ,Sessler DI,Kasuya Y,Turan A

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Total hemoglobin (tHb) is one the most frequently ordered laboratory measurements. Pulse CO-Oximetry™ (Masimo Corp., Irvine, CA) is a multi-wavelength spectrophotometric method for noninvasive and continuous hemoglobin monitoring (SpHb). In this study, we evaluated the accuracy of SpHb compared with laborato...

journal_title：Anesthesia and analgesia

authors： Macknet MR,Allard M,Applegate RL 2nd,Rook J

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Cigarette smoking by surgical patients is associated with increased complications, particularly perioperative respiratory problems and poor wound healing. In this study, we sought to determine whether a pragmatic perioperative smoking cessation intervention designed for a busy preadmission clinic would be su...

journal_title：Anesthesia and analgesia

authors： Lee SM,Landry J,Jones PM,Buhrmann O,Morley-Forster P

更新日期：2013-09-01 00:00:00

abstract：UNLABELLED:Urethane is widely used as an anesthetic for animal studies because of its minimal effects on cardiovascular and respiratory systems and maintenance of spinal reflexes. Despite its usefulness in animal research, there are no reports concerning its molecular actions. We designed this study to determine whethe...

journal_title：Anesthesia and analgesia

authors： Hara K,Harris RA

更新日期：2002-02-01 00:00:00

abstract：IMPLICATIONS:The number of patients supported by ventricular assist devices (VADs) that present for noncardiac surgery is increasing in our institution. Our recent experience with eight such patients is reported, along with a review of the most commonly implanted VADs and the anesthetic implications and considerations ...

journal_title：Anesthesia and analgesia

authors： Stone ME,Soong W,Krol M,Reich DL

更新日期：2002-07-01 00:00:00

abstract：:Antagonists of the serotonergic 5-hydroxytryptamine 3A receptor (5-HT(3A)R) and muscle nicotinic acetylcholine receptors (nAChR) are widely used in anesthesia practice. Both 5-HT(3A)R and nAChR are ligand-gated ion channels with known pharmacological overlap between some of their agonists and antagonists. We studied t...

journal_title：Anesthesia and analgesia

authors： Paul M,Callahan R,Au J,Kindler CH,Yost CS

更新日期：2005-09-01 00:00:00

abstract：:All patients undergoing heart surgery experience a certain amount of nonspecific myocardial injury documented by the release of cardiac biomarkers and associated with poor outcome. We investigated the role of unipolar radiofrequency ablation of atrial fibrillation on the release of cardiac biomarkers in 71 patients un...

journal_title：Anesthesia and analgesia

authors： Zangrillo A,Crescenzi G,Landoni G,Benussi S,Crivellari M,Pappalardo F,Dorigo E,Pappone C,Alfieri O

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Surveys suggest that, consistent with a high smoking prevalence, Chinese smokers in the general population report little interest in quitting. In other cultures, surgery is a powerful teachable moment for smoking cessation, increasing the rate of spontaneous quitting. We determined the perioperative tobacco ...

journal_title：Anesthesia and analgesia

authors： Yu C,Shi Y,Kadimpati S,Sheng Y,Jing J,Schroeder D,Luo A,Warner DO

更新日期：2013-06-01 00:00:00

abstract：UNLABELLED:We evaluated the pretreatment of small-dose of ketamine or normal saline in the reduction of withdrawal movements induced by rocuronium injection. One-hundred pediatric patients (aged 1-6 yr) were randomly assigned into 2 groups. A 22-gauge IV cannula was inserted into the dorsum of the hand, and ketamine 0....

journal_title：Anesthesia and analgesia

authors： Liou JT,Hsu JC,Liu FC,Ching-Wah Sum D,Lui PW

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Perineural dexamethasone has gained popularity in regional anesthesia to prolong analgesia duration. However, uncertainty remains regarding the optimal perineural dose. Clarification of this characteristic is of significant importance as the administration of dexamethasone may lead to dose-dependent complica...

journal_title：Anesthesia and analgesia

authors： Kirkham KR,Jacot-Guillarmod A,Albrecht E

更新日期：2018-01-01 00:00:00

abstract：:The pharmacokinetics of fentanyl were studied in fourteen neonates undergoing major surgical procedures. Five patients were less than 1 day of age, seven were 1-4 days old, and two were 7-14 days old. Fentanyl was given intravenously, 10 micrograms/kg (n = 1), 25 micrograms/kg (n = 4), or 50 micrograms/kg (n = 9), and...

journal_title：Anesthesia and analgesia

authors： Koehntop DE,Rodman JH,Brundage DM,Hegland MG,Buckley JJ

更新日期：1986-03-01 00:00:00

abstract：:Multiple pharmaceutical products contain excipients, or additive chemicals, to improve stability, bioavailability, antimicrobial activity, or palatability. Two of the most common excipients are propylene glycol and parabens. We report the successful anesthetic management of a patient with idiosyncratic reactions to pr...

journal_title：Anesthesia and analgesia

authors： Farber MK,Angelo TE,Castells M,Tsen LC

更新日期：2010-03-01 00:00:00

abstract：:The Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research, established by the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks public-private partnership with the US Food and Drug Administration, convened a meeting of sedation e...

journal_title：Anesthesia and analgesia

authors： Williams MR,Ward DS,Carlson D,Cravero J,Dexter F,Lightdale JR,Mason KP,Miner J,Vargo JJ,Berkenbosch JW,Clark RM,Constant I,Dionne R,Dworkin RH,Gozal D,Grayzel D,Irwin MG,Lerman J,O'Connor RE,Pandharipande P,Rappap

更新日期：2017-03-01 00:00:00

abstract：:Lidocaine and MgSO4 are often coadministered to patients with pregnancy-induced hypertension. This study examined whether MgSO4 alters the lidocaine-seizure threshold in the rat and, if so, whether systemic MgSO4 administration is as effective as intracerebroventricular MgSO4 infusion. In Experiment 1, rats were admin...

journal_title：Anesthesia and analgesia

authors： Kim YJ,McFarlane C,Warner DS,Baker MT,Choi WW,Dexter F

更新日期：1996-12-01 00:00:00

abstract：:Because no completely effective antiemetic exists for the prevention of postoperative nausea and vomiting (PONV), we hypothesize that a multimodal approach to management of PONV may reduce both vomiting and the need for rescue antiemetics in high-risk patients. After IRB approval, women undergoing outpatient laparosco...

journal_title：Anesthesia and analgesia

authors： Scuderi PE,James RL,Harris L,Mims GR 3rd

更新日期：2000-12-01 00:00:00