Small-dose ketamine reduces the pain of propofol injection.

Abstract:

BACKGROUND:I.v. injection of propofol during anesthetic induction induces pain. Ketamine has been shown to reduce injection pain. In this study, we established the optimal dose of ketamine to prevent the pain of injection with propofol. METHODS:Two hundred forty patients presenting for elective surgery were randomly allocated into eight groups; five groups during the first part of the study and three groups during the second part. In Part 1, patients received saline (Group S), lidocaine (Group L), ketamine 10 microg/kg (Group K10), 50 microg/kg (Group K50), or 100 microg/kg (Group K100), respectively, immediately followed by propofol 2.5 mg/kg. In Part 2, the optimal dose of ketamine (100 microg/kg) was administered 3 min before propofol (Group Pre), mixed with propofol solution (Group KP), or after oral midazolam premedication (Group M). An anesthesiologist blinded to the study group monitored each patient's pain score at 5-s intervals. RESULTS:In Part 1, the incidence and intensity of pain were the lowest in the K100 and L groups (P < 0.001). In Part 2, the patients in the K100 and M groups had significantly lower pain scores compared with the KP and Pre groups (P < 0.05). During induction, there were no significant intergroup differences in mean arterial blood pressure and heart rate in all groups. CONCLUSIONS:Administration of ketamine 100 microg/kg immediately before propofol injection provided the optimal dose and timing to reduce propofol-induced pain on injection.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Koo SW,Cho SJ,Kim YK,Ham KD,Hwang JH

doi

10.1213/01.ane.0000243334.83816.53

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

1444-7

issue

6

eissn

0003-2999

issn

1526-7598

pii

103/6/1444

journal_volume

103

pub_type

杂志文章,随机对照试验
  • Splanchnic and renal sympathetic activity in relation to hemodynamics during isoflurane administration in pigs.

    abstract::The aim of the present study was to investigate the impact of isoflurane on regional neurogenic mechanisms in the control of vascular tone. Therefore, regional determinations of sympathetic activity and hemodynamics were made in chloralose-anesthetized swine before and during administration of 1.4% isoflurane. Sympath...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199501000-00023

    authors: Aneman A,Pontén J,Fändriks L,Eisenhofer G,Friberg P,Biber B

    更新日期:1995-01-01 00:00:00

  • Changes in anterior fontanel pressure in preterm neonates receiving isoflurane, halothane, fentanyl, or ketamine.

    abstract::The effects of anesthetics on intracranial pressure (ICP) may be different in preterm neonates than in adults because the neonate's cranial sutures are not yet fused. The authors monitored changes in anterior fontanel pressure (AFP), a noninvasive indicator of ICP, during anesthesia in 44 preterm neonates without neur...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-198705000-00011

    authors: Friesen RH,Thieme RE,Honda AT,Morrison JE Jr

    更新日期:1987-05-01 00:00:00

  • Lung recruitment and positive end-expiratory pressure have different effects on CO2 elimination in healthy and sick lungs.

    abstract:BACKGROUND:We studied the effects that the lung recruitment maneuver (RM) and positive end-expiratory pressure (PEEP) have on the elimination of CO(2) per breath (Vtco(2,br)). METHODS:In 7 healthy and 7 lung-lavaged pigs at constant ventilation, PEEP was increased from 0 to 18 cm H(2)O and then decreased to 0 in steps...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e3181f0c2da

    authors: Tusman G,Bohm SH,Suarez-Sipmann F,Scandurra A,Hedenstierna G

    更新日期:2010-10-01 00:00:00

  • Intrathecal administration of botulinum neurotoxin type A attenuates formalin-induced nociceptive responses in mice.

    abstract:BACKGROUND:Botulinum neurotoxin type A (BoNT/A) has been used as an analgesic for myofascial pain syndromes, migraine, and other types of headaches. Although an antinociceptive effect of central or peripheral administration of BoNT/A is suggested, the effect at the spinal level is still unclear. In this study, we evalu...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e3181ffa1d7

    authors: Lee WH,Shin TJ,Kim HJ,Lee JK,Suh HW,Lee SC,Seo K

    更新日期:2011-01-01 00:00:00

  • Hypoxemic fetoplacental vasoconstriction: a graduated response to reduced oxygen conditions in the human placenta.

    abstract::We investigated the characteristics of hypoxemic fetoplacental vasoconstriction (HFPV) in the dual perfused, single isolated human placental cotyledon. Fetal arterial blood pressures (FAP) were measured in four cotyledons (Group 1) equilibrated with 21% oxygen (O2), 5% carbon dioxide (CO2), and nitrogen (N2) [control]...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000222468.76942.d8

    authors: Ramasubramanian R,Johnson RF,Downing JW,Minzter BH,Paschall RL

    更新日期:2006-08-01 00:00:00

  • Interaction between mivacurium and succinylcholine.

    abstract::We investigated the interaction between mivacurium and succinylcholine when mivacurium was administered during the early recovery from succinylcholine block. We studied 40 adult patients during propofol-alfentanil-N2O-O2 anesthesia. Neuromuscular function was monitored using an electromyographic method (Relaxograph, D...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199503000-00017

    authors: Erkola O,Rautoma P,Meretoja OA

    更新日期:1995-03-01 00:00:00

  • Autonomous Systems in Anesthesia: Where Do We Stand in 2020? A Narrative Review.

    abstract::As most of us are aware, almost every facet of our society is becoming, for better or worse, progressively more technology-dependent. Technological advancement has made autonomous systems, also known as robots, an integral part of our life in several fields, including medicine. The application of robots in anesthesia ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0000000000004646

    authors: Zaouter C,Joosten A,Rinehart J,Struys MMRF,Hemmerling TM

    更新日期:2020-05-01 00:00:00

  • Receptor specificity defines algogenic properties of propofol and fospropofol.

    abstract:BACKGROUND:Propofol-evoked injection site pain is not observed with fospropofol. We hypothesized that unlike propofol, fospropofol does not activate the irritant receptor, transient receptor potential 1 (TRPA1). METHODS:We tested the hypothesis using electrophysiology and behavioral studies. RESULTS:Our data demonstr...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e318258b9db

    authors: Patwardhan A,Edelmayer R,Annabi E,Price T,Malan P,Dussor G

    更新日期:2012-10-01 00:00:00

  • Performance of computer-assisted continuous infusion at low concentrations of intravenous sedatives.

    abstract::We studied the performance of a target-controlled drug infusion device, computer-assisted continuous infusion (CACI). Forty-one volunteers received one of midazolam (n = 11), propofol (n = 10), thiopental (n = 10), or fentanyl (n = 10) in sedative concentrations. Concentrations were kept constant for 45-70 min at five...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199705000-00018

    authors: Veselis RA,Glass P,Dnistrian A,Reinsel R

    更新日期:1997-05-01 00:00:00

  • The effects of olprinone (a phosphodiesterase III inhibitor) on hepatic vascular bed in a porcine model of endotoxemia.

    abstract:UNLABELLED:Decreased hepatic blood flow, and impaired hepatic oxygen delivery caused by endotoxin, result in hepatic metabolic deterioration followed by liver dysfunction and multiple organ failure. Among phosphodiesterase III inhibitors, only olprinone increases hepatosplanchnic blood flow. We evaluated the effects of...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200103000-00024

    authors: Nagata E,Kakihana Y,Tobo K,Isowaki S,Kanmura Y

    更新日期:2001-03-01 00:00:00

  • The effect of outpatient preoperative evaluation of hospital inpatients on cancellation of surgery and length of hospital stay.

    abstract:UNLABELLED:To evaluate the possible effects of outpatient preoperative evaluation (OPE) for new surgical patients who will be inpatients, we conducted an observational study at a university hospital in The Netherlands. Various outcomes before and after the introduction of an OPE clinic were compared. The study populati...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200203000-00030

    authors: van Klei WA,Moons KG,Rutten CL,Schuurhuis A,Knape JT,Kalkman CJ,Grobbee DE

    更新日期:2002-03-01 00:00:00

  • Nitrous oxide minimum alveolar anesthetic concentration in rats is greater than previously reported.

    abstract::Recent determinations of the minimum alveolar anesthetic concentration (MAC) for nitrous oxide in rats yield values of 1.51-1.55 atm. When combined with results from other reports, these results suggest a deviation from linear additivity, and call into question the unitary theory of narcosis. The present report provid...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199410000-00016

    authors: Gonsowski CT,Eger EI 2nd

    更新日期:1994-10-01 00:00:00

  • Adding clonidine to the induction bolus and postoperative infusion during continuous femoral nerve block delays recovery of motor function after total knee arthroplasty.

    abstract::We evaluated the effects of adding clonidine for continuous peripheral nerve infusions. Sixty patients undergoing total knee arthroplasty under combined single-injection sciatic block and continuous femoral infusion were randomly allocated to three groups: block induction with 0.75% ropivacaine followed by 0.2% ropiva...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/01.ANE.0000143952.75985.8F

    authors: Casati A,Vinciguerra F,Cappelleri G,Aldegheri G,Fanelli G,Putzu M,Chelly JE

    更新日期:2005-03-01 00:00:00

  • Myocardial perfusion following acute subarachnoid hemorrhage in patients with an abnormal electrocardiogram.

    abstract::To test the hypothesis that acute subarachnoid hemorrhage is associated with abnormal myocardial perfusion, we assessed myocardial blood flow with thallium scintigraphy in 19 patients with a confirmed subarachnoid hemorrhage and an abnormal electrocardiogram. A thallium scan was performed at the bedside of each patien...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199302000-00009

    authors: Szabo MD,Crosby G,Hurford WE,Strauss HW

    更新日期:1993-02-01 00:00:00

  • A multicenter study of the epidemiology of hepatitis B in anesthesia residents.

    abstract::Practicing anesthesiologists are at high risk of hepatitis B infection, but the risk for anesthesia residents has not been assessed. Anesthesia residents at seven universities were surveyed to study the epidemiology of hepatitis B in these trainees. Hepatitis B virus markers in serum were measured and data from questi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Berry AJ,Isaacson IJ,Kane MA,Schatz GC,Clark BT,Beaupre P,Derrer S,Kapur P,Thompson J,Martin D

    更新日期:1985-07-01 00:00:00

  • An In Vitro Model for Identifying Cardiac Side Effects of Anesthetics.

    abstract::The understanding of anesthetic side effects on the heart has been hindered by the lack of sophisticated clinical models. Using micropatterned human-induced pluripotent stem cell-derived cardiomyocytes, we obtained cardiac muscle depressant profiles for propofol, etomidate, and our newly identified anesthetic compound...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000003757

    authors: Chang ACY,Chang ACH,Nicin L,Weber GJ,Holbrook C,Davies MF,Blau HM,Bertaccini EJ

    更新日期:2020-01-01 00:00:00

  • Epinephrine injection in lipid-based resuscitation from bupivacaine-induced cardiac arrest: transient circulatory return in rabbits.

    abstract:BACKGROUND:IV lipid emulsion has demonstrated to be effective therapy for bupivacaine-induced cardiotoxicity. However, the role of epinephrine when coadministered with lipid emulsion in toxin-induced cardiac arrest is unclear. We postulated superior resuscitation outcome in the absence of epinephrine in a rabbit model ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e3181e66050

    authors: Harvey M,Cave G,Prince G,Lahner D

    更新日期:2010-09-01 00:00:00

  • Electroanesthesia (EA) studies: EA produced by stimulation of sensory nerves of the scalp in Rhesus monkeys.

    abstract::After it was learned that electroanesthesia (EA) could not be produced in a Rhesus monkey which had undergone a circumferential scalp block with 0.25% lidocaine, it was postulated that EA could be produced by electrostimulation of the sensory nerves of the scalp in the rhesus. The work reported here verifies that EA c...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-197607000-00018

    authors: Kano T,Cowan GS,Smith RH

    更新日期:1976-07-01 00:00:00

  • Use of ProSeal laryngeal mask airway in 2114 adult patients: a prospective study.

    abstract:BACKGROUND:There have been numerous studies published on the ProSeal laryngeal mask airway (PLMA). However, few have investigated its utility in a large practice setting. We sought to gather comprehensive data about the characteristics, efficacy, and safety of its use by a representative group of anesthesiologists work...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e318189ac84

    authors: Goldmann K,Hechtfischer C,Malik A,Kussin A,Freisburger C

    更新日期:2008-12-01 00:00:00

  • Plasma atrial natriuretic polypeptide and angiotensin II in rats during anesthesia and volume loading.

    abstract::These experiments investigated the effect of halothane or fentanyl anesthesia on plasma atrial natriuretic polypeptide (ANP) and angiotensin II (AII) concentrations and the response to a 30% blood volume load in rats. Halothane (1.1% and 2.2% inspired) or fentanyl (50 and 200 micrograms/kg) anesthesia alone produced l...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Hoffman WE,Phillips MI,Kimura B

    更新日期:1989-01-01 00:00:00

  • The influence of p38 mitogen-activated protein kinase inhibitor on synthesis of inflammatory cytokine tumor necrosis factor alpha in spinal cord of rats with chronic constriction injury.

    abstract:BACKGROUND:Tumor necrosis factor alpha (TNF-alpha) could trigger p38 mitogen-activated protein kinase (MAPK) activation. Conversely phosphorylated p38 (p-p38) could induce the upregulation of TNF-alpha. In this study, we examined the hypothesis that chronic constrictive injury (CCI) of the sciatic nerve could promote s...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000287660.29297.7b

    authors: Xu L,Huang Y,Yu X,Yue J,Yang N,Zuo P

    更新日期:2007-12-01 00:00:00

  • Duration of intrathecal labor analgesia: early versus advanced labor.

    abstract::Early first-stage labor pain is primarily visceral in origin. Increasing pain intensity and transition to somatic nociceptive input characterizes late first- and second-stage labor pain. The effect of this change in nociceptive input on the duration of intrathecal labor analgesia has not been well studied. This prospe...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199705000-00028

    authors: Viscomi CM,Rathmell JP,Pace NL

    更新日期:1997-05-01 00:00:00

  • The effect of short-term epidural local anesthetic blockade on urinary levels of substance P in interstitial cystitis.

    abstract:UNLABELLED:We investigated the effect of epidural local anesthetic blockade on urinary substance P levels in five patients suffering from painful flare-ups of interstitial cystitis. Urine was collected in 24-h intervals commencing at the onset of an epidural bolus of 0.25% bupivacaine followed by maintenance epidural i...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1213/01.ane.0000099362.01312.3a

    authors: Sukiennik A,Carr DB,Bonney I,Marchand JE,Wurm H,Sant GR

    更新日期:2004-03-01 00:00:00

  • The dose-response of nitrous oxide in postoperative nausea in patients undergoing gynecologic laparoscopic surgery: a preliminary study.

    abstract:BACKGROUND:Whether nitrous oxide (N(2)O) increases the incidence of postoperative nausea and vomiting (PONV) after laparoscopic gynecologic surgery is still controversial, which may be due to the administration of different concentrations of inspired N(2)O. We investigated whether N(2)O results in a dose-response incre...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ane.0b013e318181f4aa

    authors: Mraovic B,Simurina T,Sonicki Z,Skitarelic N,Gan TJ

    更新日期:2008-09-01 00:00:00

  • The incidence of complex regional pain syndrome after fasciectomy for Dupuytren's contracture: a prospective observational study of four anesthetic techniques.

    abstract::The development of complex regional pain syndrome (CRPS) is not an uncommon complication after Dupuytren's surgery. Despite increasing research interest, little is known regarding which patients are at increased risk for developing CRPS and what is the optimal perioperative treatment strategy for preventing the occurr...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,收录出版

    doi:10.1213/01.ane.0000194879.85643.ff

    authors: Reuben SS,Pristas R,Dixon D,Faruqi S,Madabhushi L,Wenner S

    更新日期:2006-02-01 00:00:00

  • End-tidal sevoflurane concentration for tracheal extubation and skin incision in children.

    abstract:UNLABELLED:We sought to determine minimum alveolar anesthetic concentrations for skin incision (MAC) and for tracheal extubation (MAC(Ex)) for sevoflurane and its associated awakening time and respiratory complications during emergence from sevoflurane anesthesia in children. We studied 40 (20 in each group) unpremedic...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199812000-00010

    authors: Inomata S,Suwa T,Toyooka H,Suto Y

    更新日期:1998-12-01 00:00:00

  • Characterization of the Rapid Drop in Pulse Oximetry Reading After Intraoperative Administration of Methylene Blue in Open Thoracoabdominal Aortic Repairs.

    abstract::This study evaluates the changes of oxygen saturation (SpO2) after intravenous administration of methylene blue in 103 patients undergoing open repair of thoracoabdominal aortic aneurysms. We found that SpO2 decreased by a median (interquartile range [IQR]) of 49% (37%-81%) <1 minute after methylene blue administratio...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000004325

    authors: Rong LQ,Mauer E,Mustapich TL,White RS,Di Franco A,Girardi LN,Gaudino M,Pryor KO

    更新日期:2019-11-01 00:00:00

  • Recurring brachial plexus neuropathy in a diabetic patient after shoulder surgery and continuous interscalene block.

    abstract:IMPLICATIONS:The performance of regional blockade on a patient with a preexisting neurologic condition or a history of neurologic complications after regional anesthesia is controversial. We present a case of recurring brachial plexus neuropathy in a diabetic patient after two shoulder procedures performed 4 mo apart. ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200009000-00035

    authors: Horlocker TT,O'Driscoll SW,Dinapoli RP

    更新日期:2000-09-01 00:00:00

  • Central administration of minocycline and riluzole prevents morphine-induced tolerance in rats.

    abstract:BACKGROUND:Long-term exposure to opiates induces tolerance to the analgesic effect. The neurobiological mechanism of this phenomenon is not completely clear. In this study, we evaluated the effects of central administration of minocycline (a tetracycline derivative) and riluzole (an antiglutamatergic drug) on morphine-...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e3181ae5f13

    authors: Habibi-Asl B,Hassanzadeh K,Charkhpour M

    更新日期:2009-09-01 00:00:00

  • A Perioperative Evaluation of Respiratory Mechanics Using the Forced Oscillation Technique.

    abstract:BACKGROUND:The forced oscillation technique is a new approach for assessing perioperative respiratory function. METHODS:This study enrolled 40 patients undergoing general anesthesia: 20 for ≥2 hours and 20 for <2 hours. Respiratory parameters were measured the day before and after surgery using forced oscillation duri...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000000720

    authors: Kuzukawa Y,Nakahira J,Sawai T,Minami T

    更新日期:2015-11-01 00:00:00