Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorphisms and acute pain in sickle cell disease.


BACKGROUND:Pain in sickle cell disease (SCD) is characterized by episodes of acute pain, primarily responsible for acute health care utilization, and persistent chronic pain. Pain severity and frequency vary significantly among patients with SCD. In this study, we investigated the possible contribution of monoamine gene polymorphisms to pain variation. METHODS:Adult subjects with SCD completed PAINReportIt, a computerized McGill Pain Questionnaire, from which we calculated the Composite Pain Index. Utilization data were obtained from the medical record and biweekly telephone calls for 12 months. Utilization is defined as admissions to the emergency department and/or the acute care center resulting from a sickle cell pain crisis. We performed genotyping for catechol-O-methyltransferase (COMT) Val158Met (rs4680) and dopamine D3 receptor (DRD3) Ser9Gly (rs6280) polymorphisms, which were analyzed for associations with pain phenotypes. RESULTS:Binary logistic models revealed that DRD3 Ser9Gly heterozygote patients were more likely not to have an acute pain crisis (odds ratio [OR] [95% confidence interval {CI}], 4.37 [1.39-22.89]; P = 0.020), which remained so when demographic variables were considered (OR [95% CI], 4.53 [1.41-28.58]; P = 0.016). COMT Val158Met Met allele showed lower probability for zero utilization (OR [95% CI], 0.32 [0.12-0.83]; P = 0.020) than the Val allele. In the negative binomial regression analysis, subjects with COMT Met/Met genotype had utilization incident rate ratio (95% CI) of 2.20 (1.21-3.99) over those with Val/Val (P = 0.010). CONCLUSIONS:These exploratory findings suggest that DRD3 Ser9Gly and COMT Val158Met may contribute to pain heterogeneity in SCD, as suggested by the different rates of acute pain crisis. Specifically, SCD patients with the DRD3 homozygote genotypes, COMT 158 Met allele or Met/Met genotype, are more likely to have acute care utilization, an indicator of acute pain. These results, however, will need to be further examined in future large prospective studies.


Anesth Analg


Anesthesia and analgesia


Jhun E,He Y,Yao Y,Molokie RE,Wilkie DJ,Wang ZJ




Has Abstract


2014-11-01 00:00:00












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    更新日期:2019-03-01 00:00:00

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    更新日期:2013-06-01 00:00:00

  • Ketamine potentiates nondepolarizing neuromuscular relaxants in a primate.

    abstract::Ketamine has many neuromuscular effects in vitro. Its neuromuscular effects in vivo have been controversial and inconsistent. To systematically examine its neuromuscular effects over a wide dose range and its interaction with all popular nondepolarizing neuromuscular relaxants, the effects of ketamine 2, 5, and 10 mg/...

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    authors: Tsai SK,Lee C

    更新日期:1989-01-01 00:00:00

  • Systemic mexiletine relieves chronic allodynialike symptoms in rats with ischemic spinal cord injury.

    abstract::We have recently reported a chronic allodynialike symptom in rats after ischemic spinal cord injury. This pain-related behavior is resistant to a number of pharmacologic treatments, including morphine, clonidine, carbamazepine, baclofen, and muscimol. In the present report, we present evidence indicating that systemic...

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    pub_type: 杂志文章


    authors: Xu XJ,Hao JX,Seiger A,Arnér S,Lindblom U,Wiesenfeld-Hallin Z

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  • Sequential use of midazolam and propofol for long-term sedation in postoperative mechanically ventilated patients.

    abstract:UNLABELLED:Acute withdrawal syndromes, including agitation and a long weaning time, are common adverse effects after long-term sedation with midazolam. We performed this study to determine whether the sequential use of midazolam and propofol could reduce adverse effects as compared with midazolam alone. We studied 26 p...

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    authors: Saito M,Terao Y,Fukusaki M,Makita T,Shibata O,Sumikawa K

    更新日期:2003-03-01 00:00:00

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    abstract:UNLABELLED:In this prospective investigation, we evaluated the efficacy and accuracy of transcutaneous monitoring of CO2 (TC-CO2) in infants and children after cardiothoracic surgery. Cardiothoracic surgery patients whose ETCO2 and arterial CO2 values did not correlate (gradient > or = 5 mm Hg) during the first postope...

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    authors: Tobias JD,Wilson WR Jr,Meyer DJ

    更新日期:1999-03-01 00:00:00

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    pub_type: 杂志文章


    authors: Saegusa K,Furukawa Y,Takeda M,Chiba S

    更新日期:1992-12-01 00:00:00

  • The anesthetic mechanism of urethane: the effects on neurotransmitter-gated ion channels.

    abstract:UNLABELLED:Urethane is widely used as an anesthetic for animal studies because of its minimal effects on cardiovascular and respiratory systems and maintenance of spinal reflexes. Despite its usefulness in animal research, there are no reports concerning its molecular actions. We designed this study to determine whethe...

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    authors: Hara K,Harris RA

    更新日期:2002-02-01 00:00:00

  • Multiple-dose evaluation of intravenous hydromorphone pharmacokinetics in normal human subjects.

    abstract::We measured the pharmacokinetics of hydromorphone in normal volunteers given three doses of the drug (10, 20, and 40 micrograms/kg) as intravenous 45-s injections on different days. Concentrations of hydromorphone in plasma from serial blood samples were measured by a high-performance liquid chromatography method spec...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Hill HF,Coda BA,Tanaka A,Schaffer R

    更新日期:1991-03-01 00:00:00

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    abstract::Bolus doses of propofol in patients for cardioversion often produce hypotension and apnea. Etomidate provides cardiovascular stability in these patients, but myoclonus may interfere with electrocardiographic interpretation. This study was designed to demonstrate whether propofol, when given as a low-dose infusion, can...

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    authors: Hullander RM,Leivers D,Wingler K

    更新日期:1993-10-01 00:00:00

  • Antiemetics of the 5-hydroxytryptamine 3A antagonist class inhibit muscle nicotinic acetylcholine receptors.

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    journal_title:Anesthesia and analgesia

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    authors: Paul M,Callahan R,Au J,Kindler CH,Yost CS

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    authors: Cassuto J,Wallin G,Högström S,Faxén A,Rimbäck G

    更新日期:1985-10-01 00:00:00

  • Nitrogen purging of oxygen pipelines: an unusual cause of intraoperative hypoxia.

    abstract::Intraoperative hypoxia occurred in two patients during the maintenance of the medical gas system. Engineers were purging oxygen pipelines with nitrogen to remove particulate debris but were unaware of a connection to operating room pipelines. This case illustrates the importance of communication between anesthesia pro...

    journal_title:Anesthesia and analgesia

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    authors: Elizaga AM,Frerichs RL

    更新日期:2000-07-01 00:00:00

  • The pharmacokinetics of droperidol in anesthetized children.

    abstract::Despite the wide use of droperidol to reduce nausea and vomiting in children, its pharmacokinetics have not been described in pediatric patients. Twelve ASA Class I-II children, undergoing tonsillectomy and adenoidectomy, received standardized anesthesia; none of the children received premedication. After induction of...

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    authors: Grunwald Z,Torjman M,Schieren H,Bartkowski RR

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    更新日期:2010-10-01 00:00:00

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    authors: Kutza J,Gratz I,Afshar M,Murasko DM

    更新日期:1997-10-01 00:00:00

  • Physiologic characteristics of cold perfluorocarbon-induced hypothermia during partial liquid ventilation in normal rabbits.

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    authors: Hong SB,Koh Y,Shim TS,Lee SD,Kim WS,Kim DS,Kim WD,Lim CM

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  • Capnography accurately detects apnea during monitored anesthesia care.

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    authors: Soto RG,Fu ES,Vila H Jr,Miguel RV

    更新日期:2004-08-01 00:00:00

  • Statistical grand rounds: Importance of appropriately modeling procedure and duration in logistic regression studies of perioperative morbidity and mortality.

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    authors: Kochi T,Hagiya M,Mizuguchi T

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    pub_type: 杂志文章


    authors: Saegusa K,Furukawa Y,Ogiwara Y,Takeda M,Chiba S

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