The effect of perioperative aspirin therapy in peripheral vascular surgery: a decision analysis.


:Patients who undergo infrainguinal revascularization surgery are at increased risk for perioperative thrombotic complications. Aspirin decreases thrombotic events in the nonoperative setting; however, aspirin is often discontinued to avoid perioperative hemorrhagic complications. We used a decision analysis to determine whether aspirin should be discontinued before infrainguinal revascularization surgery. Two strategies were compared: aspirin cessation 2 wk before surgery and aspirin continuation throughout the perioperative period. Clinical events examined included myocardial infarction, thrombotic cerebrovascular accident, hemorrhagic cerebrovascular accident, gastrointestinal hemorrhage, and incisional hemorrhagic complications. Event rates and effect of aspirin were obtained by using MEDLINE. The outcomes were perioperative mortality, life expectancy, and quality-adjusted life expectancy. According to the model, continued aspirin use decreased perioperative mortality rates from 2.78% to 2.05%. Continued aspirin use increased life expectancy from 14.83 to 14.89 yr and increased quality-adjusted life expectancy from 14.72 to 14.79 yr. Aspirin increased the number of hemorrhagic complications by 2.46%, primarily because of an increased incidence of non-life-threatening complications.


Anesth Analg


Anesthesia and analgesia


Neilipovitz DT,Bryson GL,Nichol G




Has Abstract


2001-09-01 00:00:00












  • Factors that influence parents' decisions to consent to their child's participation in clinical anesthesia research.

    abstract:UNLABELLED:There is concern that the environment in which consent for anesthesia research is sought may be coercive. We therefore designed this study to determine the factors that parents consider in consenting to their child's participation in clinical anesthesia research. The study sample consisted of 246 parents who...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Tait AR,Voepel-Lewis T,Siewert M,Malviya S

    更新日期:1998-01-01 00:00:00

  • Intraoperative monitoring of tibialis anterior muscle motor evoked responses to transcranial electrical stimulation during partial neuromuscular blockade.

    abstract::We studied the feasibility of recording motor evoked responses to transcranial electrical stimulation (tce-MERs) during partial neuromuscular blockade (NMB). In 11 patients, compound muscle action potentials were recorded from the tibialis anterior muscle in response to transcranial electrical stimulation during vario...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Kalkman CJ,Drummond JC,Kennelly NA,Patel PM,Partridge BL

    更新日期:1992-10-01 00:00:00

  • Evaluating the long-term retention of a multidisciplinary electroencephalography instructional model.

    abstract:BACKGROUND:Clinical decision making and problem solving require a core of basic factual knowledge that must be accessed sometimes months or years after it has been learned. We examined whether 10 compared with 20 total electroencephalogram (EEG) interpretations impacted scores for long-term retention with the residents...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Fahy BG,Chau DF,Ozrazgat-Baslanti T,Owen MB

    更新日期:2014-03-01 00:00:00

  • Spontaneous positive end-expiratory pressure (sPEEP).

    abstract::Spontaneous positive end-expiratory pressure (sPEEP) is a simple, low-cost method of providing low to moderate levels of PEEP as an alternative to continuous positive airway pressure (CPAP), whether used alone or with continuous positive pressure ventilation (CPPV) in intermittent mandatory ventilation (IMV). The ther...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Gillick JS

    更新日期:1977-09-01 00:00:00

  • Pulmonary gas exchange in coronary artery surgery patients during sevoflurane and isoflurane anesthesia.

    abstract:UNLABELLED:As the surgical population ages, the number of patients presenting with coronary artery disease and age-related loss of pulmonary recoil will increase. Although their influence on gas exchange in this population remains unknown, sevoflurane and isoflurane are used for an increasing variety of surgical proced...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Loeckinger A,Keller C,Lindner KH,Kleinsasser A

    更新日期:2002-05-01 00:00:00

  • Effects of Electrical Transcutaneous Vagus Nerve Stimulation on the Perceived Intensity of Repetitive Painful Heat Stimuli: A Blinded Placebo- and Sham-Controlled Randomized Crossover Investigation.

    abstract:BACKGROUND:Transcutaneous vagus nerve stimulation (TVNS) is a promising treatment for acute and chronic pain. However, experimental studies yielded controversial results. We examined if TVNS reduces the perceived intensity of repetitive painful heat stimulation and temporal summation of pain (TSP) in healthy volunteers...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Janner H,Klausenitz C,Gürtler N,Hahnenkamp K,Usichenko TI

    更新日期:2018-06-01 00:00:00

  • R(+)-, Rac-, and S(-)-bupivacaine stereostructure-specifically interact with membrane lipids at cardiotoxically relevant concentrations.

    abstract::It remains questionable whether local anesthetics can interact with membrane lipids at clinically relevant concentrations to show the difference between enantiomers. We compared the effects of bupivacaine stereoisomers on biomimetic membranes containing cardiolipin and cholesterol. Bupivacaine interacted with the memb...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Tsuchiya H,Mizogami M

    更新日期:2012-02-01 00:00:00

  • Volatile anesthetic requirements differ in mice selectively bred for sensitivity or resistance to diazepam: implications for the site of anesthesia.

    abstract::One approach to elucidating the general anesthetic target has used genetic selection procedures, wherein animals are bred for sensitivity or resistance to general anesthetics and correlations are sought with a specific neuronal structural or functional defect. For example, murine strains have been developed that are e...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: McCrae AF,Gallaher EJ,Winter PM,Firestone LL

    更新日期:1993-06-01 00:00:00

  • Dilation by isoflurane of preconstricted, very small arterioles from human right atrium is mediated in part by K(+)-ATP channel opening.

    abstract:UNLABELLED:The adenosine triphosphate (ATP)-sensitive potassium channels (K(+)-ATP channels) are activated by decreases in intracellular ATP and help to match blood flow to tissue needs. Such metabolism-flow coupling occurs predominantly in the smallest arterioles measuring 50 microm or less in diameter. Previous studi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Park KW,Dai HB,Comunale ME,Gopal A,Sellke FW

    更新日期:2000-07-01 00:00:00

  • Cardiovascular effects of morphine in patients with coronary arterial disease.

    abstract::Large doses of morphine sulfate have been reported to cause myocardial lactate production and reduction in coronary blood flow in animals. Similar effects with clinical doses in man would significantly alter the management of cardiac patients. Eleven adult patients with significant coronary arterial disease and normal...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Sethna DH,Moffitt EA,Gray RJ,Bussell J,Raymond M,Conklin C,Shell WE,Matloff JM

    更新日期:1982-02-01 00:00:00

  • Comparison of tropisetron, droperidol, and saline in the prevention of postoperative nausea and vomiting after gynecologic surgery.

    abstract::This study was performed to compare the efficacy of tropisetron, droperidol, and saline in the prevention of postoperative nausea and vomiting (PONV) and to compare the possible adverse effects of these drugs in gynecologic incontinence surgery. Using a randomized, double-blind study design, we studied 150 women under...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Purhonen S,Kauko M,Koski EM,Nuutinen L

    更新日期:1997-03-01 00:00:00

  • Clinical Uses and Impacts of Emergency Manuals During Perioperative Crises.

    abstract:BACKGROUND:Performing key actions efficiently during crises can determine clinical outcomes, yet even expert clinicians omit key actions. Simulation-based studies of crises show that correct performance of key actions dramatically increases when emergency manuals (EMs) are used. Despite widespread dissemination of EMs,...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,多中心研究


    authors: Goldhaber-Fiebert SN,Bereknyei Merrell S,Agarwala AV,De La Cruz MM,Cooper JB,Howard SK,Asch SM,Gaba DM

    更新日期:2020-12-01 00:00:00

  • Little Black Boxes: Noncardiac Implantable Electronic Medical Devices and Their Anesthetic and Surgical Implications.

    abstract::Implanted electronic medical devices. or stimulators such as pacemakers and nerve stimulators have grown enormously in diversity and complexity over recent decades. The function and potential interaction of these devices with the perioperative environment is of increasing concern for anesthesiologists and surgeons. Be...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Srejic U,Larson P,Bickler PE

    更新日期:2017-07-01 00:00:00

  • The efficacy of the "BURP" maneuver during a difficult laryngoscopy.

    abstract::The displacement of the larynx in the three specific directions (a) posteriorly against the cervical vertebrae, (b) superiorly as possible, and (c) slightly laterally to the right have been reported and named the "BURP" maneuver. We evaluated the efficacy of the BURP maneuver in improving visualization of the larynx. ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Takahata O,Kubota M,Mamiya K,Akama Y,Nozaka T,Matsumoto H,Ogawa H

    更新日期:1997-02-01 00:00:00

  • The effects of general anesthesia and surgery on basal and interferon stimulated natural killer cell activity of humans.

    abstract:UNLABELLED:Natural killer (NK) cells can lyse certain tumor cells as well as virally infected cells without prior sensitization. Animal studies have shown that general anesthesia (GA) alone or GA followed by surgery decreases both basal NK cytotoxicity and enhancement of NK activity by interferon (IFN). The purpose of ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Kutza J,Gratz I,Afshar M,Murasko DM

    更新日期:1997-10-01 00:00:00

  • Cardiovascular effects of sufentanil anesthesia.

    abstract::Sufentanil is a new synthetic opiate analgesic that is 4520 times more potent than morphine in animal experiments. This study evaluated the cardiovascular effects of sufentanil, 15 micrograms/kg, and air/O2 used as a complete anesthetic with 50% inspired oxygen (air/O2 mixture) in 40 adult patients undergoing elective...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Sebel PS,Bovil JG

    更新日期:1982-02-01 00:00:00

  • Effect of Interscalene Brachial Plexus Block on the Pulmonary Function of Obese Patients: A Prospective, Observational Cohort Study.

    abstract:BACKGROUND:The effect of interscalene block (ISB) on pulmonary function of obese participants has not been investigated. The goal of this study is to assess the association of obesity (body mass index [BMI] >29 kg/m vs BMI <25 kg/m) and change in forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Melton MS,Monroe HE,Qi W,Lewis SL,Nielsen KC,Klein SM

    更新日期:2017-07-01 00:00:00

  • Use of analgesic, anesthetic, and sedative medications during pediatric hospitalizations in the United States 2008.

    abstract:BACKGROUND:The wide need for analgesia, anesthesia, and sedation in children and the lack of pediatric labeling leads to widespread off-label use of medications for pain and sedation in children. Any attempt to address the lack of labeling will require national estimates of the numbers of children using each medication...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Lasky T,Ernst FR,Greenspan J

    更新日期:2012-11-01 00:00:00

  • COVID-19-Associated Coagulopathy and Inflammatory Response: What Do We Know Already and What Are the Knowledge Gaps?

    abstract::Patients with coronavirus disease 2019 (COVID-19) frequently experience a coagulopathy associated with a high incidence of thrombotic events leading to poor outcomes. Here, biomarkers of coagulation (such as D-dimer, fibrinogen, platelet count), inflammation (such as interleukin-6), and immunity (such as lymphocyte co...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Görlinger K,Dirkmann D,Gandhi A,Simioni P

    更新日期:2020-11-01 00:00:00

  • Propofol inhibits ketamine-induced c-fos expression in the rat posterior cingulate cortex.

    abstract:UNLABELLED:Ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, has psychotomimetic activity. NMDA receptor antagonists cause morphological damage in the posterior cingulate cortex, which may be the brain region responsible for their psychotomimetic effects. Benzodiazepines are effective in preve...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Nagata A,Nakao S,Miyamoto E,Inada T,Tooyama I,Kimura H,Shingu K

    更新日期:1998-12-01 00:00:00

  • Surgical stress induces endotoxin hyporesponsiveness and an early decrease of monocyte mCD14 and HLA-DR expression during surgery.

    abstract:UNLABELLED:It is generally accepted that major surgery is associated with severe alterations of the host-defense mechanisms. We investigated the effect of surgical stress on the immune system. Specifically, we studied the relationship between perioperative lipopolysaccharide (LPS) hyporesponsiveness and monocyte human ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Kawasaki T,Ogata M,Kawasaki C,Tomihisa T,Okamoto K,Shigematsu A

    更新日期:2001-05-01 00:00:00

  • Hemodynamic dose-responses to halothane and isoflurane are different in swine with and without critical coronary artery stenosis.

    abstract::This study examined global hemodynamic responses to increasing concentrations of halothane and isoflurane in pigs with an acute critical coronary stenosis (CCS) on the left anterior descending coronary artery (LAD). The CCS was caused by graded inflation of an hydraulic occluder to the point where no hyperemic respons...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Gilbert M,Mori M,Myhre ES

    更新日期:1989-06-01 00:00:00

  • Operating room managerial decision-making on the day of surgery with and without computer recommendations and status displays.

    abstract:BACKGROUND:There are three basic types of decision aids to facilitate operating room (OR) management decision-making on the day of surgery. Decision makers can rely on passive status displays (e.g., big screens or whiteboards), active status displays (e.g., text pager notification), and/or command displays (e.g., text ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Dexter F,Willemsen-Dunlap A,Lee JD

    更新日期:2007-08-01 00:00:00

  • The pronociceptive effect of ondansetron in the setting of P-glycoprotein inhibition.

    abstract::Ondansetron is a potent antiemetic drug that acts through inhibition of the 5HT3 receptors for serotonin. Minimum alveolar concentration (MAC) for isoflurane is not affected by systemic ondansetron; however ondansetron is a substrate of P-glycoprotein, a transport pump expressed in the blood-brain barrier. Thus, we hy...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Scott JA,Wood M,Flood P

    更新日期:2006-09-01 00:00:00

  • Differences in production of reactive oxygen species and mitochondrial uncoupling as events in the preconditioning signaling cascade between desflurane and sevoflurane.

    abstract:BACKGROUND:Signal transduction cascade of anesthetic-induced preconditioning has been extensively studied, yet many aspects of it remain unsolved. Here, we investigated the roles of reactive oxygen species (ROS) and mitochondrial uncoupling in cardiomyocyte preconditioning by two modern volatile anesthetics: desflurane...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Sedlic F,Pravdic D,Ljubkovic M,Marinovic J,Stadnicka A,Bosnjak ZJ

    更新日期:2009-08-01 00:00:00

  • Serum ammonia levels in response to glycine infusion in normal and cirrhotic rats.

    abstract::Elevated serum ammonia may play a role in central nervous system derangement after transurethral resection of the prostate. Glycine used as a surgical irrigant for prostate resection produces ammonia as a by-product after liver and renal metabolism. The presence of liver dysfunction often leads to an inability to remo...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Frink EJ Jr,DiGiovanni DA,Davis JR,Brown BR Jr

    更新日期:1989-12-01 00:00:00

  • Plasma potentiates the priming effects of endotoxin on platelet activating factor-induced pulmonary hypertension in the rabbit lung.

    abstract::During Gram-negative sepsis, endotoxin lipopolysaccharide (LPS) may activate host inflammatory responses, resulting in the systemic inflammatory response syndrome and the adult respiratory distress syndrome. In cell culture systems, LPS activation of cellular responses may be potentiated by plasma proteins. In the iso...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Goldsmith JA,Kavanagh BP,Pearl RG

    更新日期:1996-08-01 00:00:00

  • Anesthetic action of opiates: correlations of lipid solubility and spectral edge.

    abstract::The ability of opiates to be a complete anesthetic has been assessed in animals. These studies have investigated the serum levels of opiate required to produce a decrease in anesthetic requirement for a concomitantly administered inhalation anesthetic. A linear dose-response relation has been observed between opiate s...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Stone DJ,DiFazio CA

    更新日期:1988-07-01 00:00:00

  • Postoperative analgesia after spinal blockade in infants and children undergoing cardiac surgery.

    abstract::The aim of this prospective, randomized, controlled clinical trial was to define the opioid analgesic requirement after a remifentanil (REMI)-based anesthetic with spinal anesthetic blockade (SAB+REMI) or without (REMI) spinal blockade for open-heart surgery in children. We enrolled 45 patients who were candidates for...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hammer GB,Ramamoorthy C,Cao H,Williams GD,Boltz MG,Kamra K,Drover DR

    更新日期:2005-05-01 00:00:00

  • The effect of celiac plexus block in critically ill patients intolerant of enteral nutrition: a randomized, placebo-controlled study.

    abstract:BACKGROUND:In this study, we evaluated the efficacy of celiac plexus block for the treatment of feeding intolerance in critically ill patients. METHODS:Nineteen mechanically ventilated medical patients intolerant of enteral nutrition and receiving metoclopramide underwent bilateral celiac plexus block. The anterior pr...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验,收录出版


    authors: Memis D,Inal MT,Temizoz O,Genchallac H,Ozdemir H,Sut N

    更新日期:2010-04-01 00:00:00