Lack of CNS depression from large doses of trimethaphan in sheep.

Abstract:

:It is not uncommon to observe prolonged CNS depression for several hours following controlled hypotension and halothane anesthesia for neurosurgery. The present study evaluates possible contribution of large doses of trimethaphan to CNS depression. Four adult sheep were placed on transapical left ventricular bypass (TALVB) withdrawing blood from the apex of the left ventricle through a roller pump, Pall Ultipor filter, and returning the blood to a carotid artery. In the awake and unanesthetized animals, 1 to 2 gm of trimethaphan were administered IV during each experiment while maintaining mean arterial pressure at 60 to 75 torr. Two sheep stood up and knelt down without obvious correlation with dose of trimethaphan administered at the time; two remained standing and continued eating during the trimethaphan infusion. Cardiovascular recovery from these large doses of trimethaphan was within 15 to 30 minutes after the conclusion of drug infusion. The data strongly suggest that large doses of trimethaphan have no significant CNS depression in the awake and unanesthetized sheep.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Wong KC,Peters JL,Roberts TS,McRea JC,Fukumasu H

doi

10.1213/00000539-197701000-00005

subject

Has Abstract

pub_date

1977-01-01 00:00:00

pages

6-8

issue

1

eissn

0003-2999

issn

1526-7598

journal_volume

56

pub_type

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