Comparison of ketamine and thiopental in healthy volunteers: effects on mental status, mood, and personality.

Abstract:

:The purpose of this study was to compare the psychological effects of ketamine and thiopental anesthesia. In a double-blind comparison, 20 normal female volunteers were given 2.5 mg/kg ketamine intravenously and 20 were given 5.0 mg/kg thiopental intravenously. Subjects were assessed with a variety of objective and subjective psychological measures before, immediately after, and 24 hr, 2 weeks, and 4 months after anesthesia. Immediately after anesthesia, there was a significantly greater incidence of abnormalities of mental status in subjects given ketamine than in those who had received thiopental. Changes were generally short-lived and were no longer evident on the following day. No significant differences were found between the two groups with regard to long-term changes in personality. Changes in mental status are attributed to the slower, more uneven return to consciousness of the subjects receiving ketamine.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Moretti RJ,Hassan SZ,Goodman LI,Meltzer HY

subject

Has Abstract

pub_date

1984-12-01 00:00:00

pages

1087-96

issue

12

eissn

0003-2999

issn

1526-7598

journal_volume

63

pub_type

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