Neuraxial Anesthesia Reduces Lymphatic Flow: Proof-of-Concept in First In-Human Study.

abstract：:The purpose of this study was to compare the psychological effects of ketamine and thiopental anesthesia. In a double-blind comparison, 20 normal female volunteers were given 2.5 mg/kg ketamine intravenously and 20 were given 5.0 mg/kg thiopental intravenously. Subjects were assessed with a variety of objective and su...

journal_title：Anesthesia and analgesia

authors： Moretti RJ,Hassan SZ,Goodman LI,Meltzer HY

更新日期：1984-12-01 00:00:00

abstract：:A previous demonstration that the ratio of analgesic to anesthetic endpoints is not constant across inhalation anesthetic agents implies that more than one mechanism of action may be operant in general anesthesia. We hypothesized that the endogenous opiate systems might account for this observed disparity in ratios. T...

journal_title：Anesthesia and analgesia

authors： Levine LL,Winter PM,Nemoto EM,Uram M,Lin MR

更新日期：1986-04-01 00:00:00

abstract：:The relative safety of epidural catheter placement with subsequent heparinization has been well documented. However, what is the risk of neurologic sequelae in such patients who receive warfarin perioperatively? This study retrospectively evaluates the risk of spinal hematoma in patients receiving postoperative epidur...

journal_title：Anesthesia and analgesia

authors： Horlocker TT,Wedel DJ,Schlichting JL

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:We evaluated the efficacy and gastroenterologist/patient satisfaction of midazolam combined with oxycodone, relative to that of midazolam combined with sufentanil, for anesthesia during endoscopic injection sclerotherapy (EIS) in patients with cirrhosis and esophageal varices. METHODS:Patients with cirrhosi...

journal_title：Anesthesia and analgesia

authors： Quan Z,Luo C,Chi P,Wang L,He H

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:We have developed a proportional-integral-derivative controller allowing the closed-loop coadministration of propofol and remifentanil, guided by a Bispectral Index (BIS) monitor, during induction and maintenance of general anesthesia. The controller was compared with manual target-controlled infusion. METH...

journal_title：Anesthesia and analgesia

authors： Liu N,Chazot T,Hamada S,Landais A,Boichut N,Dussaussoy C,Trillat B,Beydon L,Samain E,Sessler DI,Fischler M

更新日期：2011-03-01 00:00:00

abstract：UNLABELLED:Linking physiological pharmacokinetic models to models of the cardiovascular system requires knowledge of the sites in the body that mediate a drug's cardiovascular effects. We examined the role of the coronary concentrations of propofol. Nine sheep anesthetized with isoflurane (2%) were instrumented acutely...

journal_title：Anesthesia and analgesia

authors： Zheng D,Upton RN,Martinez AM

更新日期：2003-06-01 00:00:00

abstract：UNLABELLED:The effects of intravascular volume replacement regimens on tissue oxygen tension (ptiO(2)) are not definitely known. Forty-two consecutive patients scheduled for elective major abdominal surgery were prospectively randomized to receive either 6% hydroxyethyl starch (HES) (mean molecular weight 130 kd, degre...

journal_title：Anesthesia and analgesia

authors： Lang K,Boldt J,Suttner S,Haisch G

更新日期：2001-08-01 00:00:00

abstract：:To evaluate the effect of propranolol on anesthetic requirement, changes in minimum alveolar concentration (MAC) of halothane accompanying acute (2 and 10 mg/kg IV) and chronic (200 mg/day orally for 10 days) propranolol administration were determined in dogs. MAC did not change significantly in either case. Beta-adre...

journal_title：Anesthesia and analgesia

authors： Tanifuji Y,Eger EI II

更新日期：1976-05-01 00:00:00

abstract：BACKGROUND:Although our understanding of nociceptive processing during anesthesia has increased greatly over the last decade, many patients still experience hyperalgesia and acute pain postoperatively. The noxious-induced withdrawal reflex (NIWR) model is specifically designed and validated to quantitatively study the ...

journal_title：Anesthesia and analgesia

authors： Sommers MG,Nguyen NK,Veening JG,Vissers KC,Ritskes-Hoitinga M,van Egmond J

更新日期：2008-04-01 00:00:00

abstract：:Leakge of lymph following puncture of the right subclavian vein occurred in a patient, requiring a pacemaker catheter. The lymph drainage settled spontaneously after 4 days on remanipulation of the pacing wire. ...

journal_title：Anesthesia and analgesia

authors： Ryan DW

更新日期：1978-01-01 00:00:00

abstract：:During Gram-negative sepsis, endotoxin lipopolysaccharide (LPS) may activate host inflammatory responses, resulting in the systemic inflammatory response syndrome and the adult respiratory distress syndrome. In cell culture systems, LPS activation of cellular responses may be potentiated by plasma proteins. In the iso...

journal_title：Anesthesia and analgesia

authors： Goldsmith JA,Kavanagh BP,Pearl RG

更新日期：1996-08-01 00:00:00

abstract：UNLABELLED:alpha(2) Adrenoceptor activity is involved in the mechanism of anesthesia. Clonidine, a alpha(2) adrenoceptor agonist, and yohimbine, a alpha(2) adrenoceptor antagonist, increase and decrease barbiturate-induced sleep times. In this study, we examined the effects of these drugs on propofol-induced sleep time...

journal_title：Anesthesia and analgesia

authors： Kushikata T,Hirota K,Yoshida H,Kubota T,Ishihara H,Matsuki A

更新日期：2002-05-01 00:00:00

abstract：:Early first-stage labor pain is primarily visceral in origin. Increasing pain intensity and transition to somatic nociceptive input characterizes late first- and second-stage labor pain. The effect of this change in nociceptive input on the duration of intrathecal labor analgesia has not been well studied. This prospe...

journal_title：Anesthesia and analgesia

authors： Viscomi CM,Rathmell JP,Pace NL

更新日期：1997-05-01 00:00:00

abstract：:The mechanisms of succinylcholine-induced cardiac effects have not been fully elucidated. Accordingly, we studied the effects of succinylcholine on atrial rate and contractile force in the isolated canine atrium perfused with donor blood. The sinus node artery was perfused with heparinized blood from the common caroti...

journal_title：Anesthesia and analgesia

authors： Saegusa K,Furukawa Y,Takeda M,Chiba S

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:The clinical utility of focused transthoracic echocardiography (TTE) is increasingly recognized in perioperative medicine. However its use is limited among anesthesiologists because of a lack of training. The most efficient training methods have not been determined. We hypothesized that simulation-based TTE ...

journal_title：Anesthesia and analgesia

authors： Neelankavil J,Howard-Quijano K,Hsieh TC,Ramsingh D,Scovotti JC,Chua JH,Ho JK,Mahajan A

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Acute lung injury is a recognized complication of lower limb ischemia-reperfusion that has been demonstrated experimentally and in the clinical setting of aortic surgery. The application of a tourniquet can cause lower limb ischemia-reperfusion in orthopedic surgery. We studied the effect of unilateral thigh...

journal_title：Anesthesia and analgesia

authors： Lin LN,Wang LR,Wang WT,Jin LL,Zhao XY,Zheng LP,Jin LD,Jiang LM,Xiong XQ

更新日期：2010-08-01 00:00:00

abstract：INTRODUCTION:Exposure to isoflurane before and during early reperfusion protects against myocardial infarction by activating phosphatidylinositol-3-kinase (PI3K)-mediated signaling. The apoptotic protein, p53, is regulated by PI3K, and inhibition of p53 protects against ischemic injury. We tested the hypothesis that p5...

journal_title：Anesthesia and analgesia

authors： Venkatapuram S,Wang C,Krolikowski JG,Weihrauch D,Kersten JR,Warltier DC,Pratt PF Jr,Pagel PS

更新日期：2006-12-01 00:00:00

abstract：IMPLICATIONS:We report the successful use of the laryngeal mask airway for percutaneous endoscopic gastrostomy in an adult patient with a known difficult airway and severe cerebral palsy. ...

journal_title：Anesthesia and analgesia

authors： Brimacombe J,Newell S,Bergin A,McCarthy J,Barry J

更新日期：2000-09-01 00:00:00

abstract：:The effects of enflurane and halothane anesthesia on systolic time intervals were studied in 12 healthy patients. Cardiovascular measurements were made at equipotent levels of anesthesia: enflurane 1.23% end-tidal and halothane 0.65% end-tidal. These agents were studied first with 50% N2O and then without N2O. Systoli...

journal_title：Anesthesia and analgesia

authors： Kaplan JA,Miller ED,Bailey DR

更新日期：1976-03-01 00:00:00

abstract：:Ketamine given IV in a dose of 2 mg/kg caused a significant reduction in Pao2 in 7 patients spontaneously breathing with an unassisted airway. Under the same conditions, in 7 patients, ketamine (2 mg/kg IV) preceded by diazepam (0.2 mg/kg IV) also caused a reduction in Pao2 not significantly different from that caused...

journal_title：Anesthesia and analgesia

authors： Zsigmond EK,Matsuki A,Kothary SP,Jallad M

更新日期：1976-05-01 00:00:00

abstract：:The choice between morphine and meperidine for postoperative pain is usually based on the preference of the prescriber, as few objective comparative data are available. This blind, randomized study compared the efficacy and side effects of morphine and meperidine administered by patient-controlled analgesia (PCA) for ...

journal_title：Anesthesia and analgesia

authors： Plummer JL,Owen H,Ilsley AH,Inglis S

更新日期：1997-04-01 00:00:00

abstract：:A pharmacokinetic evaluation of bupivacaine was carried out after intercostal nerve blocks performed on 28 occasions in 27 children varying in age from 3 months to 16 yr. Bupivacaine HCl, 0.5%, with epinephrine 1:200,000 was employed. Doses of 2 mg/kg, 3 mg/kg, and 4 mg/kg resulted in peak whole blood arterial bupivac...

journal_title：Anesthesia and analgesia

authors： Rothstein P,Arthur GR,Feldman HS,Kopf GS,Covino BG

更新日期：1986-06-01 00:00:00

abstract：BACKGROUND:A single preoperative dose of 600 mg gabapentin, combined with multimodal analgesia, has previously been shown to reduce postcesarean pain and improve maternal satisfaction but was associated with increased maternal sedation. We hypothesized that a lower dose of gabapentin may be effective with less sedation...

journal_title：Anesthesia and analgesia

authors： Short J,Downey K,Bernstein P,Shah V,Carvalho JC

更新日期：2012-12-01 00:00:00

abstract：:Only 1 in about 110 sex acts results in a conception and 1 in 270 in a live birth. Of all conceptions, 40% result in live births, 5% in stillbirths, and 55% never develop. 1/3 of all known conceptions ends in abortion, spontaneous or induced. It appears that the population problem depends on a small fraction of the...

journal_title：Anesthesia and analgesia

authors： Berelson B

更新日期：1971-07-01 00:00:00

abstract：:To test the relative effects on serum creatinine (CRE), blood urea nitrogen (BUN), and urine output of small-dose dopamine and fenoldopam in patients undergoing liver transplantation, we randomized 43 patients to 1 of 2 continuous infusions over 48 h, starting with anesthesia induction: fenoldopam, 0.1 microg . kg(-1)...

journal_title：Anesthesia and analgesia

authors： Della Rocca G,Pompei L,Costa MG,Coccia C,Scudeller L,Di Marco P,Monaco S,Pietropaoli P

更新日期：2004-12-01 00:00:00

abstract：:Cytokine release during surgery can produce a long-lasting hyperalgesia. Thus, preoperatively-administered cytokine inhibitors might reduce the production of cytokines, decreasing central nervous system sensitization and improving the quality of postoperative pain relief. We investigated the hypothesis that preincisio...

journal_title：Anesthesia and analgesia

authors： Lu CH,Chao PC,Borel CO,Yang CP,Yeh CC,Wong CS,Wu CT

更新日期：2004-11-01 00:00:00

abstract：:In Japan, an ever-present problem in the preoperative evaluation of patients with ischemic heart disease is that although such evaluations are based on Western data, these data serve as the basis for determining perioperative risk in Japanese patients. To remedy this problem, the Cardiac Ischemia and Anesthesia Resear...

journal_title：Anesthesia and analgesia

authors： Seki M,Kashimoto S,Nagata O,Yoshioka H,Ishiguro T,Nishimura K,Honda O,Sakamoto A,Omi A,Ogihara Y,Fujimoto K,Iwade M,Yamada T,Nomura M,Takeda J

更新日期：2005-05-01 00:00:00

abstract：:Postoperative sensitivity to tactile stimuli differs as a function of age. In this study, we hypothesized that preoperative sciatic nerve block (SNB), by providing preemptive analgesia, would result in better analgesia than postoperative SNB in the young rat. With the paw incision model of postoperative pain, male Spr...

journal_title：Anesthesia and analgesia

authors： Ririe DG,Barclay D,Prout H,Tong C,Tobin JR,Eisenach JC

更新日期：2004-07-01 00:00:00

abstract：:We compared intrathecal ropivacaine to bupivacaine in patients scheduled for transurethral resection of bladder or prostate. Doses of ropivacaine and bupivacaine were chosen according to a 3:2 ratio found to be equipotent in orthopedic surgery. One hundred patients were randomly assigned to blindly receive either 10 m...

journal_title：Anesthesia and analgesia

authors： Malinovsky JM,Charles F,Kick O,Lepage JY,Malinge M,Cozian A,Bouchot O,Pinaud M

更新日期：2000-12-01 00:00:00

abstract：:This study was designed to determine whether preoperative administration of 6% hetastarch decreases the incidence and severity of hypotension after spinal anesthesia for cesarean section. Forty nonlaboring ASA class I and II women having nonurgent cesarean sections were randomized to receive either 500 mL of 6% hetast...

journal_title：Anesthesia and analgesia

authors： Riley ET,Cohen SE,Rubenstein AJ,Flanagan B

更新日期：1995-10-01 00:00:00