Desflurane affords greater protection than halothane in the function of mitochondria against forebrain ischemia reperfusion injury in rats.

Abstract:

BACKGROUND:Halothane and desflurane have been shown to attenuate neuronal injury; however, the effects of these anesthetics on mitochondria are unclear. We investigated whether halothane and desflurane affect the function of mitochondria after cerebral ischemia in rats. METHODS:Forty male Wistar rats were randomly divided into four groups (n = 10 each): sham group; 1.5 minimal alveolar concentration (MAC) halothane group; 1.0 MAC desflurane; and 1.5 MAC desflurane group. Forebrain ischemia was induced after 40-min inhalation of 1.5 MAC halothane, 1.0 MAC or 1.5 MAC desflurane by clamping the bilateral common carotid arteries and decreasing arterial blood pressure. After isolation of the brain mitochondria, mitochondrial membrane permeability was assayed spectrophotometrically with 40-200 microM Ca(2+), and mitochondrial membrane potentials were measured by a fluorospectrophotometer with the addition of rhodamine 123. The activities of mitochondrial respiratory chain complexes were also assayed spectrophotometrically. RESULTS:The results showed obvious mitochondrial swelling, loss of membrane potential with the addition of Ca(2+), and inhibition of the activities of complexes I + III and IV after forebrain ischemia reperfusion injury. Compared with the 1.5 MAC halothane group, 1.0 and 1.5 MAC desflurane reduced mitochondrial swelling by 23.9% (P < 0.001) and 23.2% (P < 0.001), whereas membrane potential dissipation was suppressed by 22.4% (P = 0.013) and 20.4% (P = 0.027). The activities of complexes I + III and IV were better preserved in 1.0 MAC and 1.5 MAC desflurane groups than in the 1.5 MAC halothane group by 34.6% (P = 0.027), 38.7% (P = 0.011), 53.9% (P = 0.009), and 55.8% (P = 0.007), respectively. CONCLUSIONS:Desflurane shows better preservation of mitochondrial function at 4 h after cerebral ischemia reperfusion injury, indicated by inhibition of mitochondrial swelling, increase of membrane potential, and improvement of functions of mitochondria respiratory complexes I + III and IV when compared with halothane.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Zhang B,Wei X,Cui X,Zhou H,Ding W,Li W

doi

10.1213/ane.0b013e318164f2a5

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

1242-9, table of contents

issue

4

eissn

0003-2999

issn

1526-7598

pii

106/4/1242

journal_volume

106

pub_type

杂志文章
  • Postoperative epidural analgesia and oral anticoagulant therapy.

    abstract::The relative safety of epidural catheter placement with subsequent heparinization has been well documented. However, what is the risk of neurologic sequelae in such patients who receive warfarin perioperatively? This study retrospectively evaluates the risk of spinal hematoma in patients receiving postoperative epidur...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199407000-00017

    authors: Horlocker TT,Wedel DJ,Schlichting JL

    更新日期:1994-07-01 00:00:00

  • Cerebral Small Vessel, But Not Large Vessel Disease, Is Associated With Impaired Cerebral Autoregulation During Cardiopulmonary Bypass: A Retrospective Cohort Study.

    abstract:BACKGROUND:Impaired cerebral blood flow (CBF) autoregulation during cardiopulmonary bypass (CPB) is associated with stroke and other adverse outcomes. Large and small arterial stenosis is prevalent in patients undergoing cardiac surgery. We hypothesize that large and/or small vessel cerebral arterial disease is associa...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0000000000003384

    authors: Nomura Y,Faegle R,Hori D,Al-Qamari A,Nemeth AJ,Gottesman R,Yenokyan G,Brown C,Hogue CW

    更新日期:2018-12-01 00:00:00

  • Central administration of minocycline and riluzole prevents morphine-induced tolerance in rats.

    abstract:BACKGROUND:Long-term exposure to opiates induces tolerance to the analgesic effect. The neurobiological mechanism of this phenomenon is not completely clear. In this study, we evaluated the effects of central administration of minocycline (a tetracycline derivative) and riluzole (an antiglutamatergic drug) on morphine-...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e3181ae5f13

    authors: Habibi-Asl B,Hassanzadeh K,Charkhpour M

    更新日期:2009-09-01 00:00:00

  • Systemic ondansetron antagonizes the sensory block produced by intrathecal lidocaine.

    abstract::In this prospective randomized, double-blind study, we investigated the effect of ondansetron on the lidocaine subarachnoid block. Fifty-four male patients scheduled for transurethral surgery under subarachnoid anesthesia received oral ondansetron 4 mg the evening before surgery and 4 mg IV 15 min before subarachnoid ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/01.ANE.0000152616.57107.F6

    authors: Fassoulaki A,Melemeni A,Zotou M,Sarantopoulos C

    更新日期:2005-06-01 00:00:00

  • Perioperative pain management of a complex orthopedic surgical procedure with double continuous nerve blocks in a burned child.

    abstract:UNLABELLED:The use of catheters for continuous nerve blocks has been established in children, although in most series only one catheter was used. We report a case of a 3-yr-old child who underwent a toe-to-finger transfer managed with 2 regional catheters: axillary and sciatic. A pain score of 0 was noted during the en...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000114084.01266.e5

    authors: Dadure C,Acosta C,Capdevila X

    更新日期:2004-06-01 00:00:00

  • Thromboelastography for monitoring prolonged hypercoagulability after major abdominal surgery.

    abstract:UNLABELLED:Despite clinical and laboratory evidence of perioperative hypercoagulability, there are no consistent data evaluating the extent, duration, and specific contribution of platelets and procoagulatory proteins by in vitro testing. We tested the hypothesis that the parallel use of standard and abciximab-cytochal...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200103000-00004

    authors: Mahla E,Lang T,Vicenzi MN,Werkgartner G,Maier R,Probst C,Metzler H

    更新日期:2001-03-01 00:00:00

  • Studies of desflurane in outpatient anesthesia.

    abstract::The low solubility of desflurane contributes to rapid emergence after outpatient anesthesia. Compared with isoflurane, recovery times to eye opening, response to verbal commands, and orientation to person, place, and time have been significantly shorter. Even when compared with the rapid, short-acting intravenous anes...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:

    authors: White PF

    更新日期:1992-10-01 00:00:00

  • Late presentation of esophageal injury after transesophageal echocardiography.

    abstract::Esophageal injury is a rare complication of intraoperative transesophageal echocardiography (TEE) associated with cardiac surgery. We report two cases of delayed presentation (2 and 6 days after surgery) of esophageal injury that were likely due to TEE. The differential diagnosis of postoperative pleural effusion or a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000120085.40108.24

    authors: MacGregor DA,Zvara DA,Treadway RM Jr,Ibdah JA,Maloney JD,Kon ND,Riley RD

    更新日期:2004-07-01 00:00:00

  • Development and Evaluation of a Risk-Adjusted Measure of Intraoperative Hypotension in Patients Having Nonemergent, Noncardiac Surgery.

    abstract:BACKGROUND:Intraoperative hypotension is common and associated with organ injury and death, although randomized data showing a causal relationship remain sparse. A risk-adjusted measure of intraoperative hypotension may therefore contribute to quality improvement efforts. METHODS:The measure we developed defines hypot...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000005287

    authors: Christensen AL,Jacobs E,Maheshwari K,Xing F,Zhao X,Simon SE,Domino KB,Posner KL,Stewart AF,Sanford JA,Sessler DI

    更新日期:2020-11-23 00:00:00

  • Development and Validation of an Algorithm to Classify as Equivalent the Procedures in ICD-10-PCS That Differ Only by Laterality.

    abstract:BACKGROUND:The switch from International Classification of Diseases, Ninth Revision, Clinical Modification to International Classification of Diseases, Tenth Revision, Procedure Coding System (ICD-10-PCS) for coding of inpatient procedures in the United States increased the number of procedural codes more than 19-fold,...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000003340

    authors: Epstein RH,Dexter F,O'Neill L

    更新日期:2019-06-01 00:00:00

  • Solubility of I-653, sevoflurane, isoflurane, and halothane in plastics and rubber composing a conventional anesthetic circuit.

    abstract::This study defines some characteristics of a standard anesthetic circuit that may impede anesthetic induction and recovery with I-653, sevoflurane, isoflurane, and halothane. Partition coefficients for anesthetic circuit components (masks, bellows, bags, airways, and circuit tubes) consistently ranked halothane greate...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Targ AG,Yasuda N,Eger EI 2nd

    更新日期:1989-08-01 00:00:00

  • The clinical onset of heparin is rapid.

    abstract::This study used the activated clotting time (ACT) to determine the clinical onset of four different doses of heparin after bolus injection into the central circulation. Ten consenting adults (Group A) undergoing coronary artery bypass grafting were given 350 U/kg of bovine lung heparin and had simultaneous duplicate a...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000539-200106000-00006

    authors: Heres EK,Speight K,Benckart D,Marquez J,Gravlee GP

    更新日期:2001-06-01 00:00:00

  • Rapid and accurate detection of atypical and Kalow variants in the butyrylcholinesterase gene using denaturing high performance liquid chromatography.

    abstract:BACKGROUND:Variations in the butyrylcholinesterase (BCHE) gene can prolong neuromuscular block after the administration of the neuromuscular blocking drugs succinylcholine and mivacurium. The most frequent variations in the BCHE gene are the atypical (A) and Kalow (K) variants. We, therefore, developed a detection appr...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000296455.31211.bd

    authors: Levano S,Keller D,Schobinger E,Urwyler A,Girard T

    更新日期:2008-01-01 00:00:00

  • The Analgesic Effect of Ultrasound-Guided Quadratus Lumborum Block After Cesarean Delivery: A Randomized Clinical Trial.

    abstract:BACKGROUND:Landmark and ultrasound-guided transversus abdominis plane blocks have demonstrated an opioid-sparing effect postoperatively after cesarean delivery. The more posterior quadratus lumborum (QL) might provide superior local anesthetic spread to the thoracolumbar fascia and paravertebral space. The aim of our s...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000002648

    authors: Krohg A,Ullensvang K,Rosseland LA,Langesæter E,Sauter AR

    更新日期:2018-02-01 00:00:00

  • The effect of nitroglycerin on pacing-induced changes in myocardial oxygen consumption and metabolic coronary vasodilation in patients with coronary artery disease.

    abstract:UNLABELLED:In the present study, we assessed the potential effect of nitroglycerin IV (NTG), a donor of exogenous nitric oxide, on metabolic coronary flow control in patients with coronary artery disease. In 12 patients scheduled for coronary artery surgery, arterial blood pressure, pulmonary capillary wedge pressure, ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199902000-00009

    authors: Kal JE,Vergroesen I,van Wezel HB

    更新日期:1999-02-01 00:00:00

  • In vitro, inhibition of mitogen-activated protein kinase pathways protects against bupivacaine- and ropivacaine-induced neurotoxicity.

    abstract:BACKGROUND:Animal models show us that specific activation of the p38 mitogen-activated protein kinase (MAPK) may be a pivotal step in lidocaine neurotoxicity, but this has not been investigated in the case of two very widely used local anesthetics, bupivacaine and ropivacaine. We investigated the hypotheses that these ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e318168514b

    authors: Lirk P,Haller I,Colvin HP,Lang L,Tomaselli B,Klimaschewski L,Gerner P

    更新日期:2008-05-01 00:00:00

  • Gastric tubes and airway management in patients at risk of aspiration: history, current concepts, and proposal of an algorithm.

    abstract::Rapid sequence induction and intubation (RSII) and awake tracheal intubation are commonly used anesthetic techniques in patients at risk of pulmonary aspiration of gastric or esophageal contents. Some of these patients may have a gastric tube (GT) placed preoperatively. Currently, there are no guidelines regarding whi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0b013e3182917f11

    authors: Salem MR,Khorasani A,Saatee S,Crystal GJ,El-Orbany M

    更新日期:2014-03-01 00:00:00

  • Emerging techniques in the management of acute pain: epidural analgesia.

    abstract::Epidural analgesia, often using opioids intraoperatively and postoperatively, is widely accepted as a valuable modality for perioperative pain management. In this review I present data from meta-analyses and recently published trials that evaluate the perioperative use of opioids administered epidurally or parenterall...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/01.ane.0000179686.73009.2b

    authors: Viscusi ER

    更新日期:2005-11-01 00:00:00

  • Residual neuromuscular block: lessons unlearned. Part I: definitions, incidence, and adverse physiologic effects of residual neuromuscular block.

    abstract::In this review, we summarize the clinical implications of residual neuromuscular block. Data suggest that residual neuromuscular block is a common complication in the postanesthesia care unit, with approximately 40% of patients exhibiting a train-of-four ratio <0.9. Volunteer studies have demonstrated that small degre...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0b013e3181da832d

    authors: Murphy GS,Brull SJ

    更新日期:2010-07-01 00:00:00

  • Catheter-associated masses in patients receiving intrathecal analgesic therapy.

    abstract:UNLABELLED:A cohort of seven patients receiving intrathecal analgesic drug therapy for chronic intractable pain underwent radiocontrast myelography and computed tomography (CT) scanning to screen for catheter-associated intrathecal masses. Three of seven patients examined had intraspinal masses associated with the tip ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200301000-00039

    authors: McMillan MR,Doud T,Nugent W

    更新日期:2003-01-01 00:00:00

  • Effect of halothane on cardiac output and regional flow in the fetal lamb in utero.

    abstract::We studied the effect of halothane on the fetal cardiovascular system of six lambs in utero by measuring fetal heart rate and femoral arterial blood pressure and by injecting labeled microspheres during a control period and again after 60 and 90 min of halothane anesthesia administered to six pregnant ewes at an inspi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Biehl DR,Tweed WA,Cote J,Wade JG,Sitar D

    更新日期:1983-05-01 00:00:00

  • Effects of augmenting cardiac contractility, preload, and heart rate on cardiac output during enflurane anesthesia.

    abstract::Changes in cardiac output in response to augmenting cardiac contractility, preload, and heart rate during enflurane anesthesia were examined in 12 open-chested dogs. Cardiac contractility was assessed by the slope of the end-systolic pressure-volume relation (Emax). Dobutamine (3, 6, and 9 micrograms.kg-1.min-1) was a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199111000-00014

    authors: Sato M,Hoka S,Arimura H,Ono K,Yoshitake J

    更新日期:1991-11-01 00:00:00

  • Digital skin blood flow as an indicator for intravascular injection of epinephrine-containing simulated epidural test dose in sevoflurane-anesthetized adults.

    abstract:UNLABELLED:I designed this study to determine the efficacy of heart rate (HR), systolic blood pressure (SBP), and digital skin blood flow (DSBF) in detecting intravascular injection after a simulated epidural test dose containing 15 mug of epinephrine in sevoflurane-anesthetized adults. In addition, the testing thresho...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/01.ANE.0000157571.00717.08

    authors: Mowafi HA

    更新日期:2005-08-01 00:00:00

  • The Effects of Continuous Positive Airway Pressure on Postoperative Outcomes in Obstructive Sleep Apnea Patients Undergoing Surgery: A Systematic Review and Meta-analysis.

    abstract:BACKGROUND:Obstructive sleep apnea (OSA) is a commonly encountered comorbid condition in patients undergoing surgery and is associated with a greater risk of postoperative adverse events. Our objective in this review was to investigate the effectiveness of continuous positive airway pressure (CPAP) in reducing the risk...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,meta分析,评审

    doi:10.1213/ANE.0000000000000634

    authors: Nagappa M,Mokhlesi B,Wong J,Wong DT,Kaw R,Chung F

    更新日期:2015-05-01 00:00:00

  • Evidence-based management of critically ill patients: analysis and implementation.

    abstract::A number of important clinical trials focusing on critically ill patients have been completed in the last few years. These trials have been among the first critical care clinical trials to demonstrate mortality reduction in the critically ill. As in any adaptation of evidence-based medicine, it is essential to closely...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/01.ANE.0000123494.40145.B3

    authors: Gropper MA

    更新日期:2004-08-01 00:00:00

  • Single-injection percutaneous peribulbar anesthesia with a short needle as an alternative to the double-injection technique for cataract extraction.

    abstract:BACKGROUND:We evaluated the efficacy of a single-injection technique for percutaneous peribulbar anesthesia with a short needle as an alternative to the double-injection technique for cataract extraction. METHODS:We included 200 patients who underwent elective cataract surgery randomized into 2 equal groups. They rece...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0b013e3181c293bd

    authors: Ghali AM,Hafez A

    更新日期:2010-01-01 00:00:00

  • The incidence and prediction of automatically detected intraoperative cardiovascular events in noncardiac surgery.

    abstract:UNLABELLED:The objective of this study was to evaluate prognostic models for quality assurance purposes in predicting automatically detected intraoperative cardiovascular events (CVE) in 58458 patients undergoing noncardiac surgery. To this end, we assessed the performance of two established models for risk assessment ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000103262.26387.9c

    authors: Röhrig R,Junger A,Hartmann B,Klasen J,Quinzio L,Jost A,Benson M,Hempelmann G

    更新日期:2004-03-01 00:00:00

  • The influence of endotoxemia on the electroencephalographic and antinociceptive effects of isoflurane in a swine model.

    abstract:BACKGROUND:We have previously reported that hemorrhagic shock decreases the minimum alveolar anesthetic concentration (MAC) of isoflurane but minimally alters the electroencephalographic (EEG) effect. In this study, we investigated the influence of endotoxemia on the EEG effect and the MAC of isoflurane. METHODS:Eight...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e3181c22146

    authors: Kurita T,Takata K,Morita K,Uraoka M,Sato S

    更新日期:2010-01-01 00:00:00

  • Estimation of the length of the nares-vocal cord.

    abstract::The nasal route is preferred for fiberoptic intubation. Placing a lubricated endotracheal tube through the nostril can guide the fiberoptic scope towards the larynx. It would be helpful for optimal visualization of the vocal cord when the scope is passed through the endotracheal tube if the length of nares-vocal cord ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ANE.0000149900.68354.33

    authors: Han DW,Shim YH,Shin CS,Lee YW,Lee JS,Ahn SW

    更新日期:2005-05-01 00:00:00

  • Continuous gastric decompression for postoperative nausea and vomiting after coronary revascularization surgery.

    abstract::Postoperative nausea and vomiting is common after cardiac surgery and may contribute to significant morbidity. Gastric decompression during anesthesia has been used for postoperative nausea and vomiting prophylaxis in shorter duration noncardiac surgery with conflicting results. We tested the hypothesis that gastric d...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/01.ANE.0000143567.51304.1A

    authors: Burlacu CL,Healy D,Buggy DJ,Twomey C,Veerasingam D,Tierney A,Moriarty DC

    更新日期:2005-02-01 00:00:00