Right Ventricular Longitudinal Strain Is Depressed in a Bovine Model of Pulmonary Hypertension.

Abstract:

BACKGROUND:Pulmonary hypertension and resulting right ventricular (RV) dysfunction are associated with significant perioperative morbidity and mortality. Although echocardiography permits real-time, noninvasive assessment of RV function, objective and comparative measures are underdeveloped, and appropriate animal models to study their utility are lacking. Longitudinal strain analysis is a novel echocardiographic method to quantify RV performance. Herein, we hypothesized that peak RV longitudinal strain would worsen in a bovine model of pulmonary hypertension compared with control animals. METHODS:Newborn Holstein calves were randomly chosen for induction of pulmonary hypertension versus control conditions. Pulmonary hypertension was induced by exposing animals to 14 days of hypoxia (equivalent to 4570 m above sea level or 430 mm Hg barometric pressure). Control animals were kept at ambient pressure/normoxia. At the end of the intervention, transthoracic echocardiography was performed in awake calves. Longitudinal wall strain was analyzed from modified apical 4-chamber views focused on the RV. Comparisons between measurements in hypoxic versus nonhypoxic conditions were performed using Student t test for independent samples and unequal variances. RESULTS:After 14 days at normoxic versus hypoxic conditions, 15 calves were examined with echocardiography. Pulmonary hypertension was confirmed by right heart catheterization and associated with reduced RV systolic function. Mean systolic strain measurements were compared in normoxia-exposed animals (n = 8) and hypoxia-exposed animals (n = 7). Peak global systolic longitudinal RV strain after hypoxia worsened compared to normoxia (-10.5% vs -16.1%, P = 0.0031). Peak RV free wall strain also worsened after hypoxia compared to normoxia (-9.6% vs -17.3%, P = 0.0031). Findings from strain analysis were confirmed by measurement of tricuspid annular peak systolic excursion. CONCLUSIONS:Peak longitudinal RV strain detected worsened RV function in animals with hypoxia-induced pulmonary hypertension compared with control animals. This relationship was demonstrated in the transthoracic echocardiographic 4-chamber view independently for the RV free wall and for the combination of the free and septal walls. This innovative model of bovine pulmonary hypertension may prove useful to compare different monitoring technologies for the assessment of early events of RV dysfunction. Further studies linking novel RV imaging applications with mechanistic and therapeutic approaches are needed.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Bartels K,Brown RD,Fox DL,Bull TM,Neary JM,Dorosz JL,Fonseca BM,Stenmark KR

doi

10.1213/ANE.0000000000001215

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

1280-6

issue

5

eissn

0003-2999

issn

1526-7598

journal_volume

122

pub_type

杂志文章
  • The Efficacy of Eslicarbazepine Acetate in Models of Trigeminal, Neuropathic, and Visceral Pain: The Involvement of 5-HT1B/1D Serotonergic and CB1/CB2 Cannabinoid Receptors.

    abstract:BACKGROUND:Many clinical pain states that are difficult to treat share a common feature of sensitization of nociceptive pathways. Drugs that could normalize hyperexcitable neural activity (e.g., antiepileptic drugs) may be useful in relieving these pain states. Eslicarbazepine acetate (ESL) is a novel antiepileptic dru...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000000953

    authors: Tomić MA,Pecikoza UB,Micov AM,Stepanović-Petrović RM

    更新日期:2015-12-01 00:00:00

  • Effect of local anesthetic dilution on the onset time and duration of double-injection sciatic nerve block: a prospective, randomized, blinded evaluation.

    abstract:BACKGROUND:Among the various factors influencing the success rate, onset time, and duration of peripheral nerve blocks, the role of local anesthetics concentration remains uncertain. In this prospective, randomized, single-blinded study, we evaluated whether varying the dilution of a fixed dose of mepivacaine solution ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0000000000000293

    authors: Cappelleri G,Ambrosoli AL,Turconi S,Gemma M,Ricci EB,Cornaggia G

    更新日期:2014-08-01 00:00:00

  • The clinical onset of heparin is rapid.

    abstract::This study used the activated clotting time (ACT) to determine the clinical onset of four different doses of heparin after bolus injection into the central circulation. Ten consenting adults (Group A) undergoing coronary artery bypass grafting were given 350 U/kg of bovine lung heparin and had simultaneous duplicate a...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000539-200106000-00006

    authors: Heres EK,Speight K,Benckart D,Marquez J,Gravlee GP

    更新日期:2001-06-01 00:00:00

  • Postoperative epidural analgesia and oral anticoagulant therapy.

    abstract::The relative safety of epidural catheter placement with subsequent heparinization has been well documented. However, what is the risk of neurologic sequelae in such patients who receive warfarin perioperatively? This study retrospectively evaluates the risk of spinal hematoma in patients receiving postoperative epidur...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199407000-00017

    authors: Horlocker TT,Wedel DJ,Schlichting JL

    更新日期:1994-07-01 00:00:00

  • The interaction of FK409, a novel nitric oxide releaser, and peripherally administered morphine during experimental inflammation.

    abstract:UNLABELLED:Nitric oxide (NO) may play an important role in central and peripheral nociceptive processes. However, its contribution to peripheral antinociception is still not clear. In the present study, we investigated the effect of peripherally administered FK409, a spontaneous NO releaser, and its interaction with pe...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199802000-00028

    authors: Nozaki-Taguchi N,Yamamoto T

    更新日期:1998-02-01 00:00:00

  • Thoracic epidural anesthesia for bilateral reduction mammoplasty in a patient with Klippel-Feil syndrome.

    abstract::General anesthesia is best avoided in cases of Klippel-Feil syndrome where tracheal intubation is potentially difficult. The syndrome features severe abnormalities of the neck and upper thoracic spine, which may also lead to difficulties with neuraxial blockade. We describe the use of epidural anesthesia for bilateral...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200102000-00043

    authors: O'Connor PJ,Moysa GL,Finucane BT

    更新日期:2001-02-01 00:00:00

  • Beta-adrenergic blockers and vasovagal episodes during shoulder surgery in the sitting position under interscalene block.

    abstract:UNLABELLED:Shoulder surgery is often performed with patients in the sitting position under interscalene block anesthesia. Vasovagal episodes, characterized by a sudden decrease in heart rate and/or blood pressure, have a reported incidence of 17%-24% in this setting. We performed a retrospective study to determine whet...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Kahn RL,Hargett MJ

    更新日期:1999-02-01 00:00:00

  • The efficacy of intrathecal morphine with or without clonidine for postoperative analgesia after radical prostatectomy.

    abstract:BACKGROUND:In this randomized study, we compared intrathecal (i.t.) morphine with or without clonidine and i.v. postoperative patient-controlled analgesia (PCA) morphine for analgesia after radical retropubic prostatectomy. METHODS:Fifty patients were randomly divided into three groups. They were allocated to receive ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ane.0b013e3181a30182

    authors: Andrieu G,Roth B,Ousmane L,Castaner M,Petillot P,Vallet B,Villers A,Lebuffe G

    更新日期:2009-06-01 00:00:00

  • Odds of transfusion for older adults compared to younger adults undergoing surgery.

    abstract:BACKGROUND:Recent randomized controlled trials have shown no benefit for transfusion to a hemoglobin >10 g/dL compared with lower hemoglobin thresholds in the perioperative period, even among older adults. Nevertheless, physicians may choose to transfuse older adults more liberally than younger adults. It is unclear wh...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000000033

    authors: Brown CH 4th,Savage WJ,Masear CG,Walston JD,Tian J,Colantuoni E,Hogue CW,Frank SM

    更新日期:2014-06-01 00:00:00

  • Transient atrioventricular block after release of aortic cross-clamp.

    abstract::To determine the incidence of atrioventricular (A-V) block, 86 patients, aged 58.9 +/- 10.4 yr, undergoing elective coronary artery bypass grafting (CABG) during aortic cross-clamping (ACC) and cold potassium cardioplegia were investigated. The incidence and duration of complete A-V block after release of the aortic c...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199501000-00009

    authors: Baraka AS,Taha SK,Yazbeck VK,Rizkallah PA,Zughbi JP,Aouad MJ,Rouhana CS,Nader AM

    更新日期:1995-01-01 00:00:00

  • Postoperative analgesia for outpatient arthroscopic knee surgery with intraarticular clonidine and/or morphine.

    abstract::Both clonidine, an alpha(2) agonist, and morphine, an opioid agonist, provide enhanced patient analgesia after arthroscopic knee surgery when administered via the intraarticular (IA) route. Clonidine potentiates morphine analgesia in the animal model. We designed this study to determine whether clonidine or morphine r...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-200005000-00018

    authors: Joshi W,Reuben SS,Kilaru PR,Sklar J,Maciolek H

    更新日期:2000-05-01 00:00:00

  • Atrial fibrillation after coronary artery bypass graft surgery is unrelated to cardiac abnormalities detected by transesophageal echocardiography.

    abstract:UNLABELLED:Atrial fibrillation is a common complication of coronary artery bypass graft (CABG) surgery that is associated with adverse patient outcomes. We evaluated whether preexisting abnormalities of cardiac structure or function detected with transesophageal echocardiography (TEE) are prevalent in patients later de...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000539-200107000-00004

    authors: Skubas NJ,Barzilai B,Hogue CW Jr

    更新日期:2001-07-01 00:00:00

  • A randomized comparison between midazolam and thiopental for elective cesarean section anesthesia: III. Placental transfer and elimination in neonates.

    abstract::Forty neonates delivered by cesarean section were studied, half being delivered of mothers in whom anesthesia was induced with midazolam (0.3 mg/kg intravenously) and half of mothers given thiopental (4 mg/kg). At delivery, blood samples from mother and the umbilical vein were drawn for determination of plasma concent...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Bach V,Carl P,Ravlo O,Crawford ME,Jensen AG,Mikkelsen BO,Crevoisier C,Heizmann P,Fattinger K

    更新日期:1989-03-01 00:00:00

  • A comparison of a new indicator-guided with a conventional wire-guided percutaneous cricothyroidotomy device in mannequins.

    abstract:BACKGROUND:Percutaneous cricothyroidotomy may be a life-saving procedure in cannot intubate-cannot ventilate situations. In this study we compared the insertion times of a new indicator-guided cricothyroidotomy device and a wire-guided device in mannequins. METHODS:This study was a crossover trial comparing the insert...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000266439.43797.9e

    authors: Assmann NM,Wong DT,Morales E

    更新日期:2007-07-01 00:00:00

  • Whole Blood Point-of-Care Testing for Incomplete Reversal With Idarucizumab in Supratherapeutic Dabigatran.

    abstract:BACKGROUND:Incomplete reversal with a recommended 5-g dose of idarucizumab has been reported in patients with excessively high dabigatran concentrations. A timely detection of reversal failure after idarucizumab using whole blood (WB) coagulation testing is clinically useful. The aims of this study were to determine re...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000004419

    authors: Takeshita S,Tanaka KA,Sawa T,Sanda M,Mizobe T,Ogawa S

    更新日期:2020-02-01 00:00:00

  • Effects of end-tidal gas monitoring and flow rates on hemodynamic stability and recovery profiles.

    abstract::This study was designed to evaluate the impact of routine end-tidal anesthetic gas monitoring on the intraoperative hemodynamic stability and early recovery profile in 253 consenting ASA physical status I-III patients undergoing elective otolaryngologic procedures with isoflurane or enflurane anesthesia. Patients were...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/00000539-199409000-00023

    authors: Wang J,Liu J,White PF,Klein KW,Browne RH

    更新日期:1994-09-01 00:00:00

  • Preoperative Echocardiographic Indices of Diastolic Dysfunction and Brain Natriuretic Peptide in Predicting Postoperative Atrial Fibrillation After Noncardiac Surgery.

    abstract:BACKGROUND:We have shown previously that either echocardiographic indices of diastolic dysfunction or increased preoperative brain natriuretic peptide (BNP) predict postoperative atrial fibrillation (POAF). Because these 2 predictors of POAF have not been evaluated together, our goal was to further elucidate their conc...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000001471

    authors: Brecher O,Gulati H,Roistacher N,Zhang H,Shi W,Thaler HT,Amar D

    更新日期:2017-04-01 00:00:00

  • The peripheral antinociceptive effects of endomorphin-1 and kynurenic acid in the rat inflamed joint model.

    abstract:BACKGROUND:Several data suggest that both opioid and N-methyl-d-aspartate (NMDA) receptors are localized at the peripheral level, and drugs acting on these receptors may produce antinociception after topical administration; however, the antinociceptive effect of endogenous ligands at these receptors is poorly clarified...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e3181b21c5e

    authors: Mecs L,Tuboly G,Nagy E,Benedek G,Horvath G

    更新日期:2009-10-01 00:00:00

  • Clinical assessment of the Augustine Guide for endotracheal intubation.

    abstract::The Augustine Guide (AG) allows oral endotracheal intubations to be performed blindly; head and neck manipulation are unnecessary. It is a premolded device designed to fit in a lock and key fashion in the glottis, thus serving as a guide to allow blind laryngeal insertion of an endotracheal tube. Intubation success ra...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199405000-00026

    authors: Carr RJ,Belani KG

    更新日期:1994-05-01 00:00:00

  • The efficacy of the "BURP" maneuver during a difficult laryngoscopy.

    abstract::The displacement of the larynx in the three specific directions (a) posteriorly against the cervical vertebrae, (b) superiorly as possible, and (c) slightly laterally to the right have been reported and named the "BURP" maneuver. We evaluated the efficacy of the BURP maneuver in improving visualization of the larynx. ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199702000-00033

    authors: Takahata O,Kubota M,Mamiya K,Akama Y,Nozaka T,Matsumoto H,Ogawa H

    更新日期:1997-02-01 00:00:00

  • Cerebral metabolism assessed with microdialysis in uncontrolled hemorrhagic shock after penetrating liver trauma.

    abstract::In a porcine model of uncontrolled hemorrhagic shock, we evaluated the effects of fluid resuscitation versus arginine vasopressin (AVP) combined with hypertonic-hyperoncotic hydroxyethyl starch solution (HHS) on cerebral perfusion pressure (CPP) and on cerebral metabolism using intracerebral microdialysis. Sixteen ane...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000237125.42376.b5

    authors: Meybohm P,Cavus E,Bein B,Steinfath M,Brand PA,Scholz J,Dörges V

    更新日期:2006-10-01 00:00:00

  • The modified nasal trumpet maneuver.

    abstract:UNLABELLED:The last decade has witnessed a proliferation of devices or methods that facilitate intubation in difficult circumstances, maintain ventilation, or which do both. These all require properly functioning and specially designed apparatus, the use of which requires variable degrees of expertise. This technical c...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200202000-00045

    authors: Beattie C

    更新日期:2002-02-01 00:00:00

  • The impact of carrier flow rate and infusion set dead-volume on the dynamics of intravenous drug delivery.

    abstract::The dynamics of IV drug delivery resulting from drug infusions connected to main-line crystalloid carriers can be complex and depend on infusion set dead-volume, drug flow rate, and carrier flow rate. While the concept of dead-volume is intuitive, a lack of appreciation of the interaction with the carrier and drug flo...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ANE.0000146942.51020.88

    authors: Lovich MA,Doles J,Peterfreund RA

    更新日期:2005-04-01 00:00:00

  • Capturing Essential Information to Achieve Safe Interoperability.

    abstract::In this article, we describe the role of "clinical scenario" information to assure the safety of interoperable systems, as well as the system's ability to deliver the requisite clinical functionality to improve clinical care. Described are methods and rationale for capturing the clinical needs, workflow, hazards, and ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000001351

    authors: Weininger S,Jaffe MB,Rausch T,Goldman JM

    更新日期:2017-01-01 00:00:00

  • Effect of cardiopulmonary bypass on plasma levels of nifedipine.

    abstract::Blood levels of many medications are acutely lowered by cardiopulmonary bypass (CPB). Because nifedipine is often used to provide protection from coronary ischemia, a determination of the effect of CPB on plasma nifedipine levels might help to determine the potential clinical benefit of nifedipine during and after byp...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1213/00000539-199010000-00016

    authors: Katz RI,Kanchuger MS,Patton KF,Eide TR

    更新日期:1990-10-01 00:00:00

  • Large-dose intrathecal sufentanil prevents the hormonal stress response during major abdominal surgery: a comparison with intravenous sufentanil in a prospective randomized trial.

    abstract::We studied the effect of large-dose intrathecal sufentanil (ITS) for major abdominal surgery on the hormonal stress response. Forty patients were randomly allocated to receive either IV sufentanil (IVS) or 150 microg of ITS as part of general anesthesia. In the IVS group, adrenocorticotropic hormone (ACTH) and cortiso...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/01.ANE.0000131728.68125.4E

    authors: Borgdorff PJ,Ionescu TI,Houweling PL,Knape JT

    更新日期:2004-10-01 00:00:00

  • Lack of CNS depression from large doses of trimethaphan in sheep.

    abstract::It is not uncommon to observe prolonged CNS depression for several hours following controlled hypotension and halothane anesthesia for neurosurgery. The present study evaluates possible contribution of large doses of trimethaphan to CNS depression. Four adult sheep were placed on transapical left ventricular bypass (T...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-197701000-00005

    authors: Wong KC,Peters JL,Roberts TS,McRea JC,Fukumasu H

    更新日期:1977-01-01 00:00:00

  • Myocardial perfusion following acute subarachnoid hemorrhage in patients with an abnormal electrocardiogram.

    abstract::To test the hypothesis that acute subarachnoid hemorrhage is associated with abnormal myocardial perfusion, we assessed myocardial blood flow with thallium scintigraphy in 19 patients with a confirmed subarachnoid hemorrhage and an abnormal electrocardiogram. A thallium scan was performed at the bedside of each patien...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199302000-00009

    authors: Szabo MD,Crosby G,Hurford WE,Strauss HW

    更新日期:1993-02-01 00:00:00

  • Effect of hydroxyzine on morphine analgesia for the treatment of postoperative pain.

    abstract::In a double-blind, single-dose study hydroxyzine combined with morphine was administered intramuscularly to postoperative patients to determine the efficacy of this combination in the relief of postoperative pain, and to compare its effect to that produced by morphine alone. Eighty-two patients received morphine (5 or...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Hupert C,Yacoub M,Turgeon LR

    更新日期:1980-09-01 00:00:00

  • Initial Preference for Labor Without Neuraxial Analgesia and Actual Use: Results from a National Survey in France.

    abstract:BACKGROUND:The rate of neuraxial analgesia during labor in France is one of the highest among high-income countries: 77% of vaginal deliveries in 2010. In this context, the question of how women's preferences for delivering without neuraxial analgesia relate to actual use is of interest. Our objective was to study the ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000000832

    authors: Kpéa L,Bonnet MP,Le Ray C,Prunet C,Ducloy-Bouthors AS,Blondel B

    更新日期:2015-09-01 00:00:00