Postoperative analgesia for outpatient arthroscopic knee surgery with intraarticular clonidine and/or morphine.

Abstract:

:Both clonidine, an alpha(2) agonist, and morphine, an opioid agonist, provide enhanced patient analgesia after arthroscopic knee surgery when administered via the intraarticular (IA) route. Clonidine potentiates morphine analgesia in the animal model. We designed this study to determine whether clonidine or morphine results in better analgesia and whether their combination would provide superior analgesia to either drug alone. We evaluated 60 patients undergoing arthroscopic knee meniscus repair under local anesthesia with sedation. After surgery, patients were randomized into four IA groups: Group B received 30 mL 0.25% bupivacaine; Group BC received 30 mL 0.25% bupivacaine and clonidine 1 microg/kg; Group BM received 30 mL 0.25% bupivacaine and morphine 3 mg; and Group BCM received 30 mL 0.25% bupivacaine, clonidine 1 microg/kg, and morphine 3 mg. This study revealed a significant benefit from the individual IA administration of both clonidine and morphine. The combination of these drugs resulted in decreased postoperative pain and analgesic use, as well as an increased analgesic duration compared with either drug alone. We conclude that IA clonidine and morphine improved comfort compared with either drug alone in patients undergoing knee arthroscopy.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Joshi W,Reuben SS,Kilaru PR,Sklar J,Maciolek H

doi

10.1097/00000539-200005000-00018

subject

Has Abstract

pub_date

2000-05-01 00:00:00

pages

1102-6

issue

5

eissn

0003-2999

issn

1526-7598

journal_volume

90

pub_type

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