Cerebral metabolism assessed with microdialysis in uncontrolled hemorrhagic shock after penetrating liver trauma.

Abstract:

:In a porcine model of uncontrolled hemorrhagic shock, we evaluated the effects of fluid resuscitation versus arginine vasopressin (AVP) combined with hypertonic-hyperoncotic hydroxyethyl starch solution (HHS) on cerebral perfusion pressure (CPP) and on cerebral metabolism using intracerebral microdialysis. Sixteen anesthetized pigs were subjected to uncontrolled liver bleeding until hemodynamic decompensation, followed by resuscitation using either fluid (n = 8) or AVP/HHS (n = 8). Thirty minutes after drug administration, bleeding was controlled by manual compression, and colloid and crystalloid solutions were administered in both groups. All surviving animals were observed for one hour. After hemodynamic decompensation, fluid resuscitation resulted in a smaller increase of CPP than did AVP/HHS (mean +/- sem; 24 +/- 5 vs 45 +/- 7 mm Hg; P < 0.01). Mean (+/- sem) cerebral venous partial pressure of oxygen was significantly decreased (P < 0.01) 5 min after fluid compared with 5 min after AVP/HHS administration (36 +/- 3 vs 64 +/- 4 torr). Cerebral metabolism was comparable in both groups. In conclusion, AVP/HHS proved to be superior to fluid in the initial phase of therapy with respect to CPP and cerebral oxygenation, but was comparable to fluid regarding cerebral metabolism and secondary cell damage in surviving animals.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Meybohm P,Cavus E,Bein B,Steinfath M,Brand PA,Scholz J,Dörges V

doi

10.1213/01.ane.0000237125.42376.b5

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

948-54

issue

4

eissn

0003-2999

issn

1526-7598

pii

103/4/948

journal_volume

103

pub_type

杂志文章
  • Beta-adrenergic blockers and vasovagal episodes during shoulder surgery in the sitting position under interscalene block.

    abstract:UNLABELLED:Shoulder surgery is often performed with patients in the sitting position under interscalene block anesthesia. Vasovagal episodes, characterized by a sudden decrease in heart rate and/or blood pressure, have a reported incidence of 17%-24% in this setting. We performed a retrospective study to determine whet...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Kahn RL,Hargett MJ

    更新日期:1999-02-01 00:00:00

  • Residual halothane: Patient and personnel exposure.

    abstract::In addition to offering further data on the exposure of surgical and recovery-room personnel to low levels of halothane in room air, the authors demonstrate the presence of halothane levels in the blood of some surgical patients managed by other inhalation agents from machines previously used for halothane. The author...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-197507000-00010

    authors: Nicholson JA,Sada T,Aldrete JA

    更新日期:1975-07-01 00:00:00

  • Baseline Morphine Consumption May Explain Between-Study Heterogeneity in Meta-analyses of Adjuvant Analgesics and Improve Precision and Accuracy of Effect Estimates.

    abstract:BACKGROUND:Statistical heterogeneity can increase the uncertainty of results and reduce the quality of evidence derived from systematic reviews. At present, it is uncertain what the major factors are that account for heterogeneity in meta-analyses of analgesic adjuncts. Therefore, the aim of this review was to identify...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,meta分析,评审

    doi:10.1213/ANE.0000000000002237

    authors: Doleman B,Sutton AJ,Sherwin M,Lund JN,Williams JP

    更新日期:2018-02-01 00:00:00

  • The use of metoprolol and glycopyrrolate to prevent hypotensive/bradycardic events during shoulder arthroscopy in the sitting position under interscalene block.

    abstract:UNLABELLED:Sudden profound hypotensive and/or bradycardic events (HBE) have been reported in >20% of patients undergoing shoulder arthroscopy in the sitting position under interscalene block anesthesia. Retrospective studies suggest that the administration of beta-blockers is safe and may decrease the incidence of thes...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199812000-00020

    authors: Liguori GA,Kahn RL,Gordon J,Gordon MA,Urban MK

    更新日期:1998-12-01 00:00:00

  • Is transcutaneous electrical stimulation a realistic surrogate for genuine surgical stimulation during spinal anesthesia for cesarean delivery?

    abstract::Several studies have investigated differential block during spinal anesthesia using transcutaneous electrical stimulation (TES) applied to patient's skin. These TES stimuli are claimed to be a surrogate for surgical stimulation, but TES has never been shown to be a realistic surrogate for a surgical stimulus during re...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ANE.0000156219.47961.74

    authors: Zaidi AS,Russell IF

    更新日期:2005-05-01 00:00:00

  • Preincisional intravenous pentoxifylline attenuating perioperative cytokine response, reducing morphine consumption, and improving recovery of bowel function in patients undergoing colorectal cancer surgery.

    abstract::Cytokine release during surgery can produce a long-lasting hyperalgesia. Thus, preoperatively-administered cytokine inhibitors might reduce the production of cytokines, decreasing central nervous system sensitization and improving the quality of postoperative pain relief. We investigated the hypothesis that preincisio...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/01.ANE.0000132974.32249.C8

    authors: Lu CH,Chao PC,Borel CO,Yang CP,Yeh CC,Wong CS,Wu CT

    更新日期:2004-11-01 00:00:00

  • Severity of baseline pain and degree of analgesia in the third molar post-extraction dental pain model.

    abstract:UNLABELLED:The purpose of this study was to determine whether different levels of pain would respond similarly to analgesia. We compared the analgesic response to ibuprofen in subjects with moderate versus severe baseline pain in clinical trials using the third molar post-extraction dental pain model. We performed a po...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/01.ane.0000063827.97392.5e

    authors: Averbuch M,Katzper M

    更新日期:2003-07-01 00:00:00

  • Lymph leakage following catheterization of the right subclavian vein.

    abstract::Leakge of lymph following puncture of the right subclavian vein occurred in a patient, requiring a pacemaker catheter. The lymph drainage settled spontaneously after 4 days on remanipulation of the pacing wire. ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-197801000-00027

    authors: Ryan DW

    更新日期:1978-01-01 00:00:00

  • The application of tetanic stimulation of the unilateral tibial nerve before transcranial stimulation can augment the amplitudes of myogenic motor-evoked potentials from the muscles in the bilateral upper and lower limbs.

    abstract:BACKGROUND:Recently, we reported a new technique to augment motor-evoked potentials (MEPs) under general anesthesia, posttetanic MEP (p-MEP), in which tetanic stimulation of the peripheral nerve before transcranial stimulation enlarged amplitudes of MEPs from the muscle innervated by the nerve subjected to tetanic stim...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e318177082e

    authors: Hayashi H,Kawaguchi M,Yamamoto Y,Inoue S,Koizumi M,Ueda Y,Takakura Y,Furuya H

    更新日期:2008-07-01 00:00:00

  • Energy dose and other variables possibly affecting ventricular defibrillation during cardiac surgery.

    abstract::Previous studies have suggested that shocks of 5-10 J are required for direct ventricular defibrillation during open heart surgery. However, the efficacy of shocks of less than 5 J, the effects of thermal, biochemical, and temporal factors, and the influence of disease process on defibrillation have not been fully inv...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Lake CL,Sellers TD,Nolan SP,Crosby IK,Wellons HA Jr,Crampton RS

    更新日期:1984-08-01 00:00:00

  • Immediate tracheal extubation after liver transplantation: experience of two transplant centers.

    abstract::Early tracheal extubation has been safely performed after large operative procedures, questioning the need for routine postoperative ventilation. Because immediate postoperative tracheal extubation of liver transplantation patients has not been previously reported, we performed preliminary studies at two institutions ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199702000-00003

    authors: Mandell MS,Lockrem J,Kelley SD

    更新日期:1997-02-01 00:00:00

  • Pressure support ventilation decreases inspiratory work of breathing during general anesthesia and spontaneous ventilation.

    abstract::Spontaneous ventilation may offer advantages over controlled mechanical ventilation (CMV), but increase in work of breathing may diminish its usefulness. During general anesthesia, respiratory depression and increased work of breathing often preclude spontaneous ventilation, and patients then receive CMV. We compared ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199208000-00003

    authors: Christie JM,Smith RA

    更新日期:1992-08-01 00:00:00

  • High-dose hydromorphone (Dilaudid) for coronary artery bypass surgery.

    abstract::The hemodynamic effects of high-dose hydromorphone hydrochloride (H), 1.25 mg/kg, were investigated in 10 patients with normal ventricular function undergoing coronary artery bypass graft (CABG) surgery. One patient with unstable angina was excluded from the study because of hypotension and facial flushing after a 6-m...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Welti RS,Moldenhauer CC,Hug CC Jr,Kaplan JA,Holbrook GW

    更新日期:1984-01-01 00:00:00

  • The effects of propofol on hemodynamics and renal blood flow in healthy and in septic sheep, and combined with fentanyl in septic sheep.

    abstract::Sepsis is characterized by myocardial depression and systemic vasodilation, both of which are most likely mediated by nitric oxide. Propofol inhibits nitric oxide synthase and may therefore be beneficial in sepsis. On the other hand, renal blood flow, known to be only minimally affected by propofol in healthy subjects...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199604000-00011

    authors: Booke M,Armstrong C,Hinder F,Conroy B,Traber LD,Traber DL

    更新日期:1996-04-01 00:00:00

  • Left ventricular systolic and diastolic function is unaltered during propofol infusion in newborn swine.

    abstract:UNLABELLED:Propofol is a cardiac depressant with minimal diastolic effects in the adult myocardium. Cardiac effects of propofol in the newborn are unknown. We examined hemodynamic variables and systolic and diastolic left ventricular function in 12 newborn pigs exposed to propofol at three different infusion rates (7.5...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199804000-00008

    authors: Graham MR,Thiessen DB,Mutch WA

    更新日期:1998-04-01 00:00:00

  • Patient characteristics and anesthetic technique are additive but not synergistic predictors of successful motor evoked potential monitoring.

    abstract:BACKGROUND:Spinal cord monitoring is associated with a significantly lower rate of neurologic deficits after deformity surgery, and has been shown to have predictive value in cervical, thoracic, and lumbar surgery. Lower extremity motor evoked potentials (MEPs) are particularly sensitive to anesthetics and physiologic ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e3181e41804

    authors: Deiner SG,Kwatra SG,Lin HM,Weisz DJ

    更新日期:2010-08-01 00:00:00

  • Perioperative management of patients undergoing transsphenoidal pituitary surgery.

    abstract::Pituitary adenomas often present with the symptoms of hormonal hypersecretion, and although medical therapy is available for most hyperfunctioning states, it is not curative. As a result, transsphenoidal pituitary surgery has become a commonly performed neurosurgical procedure with unique challenges for the anesthesio...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/01.ane.0000166976.61650.ae

    authors: Nemergut EC,Dumont AS,Barry UT,Laws ER

    更新日期:2005-10-01 00:00:00

  • Comparison of tropisetron, droperidol, and saline in the prevention of postoperative nausea and vomiting after gynecologic surgery.

    abstract::This study was performed to compare the efficacy of tropisetron, droperidol, and saline in the prevention of postoperative nausea and vomiting (PONV) and to compare the possible adverse effects of these drugs in gynecologic incontinence surgery. Using a randomized, double-blind study design, we studied 150 women under...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199703000-00036

    authors: Purhonen S,Kauko M,Koski EM,Nuutinen L

    更新日期:1997-03-01 00:00:00

  • The preventive effects of mupirocin against nasotracheal intubation-related bacterial carriage.

    abstract:UNLABELLED:Nasotracheal intubation is often required during dental and maxillofacial surgery. The complications of nasotracheal intubation are well documented, but there have been few systematic attempts to find methods for their prevention. We examined intubation-related carriage of bacteria, especially methicillin-re...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/01.ane.0000066258.20778.06

    authors: Takahashi S,Minami K,Ogawa M,Miyamoto H,Ikemura K,Shigematsu A,Taniguchi H

    更新日期:2003-07-01 00:00:00

  • A comparison between meperidine, clonidine and urapidil in the treatment of postanesthetic shivering.

    abstract:UNLABELLED:Postanesthetic shivering can be treated with many types of drugs. We compared the effects of meperidine, clonidine, and urapidil on postanesthetic shivering. Sixty patients shivering during recovery from general anesthesia were treated in a randomized, double-blinded fashion with 25 mg meperidine IV, 0.15 mg...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-200101000-00051

    authors: Schwarzkopf KR,Hoff H,Hartmann M,Fritz HG

    更新日期:2001-01-01 00:00:00

  • Immobilizing doses of halothane, isoflurane or propofol, do not preferentially depress noxious heat-evoked responses of rat lumbar dorsal horn neurons with ascending projections.

    abstract:BACKGROUND:The spinal cord is an important site where volatile anesthetics decrease sensation and produce immobility. Beyond this knowledge, our understanding of a site of anesthetic action is limited. Previous evidence suggests that dorsal horn neurons with ascending projections may be more susceptible to depression b...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e318163f8f3

    authors: Barter LS,Mark LO,Jinks SL,Carstens EE,Antognini JF

    更新日期:2008-03-01 00:00:00

  • Positive end-expiratory pressure ventilation decreases plasma atrial and brain natriuretic peptide levels in humans.

    abstract::To investigate the possible role of atrial and brain natriuretic peptides (ANP and BNP) in the renal effects of mechanical ventilation with positive end-expiratory pressure (PEEP), we measured changes in plasma ANP and BNP levels during PEEP in patients undergoing subtotal esophagectomy. Application of 15 cm of H2O PE...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199312000-00006

    authors: Shirakami G,Magaribuchi T,Shingu K,Suga S,Tamai S,Nakao K,Mori K

    更新日期:1993-12-01 00:00:00

  • Tachyphylaxis and phase II block development during infusion of succinylcholine in children.

    abstract::Contraction of the adductor of the thumb in response to ulnar nerve stimulation during continuous infusion of succinylcholine (SCh) was evaluated in 22 children anesthetized with halothane (1% to 1.5%) and N2O/O2. Twitch rates of 0.1 Hz were used to evaluate the force of contraction. Train-of-four stimulation (2 Hz fo...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: DeCook TH,Goudsouzian NG

    更新日期:1980-09-01 00:00:00

  • Conservative treatment of tracheal injuries.

    abstract::Tracheal injuries, independent of their origin, may be life-threatening. Surgical repair is regarded as the treatment of choice but has not been compared with other approaches. We hypothesized that defects bridgeable by an artificial airway may enable conservative treatment. We report on five patients with tracheal in...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ANE.0000140780.14175.5A

    authors: Beiderlinden M,Adamzik M,Peters J

    更新日期:2005-01-01 00:00:00

  • Comparison of ramosetron and granisetron for preventing postoperative nausea and vomiting after gynecologic surgery.

    abstract:UNLABELLED:In a prospective, randomized, double-blinded study, we evaluated the efficacy of granisetron and ramosetron for preventing postoperative nausea and vomiting (PONV) in major gynecologic surgery. One hundred twenty patients, ASA physical status I or II, aged 23-65 yr, received i.v. granisetron 2.5 mg or ramose...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验,收录出版

    doi:10.1097/00000539-199908000-00043

    authors: Fujii Y,Saitoh Y,Tanaka H,Toyooka H

    更新日期:1999-08-01 00:00:00

  • Tyraminelike action of succinylcholine in the isolated, blood-perfused canine atrium.

    abstract::The mechanisms of succinylcholine-induced cardiac effects have not been fully elucidated. Accordingly, we studied the effects of succinylcholine on atrial rate and contractile force in the isolated canine atrium perfused with donor blood. The sinus node artery was perfused with heparinized blood from the common caroti...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199212000-00019

    authors: Saegusa K,Furukawa Y,Takeda M,Chiba S

    更新日期:1992-12-01 00:00:00

  • Closed-Loop Delivery Systems Versus Manually Controlled Administration of Total IV Anesthesia: A Meta-analysis of Randomized Clinical Trials.

    abstract::Bispectral Index Scale (BIS)-guided closed-loop delivery of anesthetics has been extensively studied. We performed a meta-analysis of all the randomized clinical trials comparing efficacy and performance between BIS-guided closed-loop delivery and manually controlled administration of total IV anesthesia. Scopus, PubM...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,meta分析,评审

    doi:10.1213/ANE.0000000000001394

    authors: Pasin L,Nardelli P,Pintaudi M,Greco M,Zambon M,Cabrini L,Zangrillo A

    更新日期:2017-02-01 00:00:00

  • Postoperative voiding interval and duration of analgesia following peripheral or caudal nerve blocks in children.

    abstract::We studied the time to postoperative micturition and the duration of analgesia in 82 children aged 6 mo to 10 yr undergoing herniorrhaphy or orchiopexy under general anesthesia with N2O and halothane. All received D5 lactate Ringer's solution equivalent to 6 h maintenance intraoperatively, and oral fluids postoperativ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/00000539-199301000-00029

    authors: Fisher QA,McComiskey CM,Hill JL,Spurrier EA,Voigt RE,Savarese AM,Beaver BL,Boltz MG

    更新日期:1993-01-01 00:00:00

  • Toxicity of chloroprocaine and sodium bisulfite on human neuroblastoma cells.

    abstract::The effects of commercial and crystalline solutions of chloroprocaine (CP) (1.6 X 10(-3)-0.4 X 10(-3)M) and sodium bisulfite (SB) (0.8 X 10(-3)-0.08 X 10(-3)M) were studied on the multiplication of human neuroblastoma cells. These cells were chosen because of putative neurotoxicity associated with CP; cell multiplicat...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Seravalli E,Lear E

    更新日期:1987-10-01 00:00:00

  • The effects of heparin, protamine, and heparinase 1 on platelets in vitro using whole blood flow cytometry.

    abstract:UNLABELLED:The effects of heparinization and the reversal of heparin activity on platelet function after cardiopulmonary bypass have not been well defined. Flow cytometry has become a convenient and powerful technique for characterizing platelets. We examined the expression of a secretion marker (P-selectin) and an agg...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200004000-00007

    authors: Kozek-Langenecker SA,Mohammad SF,Masaki T,Kamerath C,Cheung AK

    更新日期:2000-04-01 00:00:00