Bupivacaine and other amide local anesthetics inhibit the hydrolysis of chloroprocaine by human serum.

Abstract:

:The rate of hydrolysis of chloroprocaine by human serum was studied in the presence and absence of a number of aminde local anesthetics and their metabolites. Bupivacaine (2.4 microgram/ml) and etidocaine (2.3 microgram/ml) caused 38% and 21% inhibition respectively of the rate of chloroprocaine hydrolysis. Circulating concentrations of these drugs have been reported in this range by several investigators following epidural doses of 150 to 400 mg of either drug. Mepivacaine, lidocaine, and two lidocaine metabolites (glycine xylidide and monoethylglycine xylidide) were only inhibitory at levels much greater than those seen in blood following the usual local anesthetic doses of the parent compounds. Since serum is an important site of chloroprocaine metabolism in man, the probability of chloroprocaine intoxication may be increased when it is administered with local anesthetics such as bupivacaine and etidocaine.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Lalka D,Vicuna N,Burrow SR,Jones DJ,Ludden TM,Haegele KD,McNay JL

doi

10.1213/00000539-197809000-00004

subject

Has Abstract

pub_date

1978-09-01 00:00:00

pages

534-9

issue

5

eissn

0003-2999

issn

1526-7598

journal_volume

57

pub_type

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