R(+)-, Rac-, and S(-)-bupivacaine stereostructure-specifically interact with membrane lipids at cardiotoxically relevant concentrations.

abstract：BACKGROUND:The diagnosis of myocardial infarction (MI) after noncardiac surgery has traditionally relied on using relatively insensitive contemporary cardiac troponin (cTn) assays. We hypothesized that using a recently introduced novel high-sensitivity cTnT (hscTnT) assay would increase the detection rate of perioperat...

journal_title：Anesthesia and analgesia

authors： Brown JC,Samaha E,Rao S,Helwani MA,Duma A,Brown F,Gage BF,Miller JP,Jaffe AS,Apple FS,Scott MG,Nagele P

更新日期：2017-11-01 00:00:00

abstract：:During surgery, patients are exposed to multiple foreign substances including anesthetic drugs, antibiotics, blood products, heparin, polypeptides (aprotinin, latex, and protamine), and intravascular volume expanders, which have the potential to produce life-threatening allergic reactions termed "anaphylaxis." The hal...

journal_title：Anesthesia and analgesia

authors： Levy JH,Adkinson NF Jr

更新日期：2008-02-01 00:00:00

abstract：UNLABELLED:Opioid medication is the mainstay of therapy for severe acute and chronic pain. Unfortunately, the side effects of these medications can affect patient comfort and safety, thus limiting their proven therapeutic potential. Whereas the main analgesic effects of opioids are centrally mediated, many of the commo...

journal_title：Anesthesia and analgesia

authors： Bates JJ,Foss JF,Murphy DB

更新日期：2004-01-01 00:00:00

abstract：:Two hundred adults undergoing laparoscopic cholecystectomy were enrolled in a prospectively randomized, double-blind investigation comparing ondansetron, 4 mg (Group O) with the combination of droperidol, 0.625 mg, and metoclopramide, 10 mg (Group DM). Antiemetic drugs were administered intravenously (IV) after induct...

journal_title：Anesthesia and analgesia

authors： Steinbrook RA,Freiberger D,Gosnell JL,Brooks DC

更新日期：1996-11-01 00:00:00

abstract：:The nasal route is preferred for fiberoptic intubation. Placing a lubricated endotracheal tube through the nostril can guide the fiberoptic scope towards the larynx. It would be helpful for optimal visualization of the vocal cord when the scope is passed through the endotracheal tube if the length of nares-vocal cord ...

journal_title：Anesthesia and analgesia

authors： Han DW,Shim YH,Shin CS,Lee YW,Lee JS,Ahn SW

更新日期：2005-05-01 00:00:00

abstract：UNLABELLED:In this study, we examined the effectiveness of caudal blocks and correlated it with the laxity of the patients' anal sphincter before emergence from anesthesia in 178 children undergoing inguinal and/or penile surgery. Bupivacaine 0.25% in a volume of 0.6-1.25 mL/kg was used in all patients. The presence of...

journal_title：Anesthesia and analgesia

authors： Verghese ST,Mostello LA,Patel RI,Kaplan RF,Patel KM

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Human immunodeficiency virus (HIV)-related painful sensory neuropathies primarily consist of the HIV infection-related distal sensory polyneuropathy and antiretroviral toxic neuropathies. Pharmacotherapy provides only partial relief of pain in patients with HIV/acquired immune deficiency syndrome because lit...

journal_title：Anesthesia and analgesia

authors： Kanao M,Kanda H,Huang W,Liu S,Yi H,Candiotti KA,Lubarsky DA,Levitt RC,Hao S

更新日期：2015-06-01 00:00:00

abstract：UNLABELLED:We compared the effects of oral clonidine (4 microg/kg) and midazolam (0.5 mg/kg) on the preanesthetic sedation and postoperative recovery profile in children during tonsillectomy with or without adenoidectomy. In a double-blinded, double-dummy study design, 134 ASA physical status I-II children aged 4-12 yr...

journal_title：Anesthesia and analgesia

authors： Fazi L,Jantzen EC,Rose JB,Kurth CD,Watcha MF

更新日期：2001-01-01 00:00:00

abstract：:The correlation between the potency of inhaled anesthetics and their solubility in a hydrophobic phase provides an opportunity to define better the characteristics of the anesthetic site of action. The correlation implies that inhaled anesthetics act in a hydrophobic site and that the solvent used has properties repre...

journal_title：Anesthesia and analgesia

authors： Taheri S,Halsey MJ,Liu J,Eger EI 2nd,Koblin DD,Laster MJ

更新日期：1991-05-01 00:00:00

abstract：:The management of postoperative nausea and vomiting (PONV) remains a persistent problem. Despite the use of prophylactic antiemetics, breakthrough nausea and vomiting still frequently occur. There have been no published studies comparing dolasetron and ondansetron for the treatment of PONV. This was a prospective, ran...

journal_title：Anesthesia and analgesia

authors： Meyer TA,Roberson CR,Rajab MH,Davis J,McLeskey CH

更新日期：2005-02-01 00:00:00

abstract：:A 91-yr-old man (57 kg, 156 cm, ASA III) received an infraclavicular brachial plexus block for surgery of bursitis of the olecranon. Twenty minutes after infraclavicular injection of 30 mL of mepivacaine 1% (Scandicain) and 5 min after supplementation of 10 mL of prilocaine 1% (Xylonest) using an axillary approach, th...

journal_title：Anesthesia and analgesia

authors： Litz RJ,Roessel T,Heller AR,Stehr SN

更新日期：2008-05-01 00:00:00

abstract：:Clinical practice parameters have been published with greater frequency by professional societies and groups of experts. These publications run the gamut of practice standards, practice guidelines, consensus statements or practice advisories, position statements, and practice alerts. The definitions of these terms hav...

journal_title：Anesthesia and analgesia

authors： Benzon HT,Joshi GP,Gan TJ,Vetter TR

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:The perioperative assessment of right ventricular (RV) function remains a challenge. Tricuspid annular plane systolic excursion (TAPSE) using M-mode is a widely used measure of RV function. However, accurate alignment of the ultrasound beam with the direction of annular movement can be difficult with transes...

journal_title：Anesthesia and analgesia

authors： Shen T,Picard MH,Hua L,Burns SM,Andrawes MN

更新日期：2018-01-01 00:00:00

abstract：:A 62-yr-old man presented for a microdirect laryngoscopy and vocal cord fat grafting under jet ventilation. After a prolonged laryngoscopy, the patient developed hypercapnea and upper airway obstruction secondary to traumatic epiglottitis. The placement of a laryngeal mask airway provided ventilation and allowed for d...

journal_title：Anesthesia and analgesia

authors： Kidani DC,Shah NK

更新日期：2007-12-01 00:00:00

abstract：:Millions of human fetuses, infants, and children are exposed to anesthetic drugs every year in the United States and throughout the world. Anesthesia administered during critical stages of neurodevelopment has been considered safe and without adverse long-term consequences. However, recent reports provide mounting evi...

journal_title：Anesthesia and analgesia

authors： Creeley CE,Olney JW

更新日期：2010-02-01 00:00:00

abstract：:In this article, we describe the role of "clinical scenario" information to assure the safety of interoperable systems, as well as the system's ability to deliver the requisite clinical functionality to improve clinical care. Described are methods and rationale for capturing the clinical needs, workflow, hazards, and ...

journal_title：Anesthesia and analgesia

authors： Weininger S,Jaffe MB,Rausch T,Goldman JM

更新日期：2017-01-01 00:00:00

abstract：UNLABELLED:Previous investigations of the effects of potent opioid analgesics on the heart have concentrated on effects on contraction magnitude and time course, but little is known about their effects on cytosolic Ca(2+) regulation in cardiac tissue. In this study, we sought to assess the effects of alfentanil on cont...

journal_title：Anesthesia and analgesia

authors： Graham MD,Hopkins PM,Harrison SM

更新日期：2004-04-01 00:00:00

abstract：:Systemic arterial blood pressure (BP)-heart rate (HR) relationship (the pressor test) is often used as an index of baroreflex. We evaluated this index by simultaneously comparing BP-HR, right carotid sinus pressure (CSP)-nerve action potentials (NAP), and NAP-HR relationship in dogs anesthetized with pentobarbital. BP...

journal_title：Anesthesia and analgesia

authors： Behnia R,Koushanpour E,Sinclair DM

更新日期：1996-11-01 00:00:00

abstract：:The purpose of the present study was to quantify the inhibitory effect of inhaled halothane and isoflurane on acute hypercapnia-induced responses of capacitance-regulating veins and related cardiovascular variables in response to sequential 40-s periods of 5%, 10%, 15%, and 20% inspired CO2 (FICO2). Measurements were ...

journal_title：Anesthesia and analgesia

authors： Stekiel TA,Stekiel WJ,Tominaga M,Stadnicka A,Bosnjak ZJ,Kampine JP

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND:The vitalHEAT vH(2) (Dynatherm Medical, Inc., Fremont, California) system transfers heat through a single extremity using a combination of conductive heat (circulating warm water within soft fluid pads) with mild vacuum, which improves both vasodilation and contact between the heating element and the skin su...

journal_title：Anesthesia and analgesia

authors： Ruetzler K,Kovaci B,Güloglu E,Kabon B,Fleischmann E,Kurz A,Mascha E,Dietz D,Remzi F,Sessler DI

更新日期：2011-03-01 00:00:00

abstract：:Common practice during local anesthetic injection is to warn the patient using words such as: "You will feel a big bee sting; this is the worst part." Our hypothesis was that using gentler words for administration of the local anesthetic improves pain perception and patient comfort. One hundred forty healthy women at ...

journal_title：Anesthesia and analgesia

authors： Varelmann D,Pancaro C,Cappiello EC,Camann WR

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Perioperative respiratory adverse events (PRAEs) account for the major cause of morbidity and mortality in children undergoing general anesthesia. In our institutional clinical practice, we suspected that African American children experienced untoward respiratory events more frequently than other racial grou...

journal_title：Anesthesia and analgesia

authors： Tariq S,Syed M,Martin T,Zhang X,Schmitz M

更新日期：2018-07-01 00:00:00

abstract：:To determine the pharmacokinetics of local anesthetics after lumbar sympathetic blocks, total and free (unbound) plasma concentrations of bupivacaine in venous blood samples were measured in 12 patients using a high-performance liquid chromatography (HPLC) technique. Administration of 30 mL of plain bupivacaine 0.175%...

journal_title：Anesthesia and analgesia

authors： Wulf H,Gleim M,Schele HA

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:Every facility that performs cases on holidays has in some way decided on its operating room (OR) and anesthesia staffing for holidays. Previous studies have not examined how best to calculate appropriate holiday staffing. METHODS:We analyzed weekend and holiday data from a university hospital. RESULTS:The...

journal_title：Anesthesia and analgesia

authors： Dexter F,Epstein RH

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Perioperative opioid use is associated with poor survival in patients with esophageal squamous cell carcinoma. The most common histological type of esophageal cancer in western countries is adenocarcinoma. The objective of this study was to evaluate the association between intraoperative opioid consumption a...

journal_title：Anesthesia and analgesia

authors： Du KN,Feng L,Newhouse A,Mehta J,Lasala J,Mena GE,Hofstetter WL,Cata JP

更新日期：2018-07-01 00:00:00

abstract：:Target-controlled infusion of IV anesthetic drugs is approved worldwide with the exception of the United States. The purpose of this special article is to review regulatory pathways that could lead to target-controlled infusion (TCI) clearance or approval in the United States. ...

journal_title：Anesthesia and analgesia

authors： Dryden PE

更新日期：2016-01-01 00:00:00

abstract：:The decrease of cardiac index observed during portal triad clamping (PTC) with and without pneumoperitoneum has been studied only with right heart catheterization. To better understand this decrease of cardiac index, we investigated the balance between the adequacy of preload and the ability of the heart to pump again...

journal_title：Anesthesia and analgesia

authors： Decailliot F,Streich B,Heurtematte Y,Duvaldestin P,Cherqui D,Stéphan F

更新日期：2005-03-01 00:00:00

abstract：:Continuous peripheral nerve blockade is often used for the management of postoperative pain, even in ambulatory patients. The reported incidence of infectious complications after continuous nerve blockade is low. We report a case of Staphylococcus aureus sepsis after total shoulder arthroplasty in a patient who presen...

journal_title：Anesthesia and analgesia

authors： Clendenen SR,Robards CB,Wang RD,Greengrass RA

更新日期：2010-04-01 00:00:00

abstract：:A previous demonstration that the ratio of analgesic to anesthetic endpoints is not constant across inhalation anesthetic agents implies that more than one mechanism of action may be operant in general anesthesia. We hypothesized that the endogenous opiate systems might account for this observed disparity in ratios. T...

journal_title：Anesthesia and analgesia

authors： Levine LL,Winter PM,Nemoto EM,Uram M,Lin MR

更新日期：1986-04-01 00:00:00

abstract：BACKGROUND:Synergistic neuromuscular blocking effects have been observed clinically with certain pairs of nicotinic acetylcholine receptor (nAChR) competitive antagonists. The mechanism for synergy has not been elucidated. We tested the hypothesis that synergy arises from a differential selectivity of antagonists for t...

journal_title：Anesthesia and analgesia

authors： Liu M,Dilger JP

更新日期：2008-08-01 00:00:00