Bradykinin antagonists have no analgesic effect on incisional pain.


:Bradykinin, an endogenous nonapeptide and an important mediator of inflammation, is also implicated in the initiation and maintenance of pain. Both des-Arg(8), Leu(8)-bradykinin (dALBK) and HOE-140, the prototypic bradykinin B1 and B2 receptor antagonists, respectively, have been shown to reduce pain behaviors and inflammation in animal models of persistent nociception. We studied them for activity against incision-induced pain behaviors in a rat model for postoperative pain. A 1-cm plantar incision was made in the hind paw of halothane-anesthetized rats and closed with 5-0 nylon. Withdrawal responses to punctate and nonpunctate mechanical stimuli were tested with von Frey filaments and a plastic disk attached to a von Frey filament, respectively. Withdrawal latency to radiant heat was also tested. Rats were tested 1 day before the incision, 1 h after the incision, and 0.5, 1, 1.5, and 2.5 h after the injection of the drug. They were then retested at the same times before and after the injection of the drug on each of the first 2 postoperative days. The rats received the saline vehicle dALBK (0.1, 0.3, 1.0, or 3.0 mg/kg) or HOE-140 (0.1, 0.3, 1.0, or 3.0 mg/kg) IV. Another group of rats had the drug injected 1 h before incision and tested as above. Statistical significance (P < 0.05) was determined with Kruskal-Wallis test and a two-way analysis of variance. None of the doses of either dALBK or HOE-140 affected the responses to punctate or blunt mechanical stimulation or heat, either as a pretreatment or as a posttreatment. These data support the unique mechanisms for incision-induced pain relative to inflammation-related pain. Although inflammation may represent a component of incisional pain, the etiology of inflammation and its role seem different than in other models.


Anesth Analg


Anesthesia and analgesia


Leonard PA,Arunkumar R,Brennan TJ




Has Abstract


2004-10-01 00:00:00


1166-72, table of contents












  • Low concentrations of procaine and diethylaminoethanol reduce the excitability but not the action potential amplitude of hippocampal pyramidal cells.

    abstract::To determine whether concentrations of diethylaminoethanol (DEAE) and procaine below those that reduce the amplitude of action potentials might alter the excitability of brain cells, a single microelectrode intracellular recording technique was used to measure firing threshold and action potential amplitude of pyramid...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Butterworth JF 4th,Cole LR

    更新日期:1990-10-01 00:00:00

  • Sigma receptor agonists provide neuroprotection in vitro by preserving bcl-2.

    abstract:BACKGROUND:Sigma (sigma)-receptor agonists attenuate brain injury after experimental focal cerebral ischemia in several species. We tested the hypothesis that the potent, prototypical sigma(1)-receptor agonist, 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP), protects neurons by a mechanism involving the antiapoptotic pro...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Yang S,Bhardwaj A,Cheng J,Alkayed NJ,Hurn PD,Kirsch JR

    更新日期:2007-05-01 00:00:00

  • Operating room nursing directors' influence on anesthesia group operating room productivity.

    abstract:BACKGROUND:Implementation of initiatives to increase anesthesia group productivity depends not just on anesthesia groups, but on operating room (OR) nursing administration. OR nursing directors may encourage organizational change based on the needs of their hospitals and nurses. These changes may differ from those that...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Masursky D,Dexter F,Nussmeier NA

    更新日期:2008-12-01 00:00:00

  • Comparison of regional ophthalmic anesthesia produced by pH-adjusted 0.75% and 0.5% bupivacaine and 1% and 1.5% etidocaine, all with hyaluronidase.

    abstract::Two concentrations of etidocaine (1 and 1.5%) and of pH-adjusted bupivacaine (0.5 and 0.75%, pH 6.8), all fortified with hyaluronidase, were compared as local anesthetics in regional ophthalmic surgery for cataract extraction. The series comprised 160 patients assigned randomly to four groups (n = 40). Each patient re...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Sarvela PJ

    更新日期:1993-07-01 00:00:00

  • Does preoperative anxiety influence gastric fluid volume and acidity?

    abstract::Preoperative anxiety may increase gastric fluid acidity and volume. To pursue this possibility we evaluated the relationship between peroral premedication, preoperative anxiety, and gastric content in 246 consecutive patients presenting for elective gynecologic surgery. All patients fasted overnight and received eithe...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Haavik PE,Søreide E,Hofstad B,Steen PA

    更新日期:1992-07-01 00:00:00

  • Arteriovenous concentration differences of propofol during and after a stepdown infusion.

    abstract::To compare the arterial and venous concentration differences of propofol, six healthy adult patients received a propofol infusion by the Bristol three-stage manual stepdown technique. Both the mean arterial and venous concentrations of propofol remained relatively stable during the 40-min infusion. Simultaneous blood ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Wang YP,Cheng YJ,Fan SZ,Liu CC

    更新日期:1994-12-01 00:00:00

  • Atrial fibrillation after coronary artery bypass graft surgery is unrelated to cardiac abnormalities detected by transesophageal echocardiography.

    abstract:UNLABELLED:Atrial fibrillation is a common complication of coronary artery bypass graft (CABG) surgery that is associated with adverse patient outcomes. We evaluated whether preexisting abnormalities of cardiac structure or function detected with transesophageal echocardiography (TEE) are prevalent in patients later de...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Skubas NJ,Barzilai B,Hogue CW Jr

    更新日期:2001-07-01 00:00:00

  • Enhancement of α5-containing γ-aminobutyric acid type A receptors by the nonimmobilizer 1,2-dichlorohexafluorocyclobutane (F6) is abolished by the β3(N265M) mutation.

    abstract:BACKGROUND:Modulation of γ-aminobutyric acid type A receptors (GABAARs) by general anesthetics may contribute to their ability to produce amnesia. Receptors containing α5 subunits, which mediate tonic and slow synaptic inhibition, are co-localized with β3 and γ2 subunits in dendritic layers of the hippocampus and are s...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Burkat PM,Lor C,Perouansky M,Pearce RA

    更新日期:2014-12-01 00:00:00

  • Central venous access: the effects of approach, position, and head rotation on internal jugular vein cross-sectional area.

    abstract:UNLABELLED:We investigated the effects of approach (lateral versus anterior), position (supine versus Trendelenburg), and head rotation (0 degrees, 20 degrees, and maximum) during central venous catheterization on the area of the right internal jugular vein. Twenty-four patients were placed in supine position, followed...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Suarez T,Baerwald JP,Kraus C

    更新日期:2002-12-01 00:00:00

  • Decreased incidence and mortality of anaphylaxis to chymopapain.

    abstract::A recognized side effect of chemonucleolysis is life-threatening anaphylaxis to chymopapain. In the clinical trials of chymopapain, 13 cases of anaphylaxis were reported in 1585 administrations (0.82%). Two patients died. Data from a postmarketing survey (48,239 questionnaires) were reviewed to identify factors influe...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Moss J,Roizen MF,Nordby EJ,Thisted R,Apfelbaum JL,Schreider BD,McDermott DJ

    更新日期:1985-12-01 00:00:00

  • The analgesic effect of epidural clonidine after spinal surgery: a randomized placebo-controlled trial.

    abstract:BACKGROUND:Clonidine is an alpha(2) adrenoreceptor and imidazoline receptor agonist, which has analgesic, sedative, and minimum alveolar anesthetic concentration-sparing effects. It has been used orally, IV, and epidurally. In spinal surgery, there is a reluctance to use local anesthetic-based epidural analgesia postop...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Farmery AD,Wilson-MacDonald J

    更新日期:2009-02-01 00:00:00

  • The influence of chronic administration of hypnotics and analgesics on rate of recovery from inhalation anesthesia in rats.

    abstract::A series of groups of Sprague-Dawley rats were given either secobarbital, phenobarbital, morphine, pentazocine, diazepam, methotrimeprazine, or saline (control) intraperitoneally on 4 consecutive days and then, on day 5, anesthetized with chloroform, trichlorethylene, fluroxene, halothane, methoxyflurane, enflurane, i...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Dobkin AB,Borgstedt HH,Rohner RF,KURLAN RM,Fein AB

    更新日期:1975-01-01 00:00:00

  • The effect of concomitant radiofrequency ablation and surgical technique (repair versus replacement) on release of cardiac biomarkers during mitral valve surgery.

    abstract::All patients undergoing heart surgery experience a certain amount of nonspecific myocardial injury documented by the release of cardiac biomarkers and associated with poor outcome. We investigated the role of unipolar radiofrequency ablation of atrial fibrillation on the release of cardiac biomarkers in 71 patients un...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Zangrillo A,Crescenzi G,Landoni G,Benussi S,Crivellari M,Pappalardo F,Dorigo E,Pappone C,Alfieri O

    更新日期:2005-07-01 00:00:00

  • Effects of end-tidal gas monitoring and flow rates on hemodynamic stability and recovery profiles.

    abstract::This study was designed to evaluate the impact of routine end-tidal anesthetic gas monitoring on the intraoperative hemodynamic stability and early recovery profile in 253 consenting ASA physical status I-III patients undergoing elective otolaryngologic procedures with isoflurane or enflurane anesthesia. Patients were...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wang J,Liu J,White PF,Klein KW,Browne RH

    更新日期:1994-09-01 00:00:00

  • Carbon monoxide production from degradation of desflurane, enflurane, isoflurane, halothane, and sevoflurane by soda lime and Baralyme.

    abstract::Anecdotal reports suggest that soda lime and Baralyme brand absorbent can degrade inhaled anesthetics to carbon monoxide (CO). We examined the factors that govern CO production and found that these include: 1) The anesthetic used: for a given minimum alveolar anesthetic concentration (MAC)-multiple, the magnitude of C...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Fang ZX,Eger EI 2nd,Laster MJ,Chortkoff BS,Kandel L,Ionescu P

    更新日期:1995-06-01 00:00:00

  • Perioperative beta-blockers for preventing surgery-related mortality and morbidity: a systematic review and meta-analysis.

    abstract:BACKGROUND:Perioperative beta-blockers are suggested to reduce cardiovascular mortality, myocardial-ischemia/infarction, and supraventricular arrhythmias after surgery. We reviewed the evidence regarding the effectiveness of perioperative beta-blockers for improving patient outcomes after cardiac and noncardiac surgery...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Wiesbauer F,Schlager O,Domanovits H,Wildner B,Maurer G,Muellner M,Blessberger H,Schillinger M

    更新日期:2007-01-01 00:00:00

  • Distal nerve blocks at the wrist for outpatient carpal tunnel surgery offer intraoperative cardiovascular stability and reduce discharge time.

    abstract:UNLABELLED:Carpal tunnel release is often performed as an outpatient procedure. We designed this retrospective study to assess the effect of different anesthesia techniques on intraoperative cardiovascular stability and discharge time. According to the anesthesia technique received, 62 consecutive patients were categor...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Gebhard RE,Al-Samsam T,Greger J,Khan A,Chelly JE

    更新日期:2002-08-01 00:00:00

  • Butorphanol and morphine: a double-blind comparison of their parenteral analgesic activity.

    abstract::The analgesic effects of butorphanol tartrate and morphine sulfate were compared in 127 patients judged to have moderate to severe pain following major operations. The study was double-blind, and the drugs were given IM at several dosage levels. Scores for pain intensity and relief, as well as pain-intensity differenc...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Tavakoli M,Corssen G,Caruso FS

    更新日期:1976-05-01 00:00:00

  • American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Patient-Reported Outcomes in an Enhanced Recovery Pathway.

    abstract::Patient-reported outcomes (PROs) are measures of health status that come directly from the patient. PROs are an underutilized tool in the perioperative setting. Enhanced recovery pathways (ERPs) have primarily focused on traditional measures of health care quality such as complications and hospital length of stay. The...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Abola RE,Bennett-Guerrero E,Kent ML,Feldman LS,Fiore JF Jr,Shaw AD,Thacker JKM,Gan TJ,Miller TE,Hedrick TL,McEvoy MD,Mythen MG,Bergamaschi R,Gupta R,Holubar SD,Senagore AJ,Wischmeyer PE,Carli F,Evans DC,Guilbert S,

    更新日期:2018-06-01 00:00:00

  • A new highly reliable instrument for the assessment of pre- and postoperative gynecological pain.

    abstract:UNLABELLED:In this study, we evaluated the reliability of a newly developed method for pain assessment, which is based on perceptual matching by Pain Matcher, Cefar Medical AB, Lund, Sweden, during minor gynecological surgery. In addition, the responsiveness to two different anesthetic methods-electro-acupuncture or a ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Stener-Victorin E,Kowalski J,Lundeberg T

    更新日期:2002-07-01 00:00:00

  • The detection of interatrial flow patency in awake and anesthetized patients: a comparative study using transnasal transesophageal echocardiography.

    abstract:UNLABELLED:The Valsalva maneuver in the awake patient and the ventilation maneuver in the tracheally intubated anesthetized patient are two provocation methods to detect a patent foramen ovale (PFO) by means of contrast transesophageal echocardiography. In 60 patients undergoing posterior fossa surgery, a contrast agen...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Greim CA,Trautner H,Krämer K,Zimmermann P,Apfel CC,Roewer N

    更新日期:2001-05-01 00:00:00

  • The effect of dexmedetomidine on perioperative hemodynamics in patients undergoing craniotomy.

    abstract:BACKGROUND:The perioperative course of patients undergoing intracranial surgery is frequently complicated by hypertensive episodes. Dexmedetomidine (DEX), an alpha-2 adrenoreceptor agonist, is gaining popularity in neuroanesthesia, because its sympatholytic and antinociceptive properties may improve hemodynamic stabili...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Bekker A,Sturaitis M,Bloom M,Moric M,Golfinos J,Parker E,Babu R,Pitti A

    更新日期:2008-10-01 00:00:00

  • Vasodilation from sufentanil in humans.

    abstract::Sufentanil is a potent opioid that occasionally has been associated with hypotension. The mechanism behind this hypotension is unclear. We hypothesized that sufentanil had a direct effect on vascular smooth muscle to cause vasodilation. Sufentanil was infused into the brachial artery of 10 young, healthy volunteers at...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Ebert TJ,Ficke DJ,Arain SR,Holtz MN,Shankar H

    更新日期:2005-12-01 00:00:00

  • Levobupivacaine-sufentanil with or without epinephrine during epidural labor analgesia.

    abstract::In a prospective, randomized, double-blind study, we investigated whether epinephrine increased the efficacy of levobupivacaine and sufentanil during epidural labor analgesia. Seventy term parturients received an epidural injection of levobupivacaine 0.125% and sufentanil 0.75 microg/mL with or without 1:800,000 epine...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Soetens FM,Soetens MA,Vercauteren MP

    更新日期:2006-07-01 00:00:00

  • The influence of endotracheal tube tip design on nasal trauma during nasotracheal intubation: magill-tip versus murphy-tip.

    abstract:UNLABELLED:We performed this study to assess the influence of endotracheal tube (ETT) tip design (Murphy-tip versus Magill-tip) on nasal trauma during nasotracheal intubation with a conventional polyvinyl chloride ETT. Patients were randomly allocated to one of four groups (n = 25 each): Magill-tipped ETT and Murphy-ti...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Lee JH,Kim CH,Bahk JH,Park KS

    更新日期:2005-10-01 00:00:00

  • Patient preferences for early discharge after laparoscopic cholecystectomy.

    abstract:UNLABELLED:Patients may have concerns about their ability to manage postoperative symptoms at home after ambulatory surgery. We assessed patients' attitudes toward postoperative care at home or in the hospital after laparoscopic cholecystectomy. Thirty-eight patients undergoing elective laparoscopic cholecystectomy wer...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Lehmann HP,Fleisher LA,Lam J,Frink BA,Bass EB

    更新日期:1999-06-01 00:00:00

  • Hemostatic analysis of a patient undergoing off-pump coronary artery bypass surgery with argatroban anticoagulation.

    abstract:IMPLICATIONS:This case describes the impact of argatroban and off-pump coronary revascularization on hemostasis as assessed by conventional hemostatic measures and Thrombelastography in a patient with heparin-induced thrombocytopenia. ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Kieta DR,McCammon AT,Holman WL,Nielsen VG

    更新日期:2003-04-01 00:00:00

  • Do intraoperative analgesics influence breast cancer recurrence after mastectomy? A retrospective analysis.

    abstract:BACKGROUND:Whether intraoperative analgesics have an impact on postoperative cancer recurrence is unknown. Some investigations suggest that the opioids could favor relapse and that regional analgesia and nonsteroidal antiinflammatory drugs could improve cancer prognosis. We retrospectively reviewed our series of breast...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Forget P,Vandenhende J,Berliere M,Machiels JP,Nussbaum B,Legrand C,De Kock M

    更新日期:2010-06-01 00:00:00

  • Small-dose hypobaric lidocaine-fentanyl spinal anesthesia for short duration outpatient laparoscopy. I. A randomized comparison with conventional dose hyperbaric lidocaine.

    abstract::A randomized, single-blind trial of two spinal anesthetic solutions for outpatient laparoscopy was conducted to compare intraoperative conditions and postoperative recovery. Thirty women (ASA physical status I and II) were assigned to one of two groups. Group I patients received a small-dose hypobaric solution of 1% l...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Vaghadia H,McLeod DH,Mitchell GW,Merrick PM,Chilvers CR

    更新日期:1997-01-01 00:00:00

  • Analgesic Effects of Oxycodone Relative to Those of Sufentanil, in the Presence of Midazolam, During Endoscopic Injection Sclerotherapy for Patients With Cirrhosis and Esophageal Varices.

    abstract:BACKGROUND:We evaluated the efficacy and gastroenterologist/patient satisfaction of midazolam combined with oxycodone, relative to that of midazolam combined with sufentanil, for anesthesia during endoscopic injection sclerotherapy (EIS) in patients with cirrhosis and esophageal varices. METHODS:Patients with cirrhosi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Quan Z,Luo C,Chi P,Wang L,He H

    更新日期:2018-08-01 00:00:00