Long-term metoprolol therapy and neuroleptanesthesia in coronary artery surgery: withdrawal versus maintenance of beta 1-adrenoreceptor blockade.

Abstract:

:Patients receiving metoprolol before cardiac revascularization surgery were randomly divided into those in whom metoprolol was discontinued before the operation (N = 10) and those in whom metoprolol was continued up to the time of operation (N = 10). Cardiovascular responses to neuroleptanesthesia and sternotomy were studied. Coronary sinus catheterization for blood-flow measurement and sampling was performed in 5 patients in each group. Two of 10 patients had a myocardial infarction after discontinuation of metoprolol and surgery was therefore postponed. Tachycardias were common during intubation after discontinuation of metoprolol, but otherwise hemodynamic responses and myocardial oxygen consumption were similar in both groups. Recurrent ST-T depression occurred in 7 of 8 patients and myocardial lactate release in 2 of 5 patients in whom metoprolol was withdrawn, whereas patients who continued to receive metoprolol showed few episodes of ST-T depression (2 of 10) and no lactate release. The latter had lower plasma norepinephrine (NE) levels, but myocardial release of NE was similar in both groups. Preoperative metoprolol withdrawal seemed to precipitate myocardial ischemia, whereas maintenance of therapy was well tolerated.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Pontén J,Häggendal J,Milocco I,Waldenström A

subject

Has Abstract

pub_date

1983-04-01 00:00:00

pages

380-90

issue

4

eissn

0003-2999

issn

1526-7598

journal_volume

62

pub_type

临床试验,杂志文章,随机对照试验
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    abstract:UNLABELLED:Mitral regurgitation (MR) is a major determinant of outcome in cardiac surgery. The location and mechanism of mitral lesions determine the approach to various repairs and their feasibility. Because of incomplete evaluations or change in patient condition, detailed intraoperative transesophageal echocardiogra...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000539-199906000-00004

    authors: Lambert AS,Miller JP,Merrick SH,Schiller NB,Foster E,Muhiudeen-Russell I,Cahalan MK

    更新日期:1999-06-01 00:00:00

  • Possible air embolism during eye surgery.

    abstract::We report a case of possible air embolism during a three-port pars plana vitrectomy and air-fluid exchange of the vitreous cavity of the eye. After the start of intraocular air flushing, sudden tachycardia, a decrease in oxygen saturation and end-tidal carbon dioxide tension, and a distinct "mill-wheel" murmur were ob...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ANE.0000154304.63828.C0

    authors: Ledowski T,Kiese F,Jeglin S,Scholz J

    更新日期:2005-06-01 00:00:00

  • Resistin Is a Novel Marker for Postoperative Pain Intensity.

    abstract:BACKGROUND:Pro- and anti-inflammatory cytokines (adipokines) associated with adipose tissue can modulate inflammatory processes and lead to systemic inflammatory conditions such as metabolic syndrome. In the present pilot study, we investigated 3 major adipokines (leptin, adiponectin, and resistin) and 2 nonspecific pr...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000003363

    authors: Hozumi J,Sumitani M,Nishizawa D,Nagashima M,Ikeda K,Abe H,Kato R,Kusakabe Y,Yamada Y,Japanese Translational Research-Cancer Pain Research Group.

    更新日期:2019-03-01 00:00:00

  • Dexmedetomidine, an alpha 2-adrenergic agonist, decreases cerebral blood flow in the isoflurane-anesthetized dog.

    abstract::The purpose of this study was to examine the effects of dexmedetomidine, an alpha 2-adrenergic agonist, on cerebral blood flow and metabolic rate in dogs anesthetized with 0.64% isoflurane. After intubation and institution of mechanical ventilation, arterial, venous, pulmonary artery, and sagittal sinus catheters were...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199006000-00008

    authors: Zornow MH,Fleischer JE,Scheller MS,Nakakimura K,Drummond JC

    更新日期:1990-06-01 00:00:00

  • Barbiturate-benzodiazepine interactions at the gamma-aminobutyric acidA receptor in rat cerebral cortical synaptoneurosomes.

    abstract::Combinations of benzodiazepines (midazolam and diazepam) with barbiturates (pentobarbital and phenobarbital) exhibit synergistic (supra-additive) hypnotic interactions in rats. Because both benzodiazepines and barbiturates interact with the gamma-aminobutyric acidA (GABAA) receptor complex, we have tested the hypothes...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199309000-00030

    authors: DeLorey TM,Kissin I,Brown P,Brown GB

    更新日期:1993-09-01 00:00:00

  • Supraventricular arrhythmias in intensive care unit patients: short and long-term consequences.

    abstract:BACKGROUND:Supraventricular arrhythmias (SVA), including atrial fibrillation and flutter, are common in surgical and nonsurgical intensive care unit (ICU) patients. There is increased mortality among surgical ICU patients who develop new-onset atrial arrhythmias after noncardiac, non-thoracic surgery. We sought to dete...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000255759.41131.05

    authors: Goodman S,Shirov T,Weissman C

    更新日期:2007-04-01 00:00:00

  • A randomized crossover study to determine the effect of a 30° head-up versus a supine position on the functional residual capacity of term parturients.

    abstract:BACKGROUND:Airway management continues to pose challenges to the obstetric anesthesiologist. Functional residual capacity (FRC), which acts as an oxygen reservoir, is reduced from the second trimester onwards and is exacerbated in the supine position. Mechanisms to increase FRC may delay the onset of hypoxemia during p...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0b013e31822bf1d2

    authors: Hignett R,Fernando R,McGlennan A,McDonald S,Stewart A,Columb M,Adamou T,Dilworth P

    更新日期:2011-11-01 00:00:00

  • Novel small molecule α9α10 nicotinic receptor antagonist prevents and reverses chemotherapy-evoked neuropathic pain in rats.

    abstract:BACKGROUND:Peripheral neuropathy is a common dose-limiting side effect of chemotherapy. There are no clinically proven analgesics for the treatment of this condition. Drugs from different classes have been tested with mixed results. Identification of novel molecular targets for analgesic(s) is important. Antagonism of ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e31825a3c72

    authors: Wala EP,Crooks PA,McIntosh JM,Holtman JR Jr

    更新日期:2012-09-01 00:00:00

  • Anesthetic preconditioning: the role of free radicals in sevoflurane-induced attenuation of mitochondrial electron transport in Guinea pig isolated hearts.

    abstract::Cardioprotection by anesthetic preconditioning (APC) can be abolished by nitric oxide (NO*) synthase inhibitors or by reactive oxygen species (ROS) scavengers. We previously reported attenuated mitochondrial electron transport (ET) and increased ROS generation during preconditioning sevoflurane exposure as part of the...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ANE.0000139346.76784.72

    authors: Riess ML,Kevin LG,McCormick J,Jiang MT,Rhodes SS,Stowe DF

    更新日期:2005-01-01 00:00:00

  • Residual neuromuscular block: lessons unlearned. Part I: definitions, incidence, and adverse physiologic effects of residual neuromuscular block.

    abstract::In this review, we summarize the clinical implications of residual neuromuscular block. Data suggest that residual neuromuscular block is a common complication in the postanesthesia care unit, with approximately 40% of patients exhibiting a train-of-four ratio <0.9. Volunteer studies have demonstrated that small degre...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0b013e3181da832d

    authors: Murphy GS,Brull SJ

    更新日期:2010-07-01 00:00:00

  • The effects of systemic lidocaine on airway tone and pulmonary function in asthmatic subjects.

    abstract:BACKGROUND:To prevent reflex-induced bronchoconstriction in patients with asthma, local anesthetics are commonly administered by aerosol or IV as adjunct medication. Lidocaine attenuates responsiveness to a neurally active stimulus that increases tone, but there is scant information about the effect of lidocaine on bas...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000260638.57139.87

    authors: Chang HY,Togias A,Brown RH

    更新日期:2007-05-01 00:00:00

  • Effects of sufentanil on cerebral blood flow, cerebral blood flow velocity, and metabolism in dogs.

    abstract::The intracranial and systemic hemodynamic effects of sufentanil (20 micrograms/kg) were studied in 10 mongrel dogs. Baseline anesthesia was maintained with 0.7% end-tidal isoflurane and 50% nitrous oxide in oxygen. Catheters were inserted for blood pressure measurement, arterial and sagittal sinus blood sampling, radi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199102000-00006

    authors: Werner C,Hoffman WE,Baughman VL,Albrecht RF,Schulte J

    更新日期:1991-02-01 00:00:00

  • Incorporating simulation-based objective structured clinical examination into the Israeli National Board Examination in Anesthesiology.

    abstract::We describe the unique process whereby simulation-based, objective structured clinical evaluation (OSCE) has been incorporated into the Israeli board examination in anesthesiology. Development of the examination included three steps: a) definition of clinical conditions that residents are required to handle competentl...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000194934.34552.ab

    authors: Berkenstadt H,Ziv A,Gafni N,Sidi A

    更新日期:2006-03-01 00:00:00

  • A multicenter study of the epidemiology of hepatitis B in anesthesia residents.

    abstract::Practicing anesthesiologists are at high risk of hepatitis B infection, but the risk for anesthesia residents has not been assessed. Anesthesia residents at seven universities were surveyed to study the epidemiology of hepatitis B in these trainees. Hepatitis B virus markers in serum were measured and data from questi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Berry AJ,Isaacson IJ,Kane MA,Schatz GC,Clark BT,Beaupre P,Derrer S,Kapur P,Thompson J,Martin D

    更新日期:1985-07-01 00:00:00

  • Determination of Perioperative Blood Loss: Accuracy or Approximation?

    abstract:BACKGROUND:Various different interventions can be used to reduce surgical blood loss; however, there is no "gold standard" for accurately measuring the volume of perioperative blood loss, and this makes it difficult to assess the efficacy of these interventions. METHODS:We used data from a previous multicenter double-...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1213/ANE.0000000000001992

    authors: Lopez-Picado A,Albinarrate A,Barrachina B

    更新日期:2017-07-01 00:00:00

  • Intravenous administration of flurbiprofen does not affect cerebral blood flow velocity and cerebral oxygenation under isoflurane and propofol anesthesia.

    abstract:UNLABELLED:Flurbiprofen, a nonsteroidal antiinflammatory drug (NSAID), has been used to treat rheumatic and osteoarthritic pain and to reduce postoperative pain. Although other NSAIDs, such as indomethacin, reduce cerebral blood flow (CBF), the effect of flurbiprofen on CBF is unknown. In the present study, we investig...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/01.ane.0000099755.97885.3c

    authors: Yoshitani K,Kawaguchi M,Tatsumi K,Sasaoka N,Kurumatani N,Furuya H

    更新日期:2004-02-01 00:00:00

  • Suspected sodium nitroprusside-induced cyanide intoxication.

    abstract::Sodium nitroprusside-induced cyanide intoxication has been demonstrated in the laboratory animal and has been experienced clinically during induced hypotensive anesthesia. This is a care report of a successful resuscitation of a severe cardiovascular collapse secondary to suspected sodium nitroprusside-induced cyanide...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-197707000-00015

    authors: Perschau RA,Modell JH,Bright RW,Shirley PD

    更新日期:1977-07-01 00:00:00

  • Pancuronium infusion for neuromuscular block in children in the pediatric intensive care unit.

    abstract::When neuromuscular blockade becomes necessary in the intensive care unit, there are several options available in regard to both the drug and the mode of delivery (continuous versus intermittent administration). Despite extensive experience with intermediate acting drugs such as atracurium or vecuronium, these muscle r...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000539-199507000-00003

    authors: Tobias JD,Lynch A,McDuffee A,Garrett JS

    更新日期:1995-07-01 00:00:00

  • Associations Between Impaired Cerebral Blood Flow Autoregulation, Cerebral Oxygenation, and Biomarkers of Brain Injury and Postoperative Cognitive Dysfunction in Elderly Patients After Major Noncardiac Surgery.

    abstract:BACKGROUND:Increasing evidence links postoperative cognitive dysfunction (POCD) to surgery and anesthesia. POCD is recognized as an important neuropsychological adverse outcome in surgical patients, particularly the elderly. This prospective cohort study aimed to investigate whether POCD is associated with impaired int...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000001803

    authors: Goettel N,Burkhart CS,Rossi A,Cabella BC,Berres M,Monsch AU,Czosnyka M,Steiner LA

    更新日期:2017-03-01 00:00:00

  • Enantioselectivity of thiopental distribution into the central neural tissue of rats: an interaction with halothane.

    abstract:UNLABELLED:Thiopental is a racemate. In this study, we examined whether thiopental total body clearance and its distribution into central nervous system (CNS) tissue of rats was enantioselective. Rats, either anesthetized with halothane or conscious and restrained, were infused to stepwise steady-state targets of 5, 10...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199907000-00042

    authors: Mather LE,Edwards SR,Duke CC,Cousins MJ

    更新日期:1999-07-01 00:00:00

  • Effects of sodium pentobarbital, ketamine, halothane, and chloralose on brainstem auditory evoked responses.

    abstract::A parametric study was performed in cats comparing the effects on the brainstem auditory evoked response of four anesthetic agents used either in the operating room or the laboratory: sodium pentobarbital, ketamine, halothane, and chloralose. Each anesthetic agent was administered to each of four cats in varying seque...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Cohen MS,Britt RH

    更新日期:1982-04-01 00:00:00

  • Pain as a factor complicating recovery and discharge after ambulatory surgery.

    abstract:UNLABELLED:Pain complicates the recovery process after ambulatory surgery. We surveyed 175 ambulatory surgery patients to determine pain severity, analgesic use, relationship of pain to duration of recovery, and the relative importance of various factors to predicting these outcomes. Multivariate regression analysis wa...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000539-200209000-00025

    authors: Pavlin DJ,Chen C,Penaloza DA,Polissar NL,Buckley FP

    更新日期:2002-09-01 00:00:00

  • The pulmonary absorption-excretion volume effect.

    abstract::An in-vitro experiment demonstrated the concentration effect of N2O (3% versus 75%) during elimination and during uptake. Other pulmonary absorption-excretion phenomena also occur simultaneously, as paired events during uptake and then during elimination:diffusion hyperoxia and diffusion anoxia; alveolar concentration...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-197601000-00013

    authors: Rackow H,Salanitre E

    更新日期:1976-01-01 00:00:00

  • A comparison of remifentanil and sufentanil as adjuvants during sevoflurane anesthesia with epidural analgesia for upper abdominal surgery: effects on postoperative recovery and respiratory function.

    abstract:UNLABELLED:We compared the recovery profile and postoperative SpO(2) after the administration of general anesthesia with either sevoflurane-remifentanil or sevoflurane-sufentanil in 30 healthy patients undergoing upper abdominal surgery. They were randomly allocated to receive general anesthesia with sevoflurane and sm...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-200011000-00040

    authors: Casati A,Albertin A,Fanelli G,Deni F,Berti M,Danelli G,Grifoni F,Torri G

    更新日期:2000-11-01 00:00:00

  • Safety and Efficacy of Volatile Anesthetic Agents Compared With Standard Intravenous Midazolam/Propofol Sedation in Ventilated Critical Care Patients: A Meta-analysis and Systematic Review of Prospective Trials.

    abstract:BACKGROUND:Inhalation agents are being used in place of intravenous agents to provide sedation in some intensive care units. We performed a systematic review and meta-analysis of prospective randomized controlled trials, which compared the use of volatile agents versus intravenous midazolam or propofol in critical care...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,meta分析,评审

    doi:10.1213/ANE.0000000000001634

    authors: Jerath A,Panckhurst J,Parotto M,Lightfoot N,Wasowicz M,Ferguson ND,Steel A,Beattie WS

    更新日期:2017-04-01 00:00:00

  • Intravenous droperidol causes a reduction in the bispectral index in propofol-sedated patients during spinal anesthesia.

    abstract:UNLABELLED:We investigated the effect of IV droperidol on the bispectral index (BIS) in conscious and propofol-sedated patients during spinal anesthesia. Thirty minutes after the induction of spinal anesthesia, 20 patients were given 2 mg of droperidol IV without administration of other sedatives (conscious group). Ano...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

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    authors: Nakayama M,Kanaya N,Ichinose H,Yamamoto S,Namiki A

    更新日期:2003-03-01 00:00:00

  • Comparison of nalbuphine and fentanyl anesthesia for coronary artery bypass surgery. Hemodynamics, hormonal response, and postoperative respiratory depression.

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    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1213/00000539-199111000-00002

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    更新日期:1991-11-01 00:00:00

  • Anesthetic management of patients with Takayasu's arteritis: a case series and review.

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    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200107000-00014

    authors: Kathirvel S,Chavan S,Arya VK,Rehman I,Babu V,Malhotra N,Bhukal I,Chari P

    更新日期:2001-07-01 00:00:00

  • Perioperative care of a patient with acute fatty liver of pregnancy.

    abstract::Acute fatty liver of pregnancy (AFLP) is a late gestational complication with biochemical similarities to the inherited disorders of mitochondrial fatty acid oxidation and clinical similarities to fulminant hepatic failure. The following case illustrates our perioperative management of this rarely encountered disorder...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200105000-00036

    authors: Holzman RS,Riley LE,Aron E,Fetherston J

    更新日期:2001-05-01 00:00:00

  • Prevention of postoperative nausea and vomiting with granisetron and dolasetron in relation to CYP2D6 genotype.

    abstract::We investigated the efficacy of granisetron and dolasetron in preventing postoperative nausea and vomiting. Because the metabolism of the various antiemetic 5-hydroxytryptamine type 3 (5-HT3) antagonists involves different isoforms of the hepatic cytochrome P450 system, we examined the relationship between the clinica...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/01.ane.0000200364.55798.3f

    authors: Janicki PK,Schuler HG,Jarzembowski TM,Rossi M 2nd

    更新日期:2006-04-01 00:00:00