Abstract：
:The intracranial and systemic hemodynamic effects of sufentanil (20 micrograms/kg) were studied in 10 mongrel dogs. Baseline anesthesia was maintained with 0.7% end-tidal isoflurane and 50% nitrous oxide in oxygen. Catheters were inserted for blood pressure measurement, arterial and sagittal sinus blood sampling, radioactive microsphere injections, and intracranial pressure monitoring. Blood flow velocity was measured continuously in the middle cerebral artery using a transtemporal approach through a cranial window with a pulsed 8 MHz transcranial Doppler system (TCD). Cardiac output was measured using an electromagnetic flow probe on the pulmonary artery. After baseline measurements, sufentanil was injected and data were recorded at 5, 15, and 30 min. In group 1 (n = 5) blood pressure was not controlled, whereas in group 2 (n = 5) blood pressure was maintained at baseline levels with a phenylephrine infusion. Sufentanil decreased blood pressure from 120 +/- 10 mm Hg (mean +/- SEM) to 82 +/- 11 mm Hg in group 1. Cardiac output decreased 40%-50% in both groups. Intracranial pressure did not change. Cerebral blood flow (CBF) and TCD blood flow velocity decreased significantly (35%-40%) with no difference between groups. Relative decreases in CBF and TCD blood flow velocity were closely correlated (r = 0.82). The cerebral hemodynamic changes were associated with a 35%-40% decrease in cerebral oxygen consumption. We conclude that sufentanil decreases CBF in response to decreased metabolic demand without significantly affecting intracranial pressure. Relative changes in CBF can be reproducibly monitored using TCD.
journal_name
Anesth Analgjournal_title
Anesthesia and analgesiaauthors
Werner C,Hoffman WE,Baughman VL,Albrecht RF,Schulte Jdoi
10.1213/00000539-199102000-00006subject
Has Abstractpub_date
1991-02-01 00:00:00pages
177-81issue
2eissn
0003-2999issn
1526-7598journal_volume
72pub_type
杂志文章abstract：BACKGROUND:We implemented a previously described barcode-based drug safety system in all of our anesthetizing locations. Providers were instructed to scan the barcode on syringes using our Anesthesia Information Management System before drug administration, but the rate of provider adherence was low. We studied an impl...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/ANE.0000000000003861
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:Goal-directed fluid therapy (GDFT) is associated with improved outcomes after surgery. The esophageal Doppler monitor (EDM) is widely used, but has several limitations. The NICOM, a completely noninvasive cardiac output monitor (Cheetah Medical), may be appropriate for guiding GDFT. No prospective studies ha...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/ANE.0000000000000182
更新日期：2014-05-01 00:00:00
abstract：BACKGROUND:In this study we sought to determine whether the topographical measurement along the course of the central veins can estimate the approximate insertion depths of central venous catheters (CVC). METHODS:Two hundred central venous catheterizations were performed via the right and left internal jugular vein (I...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/ANE.0b013e31820902bf
更新日期：2011-06-01 00:00:00
abstract：:Controversy exists concerning the choice of anesthetic technic for elective cesarean section. Several maternal and newborn parameters were compared during general anesthesia (GA) and lumbar epidural analgesia (LEA). High inspired maternal O2 levels were achieved with both technics. Vigorous, well-oxygenated infants wi...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：
更新日期：1977-03-01 00:00:00
abstract：:Delirium is an acute change in cognition and attention, which may include alterations in consciousness and disorganized thinking. Although delirium may affect any age group, it is most common in older patients, especially those with preexisting cognitive impairment. Patients with delirium after surgery recover more sl...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章,评审
doi：10.1213/ANE.0b013e3182147f6d
更新日期：2011-05-01 00:00:00
abstract：IMPLICATIONS:We describe a technique of one-lung high-frequency jet ventilation surgery with continuous monitoring of airway pressures that achieves satisfactory operating conditions with less complications than other similar approaches. ...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章
doi：10.1097/00000539-200301000-00059
更新日期：2003-01-01 00:00:00
abstract：:There are limited and conflicting data on how a confirmatory step using high-dose heparin can improve diagnostic specificity of the antiplatelet factor 4/heparin enzyme immunoassay for heparin-induced thrombocytopenia (HIT). We investigated sera from a recently published study on cardiac surgery patients and found tha...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/ANE.0b013e31820b5f39
更新日期：2011-04-01 00:00:00
abstract：:Hemispheric synchronization is currently promoted as a treatment for preoperative anxiety and for reduction of intraoperative anesthetic and analgesic consumption. We designed this study to examine the effect of Hemisync sounds on anesthetic hypnotic depth. After obtaining informed consent, we randomized subjects unde...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1213/01.ane.0000076145.83783.e7
更新日期：2003-09-01 00:00:00
abstract：BACKGROUND:Postpartum depression (PPD) is associated with pain during and after delivery, with studies showing reduced rates among women delivering with labor epidural analgesia (LEA). We hypothesized that women who intend to deliver with LEA but do not receive it are at higher risk for PPD at 6 weeks due to the combin...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/ANE.0000000000002501
更新日期：2018-05-01 00:00:00
abstract：:Using a standardized technique, spinal anesthesia was induced in 50 term parturients to study the correlation between patient height, weight, and body mass index (BMI) and the spread of sensory blockade. All patients received 12 mg hyperbaric bupivacaine while in the right lateral decubitus position on a horizontal op...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：
更新日期：1988-06-01 00:00:00
abstract：BACKGROUND:In vivo animal assays are a cornerstone of preclinical pain research. An optimal stimulus for determining the activity of potential analgesics would produce responses of a consistent magnitude on repeated testing. Intraplantar (i.pl.) injection of hypertonic saline (HS) in mice produces robust nociceptive re...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/ANE.0000000000003593
更新日期：2019-07-01 00:00:00
abstract：:In a double-blind, single-dose study hydroxyzine combined with morphine was administered intramuscularly to postoperative patients to determine the efficacy of this combination in the relief of postoperative pain, and to compare its effect to that produced by morphine alone. Eighty-two patients received morphine (5 or...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：
更新日期：1980-09-01 00:00:00
abstract：UNLABELLED:Atrial fibrillation is a common complication of coronary artery bypass graft (CABG) surgery that is associated with adverse patient outcomes. We evaluated whether preexisting abnormalities of cardiac structure or function detected with transesophageal echocardiography (TEE) are prevalent in patients later de...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章
doi：10.1097/00000539-200107000-00004
更新日期：2001-07-01 00:00:00
abstract：:Alkalinized bupivacaine 0.75% (pH 6.8) and a mixture (1:1) of bupivacaine 0.75% and lidocaine 2%, both with hyaluronidase, were compared in regional ophthalmic anesthesia for day-case cataract surgery. Eighty-two patients were randomized into two groups (n = 39 and 43) to receive one of the two solutions in a double-b...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1213/00000539-199407000-00008
更新日期：1994-07-01 00:00:00
abstract：BACKGROUND:In children, postoperative respiratory rate (RR) monitoring by transthoracic impedance (TI), capnography, and manual counting has limitations. The rainbow acoustic monitor (RAM) measures continuous RR noninvasively by a different methodology. Our primary aim was to compare the degree of agreement and accurac...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章,多中心研究
doi：10.1213/ANE.0000000000002062
更新日期：2017-06-01 00:00:00
abstract：:In order to evaluate the possible physiologic significance of intra- and postoperative hypotension, we monitored arterial blood pressure and heart rate continuously for 36 hr starting the night before and ending the morning after operation in 34 gynecologic patients. The lowest pressures that occurred during physiolog...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：
更新日期：1984-07-01 00:00:00
abstract：UNLABELLED:Propofol and thiopental have been used clinically in combination for induction of anesthesia. Studies suggest that this mixture has synergistic activity, recovery characteristics similar to propofol alone, and bactericidal effects on multiple organisms. It may therefore be both clinically useful and cost-eff...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1097/00000539-199802000-00038
更新日期：1998-02-01 00:00:00
abstract：UNLABELLED:Suppression of nitric oxide (NO) production alters the toxicity of cocaine and bupivacaine. We undertook this study to determine whether the systemic toxicity of two other local anesthetics that differ in antiarrhythmic activity, plasma clearance, and biotransformation are similarly affected by nitric oxide ...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1097/00000539-199904000-00003
更新日期：1999-04-01 00:00:00
abstract：UNLABELLED:Ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, has psychotomimetic activity. NMDA receptor antagonists cause morphological damage in the posterior cingulate cortex, which may be the brain region responsible for their psychotomimetic effects. Benzodiazepines are effective in preve...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1097/00000539-199812000-00040
更新日期：1998-12-01 00:00:00
abstract：UNLABELLED:Spinal anesthesia is commonly used in former preterm infants (FPI). In these patients, hypotension induced by spinal anesthesia may impair cerebral blood flow. We measured cerebral blood flow velocity (CBFV) by transcranial Doppler ultrasound to assess the effect of hypotension induced by spinal anesthesia o...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/01.ane.0000108962.37210.69
更新日期：2004-05-01 00:00:00
abstract：:Preoperative local anesthetic blockade of somatosensory pathways involved with skin incision and other noxious perioperative stimuli may "preempt" or attenuate the postoperative pain response. Since the Pfannenstiel incision lies within the L1 dermatome, bilateral ilioinguinal, iliohypogastric nerve blocks (IINBs) sho...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00000539-199601000-00003
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND:Lung-protective ventilation (LPV) has been demonstrated to improve clinical outcomes in surgical patients. There are very limited data on the current use of LPV for patients undergoing 1-lung ventilation (1LV) despite evidence that 1LV may be a particularly important setting for its use. In this multicenter ...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章,多中心研究
doi：10.1213/ANE.0000000000002642
更新日期：2018-02-01 00:00:00
abstract：:The performance of five of the most commonly used halothane vaporizers and three enflurane vaporizers was tested under conditions encountered in low-flow and closed-circuit anesthesia. Anesthetic gas concentrations were measured continuously with a mass spectrometer connected to a circle system. The results indicated ...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：
更新日期：1980-05-01 00:00:00
abstract：:We studied the effect of halothane on the fetal cardiovascular system of six lambs in utero by measuring fetal heart rate and femoral arterial blood pressure and by injecting labeled microspheres during a control period and again after 60 and 90 min of halothane anesthesia administered to six pregnant ewes at an inspi...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：
更新日期：1983-05-01 00:00:00
abstract：UNLABELLED:This study was performed to evaluate the ability of anesthesiologists to differentiate between sevoflurane, a newer, more expensive anesthetic, and halothane. A total of 113 assessments were made by 36 anesthesiologists on 58 children, aged 6 mo to 6 yr, scheduled for bilateral myringotomy and tube placement...
journal_title：Anesthesia and analgesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00000539-199712000-00004
更新日期：1997-12-01 00:00:00
abstract：:The aim of the present study was to investigate the impact of isoflurane on regional neurogenic mechanisms in the control of vascular tone. Therefore, regional determinations of sympathetic activity and hemodynamics were made in chloralose-anesthetized swine before and during administration of 1.4% isoflurane. Sympath...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1097/00000539-199501000-00023
更新日期：1995-01-01 00:00:00
abstract：:The anesthetic effect of lidocaine was evaluated in rats by determining the change in anesthetic requirement of cyclopropane MAC that was produced by blood concentrations of lidocaine in the clinically useful range. A linear reduction in anesthetic requirement was produced with concentrations up to 1 mug/ml. Further i...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/00000539-197611000-00016
更新日期：1976-11-01 00:00:00
abstract：BACKGROUND:Recently, we reported a new technique to augment motor-evoked potentials (MEPs) under general anesthesia, posttetanic MEP (p-MEP), in which tetanic stimulation of the peripheral nerve before transcranial stimulation enlarged amplitudes of MEPs from the muscle innervated by the nerve subjected to tetanic stim...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/ane.0b013e318177082e
更新日期：2008-07-01 00:00:00
abstract：:Many inhaled anesthetics and intravenous analgesics have been alleged to produce both proconvulsant and anticonvulsant activity in humans. The reasons for these contrasting actions on the CNS are poorly understood at the present time. However, biologic variability plays an important role in determining individual pati...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章,评审
doi：10.1213/00000539-199003000-00013
更新日期：1990-03-01 00:00:00
abstract：BACKGROUND:Increasing evidence suggests that patients with eating disorders are more likely to develop chronic pain. A misaligned diet has been reported to disrupt the sleep-awake rhythms. Combined with our previous investigation on circadian pain, we aimed to investigate the role of misaligned diet in the pain sensiti...
journal_title：Anesthesia and analgesia
pub_type： 杂志文章
doi：10.1213/ANE.0000000000002727
更新日期：2018-07-01 00:00:00
