The effect of ketanserin on blood pressure and platelets during cardiopulmonary bypass.

Abstract:

:Ketanserin, a serotonin antagonist, was used to control blood pressure during cardiopulmonary bypass in 12 patients having cardiac surgery. The drug was administered as a 10 mg bolus followed by a continuous infusion of either 40, 80, or 120 mg/hr to maintain mean arterial blood pressure below 70 mm Hg. There were 16 hypertensive episodes of which 15 (93.7%) were successfully controlled with ketanserin. Mean arterial pressure decreased significantly from an average of 72 +/- 3 to 52 +/- 9 mm Hg after 1 min. The effect that ketanserin had on platelets was also evaluated. Neither adverse nor salutary effects were seen in the platelet count, though a significant inhibition of serotonin-induced platelet aggregation was observed. Ketanserin proved effective for controlling hypertension during cardiopulmonary bypass but, despite inhibition of serotonin-induced platelet aggregation, it did not prevent thrombocytopenia.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Lichtenthal PR,Wade LD,Rossi EC

subject

Has Abstract

pub_date

1987-11-01 00:00:00

pages

1151-4

issue

11

eissn

0003-2999

issn

1526-7598

journal_volume

66

pub_type

杂志文章
  • A review of intrathecal and epidural analgesia after spinal surgery in children.

    abstract::In view of the overall experience regarding regional anesthetic techniques to control postoperative pain in infants and children, it is feasible that a similar efficacy and safety profile can be obtained when using such techniques after major orthopedic procedures such as anterior or posterior spinal fusion. I reviewe...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/01.ane.0000107938.80562.75

    authors: Tobias JD

    更新日期:2004-04-01 00:00:00

  • Fentanyl-air-oxygen anesthesia for ligation of patent ductus arteriosus in preterm infants.

    abstract::In 10 premature infants (1123 +/- 263 g), fentanyl citrate (30 to 50 microgram/kg) was used in conjunction with pancuronium (0.1 mg/kg) as the sole anesthetic for transthoracic ligation of patent ductus arteriosus. Ventilation was controlled with air and oxygen in concentrations sufficient to maintain transcutaneous P...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Robinson S,Gregory GA

    更新日期:1981-05-01 00:00:00

  • Plasma level of N terminal pro-brain natriuretic peptide as a prognostic marker in critically ill patients.

    abstract::We studied whether N-terminal pro brain natriuretic peptide (NT-pro BNP) measured at intensive care unit admission is an independent predictor of mortality in critically ill patients. We conducted a prospective observational cohort study enrolling 78 patients with APACHE II scores more than 12. Serum NT-pro BNP and ca...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000217202.55909.5d

    authors: Almog Y,Novack V,Megralishvili R,Kobal S,Barski L,King D,Zahger D

    更新日期:2006-06-01 00:00:00

  • Anesthetic sensitivities to propofol and halothane in mice lacking the R-type (Cav2.3) Ca2+ channel.

    abstract:UNLABELLED:Because inhibition of voltage-dependent Ca(2+) channels can be a mechanism underlying general anesthesia, we examined sensitivities to propofol and halothane in mice lacking the R-type (Ca(v)2.3) channel widely expressed in neurons. Sleep time after propofol injection (26 mg/kg IV) and halothane MAC(RR) and ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000065548.83253.5c

    authors: Takei T,Saegusa H,Zong S,Murakoshi T,Makita K,Tanabe T

    更新日期:2003-07-01 00:00:00

  • Tissue injury from tricyclic antidepressants used as local anesthetics.

    abstract::Neurotoxicity has been reported with tricyclic antidepressants (TCAs) used as local anesthetics. We examined the hypothesis that TCAs cause tissue injury, particularly myotoxicity, as occurs with many local anesthetics. Animals were given sciatic nerve injections with 0-80 mM doxepin, amitriptyline, or bupivacaine (1....

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ANE.0000184129.50312.C1

    authors: Barnet CS,Louis DN,Kohane DS

    更新日期:2005-12-01 00:00:00

  • Desflurane hepatitis associated with hapten and autoantigen-specific IgG4 antibodies.

    abstract:BACKGROUND:Three cases of drug-induced liver injury (DILI) have been reported after desflurane anesthesia. However, no previous reports have detected serum autoantibodies such as that reported with DILI from halothane or isoflurane. METHODS AND RESULTS:We describe the first documentation of cytochrome P450 2E1 IgG4 au...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000263275.10081.47

    authors: Anderson JS,Rose NR,Martin JL,Eger EI,Njoku DB

    更新日期:2007-06-01 00:00:00

  • Pharmacokinetics of fentanyl in neonates.

    abstract::The pharmacokinetics of fentanyl were studied in fourteen neonates undergoing major surgical procedures. Five patients were less than 1 day of age, seven were 1-4 days old, and two were 7-14 days old. Fentanyl was given intravenously, 10 micrograms/kg (n = 1), 25 micrograms/kg (n = 4), or 50 micrograms/kg (n = 9), and...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Koehntop DE,Rodman JH,Brundage DM,Hegland MG,Buckley JJ

    更新日期:1986-03-01 00:00:00

  • Neostigmine and 4-aminopyridine antagonism of lincomycin-pancuronium neuromuscular blockade in man.

    abstract::Seven anesthetized patients were studied to determine the interaction between pancuronium and lincomycin and the ability of neostigmine and 4-aminopyridine to antagonize the block. Lincomycin 600 mg given IV alone did not decrease twitch tension. An 8 to 10% decrease in twitch tension occurred when lincomycin was give...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-197805000-00007

    authors: Booij LH,Miller RD,Crul JF

    更新日期:1978-05-01 00:00:00

  • The effect of heart rate control on myocardial ischemia among high-risk patients after vascular surgery.

    abstract:UNLABELLED:Patients undergoing vascular surgery have a high risk of suffering major postoperative cardiac events. Preoperative myocardial ischemia as detected by Holter monitoring identifies a high-risk subgroup whose postoperative ischemia, similarly detected, seems to herald major cardiac events. In this study, we de...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199903000-00002

    authors: Raby KE,Brull SJ,Timimi F,Akhtar S,Rosenbaum S,Naimi C,Whittemore AD

    更新日期:1999-03-01 00:00:00

  • The incidental finding of a patent foramen ovale during cardiac surgery: should it always be repaired? A core review.

    abstract::With the increased use of intraoperative transesophageal echocardiography, patent foramen ovale (PFO) has become a common finding during heart surgery. This finding presents a difficult dilemma for cardiac surgeons, since the impact of intraoperatively diagnosed PFOs on postoperative outcome is unknown. Changes in the...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/01.ane.0000278735.06194.0c

    authors: Sukernik MR,Bennett-Guerrero E

    更新日期:2007-09-01 00:00:00

  • Histological evaluation of cutaneous wound healing in presence of nitrous oxide in rats.

    abstract::Three-centimetre linear incisions were made in 90 young male Lew/f Mai rats by scalpel through skin to the investing fascia of the left flank. The skin was undermined sharply for a distance of 0.5 cm along both sides of the entire length of the incision. The wound site was closed per primam with Michel clips and left ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-197809000-00003

    authors: Shah NK,Kripke BJ,Sanzone CF,Cosman EB

    更新日期:1978-09-01 00:00:00

  • The effects of morphine, nalbuphine, and butorphanol on adrenergic function in canine saphenous veins.

    abstract::Saphenous vein rings mounted in organ chambers containing Krebs-Ringer solution were used to determine if the venodilator effects of morphine, nalbuphine, and butorphanol are the result of interference with adrenergic neurotransmission or are caused by direct depressant actions on venous smooth muscle cells. Morphine ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Muldoon S,Otto J,Freas W,Watson RL

    更新日期:1983-01-01 00:00:00

  • A Prospective, Ex Vivo Trial of Endobronchial Blockade Management Utilizing 3 Commonly Available Bronchial Blockers.

    abstract:BACKGROUND:Lung isolation with bronchial blockers is a well-described and accepted procedure, often described for use during the management of massive hemoptysis. Recommendations for balloon inflation are sparse, with some advocating for saline whereas other suggest air, including the manufacturers. We sought to evalua...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1213/ANE.0000000000004397

    authors: Gilbert CR,Mallow C,Wishire CL,Chang SC,Yarmus LB,Vallieres E,Haeck K,Gorden JA

    更新日期:2019-12-01 00:00:00

  • Conjugated estrogen reduces transfusion and coagulation factor requirements in orthotopic liver transplantation.

    abstract:UNLABELLED:We conducted a prospective, randomized study to determine the efficacy of conjugated estrogen in reducing blood product transfusion during orthotopic liver transplantation (OLT). Patients undergoing OLT were included in the study. Only those having a reaction time of more than 30 mm or 15 min (19 -28 mm) on ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199806000-00008

    authors: Frenette L,Cox J,McArdle P,Eckhoff D,Bynon S

    更新日期:1998-06-01 00:00:00

  • Effects of augmenting cardiac contractility, preload, and heart rate on cardiac output during enflurane anesthesia.

    abstract::Changes in cardiac output in response to augmenting cardiac contractility, preload, and heart rate during enflurane anesthesia were examined in 12 open-chested dogs. Cardiac contractility was assessed by the slope of the end-systolic pressure-volume relation (Emax). Dobutamine (3, 6, and 9 micrograms.kg-1.min-1) was a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199111000-00014

    authors: Sato M,Hoka S,Arimura H,Ono K,Yoshitake J

    更新日期:1991-11-01 00:00:00

  • Application of a High-Flow Nasal Cannula for Prevention of Postextubation Atelectasis in Children Undergoing Surgery: A Randomized Controlled Trial.

    abstract:BACKGROUND:General anesthesia-induced atelectasis is common, and persistent postoperative atelectasis is associated with pulmonary complications. We aimed to evaluate the preventive effects of a high-flow nasal cannula (HFNC) on postoperative atelectasis and respiratory complications in infants and small children. MET...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000005285

    authors: Lee JH,Ji SH,Jang YE,Kim EH,Kim JT,Kim HS

    更新日期:2020-11-10 00:00:00

  • Continuous Transversus Abdominis Plane Nerve Blocks: Does Varying Local Anesthetic Delivery Method-Automatic Repeated Bolus Versus Continuous Basal Infusion-Influence the Extent of Sensation to Cold?: A Randomized, Triple-Masked, Crossover Study in Volunt

    abstract:BACKGROUND:It remains unknown whether continuous or scheduled intermittent bolus local anesthetic administration is preferable for transversus abdominis plane (TAP) catheters. We therefore tested the hypothesis that when using TAP catheters, providing local anesthetic in repeated bolus doses increases the cephalad-caud...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0000000000001939

    authors: Khatibi B,Said ET,Sztain JF,Monahan AM,Gabriel RA,Furnish TJ,Tran JT,Donohue MC,Ilfeld BM

    更新日期:2017-04-01 00:00:00

  • Plasma cholinesterase: gene and variations.

    abstract::The traditional tests that have been used for the past 30 yr to determine plasma cholinesterase phenotype--measurement of esterase activity with a variety of substrates, dibucaine inhibition, fluoride inhibition, and Ro2-0683 inhibition--are inadequate for identifying some variants of this enzyme and leave many cases ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/00000539-199377020-00027

    authors: Pantuck EJ

    更新日期:1993-08-01 00:00:00

  • Maximizing prediction probability PK as an alternative semiparametric approach to estimate the plasma effect-site equilibration rate constant ke0.

    abstract:BACKGROUND:The k(e)(0) value is the first order rate constant determining the equilibration of drugs between plasma or end-tidal concentration and effect-site (e.g., brain) concentration. Parametric and semiparametric approaches have been used for estimating individual k(e)(0) values and describing the drug-response cu...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e3181b61efd

    authors: Ellerkmann RK,Bruhn J,Soehle M,Kehrer M,Hoeft A,Kreuer S

    更新日期:2009-11-01 00:00:00

  • The effects of olprinone (a phosphodiesterase III inhibitor) on hepatic vascular bed in a porcine model of endotoxemia.

    abstract:UNLABELLED:Decreased hepatic blood flow, and impaired hepatic oxygen delivery caused by endotoxin, result in hepatic metabolic deterioration followed by liver dysfunction and multiple organ failure. Among phosphodiesterase III inhibitors, only olprinone increases hepatosplanchnic blood flow. We evaluated the effects of...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200103000-00024

    authors: Nagata E,Kakihana Y,Tobo K,Isowaki S,Kanmura Y

    更新日期:2001-03-01 00:00:00

  • Decrease in vascular resistance in the isolated canine hindlimb after graded doses of alfentanil, fentanyl, and sufentanil.

    abstract::Under halothane anesthesia five dogs were prepared with both hindlimbs isolated from the systemic circulation to allow intermittent placement on extracorporeal perfusion at constant flow. One limb of each dog was surgically denervated. In this relatively anesthetic-free preparation, graded equivalent doses of alfentan...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199007000-00005

    authors: White DA,Reitan JA,Kien ND,Thorup SJ

    更新日期:1990-07-01 00:00:00

  • Comparison of hypobaric, hyperbaric, and isobaric solutions of bupivacaine during continuous spinal anesthesia.

    abstract::This study was designed to compare the anesthetic properties of hypobaric bupivacaine with those of isobaric and hyperbaric solutions when administered in the supine position in an elderly population undergoing hip surgery using continuous spinal anesthesia. Plain bupivacaine (0.5%) was mixed with equal volumes of 10%...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1213/00000539-199106000-00011

    authors: Van Gessel EF,Forster A,Schweizer A,Gamulin Z

    更新日期:1991-06-01 00:00:00

  • Pulmonary effects of methylprednisolone in patients undergoing coronary artery bypass grafting and early tracheal extubation.

    abstract:UNLABELLED:Numerous clinical studies suggest that methylprednisolone may facilitate early tracheal extubation after cardiac surgery, yet no investigation has rigorously examined the use of the drug in this setting. In this prospective, randomized, double-blind, placebo-controlled study, we examined the pulmonary effect...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199807000-00007

    authors: Chaney MA,Nikolov MP,Blakeman B,Bakhos M,Slogoff S

    更新日期:1998-07-01 00:00:00

  • Comparison of morphine, meperidine, fentanyl, and sufentanil in balanced anesthesia: a double-blind study.

    abstract::A double-blind study comparing four narcotic analgesics of different potencies, meperidine, morphine, fentanyl, and sufentanil, was performed on consenting patients undergoing general or orthopedic surgery under balanced anesthesia. Blood pressure, measured through an indwelling arterial catheter, was recorded continu...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:

    authors: Flacke JW,Bloor BC,Kripke BJ,Flacke WE,Warneck CM,Van Etten AP,Wong DH,Katz RL

    更新日期:1985-09-01 00:00:00

  • Total Joint Replacement Perioperative Surgical Home Program: 2-Year Follow-Up.

    abstract:BACKGROUND:Previously, our group successfully established one of the nation's first Perioperative Surgical Homes (PSHs) aimed at coordinating services to patients undergoing primary total hip arthroplasty (THA) and primary total knee arthroplasty (TKA). As we now focus on extending the PSH to other service lines within...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000001308

    authors: Cyriac J,Garson L,Schwarzkopf R,Ahn K,Rinehart J,Vakharia S,Cannesson M,Kain Z

    更新日期:2016-07-01 00:00:00

  • The ability of stroke volume variations obtained with Vigileo/FloTrac system to monitor fluid responsiveness in mechanically ventilated patients.

    abstract:BACKGROUND:Respiratory variations in arterial pulse pressure (DeltaPP) are accurate predictors of fluid responsiveness in mechanically ventilated patients. The aim of our study was to assess the ability of a novel algorithm for automatic estimation of stroke volume variation (SVV) to predict fluid responsiveness in mec...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e318192a36b

    authors: Cannesson M,Musard H,Desebbe O,Boucau C,Simon R,Hénaine R,Lehot JJ

    更新日期:2009-02-01 00:00:00

  • Is There Evidence for Systematic Upcoding of ASA Physical Status Coincident with Payer Incentives? A Regression Discontinuity Analysis of the National Anesthesia Clinical Outcomes Registry.

    abstract:BACKGROUND:Modifications in physician billing patterns have been shown to occur in response to payer incentives, but the phenomenon remains largely unexplored in billing for anesthesia services. Within the field of anesthesiology, Medicare's policy not to provide additional reimbursement for higher ASA physical status ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000000917

    authors: Schonberger RB,Dutton RP,Dai F

    更新日期:2016-01-01 00:00:00

  • The comparative cytotoxic effects of different local anesthetics on a human neuroblastoma cell line.

    abstract:BACKGROUND:Although local anesthetics (LAs) are generally accepted as being safe, incidental neuronal damage has been reported for all LAs in humans. Therefore, in this study, we compared the dose corresponding to 50% cell lethality (LD50) of articaine, lidocaine, mepivacaine, bupivacaine, prilocaine, and ropivacaine i...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000000562

    authors: Malet A,Faure MO,Deletage N,Pereira B,Haas J,Lambert G

    更新日期:2015-03-01 00:00:00

  • Ipsilateral shoulder pain after thoracotomy with epidural analgesia: the influence of phrenic nerve infiltration with lidocaine.

    abstract:UNLABELLED:Patients receiving effective thoracic epidural analgesia for postthoracotomy pain may still complain of severe ipsilateral shoulder pain. The etiology of this pain is unclear. In this randomized, double-blinded, placebo-controlled study, we investigated the effect of phrenic nerve infiltration with lidocaine...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-200108000-00004

    authors: Scawn ND,Pennefather SH,Soorae A,Wang JY,Russell GN

    更新日期:2001-08-01 00:00:00

  • Evaluation of an on-demand, ex vivo bedside blood gas monitor on pulmonary artery blood gas determinations.

    abstract::Critically ill patients often have cardiopulmonary perturbations that require rapid and frequent assessment for optimal care, including cardiac output determinations, measurement of cardiac filling pressures, and arterial and mixed venous blood gas determinations. We evaluated the performance of a rapid, on-demand bed...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199609000-00010

    authors: Franklin ML,Peruzzi WT,Moen SG,Shapiro BA

    更新日期:1996-09-01 00:00:00