Plasma level of N terminal pro-brain natriuretic peptide as a prognostic marker in critically ill patients.


:We studied whether N-terminal pro brain natriuretic peptide (NT-pro BNP) measured at intensive care unit admission is an independent predictor of mortality in critically ill patients. We conducted a prospective observational cohort study enrolling 78 patients with APACHE II scores more than 12. Serum NT-pro BNP and cardiac troponin T were measured at admission, and echocardiography was performed within 24 h. The primary end-point was 30-day mortality. The median NT-pro BNP levels of the 22 (28.2%) patients who died were significantly more frequent than that of those who survived (8328 versus 1016 pg/mL; P = 0.001). Patients with NT-pro BNP levels more than 1900 pg/mL had significantly more frequent mortality (47.2% versus 11.9%; P = 0.03). This group also had more frequent moderate to severe left ventricular dysfunction (30.6% versus 9.5%; P = 0.02) and abnormal cardiac troponin T levels (33.3% versus 14.3%; P = 0.05). Multivariate analyses adjusted for APACHE-II revealed that a NT-pro BNP level more than 1900 pg/mL is an independent predictor of mortality.


Anesth Analg


Anesthesia and analgesia


Almog Y,Novack V,Megralishvili R,Kobal S,Barski L,King D,Zahger D




Has Abstract


2006-06-01 00:00:00














  • Middle ear pressure changes during anesthesia with or without nitrous oxide are similar among airway devices.

    abstract::We tested the hypothesis that middle ear pressure (MEP) is influenced by the choice of airway device during anesthesia with or without nitrous oxide (N2O) in the gas mixture. Eighty consecutive anesthetized, paralyzed ventilated patients (ASA physical status I-II, 18-65 yr) were randomly allocated for airway managemen...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Hohlrieder M,Keller C,Brimacombe J,Eschertzhuber S,Luckner G,Abraham I,von Goedecke A

    更新日期:2006-01-01 00:00:00

  • Hypnotic and analgesic effects of the alpha 2-adrenergic agonist dexmedetomidine in morphine-tolerant rats.

    abstract::Combinations of alpha 2 agonists and opiates are used in the clinical management of pain to harness their potential synergistic interaction for analgesia while limiting their side-effects. To better predict the clinical consequences of this combination, we studied the behavioral effects of dexmedetomidine, a highly se...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Hayashi Y,Guo TZ,Maze M

    更新日期:1996-09-01 00:00:00

  • Bispectral-index-guided versus clinically guided remifentanil/propofol analgesia/sedation for interventional radiological procedures: an observer-blinded randomized study.

    abstract::Patients undergoing potentially painful interventional radiological procedures generally require a combination of analgesia and sedation. This sedation/analgesia should allow the patient to communicate while also remaining calm. Bispectral index (BIS) monitoring could be useful in achieving this. The primary end-point...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Dahaba AA,Lischnig U,Kronthaler R,Bornemann H,Georgiev V,Rehak PH,Metzler H

    更新日期:2006-08-01 00:00:00

  • Ondansetron versus metoclopramide in the treatment of postoperative nausea and vomiting.

    abstract::In this prospective, randomized, double-blind study, we compared the efficacy and safety of ondansetron and metoclopramide in the treatment of postoperative nausea and vomiting (PONV). One hundred seventy-five patients with PONV during recovery from anesthesia for gynecological laparoscopy were treated intravenously w...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Polati E,Verlato G,Finco G,Mosaner W,Grosso S,Gottin L,Pinaroli AM,Ischia S

    更新日期:1997-08-01 00:00:00

  • Pharyngeal Oxygen Insufflation During AirTraq Laryngoscopy Slows Arterial Desaturation in Infants and Small Children.

    abstract:BACKGROUND:The extent to which insufflation of oxygen into the posterior pharynx during laryngoscopy prolongs adequate saturation in infants and small children remains unknown. Therefore, we compared oxygen saturation over time in preoxygenated small children with and without posterior pharynx oxygen insufflation. MET...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Windpassinger M,Plattner O,Gemeiner J,Röder G,Baumann A,Zimmerman NM,Sessler DI

    更新日期:2016-04-01 00:00:00

  • Midazolam-ethanol interactions and reversal with a benzodiazepine antagonist.

    abstract::The purpose of these experiments was to analyze the cerebrovascular and cerebral metabolic effects of midazolam, a short-acting water-soluble benzodiazepine, and to investigate its interaction with alcohol in rats. A benzodiazepine antagonist, 3-carbo-t-butoxy-beta-carboline (beta-CCT), was used to test the role of th...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Van Gorder PN,Hoffman WE,Baughman V,Albrecht RF,Miletich DJ,Guzman F,Cook JM

    更新日期:1985-02-01 00:00:00

  • The safety of immediate extubation after abdominal aortic surgery: a prospective, randomized trial.

    abstract:UNLABELLED:We performed this study to assess the safety of immediate extubation after elective abdominal aortic aneurysm surgery. Consecutive patients were prospectively randomized into two groups after surgery: Group 1 (n = 29) immediate extubation; and Group 2 (n = 21) delayed (at least 4 h) extubation. All patients ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Cohen J,Loewinger J,Hutin K,Sulkes J,Zelikovski A,Singer P

    更新日期:2001-12-01 00:00:00

  • Cyclosporine can increase isoflurane MAC.

    abstract:UNLABELLED:Previous reports indicate that cyclosporine increases sleeping time from barbiturate administration, and analgesia from fentanyl administration, suggesting a possible contribution of cyclosporine to anesthesia. Accordingly, we determined whether cyclosporine pretreatment decreases isoflurane MAC (the minimum...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Niemann CU,Stabernack C,Serkova N,Jacobsen W,Christians U,Eger EI 2nd

    更新日期:2002-10-01 00:00:00

  • The effects of opioids on isolated human pregnant uterine muscles.

    abstract:UNLABELLED:We determined the effects of fentanyl, sufentanil, morphine, and meperidine on the spontaneous contractility of isolated human pregnant uterine muscle strips. Uterine specimens were obtained from normal full-term parturients undergoing elective lower-segment cesarean delivery. Longitudinal muscle strips were...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Yoo KY,Lee J,Kim HS,Jeong SW

    更新日期:2001-04-01 00:00:00

  • Effect on postoperative sore throat of spraying the endotracheal tube cuff with benzydamine hydrochloride, 10% lidocaine, and 2% lidocaine.

    abstract:BACKGROUND:Postoperative sore throat (POST) is a common complication after endotracheal intubation. We compared the effectiveness on POST of spraying the endotracheal tube (ETT) cuff with benzydamine hydrochloride, 10% lidocaine, and 2% lidocaine. METHODS:Three hundred seventy-two patients were randomly allocated into...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Hung NK,Wu CT,Chan SM,Lu CH,Huang YS,Yeh CC,Lee MS,Cherng CH

    更新日期:2010-10-01 00:00:00

  • Reassessment of the assumed A-V oxygen content difference in the shunt calculation.

    abstract::A study was undertaken in 15 patients to compare measured and assumed arteriovenous oxygen (A-V O2) content differences and their effects on resultant shunt calculations. All patients were on volume ventilators and demonstrated a stable cardiovascular state. Simultaneous measurements of the O2 content of a pulmonary a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Harrison RA,Davison R,Shapiro BA,Meyers SN

    更新日期:1975-03-01 00:00:00

  • Evidence for the Efficacy of Systemic Opioid-Sparing Analgesics in Pediatric Surgical Populations: A Systematic Review.

    abstract::While a large number of studies has examined the efficacy of opioid-sparing analgesics in adult surgical populations, fewer studies are available to guide postoperative pain treatment in pediatric patients. We systematically reviewed available publications on the use of systemic nonopioid agents for postoperative anal...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Zhu A,Benzon HA,Anderson TA

    更新日期:2017-11-01 00:00:00

  • Prevention of hypotension after spinal anesthesia for cesarean section: six percent hetastarch versus lactated Ringer's solution.

    abstract::This study was designed to determine whether preoperative administration of 6% hetastarch decreases the incidence and severity of hypotension after spinal anesthesia for cesarean section. Forty nonlaboring ASA class I and II women having nonurgent cesarean sections were randomized to receive either 500 mL of 6% hetast...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Riley ET,Cohen SE,Rubenstein AJ,Flanagan B

    更新日期:1995-10-01 00:00:00

  • A strategy to decide whether to move the last case of the day in an operating room to another empty operating room to decrease overtime labor costs.

    abstract:UNLABELLED:We examined how to program an operating room (OR) information system to assist the OR manager in deciding whether to move the last case of the day in one OR to another OR that is empty to decrease overtime labor costs. We first developed a statistical strategy to predict whether moving the case would decreas...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Dexter F

    更新日期:2000-10-01 00:00:00

  • Pharmacokinetics of thiopental and pentobarbital enantiomers after intravenous administration of racemic thiopental.

    abstract::We studied the pharmacokinetics of thiopental enantiomers in 14 healthy patients aged 37-73 yr receiving racemic thiopental by intravenous (IV) bolus or IV infusion. Plasma concentration of each enantiomer was measured by chiral high-performance liquid chromatography. After IV bolus, the total plasma clearance (CL) (2...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Nguyen KT,Stephens DP,McLeish MJ,Crankshaw DP,Morgan DJ

    更新日期:1996-09-01 00:00:00

  • A multicenter study of the epidemiology of hepatitis B in anesthesia residents.

    abstract::Practicing anesthesiologists are at high risk of hepatitis B infection, but the risk for anesthesia residents has not been assessed. Anesthesia residents at seven universities were surveyed to study the epidemiology of hepatitis B in these trainees. Hepatitis B virus markers in serum were measured and data from questi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Berry AJ,Isaacson IJ,Kane MA,Schatz GC,Clark BT,Beaupre P,Derrer S,Kapur P,Thompson J,Martin D

    更新日期:1985-07-01 00:00:00

  • Venous air embolism prophylaxis with a surface-active agent.

    abstract::The protective effect of a nonionic surface-active polyol agent (Pluronic F-68) against bolus injection and constant-rate IV infusion of air was studied in 21 dogs anesthetized with pentobarbital. Aortic, pulmonary artery and right ventricular pressures, cardiac output, end-tidal CO2 concentration, wasted ventilation,...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Perry JC,Munson ES,Malagodi MH,Shah DO

    更新日期:1975-11-01 00:00:00

  • Differential suppression of intracranial self-stimulation, food-maintained operant responding, and open field activity by paw incision and spinal nerve ligation in rats.

    abstract:BACKGROUND:Detection of ongoing spontaneous pain behaviors in laboratory animals remains a research challenge. Most preclinical pain studies measure elicited behavioral responses to an external noxious stimulus; however, ongoing spontaneous pain in humans and animals may be unrelated to hypersensitivity, and likely dim...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Ewan EE,Martin TJ

    更新日期:2014-04-01 00:00:00

  • The interaction of FK409, a novel nitric oxide releaser, and peripherally administered morphine during experimental inflammation.

    abstract:UNLABELLED:Nitric oxide (NO) may play an important role in central and peripheral nociceptive processes. However, its contribution to peripheral antinociception is still not clear. In the present study, we investigated the effect of peripherally administered FK409, a spontaneous NO releaser, and its interaction with pe...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Nozaki-Taguchi N,Yamamoto T

    更新日期:1998-02-01 00:00:00

  • Left ventricular mass in a patient with Carney's complex.

    abstract:IMPLICATIONS:Carney's complex is characterized by cardiac myxomas, adrenocortical disease, growth hormone-secreting adenomas, and other types of tumors. Its prevalence and incidence are unknown. The anesthesiologist must examine the patient or order tests to exclude cardiac tumors, signs of excess cortisol secretion, a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Szokol JW,Franklin M,Murphy GS,Wynnychenko TM,Sener SF

    更新日期:2002-10-01 00:00:00

  • Exhaled Propofol Concentrations Correlate With Plasma and Brain Tissue Concentrations in Rats.

    abstract:BACKGROUND:Propofol can be measured in exhaled gas. Exhaled and plasma propofol concentrations correlate well, but the relationship with tissue concentrations remains unknown. We thus evaluated the relationship between exhaled, plasma, and various tissue propofol concentrations. Because the drug acts in the brain, we f...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Müller-Wirtz LM,Maurer F,Brausch T,Kiefer D,Floss M,Doneit J,Volk T,Sessler DI,Fink T,Lehr T,Kreuer S

    更新日期:2021-01-01 00:00:00

  • A manual slide rule for target-controlled infusion of propofol: development and evaluation.

    abstract:UNLABELLED:We describe the development and evaluation of a simple slide rule that enables the bedside determination of the infusion rate for a particular target plasma concentration of propofol. The infusion rate to reach this target concentration at time (t) is the product of the target concentration, body weight, and...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Bruhn J,Bouillon TW,Röpcke H,Hoeft A

    更新日期:2003-01-01 00:00:00

  • Lumbar segmental nerve blocks with local anesthetics, pain relief, and motor function: a prospective double-blind study between lidocaine and ropivacaine.

    abstract::Selective segmental nerve blocks with local anesthetics are applied for diagnostic purposes in patients with chronic back pain to determine the segmental level of the pain. We performed this study to establish myotomal motor effects after L4 spinal nerve blocks by lidocaine and ropivacaine and to evaluate the relation...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wolff AP,Wilder Smith OH,Crul BJ,van de Heijden MP,Groen GJ

    更新日期:2004-08-01 00:00:00

  • The use of fentanyl added to morphine-lidocaine-epinephrine spinal solution in patients undergoing cesarean section.

    abstract::Because of its slow onset of action, intrathecal morphine may not be the optimal drug for intraoperative analgesia during short cases, such as cesarean sections. It is not known whether adding fentanyl to a morphine-lidocaine spinal solution would provide any benefits to patients undergoing cesarean sections. Sixty-tw...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Connelly NR,Dunn SM,Ingold V,Villa EA

    更新日期:1994-05-01 00:00:00

  • Limitations of the sodium fusion assay for fluorinated metabolites.

    abstract::A method involving sodium fusion and analysis by fluoride electrode, which has been used for the determination of total fluorinated metabolites of fluorine-containing drugs in physiologic fluids, is shown to be inapplicable to volatile fluorinated metabolites of volatile fluorinated anesthetic agents. The yields of in...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Ivanetich KM,Bradshaw JJ,Brittain T

    更新日期:1982-09-01 00:00:00

  • Minimum alveolar anesthetic concentration of fluorinated alkanols in rats: relevance to theories of narcosis.

    abstract:UNLABELLED:The Meyer-Overton hypothesis predicts that the potency of conventional inhaled anesthetics correlates inversely with lipophilicity: minimum alveolar anesthetic concentration (MAC) x the olive oil/gas partition coefficient equals a constant of approximately 1.82 +/- 0.56 atm (mean +/- SD), whereas MAC x the o...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Eger EI 2nd,Ionescu P,Laster MJ,Gong D,Hudlicky T,Kendig JJ,Harris RA,Trudell JR,Pohorille A

    更新日期:1999-04-01 00:00:00

  • Electroanesthesia (EA) studies: EA produced by stimulation of sensory nerves of the scalp in Rhesus monkeys.

    abstract::After it was learned that electroanesthesia (EA) could not be produced in a Rhesus monkey which had undergone a circumferential scalp block with 0.25% lidocaine, it was postulated that EA could be produced by electrostimulation of the sensory nerves of the scalp in the rhesus. The work reported here verifies that EA c...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Kano T,Cowan GS,Smith RH

    更新日期:1976-07-01 00:00:00

  • Holiday and weekend operating room on-call staffing requirements.

    abstract:BACKGROUND:Every facility that performs cases on holidays has in some way decided on its operating room (OR) and anesthesia staffing for holidays. Previous studies have not examined how best to calculate appropriate holiday staffing. METHODS:We analyzed weekend and holiday data from a university hospital. RESULTS:The...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Dexter F,Epstein RH

    更新日期:2006-12-01 00:00:00

  • Evaluation of an on-demand, ex vivo bedside blood gas monitor on pulmonary artery blood gas determinations.

    abstract::Critically ill patients often have cardiopulmonary perturbations that require rapid and frequent assessment for optimal care, including cardiac output determinations, measurement of cardiac filling pressures, and arterial and mixed venous blood gas determinations. We evaluated the performance of a rapid, on-demand bed...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Franklin ML,Peruzzi WT,Moen SG,Shapiro BA

    更新日期:1996-09-01 00:00:00

  • Epidural anesthesia for cesarean section in diabetic parturients: maternal and neonatal acid-base status and bupivacaine concentration.

    abstract::Acid-base status and blood levels of bupivacaine were determined in 16 diabetic parturients and their infants after epidural anesthesia for cesarean section. The newborn infants were divided into two groups based on umbilical artery pH at birth. Group A consisted of 10 infants who had a pH of less than 7.2 and group B...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Datta S,Brown WU Jr,Ostheimer GW,Weiss JB,Alper MH

    更新日期:1981-08-01 00:00:00