Do intraoperative analgesics influence breast cancer recurrence after mastectomy? A retrospective analysis.


BACKGROUND:Whether intraoperative analgesics have an impact on postoperative cancer recurrence is unknown. Some investigations suggest that the opioids could favor relapse and that regional analgesia and nonsteroidal antiinflammatory drugs could improve cancer prognosis. We retrospectively reviewed our series of breast cancer surgery patients. METHODS:This retrospective study included 327 consecutive women who underwent mastectomy with axillary dissection for breast cancer. The main objective was to compare the incidence of cancer recurrence among patients who received different analgesics during surgery. RESULTS:Perioperative characteristics, cancer prognostic factors, and the length of surgery were comparable regardless of the analgesics administered. Univariate and multivariate analyses showed a lower cancer recurrence rate when ketorolac was given before surgery (P = 0.019). Other analgesics (sufentanil, ketamine, and clonidine) were not associated with a significant reduction in cancer recurrence rates in our series. CONCLUSION:This retrospective analysis suggests that intraoperative administration of ketorolac decreases the risk of breast cancer relapse compared with other analgesícs.


Anesth Analg


Anesthesia and analgesia


Forget P,Vandenhende J,Berliere M,Machiels JP,Nussbaum B,Legrand C,De Kock M




Has Abstract


2010-06-01 00:00:00














  • The effect of breath termination criterion on breathing patterns and the work of breathing during pressure support ventilation.

    abstract:UNLABELLED:With pressure support ventilation (PSV), each PSV breath is flow-cycled, and the breath termination criterion (TC) is usually nonadjustable. When TC does not match the interaction between the patient's inspiratory-expiratory efforts to the opening and closing of the inspiratory and expiratory valves, patient...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Tokioka H,Tanaka T,Ishizu T,Fukushima T,Iwaki T,Nakamura Y,Kosogabe Y

    更新日期:2001-01-01 00:00:00

  • Duration of intrathecal labor analgesia: early versus advanced labor.

    abstract::Early first-stage labor pain is primarily visceral in origin. Increasing pain intensity and transition to somatic nociceptive input characterizes late first- and second-stage labor pain. The effect of this change in nociceptive input on the duration of intrathecal labor analgesia has not been well studied. This prospe...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Viscomi CM,Rathmell JP,Pace NL

    更新日期:1997-05-01 00:00:00

  • Bisulfite-containing propofol: is it a cost-effective alternative to Diprivan for induction of anesthesia?

    abstract:UNLABELLED:Propofol (Diprivan(TM); AstraZeneca, Wilmington, DE) is a commonly used drug for the induction of general anesthesia in the ambulatory setting. With the availability of a new bisulfite-containing generic formulation of propofol, questions have arisen regarding its cost effectiveness and safety compared with ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Shao X,Li H,White PF,Klein KW,Kulstad C,Owens A

    更新日期:2000-10-01 00:00:00

  • Fresh-Frozen Plasma: Ordering Patterns and Utilization in the Operating Rooms of a Tertiary Referral Hospital.

    abstract:BACKGROUND:Blood product transfusion is the most commonly performed hospital procedure. Intraoperative blood product utilization varies between institutions and anesthesiologists. In the United States in 2011, nearly 4 million plasma units were transfused. METHODS:A retrospective analysis of intraoperative plasma orde...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Meyer MJ,Dzik WH,Levine WC

    更新日期:2017-02-01 00:00:00

  • The influences of maternal albumin concentrations on the placental transfer of propofol in human dually perfused cotyledon in vitro.

    abstract:IMPLICATIONS:These results indicate that fetal exposure to propofol can vary considerably depending on maternal plasma albumin concentration. A fractional change in the maternal protein binding of propofol can result in a relatively large difference in fetal exposure. ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: He YL,Seno H,Sasaki K,Tashiro C

    更新日期:2002-05-01 00:00:00

  • Myocardial metabolism and hemodynamic responses with isoflurane anesthesia for coronary arterial surgery.

    abstract::Isoflurane-oxygen was given for induction and maintenance of anesthesia to ten patients having coronary artery bypass grafts. All had preserved ventricular function without hypertension or other cardiac lesions; treatment with beta-blocking drugs was maintained until the operation in all patients. Cardiac output, arte...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Moffitt EA,Barker RA,Glenn JJ,Imrie DD,DelCampo C,Landymore RW,Kinley CE,Murphy DA

    更新日期:1986-01-01 00:00:00

  • Gabapentin enhances the analgesic effect of morphine in healthy volunteers.

    abstract:UNLABELLED:The most effective group of drugs for the treatment of severe pain is opioid analgesics. Their use, however, is limited by decreased effects in neuropathic and chronic pain as a result of increased pain and development of tolerance. Gabapentin (GBP) is effective in both experimental models of chronic pain an...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Eckhardt K,Ammon S,Hofmann U,Riebe A,Gugeler N,Mikus G

    更新日期:2000-07-01 00:00:00

  • Mechanisms of succinylcholine-induced arrhythmias in hypoxic or hypoxic:hypercarbic dogs.

    abstract::To evaluate the effects of succinylcholine on cardiac arrhythmias and serum levels of potassium and catecholamines, dogs with hypoxia alone and with hypoxia and hypercarbia were studied during anesthesia with halothane or enflurane. After the injection of succinylcholine (0.3 mg/kg), cardiac arrhythmias occurred in al...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Leiman BC,Katz J,Butler BD

    更新日期:1987-12-01 00:00:00

  • An evaluation of the efficacy of aspirin and benzydamine hydrochloride gargle for attenuating postoperative sore throat: a prospective, randomized, single-blind study.

    abstract::Postoperative sore throat (POST), although a minor complication, remains a source of postoperative morbidity. We compared the efficacy of dispersible aspirin gargle to benzydamine hydrochloride (a topical nonsteroidal anti inflammatory drug) gargles for prevention of POST. We enrolled 60 consecutive female patients, 1...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Agarwal A,Nath SS,Goswami D,Gupta D,Dhiraaj S,Singh PK

    更新日期:2006-10-01 00:00:00

  • Pain as a factor complicating recovery and discharge after ambulatory surgery.

    abstract:UNLABELLED:Pain complicates the recovery process after ambulatory surgery. We surveyed 175 ambulatory surgery patients to determine pain severity, analgesic use, relationship of pain to duration of recovery, and the relative importance of various factors to predicting these outcomes. Multivariate regression analysis wa...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Pavlin DJ,Chen C,Penaloza DA,Polissar NL,Buckley FP

    更新日期:2002-09-01 00:00:00

  • Routine cleaning and autoclaving does not remove protein deposits from reusable laryngeal mask devices.

    abstract:UNLABELLED:We tested the hypothesis that routine cleaning and autoclaving does not remove protein deposits from reusable laryngeal mask airways (LMAs). All previously used classic and flexible LMAs from a single hospital were tested. Each LMA was hand-washed in an enzymatic solution for 3 min, machine-washed with a dis...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Clery G,Brimacombe J,Stone T,Keller C,Curtis S

    更新日期:2003-10-01 00:00:00

  • Catheter-associated masses in patients receiving intrathecal analgesic therapy.

    abstract:UNLABELLED:A cohort of seven patients receiving intrathecal analgesic drug therapy for chronic intractable pain underwent radiocontrast myelography and computed tomography (CT) scanning to screen for catheter-associated intrathecal masses. Three of seven patients examined had intraspinal masses associated with the tip ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: McMillan MR,Doud T,Nugent W

    更新日期:2003-01-01 00:00:00

  • Little Black Boxes: Noncardiac Implantable Electronic Medical Devices and Their Anesthetic and Surgical Implications.

    abstract::Implanted electronic medical devices. or stimulators such as pacemakers and nerve stimulators have grown enormously in diversity and complexity over recent decades. The function and potential interaction of these devices with the perioperative environment is of increasing concern for anesthesiologists and surgeons. Be...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Srejic U,Larson P,Bickler PE

    更新日期:2017-07-01 00:00:00

  • Ionized hypocalcemia after fresh frozen plasma administration to thermally injured children: effects of infusion rate, duration, and treatment with calcium chloride.

    abstract::A number of cardiac arrests and severe hypotensive episodes have been witnessed associated with the intravenous infusion of fresh frozen plasma (FFP). To clarify the possible role of hypocalcemia, 28 thermally injured anesthetized pediatric patients with massive blood loss were studied to examine the cardiovascular re...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Coté CJ,Drop LJ,Hoaglin DC,Daniels AL,Young ET

    更新日期:1988-02-01 00:00:00

  • Effects of fentanyl, naloxone, and clonidine on hemodynamics and plasma catecholamine levels in dogs.

    abstract::A 50-micrograms/kg dose of fentanyl, given intravenously in divided doses to dogs under enflurane-nitrous oxide anesthesia caused sharp decreases in heart rate (HR), arterial blood pressure (AP), left ventricular dP/dt, and plasma levels of catecholamines. Naloxone, 20 micrograms/kg given 65-70 min later, completely a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Flacke JW,Flacke WE,Bloor BC,Olewine S

    更新日期:1983-03-01 00:00:00

  • Lateral approach to the sciatic nerve in the popliteal fossa.

    abstract:UNLABELLED:We describe a modification of the sciatic nerve (SN) block in the popliteal fossa through the lateral approach. After a brief anatomic study using previously reported landmarks, we propose a new needle orientation associated with a double injection technique after identification of the tibial and the common ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Zetlaoui PJ,Bouaziz H

    更新日期:1998-07-01 00:00:00

  • Does dexamethasone improve the quality of intravenous regional anesthesia and analgesia? A randomized, controlled clinical study.

    abstract::We investigated the anesthetic and analgesic effectiveness of adding dexamethasone to lidocaine for IV regional anesthesia (IVRA). Seventy-five patients undergoing ambulatory hand surgery were randomly assigned to one of three groups: group L received 3 mg/kg lidocaine, group LD received 3 mg/kg lidocaine + 8 mg dexam...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Bigat Z,Boztug N,Hadimioglu N,Cete N,Coskunfirat N,Ertok E

    更新日期:2006-02-01 00:00:00

  • The Effect of Hypothyroidism on a Composite of Mortality, Cardiovascular and Wound Complications After Noncardiac Surgery: A Retrospective Cohort Analysis.

    abstract:BACKGROUND:We tested the hypothesis that hypothyroidism, as defined by thyroid-stimulating hormone (TSH) concentration, is associated with a severity-weighted composite of mortality and major cardiovascular and infectious complications after noncardiac surgery. METHODS:In this retrospective cohort study, we evaluated ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Komatsu R,You J,Mascha EJ,Sessler DI,Kasuya Y,Turan A

    更新日期:2015-09-01 00:00:00

  • Evaluating the relationship between arterial blood pressure changes and indices of pulse oximetric plethysmography.

    abstract:UNLABELLED:The finger plethysmographic waveform of pulse oximeters is a qualitative indicator of fingertip perfusion. This waveform has been used to assess the depth of anesthesia. Its cyclical changes associated with mechanical ventilation have also been used to detect changes in blood volume under normotensive condit...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Golparvar M,Naddafnia H,Saghaei M

    更新日期:2002-12-01 00:00:00

  • Intrabiliary pressure changes produced by narcotic drugs and inhalation anesthetics in guinea pigs.

    abstract::The effects of narcotic agents and two inhalation anesthetics on intrabiliary pressure (IBP) were measured before and after morphine (0.2 mg/kg), meperidine (2 mg/kg), fentanyl (0.002 mg/kg), or pentazocine (1 mg/kg) given intramuscularly to guinea pigs, and after halothane (0.5, 1.0, 1.5, or 2.0 MAC) or enflurane (sa...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Arguelles JE,Franatovic Y,Romo-Salas F,Aldrete JA

    更新日期:1979-03-01 00:00:00

  • The comparative cytotoxic effects of different local anesthetics on a human neuroblastoma cell line.

    abstract:BACKGROUND:Although local anesthetics (LAs) are generally accepted as being safe, incidental neuronal damage has been reported for all LAs in humans. Therefore, in this study, we compared the dose corresponding to 50% cell lethality (LD50) of articaine, lidocaine, mepivacaine, bupivacaine, prilocaine, and ropivacaine i...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Malet A,Faure MO,Deletage N,Pereira B,Haas J,Lambert G

    更新日期:2015-03-01 00:00:00

  • Naloxone does not antagonize the analgesic effects of inhalation anesthetics.

    abstract::A previous demonstration that the ratio of analgesic to anesthetic endpoints is not constant across inhalation anesthetic agents implies that more than one mechanism of action may be operant in general anesthesia. We hypothesized that the endogenous opiate systems might account for this observed disparity in ratios. T...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Levine LL,Winter PM,Nemoto EM,Uram M,Lin MR

    更新日期:1986-04-01 00:00:00

  • A simple technique to reduce epistaxis and nasopharyngeal trauma during nasotracheal intubation in a child with factor IX deficiency having dental restoration.

    abstract::Epistaxis and airway trauma are often associated with nasotracheal intubation. We describe a patient with Factor IX deficiency who required nasotracheal intubation. An inexpensive, nonproprietary, rapid technique was used to reduce the trauma of intubation. ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Delgado AV,Sanders JC

    更新日期:2004-10-01 00:00:00

  • Activity of the serotonergic system during isoflurane anesthesia.

    abstract:BACKGROUND:Microdialysis studies have demonstrated that the release of serotonin (5-hydroxytryptamine, 5-HT) in the serotonergic projection areas increases during waking and decreases during sleep in rat and cat, suggesting that 5-HT plays an important role in modulation of sleep. Although it might be expected that 5-H...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Mukaida K,Shichino T,Koyanagi S,Himukashi S,Fukuda K

    更新日期:2007-04-01 00:00:00

  • A Randomized Controlled Trial Comparing Two Multimodal Analgesic Techniques in Patients Predicted to Have Severe Pain After Cesarean Delivery.

    abstract:BACKGROUND:Improved pain control after cesarean delivery remains a challenging objective. Poorly treated acute pain following delivery is associated with an increased risk of chronic pain and depression. This study was conducted to determine whether the addition of systemic acetaminophen and an increased dose of intrat...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Booth JL,Harris LC,Eisenach JC,Pan PH

    更新日期:2016-04-01 00:00:00

  • Decision Support for the Capacity Management of Bronchoscopy Devices: Optimizing the Cost-Efficient Mix of Reusable and Single-Use Devices Through Mathematical Modeling.

    abstract:BACKGROUND:Increasing costs of material resources challenge hospitals to stay profitable. Particularly in anesthesia departments and intensive care units, bronchoscopes are used for various indications. Inefficient management of single- and multiple-use systems can influence the hospitals' material costs substantially....

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Edenharter GM,Gartner D,Pförringer D

    更新日期:2017-06-01 00:00:00

  • Perioperative goal-directed hemodynamic optimization using noninvasive cardiac output monitoring in major abdominal surgery: a prospective, randomized, multicenter, pragmatic trial: POEMAS Study (PeriOperative goal-directed thErapy in Major Abdominal Surg

    abstract:BACKGROUND:In this study, our objective was to determine whether a perioperative hemodynamic protocol based on noninvasive cardiac output monitoring decreases the incidence of postoperative complications and hospital length of stay in major abdominal surgery patients requiring intensive care unit admission. Secondary o...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Pestaña D,Espinosa E,Eden A,Nájera D,Collar L,Aldecoa C,Higuera E,Escribano S,Bystritski D,Pascual J,Fernández-Garijo P,de Prada B,Muriel A,Pizov R

    更新日期:2014-09-01 00:00:00

  • Halothane reduces dysrhythmias and improves contractile function after global hypoperfusion in isolated hearts.

    abstract::We investigated the effects of halothane on changes in cardiac function during hypoperfusion and recovery of function after reperfusion in the isolated perfused guinea pig heart. Heart rate, atrioventricular (AV) conduction time, the incidence and severity of dysrhythmias, and isovolumetric left ventricular systolic p...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Buljubasic N,Marijic J,Stowe DF,Kampine JP,Bosnjak ZJ

    更新日期:1992-03-01 00:00:00

  • A cryogenic machine for selective recovery of xenon from breathing system waste gases.

    abstract:BACKGROUND:Xenon has many characteristics that make it very attractive as an anesthetic and therapeutic drug. Unfortunately, the supply of xenon is fixed, and therefore reclamation and recovery from even the most efficient breathing circuits is desirable. We built and evaluated a cryogenic device to recover xenon from ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Dingley J,Mason RS

    更新日期:2007-11-01 00:00:00

  • Cyclooxygenase inhibition in ventilator-induced lung injury.

    abstract:BACKGROUND:We tested the hypothesis that inhibition of cyclooxygenase (COX) attenuates in vivo ventilator-induced lung injury (VILI) in a prospective, randomized laboratory investigation in a university-affiliated laboratory. Adult male rats were anesthetized and randomized with or without nonselective COX inhibition (...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Niitsu T,Tsuchida S,Peltekova V,Engelberts D,Copland I,Otulakowski G,Post M,Kavanagh BP

    更新日期:2011-01-01 00:00:00