Abstract:
BACKGROUND:Topical anesthesia of the upper airway is often recommended when difficulty in airway management is anticipated. There are published reports, however, of administration of topical anesthesia resulting in complete loss of airway control. Adverse effects are mostly attributed to interference with involuntary protective airway reflexes, while gross motor function itself generally is thought to be preserved. We hypothesized that if motor control is affected, measurable quantitative changes in vocalization should follow the use of topical anesthesia. METHODS:A prospective, crossover, randomized, double-blind study was conducted, in which 24 healthy volunteers each performed 2 vocal exercises, while having their glottic appearance recorded digitally via fiberoptic nasendoscopy. Subjects gargled with 3 test solutions on separate occasions (placebo, 2% lidocaine, and 4% lidocaine) and repeated the vocal exercises and nasendoscopy. The angle between the vocal cords was measured using MB-Ruler®, and the Laryngograph Speech Studio® software was used for vocal parameter analysis. RESULTS:The only significant changes in voice quality occurred between the control and test groups (P = 0.014). No difference could be found between the placebo and lidocaine groups. CONCLUSIONS:Although gargling with local anesthetic affected vocalization, no pharmacological effect attributable to local anesthetic was observed.
journal_name
Anesth Analgjournal_title
Anesthesia and analgesiaauthors
Maxwell MJ,English JD,Moppett IK,McGlashan JA,Norris AMdoi
10.1213/ANE.0b013e3182455b71subject
Has Abstractpub_date
2012-04-01 00:00:00pages
785-90issue
4eissn
0003-2999issn
1526-7598pii
ANE.0b013e3182455b71journal_volume
114pub_type
杂志文章,随机对照试验abstract:OBJECTIVE:In this study we sought to identify differences in risk factors and outcome of critically ill patients with Candida albicans and non-albicans candidemia. METHODS:Nonimmunosuppressed, nonneutropenic patients with candidemia diagnosed after intensive care unit (ICU) admission were included in a prospective obs...
journal_title:Anesthesia and analgesia
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journal_title:Anesthesia and analgesia
pub_type: 临床试验,杂志文章,随机对照试验
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