The effect of clonidine on the activity of neurons in the rat dorsal raphe nucleus in vitro.


:The dorsal raphe (DR) nucleus is a system of nuclei in the midline of the lower brainstem, which is considered one of the most important nuclei in the modulation of pain in the central nervous system. Central noradrenergic systems play an important role in the control of cardiovascular regulation and pain transmission. Clonidine, an alpha 2-adrenergic agonist is used extensively in anesthesia research. In this study, we evaluated the involvement of clonidine in the activity of DR nucleus and its possible role in pain modulation. Seventy-four neurons within the DR nucleus in the rat brainstem slice preparation were tested using extracellular recording techniques. Application of noradrenaline (NA), 50 mumol/L, induced firing activity in 68 neurons tested (92%). NA produced a regular long-lasting firing activity on the DR neurons. Fifty-six neurons (88%) previously excited by NA were inhibited by clonidine, 20 mumol/L. Clonidine suppressed the firing activity of neurons. The results indicate that the firing of DR neurons was under noradrenergic influence and was inhibited by clonidine, which in turn alters nociception by modifying the central serotonergic system.


Anesth Analg


Anesthesia and analgesia


Alojado ME,Ohta Y,Kemmotsu O




Has Abstract


1994-08-01 00:00:00












  • Comparative hemodynamic depression of halothane versus isoflurane in neonates and infants: an echocardiographic study.

    abstract::The purpose of this study was to measure and compare the relationship of cardiovascular depression and dose during equal potent levels of halothane and isoflurane anesthesia in neonates (n = 19) (16.7 +/- 6.9 days) and infants (n = 54) (6.1 +/- 3.1 mo). Seventy-three children had heart rate, arterial blood pressure, a...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Murray DJ,Forbes RB,Mahoney LT

    更新日期:1992-03-01 00:00:00

  • Divergence paresis without positional headache: an unusual presentation of cerebrospinal fluid hypovolemia after spinal anesthesia.

    abstract::We report a rare complication of spinal anesthesia-divergence paresis-which is characterized by an acquired horizontal diplopia at distance without evidence for abducens palsy. A 64-yr-old man underwent prostatectomy under spinal anesthesia with 2.5 mL of dibucaine hydrochloride 0.3% injected through a 20-gauge cuttin...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Arai M,Matsushima S,Terada H

    更新日期:2006-06-01 00:00:00

  • Transthoracic echocardiography simulation is an efficient method to train anesthesiologists in basic transthoracic echocardiography skills.

    abstract:BACKGROUND:The clinical utility of focused transthoracic echocardiography (TTE) is increasingly recognized in perioperative medicine. However its use is limited among anesthesiologists because of a lack of training. The most efficient training methods have not been determined. We hypothesized that simulation-based TTE ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Neelankavil J,Howard-Quijano K,Hsieh TC,Ramsingh D,Scovotti JC,Chua JH,Ho JK,Mahajan A

    更新日期:2012-11-01 00:00:00

  • The differential effects of midazolam and diazepam on intracellular Ca2+ transients and contraction in adult rat ventricular myocytes.

    abstract:UNLABELLED:We investigated the direct effects of midazolam and diazepam on cardiac excitation-contraction coupling in adult rat ventricular myocytes. Freshly isolated rat ventricular myocytes were loaded with fura-2/AM and field-stimulated at 28 degrees C. Intracellular Ca(2+) transients (340:380 ratio) and myocyte sho...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Kanaya N,Murray PA,Damron DS

    更新日期:2002-12-01 00:00:00

  • A clinical profile of a cohort of patients referred to an anesthesiology-based pediatric chronic pain medicine program.

    abstract:BACKGROUND:Pediatric chronic pain is very common and results in significant health care costs. Pediatric chronic pain is both an individual and a public health concern. The primary objective of this study was to generate a descriptive clinical profile of the patients referred to an anesthesiology-based pediatric chroni...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Vetter TR

    更新日期:2008-03-01 00:00:00

  • Do intraoperative analgesics influence breast cancer recurrence after mastectomy? A retrospective analysis.

    abstract:BACKGROUND:Whether intraoperative analgesics have an impact on postoperative cancer recurrence is unknown. Some investigations suggest that the opioids could favor relapse and that regional analgesia and nonsteroidal antiinflammatory drugs could improve cancer prognosis. We retrospectively reviewed our series of breast...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Forget P,Vandenhende J,Berliere M,Machiels JP,Nussbaum B,Legrand C,De Kock M

    更新日期:2010-06-01 00:00:00

  • The effects of intravenous almitrine on oxygenation and hemodynamics during one-lung ventilation.

    abstract:UNLABELLED:One-lung ventilation (OLV) induces an increase in pulmonary shunt sometimes associated with a decrease in PaO2 despite ventilation with 100% oxygen. PaO2 improvement has been reported in one-lung ventilated animals receiving IV almitrine, a pulmonary vasoconstrictor. We evaluated the ability of almitrine to ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Moutafis M,Dalibon N,Liu N,Kuhlman G,Fischler M

    更新日期:2002-04-01 00:00:00

  • Estimation of the length of the nares-vocal cord.

    abstract::The nasal route is preferred for fiberoptic intubation. Placing a lubricated endotracheal tube through the nostril can guide the fiberoptic scope towards the larynx. It would be helpful for optimal visualization of the vocal cord when the scope is passed through the endotracheal tube if the length of nares-vocal cord ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Han DW,Shim YH,Shin CS,Lee YW,Lee JS,Ahn SW

    更新日期:2005-05-01 00:00:00

  • A Device for the Quantification of Oxygen Consumption and Caloric Expenditure in the Neonatal Range.

    abstract:BACKGROUND:The accurate measurement of oxygen consumption (VO2) and energy expenditure (EE) may be helpful to optimize the treatment of critically ill patients. However, current techniques are limited in their ability to accurately quantify these end points in infants due to a low VO2, low tidal volume, and rapid respi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Nachman E,Clemensen P,Santos K,Cole AR,Polizzotti BD,Hofmann G,Leeman KT,van den Bosch SJ,Kheir JN

    更新日期:2018-07-01 00:00:00

  • Effects of halothane on the cyclic 3',5'-adenosine monophosphate enzyme system in human platelets.

    abstract::A study of the effects of halothane on the cyclic 3',5'-adenosine monophosphate (cAMP) system in human platelets was undertaken since cAMP has been implicated in the regulation of the process of platelet aggregation and this anesthetic has been reported to decrease platelet aggregation and, in other tissues, to increa...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Walter F,Vulliemoz Y,Verosky Y,Triner L

    更新日期:1980-11-01 00:00:00

  • Diagnosis of Postoperative Urinary Retention Using a Simplified Ultrasound Bladder Measurement.

    abstract:BACKGROUND:In this study, we sought to determine whether a simplified ultrasound measurement of the largest transverse diameter, using a standard ultrasound machine, could be used to diagnose postoperative urinary retention (POUR). This method may replace expensive bladder volume measuring devices or a more complex ult...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Daurat A,Choquet O,Bringuier S,Charbit J,Egan M,Capdevila X

    更新日期:2015-05-01 00:00:00

  • Ipsilateral shoulder pain after thoracotomy with epidural analgesia: the influence of phrenic nerve infiltration with lidocaine.

    abstract:UNLABELLED:Patients receiving effective thoracic epidural analgesia for postthoracotomy pain may still complain of severe ipsilateral shoulder pain. The etiology of this pain is unclear. In this randomized, double-blinded, placebo-controlled study, we investigated the effect of phrenic nerve infiltration with lidocaine...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Scawn ND,Pennefather SH,Soorae A,Wang JY,Russell GN

    更新日期:2001-08-01 00:00:00

  • Regulation of intracellular calcium by bupivacaine isomers in cardiac myocytes from Wistar rats.

    abstract::In this study we investigated the effects of a racemic mixture of bupivacaine (RS(+/-)bupivacaine) and its isomers (S(-)bupivacaine and R(+)bupivacaine) on the Ca2+ handling by ventricular myocytes from Wistar rats. Single ventricular myocytes were enzymatically isolated and loaded with the fluorescent Ca2+ indicator ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Chedid NG,Sudo RT,Aguiar MI,Trachez MM,Masuda MO,Zapata-Sudo G

    更新日期:2006-03-01 00:00:00

  • Autonomous Systems in Anesthesia: Where Do We Stand in 2020? A Narrative Review.

    abstract::As most of us are aware, almost every facet of our society is becoming, for better or worse, progressively more technology-dependent. Technological advancement has made autonomous systems, also known as robots, an integral part of our life in several fields, including medicine. The application of robots in anesthesia ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Zaouter C,Joosten A,Rinehart J,Struys MMRF,Hemmerling TM

    更新日期:2020-05-01 00:00:00

  • Resveratrol regulates N-methyl-D-aspartate receptor expression and suppresses neuroinflammation in morphine-tolerant rats.

    abstract:BACKGROUND:In the present study, we examined the effects and mechanisms of the Chinese herb resveratrol on attenuation of morphine tolerance in rats. METHODS:Male Wistar rats were implanted with 2 intrathecal catheters; one catheter was connected to a mini-osmotic pump, used for either morphine (15 μg/h) or saline (1 ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Tsai RY,Chou KY,Shen CH,Chien CC,Tsai WY,Huang YN,Tao PL,Lin YS,Wong CS

    更新日期:2012-10-01 00:00:00

  • The effects of sevoflurane and halothane anesthesia on cerebral blood flow velocity in children.

    abstract:UNLABELLED:We compared cerebral blood flow velocity during anesthesia with sevoflurane and halothane in 23 children admitted for elective surgery (age, 0.4-9.7 yr; median age, 1.9 yr; ASA physical status I-II). Inhaled induction was performed in a randomized sequence with sevoflurane or halothane. Under steady-state co...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Mönkhoff M,Schwarz U,Gerber A,Fanconi S,Bänziger O

    更新日期:2001-04-01 00:00:00

  • Laser-Doppler measurement of the effects of halothane and isoflurane on the cerebrovascular CO2 response in the rat.

    abstract::We used laser-Doppler flowmetry to compare the effects of the volatile anesthetics, isoflurane and halothane, on the cerebrovascular response to CO2 inhalation in male Sprague-Dawley rats. The effects of 0.5 and 1.5 minimum alveolar anesthetic concentrations (MAC) of halothane and isoflurane on the microcirculatory re...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Lee JG,Smith JJ,Hudetz AG,Hillard CJ,Bosnjak ZJ,Kampine JP

    更新日期:1995-04-01 00:00:00

  • The effects of general anesthetics on norepinephrine release from isolated rat cortical nerve terminals.

    abstract:UNLABELLED:Intravenous and volatile general anesthetics inhibit norepinephrine (NE) release from sympathetic neurons and other neurosecretory cells. However, the actions of general anesthetics on NE release from central nervous system (CNS) neurons are unclear. We investigated the effects of representative IV and volat...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Pashkov VN,Hemmings HC Jr

    更新日期:2002-11-01 00:00:00

  • Comparison of tropisetron, droperidol, and saline in the prevention of postoperative nausea and vomiting after gynecologic surgery.

    abstract::This study was performed to compare the efficacy of tropisetron, droperidol, and saline in the prevention of postoperative nausea and vomiting (PONV) and to compare the possible adverse effects of these drugs in gynecologic incontinence surgery. Using a randomized, double-blind study design, we studied 150 women under...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Purhonen S,Kauko M,Koski EM,Nuutinen L

    更新日期:1997-03-01 00:00:00

  • Closed-Loop Delivery Systems Versus Manually Controlled Administration of Total IV Anesthesia: A Meta-analysis of Randomized Clinical Trials.

    abstract::Bispectral Index Scale (BIS)-guided closed-loop delivery of anesthetics has been extensively studied. We performed a meta-analysis of all the randomized clinical trials comparing efficacy and performance between BIS-guided closed-loop delivery and manually controlled administration of total IV anesthesia. Scopus, PubM...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,meta分析,评审


    authors: Pasin L,Nardelli P,Pintaudi M,Greco M,Zambon M,Cabrini L,Zangrillo A

    更新日期:2017-02-01 00:00:00

  • Repeated Testing With the Hypertonic Saline Assay in Mice for Screening of Analgesic Activity.

    abstract:BACKGROUND:In vivo animal assays are a cornerstone of preclinical pain research. An optimal stimulus for determining the activity of potential analgesics would produce responses of a consistent magnitude on repeated testing. Intraplantar ( injection of hypertonic saline (HS) in mice produces robust nociceptive re...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Asiri YI,Fung T,Schwarz SKW,Barr AM,Puil E,MacLeod BA

    更新日期:2019-07-01 00:00:00

  • Cerebral hemoglobin and optical pathlength influence near-infrared spectroscopy measurement of cerebral oxygen saturation.

    abstract::Near-infrared spectroscopy (NIRS) is a noninvasive optical technique to monitor cerebral oxygen saturation at the bedside. Despite its applicability, NIRS has had limited clinical use because of concerns about accuracy, noted by intersubject variability in slope and intercept of the line between NIRS- and weighted-ave...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Kurth CD,Uher B

    更新日期:1997-06-01 00:00:00

  • The Mechanism of Mitral Regurgitation Influences the Temporal Dynamics of the Vena Contracta Area as Measured with Color Flow Doppler.

    abstract:BACKGROUND:In patients with mitral regurgitation (MR), the effective regurgitant orifice area can be estimated by measuring the vena contracta area (VCA). We hypothesize that the VCA has characteristic temporal dynamics related to the underlying mechanism of functional mitral regurgitation (FMR) versus degenerative mit...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Cobey FC,Ashihkmina E,Edrich T,Fox J,Shook D,Bollen B,Breeze JL,Ursprung WW,Shernan SK

    更新日期:2016-02-01 00:00:00

  • Diagnostic Accuracy of Point-of-Care Gastric Ultrasound.

    abstract:BACKGROUND:Pulmonary aspiration of gastric contents is associated with significant perioperative morbidity and mortality. Previous studies have investigated the validity, reliability, and possible clinical impact of gastric ultrasound for the assessment of gastric content at the bedside. In the present study, we examin...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Kruisselbrink R,Gharapetian A,Chaparro LE,Ami N,Richler D,Chan VWS,Perlas A

    更新日期:2019-01-01 00:00:00

  • Review of the off-label use of recombinant activated factor VII in pediatric cardiac surgery patients.

    abstract::In recent years the off-label use of recombinant activated factor VII (rFVIIa) has markedly increased, particularly in pediatric cardiac surgery patients, and practitioners differ widely in their usage of the drug. In 2009, the Congenital Cardiac Anesthesia Society (CCAS) assembled a task force to review the literatur...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Guzzetta NA,Russell IA,Williams GD

    更新日期:2012-08-01 00:00:00

  • Optimization of Endotracheal Tube Cuff Pressure by Monitoring CO2 Levels in the Subglottic Space in Mechanically Ventilated Patients: A Randomized Controlled Trial.

    abstract:BACKGROUND:Many of the complications of mechanical ventilation are related to inappropriate endotracheal tube (ETT) cuff pressure. The aim of the current study was to evaluate the effectiveness of automatic cuff pressure closed-loop control in patients under prolonged intubation, where presence of carbon dioxide (CO2) ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Efrati S,Bolotin G,Levi L,Zaaroor M,Guralnik L,Weksler N,Levinger U,Soroksky A,Denman WT,Gurman GM

    更新日期:2017-10-01 00:00:00

  • Clonidine added to a continuous interscalene ropivacaine perineural infusion to improve postoperative analgesia: a randomized, double-blind, controlled study.

    abstract::Although clonidine has been shown to increase the duration of local anesthetic action and prolong postoperative analgesia when included in single-injection nerve blocks, the only controlled investigation of the efficacy of this practice to improve analgesia for continuous perineural local anesthetic infusion failed to...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ilfeld BM,Morey TE,Thannikary LJ,Wright TW,Enneking FK

    更新日期:2005-04-01 00:00:00

  • The use and effectiveness of electrocardiographic telemetry monitoring in a community hospital general care setting.

    abstract:UNLABELLED:The purpose of this study was to determine if rates of telemetry events differ between patients whose monitoring is appropriately "indicated" versus "not indicated" by systematically applying rigorous criteria for appropriateness of electrocardiogram (ECG) telemetry usage. We performed a retrospective cohort...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Curry JP,Hanson CW 3rd,Russell MW,Hanna C,Devine G,Ochroch EA

    更新日期:2003-11-01 00:00:00

  • Effect of naloxone infusion on analgesia and respiratory depression after epidural fentanyl.

    abstract::The efficacy of two dosage regimens of intravenous naloxone were compared to avoid nonrespiratory side effects and respiratory depression and yet to preserve analgesia (maximum tolerance to periostial pressure over the tibia) after administration of 200 micrograms epidural fentanyl. Three groups of eight patients were...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Gueneron JP,Ecoffey Cl,Carli P,Benhamou D,Gross JB

    更新日期:1988-01-01 00:00:00

  • Methylphenidate and Morphine Combination Therapy in a Rat Model of Chronic Pain.

    abstract:BACKGROUND:The incremental dose of opioids used in chronic pain management often leads to a reduced opioid analgesic effect, opioid misuse, and addiction. Central dopamine (DA) dysfunction contributes to the chronicity of pain and a decreased opioid analgesic effect. Methylphenidate (MPH/Ritalin) enhances central DA fu...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: You Z,Ding W,Doheny JT,Shen S,Yang J,Yang L,Chen L,Zhu S,Mao J

    更新日期:2020-02-01 00:00:00