Hemodynamic responses to physostigmine in patients with a drug overdose.

Abstract:

:Hemodynamic responses to physostigmine were evaluated in eight patients with coma due to overdose with mainly anticholinergic drugs (AC) and in five patients with coma due to overdose with nonanticholinergic drugs (NAC). After correction of hypovolemia, but before administration of physostigmine, AC patients had significantly lower systemic vascular resistances, slightly higher cardiac outputs, and lower mean arterial pressures than NAC patients. Physostigmine produced negligible hemodynamic and, as expected, negligible neurological changes in NAC patients. In AC patients physostigmine produced, also as expected, improved consciousness and in addition significantly increased mean arterial pressure, cardiac output, and cardiac work without significantly affecting systemic vascular resistance.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Nilsson E,Meretoja OA,Neuvonen P

subject

Has Abstract

pub_date

1983-10-01 00:00:00

pages

885-8

issue

10

eissn

0003-2999

issn

1526-7598

journal_volume

62

pub_type

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