The influence of chronic administration of hypnotics and analgesics on rate of recovery from inhalation anesthesia in rats.


:A series of groups of Sprague-Dawley rats were given either secobarbital, phenobarbital, morphine, pentazocine, diazepam, methotrimeprazine, or saline (control) intraperitoneally on 4 consecutive days and then, on day 5, anesthetized with chloroform, trichlorethylene, fluroxene, halothane, methoxyflurane, enflurane, isoflurane, bromotrifluorocyclobutane, or chlorotrifluorocyclobutane. One control group received neither pretreatment nor anesthetics and another was given pretreatment but no anesthetics. The factor of "enzyme induction" is also evaluated, as are SGPT elevation and liver and kidney lesions. If enzyme induction occurred with the drugs used for pretreatment, the anesthetics suppressed the expected response. SGPT levels were generally within normal range. The combinations of all pretreatments with enflurane, halothane, or methoxyflurane had the fastest recovery; recovery was slower with the other anesthetic agents, but none of the prior chemotherapeutic drugs accelerated recovery from the inhalation anesthetics.


Anesth Analg


Anesthesia and analgesia


Dobkin AB,Borgstedt HH,Rohner RF,KURLAN RM,Fein AB




Has Abstract


1975-01-01 00:00:00












  • Preoperative Warming Versus no Preoperative Warming for Maintenance of Normothermia in Women Receiving Intrathecal Morphine for Cesarean Delivery: A Single-Blinded, Randomized Controlled Trial.

    abstract:BACKGROUND:Rates of hypothermia for women undergoing spinal anesthesia for cesarean delivery are high and prevention is desirable. This trial compared the effectiveness of preoperative warming versus usual care among women receiving intrathecal morphine, which is thought to exacerbate perioperative heat loss. METHODS:...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Munday J,Osborne S,Yates P,Sturgess D,Jones L,Gosden E

    更新日期:2018-01-01 00:00:00

  • A Retrospective Analysis of Clinical Research Misconduct Using FDA-Issued Warning Letters and Clinical Investigator Inspection List From 2010 to 2014.

    abstract:BACKGROUND:The US Food and Drug Administration (FDA) conducts inspections of clinical investigation sites as a component of clinical trial regulation. The FDA describes the results of these inspections in the Clinical Investigator Inspection List (CLIIL). More serious violations are followed up in FDA warning letters i...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Romano CA,Nair S,Delphin ES

    更新日期:2018-03-01 00:00:00

  • Late presentation of esophageal injury after transesophageal echocardiography.

    abstract::Esophageal injury is a rare complication of intraoperative transesophageal echocardiography (TEE) associated with cardiac surgery. We report two cases of delayed presentation (2 and 6 days after surgery) of esophageal injury that were likely due to TEE. The differential diagnosis of postoperative pleural effusion or a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: MacGregor DA,Zvara DA,Treadway RM Jr,Ibdah JA,Maloney JD,Kon ND,Riley RD

    更新日期:2004-07-01 00:00:00

  • The impact of heparin-coated cardiopulmonary bypass circuits on pulmonary function and the release of inflammatory mediators.

    abstract:UNLABELLED:Reduction of the inflammatory reaction with the use of heparin coating has been found during and after cardiopulmonary bypass (CPB). The question remains whether this reduced reaction also decreases the magnitude of CPB-induced pulmonary dysfunction. We therefore evaluated the effects of a heparin-coated cir...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: de Vroege R,van Oeveren W,van Klarenbosch J,Stooker W,Huybregts MA,Hack CE,van Barneveld L,Eijsman L,Wildevuur CR

    更新日期:2004-06-01 00:00:00

  • A multicenter randomized controlled trial comparing patient-controlled epidural with intravenous analgesia for pain relief in labor.

    abstract::In this multicenter, randomized, controlled trial, we sought to determine whether patient-controlled epidural analgesia (PCEA) for labor affected the incidence of cesarean delivery when compared with patient-controlled IV opioid analgesia (PCIA). Healthy, term nulliparous patients in 4 Canadian institutions were rando...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Halpern SH,Muir H,Breen TW,Campbell DC,Barrett J,Liston R,Blanchard JW

    更新日期:2004-11-01 00:00:00

  • Effects of halothane on intraocular pressure in anesthetized children.

    abstract::Intraocular pressure (IOP) measurements in children are usually performed under nitrous oxide and halothane anesthesia. We studied the effects of both time and end-tidal halothane concentration on IOP in 80 children (mean age +/- SD = 4.5 +/- 2.9 yr), to determine the most optimal time to make such measurements in ane...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Watcha MF,Chu FC,Stevens JL,Forestner JE

    更新日期:1990-08-01 00:00:00

  • Anesthesia by n-alkanes not consistent with the Meyer-Overton hypothesis: determinations of the solubilities of alkanes in saline and various lipids.

    abstract::Because deviations from the Meyer-Overton rule may provide insights into the attributes of the anesthetic site of action, we characterized the solubility of the n-alkanes in various hydrophobic solvents (n-tetradecane, olive oil, n-octanol, and lecithin) as well as saline using variations on standard techniques. Incre...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Taheri S,Laster MJ,Liu J,Eger EI 2nd,Halsey MJ,Koblin DD

    更新日期:1993-07-01 00:00:00

  • Determining optimum operating room utilization.

    abstract:UNLABELLED:Economic considerations suggest that it is desirable to keep operating rooms fully used when staffed, but the optimum utilization of an operating room (OR) is not known. We created a simulation of an OR to define optimum utilization. We set operational goals of having cases start within 15 min of the schedul...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Tyler DC,Pasquariello CA,Chen CH

    更新日期:2003-04-01 00:00:00

  • Functional maturity of the coagulation system in children: an evaluation using thrombelastography.

    abstract::There are quantitative deficiencies in the coagulation system for at least the first 6 mo of life. Clinical experience, however, does not indicate an increased risk of excessive bleeding during surgical procedures. Thrombelastography, a test providing a functional evaluation of coagulation, was used to assess the hemo...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Miller BE,Bailey JM,Mancuso TJ,Weinstein MS,Holbrook GW,Silvey EM,Tosone SR,Levy JH

    更新日期:1997-04-01 00:00:00

  • Succinylcholine-vecuronium (Org NC 45) sequence for cesarean section.

    abstract::Vecuronium (Org NC 45) was used in 27 parturients undergoing elective cesarean section under general anesthesia. One of the parturients had a twin pregnancy. Neuromuscular transmission was assessed clinically by stimulating the ulnar nerve and observing the contraction of the fingers. An initial bolus of 0.05 mg . kg-...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Baraka A,Noueihed R,Sinno H,Wakid N,Agoston S

    更新日期:1983-10-01 00:00:00

  • Pro- and anticonvulsant effects of anesthetics (Part I)

    abstract::Many inhaled anesthetics and intravenous analgesics have been alleged to produce both proconvulsant and anticonvulsant activity in humans. The reasons for these contrasting actions on the CNS are poorly understood at the present time. However, biologic variability plays an important role in determining individual pati...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Modica PA,Tempelhoff R,White PF

    更新日期:1990-03-01 00:00:00

  • The importance of intraoperative transesophageal echocardiography in endovascular repair of thoracic aortic aneurysms.

    abstract:UNLABELLED:Endovascular repair of the aorta (EVAR) is a promising alternative to open repair. Transesophageal echocardiography (TEE) is a sensitive imaging modality for aortic disease. We reviewed our experience with TEE in thoracic EVAR. Seven patients underwent thoracic EVAR under general anesthesia. Intraoperative a...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Swaminathan M,Lineberger CK,McCann RL,Mathew JP

    更新日期:2003-12-01 00:00:00

  • A new posterior approach to the sciatic nerve block: a prospective, randomized comparison with the classic posterior approach.

    abstract:UNLABELLED:To evaluate the efficacy and acceptance of a new posterior subgluteus approach to the sciatic nerve, as compared with the classic posterior approach, 128 patients undergoing foot orthopedic procedures were randomly allocated to receive either the classic posterior sciatic nerve block (Group Labat, n = 64) or...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: di Benedetto P,Bertini L,Casati A,Borghi B,Albertin A,Fanelli G

    更新日期:2001-10-01 00:00:00

  • Modification of suction-induced hemolysis during cell salvage.

    abstract:BACKGROUND:The efficiency of red blood cell collection during cell salvage is dictated by multiple variables, including suction pressure. In this study, we attempted to determine the influence of suction pressure on the efficiency of cell salvage and to identify methods for minimizing the impact of suction on salvaged ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Waters JH,Williams B,Yazer MH,Kameneva MV

    更新日期:2007-03-01 00:00:00

  • A single preoperative dose of gabapentin does not improve postcesarean delivery pain management: a randomized, double-blind, placebo-controlled dose-finding trial.

    abstract:BACKGROUND:A single preoperative dose of 600 mg gabapentin, combined with multimodal analgesia, has previously been shown to reduce postcesarean pain and improve maternal satisfaction but was associated with increased maternal sedation. We hypothesized that a lower dose of gabapentin may be effective with less sedation...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Short J,Downey K,Bernstein P,Shah V,Carvalho JC

    更新日期:2012-12-01 00:00:00

  • One hundred percent incidence of hemidiaphragmatic paresis associated with interscalene brachial plexus anesthesia as diagnosed by ultrasonography.

    abstract::Interscalene brachial plexus anesthesia for shoulder surgery routinely includes sensory anesthesia of the fourth and fifth cervical nerves. The authors reasoned that some degree of diaphragm paralysis should result from interscalene blocks that produce surgical C3-C5 sensory anesthesia. In this investigation, ultrason...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Urmey WF,Talts KH,Sharrock NE

    更新日期:1991-04-01 00:00:00

  • Preoperative Salivary Cortisol AM/PM Ratio Predicts Early Postoperative Cognitive Dysfunction After Noncardiac Surgery in Elderly Patients.

    abstract:BACKGROUND:The diagnosis of postoperative cognitive dysfunction (POCD) requires complicated neuropsychological testing and is often delayed. Possible biomarkers for early detection or prediction are essential for the prevention and treatment of POCD. Preoperative screening of salivary cortisol levels may help to identi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Han Y,Han L,Dong MM,Sun QC,Zhang ZF,Ding K,Zhang YD,Mannan A,Xu YF,Ou-Yang CL,Li ZY,Gao C,Cao JL

    更新日期:2019-02-01 00:00:00

  • Role of Micro-RNA for Pain After Surgery: Narrative Review of Animal and Human Studies.

    abstract::One of the most prevalent symptoms after major surgery is pain. When postoperative pain treatment is unsatisfactory, it can lead to poor surgical recovery, decreased quality of life, and increased health care costs. Current analgesics, single or in combination, have limited efficacy due to low potency, limited duratio...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Cata JP,Gorur A,Yuan X,Berg NK,Sood AK,Eltzschig HK

    更新日期:2020-06-01 00:00:00

  • Joint hypothesis testing and gatekeeping procedures for studies with multiple endpoints.

    abstract::A claim of superiority of one intervention over another often depends naturally on results from several outcomes of interest. For such studies the common practice of making conclusions about individual outcomes in isolation can be problematic. For example, an intervention might be shown to improve one outcome (e.g., p...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Mascha EJ,Turan A

    更新日期:2012-06-01 00:00:00

  • Auditory event-related potentials, bispectral index, and entropy for the discrimination of different levels of sedation in intensive care unit patients.

    abstract:BACKGROUND:Sedation protocols, including the use of sedation scales and regular sedation stops, help to reduce the length of mechanical ventilation and intensive care unit stay. Because clinical assessment of depth of sedation is labor-intensive, performed only intermittently, and interferes with sedation and sleep, pr...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Haenggi M,Ypparila-Wolters H,Buerki S,Schlauri R,Korhonen I,Takala J,Jakob SM

    更新日期:2009-09-01 00:00:00

  • The effect of short-term epidural local anesthetic blockade on urinary levels of substance P in interstitial cystitis.

    abstract:UNLABELLED:We investigated the effect of epidural local anesthetic blockade on urinary substance P levels in five patients suffering from painful flare-ups of interstitial cystitis. Urine was collected in 24-h intervals commencing at the onset of an epidural bolus of 0.25% bupivacaine followed by maintenance epidural i...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Sukiennik A,Carr DB,Bonney I,Marchand JE,Wurm H,Sant GR

    更新日期:2004-03-01 00:00:00

  • Global end-diastolic volume during different loading conditions in a pediatric animal model.

    abstract:BACKGROUND:Estimating volume status in infants and neonates is challenging. Global end-diastolic volume (GEDV) and dynamic variables of preload, such as pulse pressure variation (PPV), may be alternative variables for estimating cardiac preload and fluid responsiveness. Therefore, we designed the present study to evalu...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Renner J,Meybohm P,Gruenewald M,Steinfath M,Scholz J,Boening A,Bein B

    更新日期:2007-11-01 00:00:00

  • Active inspiratory impedance and load compensation: effects of duration of anesthesia.

    abstract::General anesthesia results in increases in respiratory elastance and flow resistance within 10-15 min after induction. Stabilization (compensation) of the respiratory system in the face of this added load is related to the addition of active (contractile) force-length and force-velocity properties to its internal impe...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Baydur A,Sassoon CS,Stiles CM

    更新日期:1986-01-01 00:00:00

  • Performance of computer-assisted continuous infusion at low concentrations of intravenous sedatives.

    abstract::We studied the performance of a target-controlled drug infusion device, computer-assisted continuous infusion (CACI). Forty-one volunteers received one of midazolam (n = 11), propofol (n = 10), thiopental (n = 10), or fentanyl (n = 10) in sedative concentrations. Concentrations were kept constant for 45-70 min at five...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Veselis RA,Glass P,Dnistrian A,Reinsel R

    更新日期:1997-05-01 00:00:00

  • N-acetylcysteine for the prevention of kidney injury in abdominal aortic surgery: a randomized, double-blind, placebo-controlled trial.

    abstract::In this prospective, randomized, placebo-controlled, double-blind trial we studied the effects of IV N-acetylcysteine for prevention of renal injury in patients undergoing abdominal aortic surgery. Seventy patients without previously documented renal dysfunction were randomly allocated to receive either N-acetylcystei...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Hynninen MS,Niemi TT,Pöyhiä R,Raininko EI,Salmenperä MT,Lepäntalo MJ,Railo MJ,Tallgren MK

    更新日期:2006-06-01 00:00:00

  • Avoiding transfusions in children undergoing cardiac surgery: a meta-analysis of randomized trials of aprotinin.

    abstract::Aprotinin, a potent antifibrinolytic drug, reduces the proportion of adults who receive blood transfusions during cardiac surgery, although the effect in children remains unclear. We performed a systematic review of the literature to identify all English language, randomized controlled trials of aprotinin involving ch...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,meta分析


    authors: Arnold DM,Fergusson DA,Chan AK,Cook RJ,Fraser GA,Lim W,Blajchman MA,Cook DJ

    更新日期:2006-03-01 00:00:00

  • Intraoperative Doppler tissue imaging is a valuable addition to cardiac anesthesiologists' armamentarium: a core review.

    abstract::Endocardial motion and surface/volume changes during the cardiac cycle are echocardiographic methods for regional (analysis of wall motion) and global (fractional area change, stroke volume, and ejection fraction) evaluation of cardiac function. These conventional methods can be subjective, and/or time consuming and, ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Skubas N

    更新日期:2009-01-01 00:00:00

  • The effect of intravenous administration of dexamethasone on postoperative pain, nausea, and vomiting after intrathecal injection of meperidine.

    abstract:BACKGROUND:Different drugs have been used to enhance postoperative neuraxial opioid analgesia and reduce adverse effects. METHODS:We randomized 60 patients into 2 groups to receive either 2 mL saline or 0.1 mg/kg dexamethasone IV before the administration of intrathecal anesthesia (15 mg and meperidine 15 mg). After s...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Movafegh A,Soroush AR,Navi A,Sadeghi M,Esfehani F,Akbarian-Tefaghi N

    更新日期:2007-04-01 00:00:00

  • The effects of morphine, nalbuphine, and butorphanol on adrenergic function in canine saphenous veins.

    abstract::Saphenous vein rings mounted in organ chambers containing Krebs-Ringer solution were used to determine if the venodilator effects of morphine, nalbuphine, and butorphanol are the result of interference with adrenergic neurotransmission or are caused by direct depressant actions on venous smooth muscle cells. Morphine ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Muldoon S,Otto J,Freas W,Watson RL

    更新日期:1983-01-01 00:00:00

  • Sigma receptor activation does not mediate fentanyl-induced attenuation of muscarinic coronary contraction.

    abstract::Our overall goal was to investigate the mechanism by which fentanyl attenuates acetylcholine-induced contraction in porcine coronary artery. We tested the hypothesis that fentanyl attenuates muscarinic coronary contraction via sigma receptor activation. Left coronary artery vascular rings were isolated from porcine he...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Tsuchida H,Schubert A,Estafanous FG,Brum JM,Murray PA

    更新日期:1996-05-01 00:00:00