The influence of chronic administration of hypnotics and analgesics on rate of recovery from inhalation anesthesia in rats.


:A series of groups of Sprague-Dawley rats were given either secobarbital, phenobarbital, morphine, pentazocine, diazepam, methotrimeprazine, or saline (control) intraperitoneally on 4 consecutive days and then, on day 5, anesthetized with chloroform, trichlorethylene, fluroxene, halothane, methoxyflurane, enflurane, isoflurane, bromotrifluorocyclobutane, or chlorotrifluorocyclobutane. One control group received neither pretreatment nor anesthetics and another was given pretreatment but no anesthetics. The factor of "enzyme induction" is also evaluated, as are SGPT elevation and liver and kidney lesions. If enzyme induction occurred with the drugs used for pretreatment, the anesthetics suppressed the expected response. SGPT levels were generally within normal range. The combinations of all pretreatments with enflurane, halothane, or methoxyflurane had the fastest recovery; recovery was slower with the other anesthetic agents, but none of the prior chemotherapeutic drugs accelerated recovery from the inhalation anesthetics.


Anesth Analg


Anesthesia and analgesia


Dobkin AB,Borgstedt HH,Rohner RF,KURLAN RM,Fein AB




Has Abstract


1975-01-01 00:00:00












  • One-lung anesthesia: percent shunt and arterial oxygen tension during continuous insufflation of oxygen to the nonventilated lung.

    abstract::Twenty-four male patients scheduled for elective pulmonary resection were studied to determine whether continuous insufflation of oxygen to the nonventilated lung would reduce intrapulmonary shunting (Qs/Qt) and arterial oxygen desaturation. Measurements of physiologic variables were made using pulmonary arterial and ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Rees DI,Wansbrough SR

    更新日期:1982-06-01 00:00:00

  • The effects of ketamine on the temporal summation (wind-up) of the R(III) nociceptive flexion reflex and pain in humans.

    abstract:UNLABELLED:Animal studies have suggested that the temporal summation of nociceptive inputs might play a significant role in the development of central sensitization (i.e., hyperexcitability of central nociceptive neurons) and hyperalgesia via the activation of N-methyl-D-aspartate receptors. To further analyze these pr...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Guirimand F,Dupont X,Brasseur L,Chauvin M,Bouhassira D

    更新日期:2000-02-01 00:00:00

  • Isoflurane has a greater margin of safety than halothane in swine with and without major surgery or critical coronary stenosis.

    abstract::The fatal/anesthetic ratio (FAR) in 44 swine weighing 32.6 +/- 0.7 kg (SEM) was determined. Fatal anesthetic concentration (the numerator for FAR) was defined as the end-tidal concentration at which the pig lived at least 10 min, during experiments that involved step increments in anesthetic concentrations. Previously...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Roberts SL,Gilbert M,Tinker JH

    更新日期:1987-06-01 00:00:00

  • Cochrane corner: sugammadex, a selective reversal medication for preventing postoperative residual neuromuscular blockade.

    abstract:BACKGROUND:Sugammadex is the first selective relaxant binding agent that has been studied for reversal of neuromuscular blockade induced by rocuronium and other steroidal non-depolarizing neuromuscular blocking agents (NMBAs). OBJECTIVES:To assess the efficacy and safety of sugammadex in reversing neuromuscular blocka...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,meta分析


    authors: Abrishami A,Ho J,Wong J,Yin L,Chung F

    更新日期:2010-04-01 00:00:00

  • A prospective comparison of a noninvasive cardiac output monitor versus esophageal Doppler monitor for goal-directed fluid therapy in colorectal surgery patients.

    abstract:BACKGROUND:Goal-directed fluid therapy (GDFT) is associated with improved outcomes after surgery. The esophageal Doppler monitor (EDM) is widely used, but has several limitations. The NICOM, a completely noninvasive cardiac output monitor (Cheetah Medical), may be appropriate for guiding GDFT. No prospective studies ha...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Waldron NH,Miller TE,Thacker JK,Manchester AK,White WD,Nardiello J,Elgasim MA,Moon RE,Gan TJ

    更新日期:2014-05-01 00:00:00

  • Plasma atrial natriuretic polypeptide and angiotensin II in rats during anesthesia and volume loading.

    abstract::These experiments investigated the effect of halothane or fentanyl anesthesia on plasma atrial natriuretic polypeptide (ANP) and angiotensin II (AII) concentrations and the response to a 30% blood volume load in rats. Halothane (1.1% and 2.2% inspired) or fentanyl (50 and 200 micrograms/kg) anesthesia alone produced l...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Hoffman WE,Phillips MI,Kimura B

    更新日期:1989-01-01 00:00:00

  • The effects of intravenous lidocaine administration on the minimum alveolar concentration of isoflurane in cats.

    abstract::Lidocaine decreases the minimum alveolar concentration (MAC) of inhaled anesthetics and has been used clinically to reduce the requirements for other anesthetic drugs. In this study we examined the effects of lidocaine on isoflurane MAC in cats. Six cats were studied. In Experiment 1, the MAC of isoflurane was determi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Pypendop BH,Ilkiw JE

    更新日期:2005-01-01 00:00:00

  • Prepared endotracheal tubes: are they a potential source for pathogenic microorganisms?

    abstract:UNLABELLED:Prepared endotracheal tubes (PETTs) are frequently used for unanticipated difficult intubation, but their storage time is highly variable and institution-dependent. We sought to determine first, if open, unused PETTs are a potential source of pathogenic microorganisms, and second, if PETTs can provide a medi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Rasic NF,Friesen RM,Anderson B,Hoban SA,Olson N,Kress J

    更新日期:2003-10-01 00:00:00

  • Efficacy Outcome Measures for Procedural Sedation Clinical Trials in Adults: An ACTTION Systematic Review.

    abstract::Successful procedural sedation represents a spectrum of patient- and clinician-related goals. The absence of a gold-standard measure of the efficacy of procedural sedation has led to a variety of outcomes being used in clinical trials, with the consequent lack of consistency among measures, making comparisons among tr...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Williams MR,McKeown A,Dexter F,Miner JR,Sessler DI,Vargo J,Turk DC,Dworkin RH

    更新日期:2016-01-01 00:00:00

  • The young: neuroapoptosis induced by anesthetics and what to do about it.

    abstract::Millions of human fetuses, infants, and children are exposed to anesthetic drugs every year in the United States and throughout the world. Anesthesia administered during critical stages of neurodevelopment has been considered safe and without adverse long-term consequences. However, recent reports provide mounting evi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Creeley CE,Olney JW

    更新日期:2010-02-01 00:00:00

  • Propofol versus propofol-ketamine sedation for retrobulbar nerve block: comparison of sedation quality, intraocular pressure changes, and recovery profiles.

    abstract:UNLABELLED:We compared sedation quality, intraocular pressure (IOP) changes, and recovery profiles in patients who received propofol or propofol-ketamine sedation during placement of the retrobulbar nerve block (RBB). Seventy elderly patients undergoing cataract extraction according to a prospective, randomized, double...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Frey K,Sukhani R,Pawlowski J,Pappas AL,Mikat-Stevens M,Slogoff S

    更新日期:1999-08-01 00:00:00

  • Urine flow is a novel hemodynamic monitoring tool for the detection of hypovolemia.

    abstract:BACKGROUND:Noticeable changes in vital signs indicating hypovolemia occur only after 15% of the blood volume is lost. More sensitive variables (e.g., cardiac output, systolic pressure variation and its Δdown component) are invasive and difficult to obtain in the early phase of bleeding. Lately, a new technology for con...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Shamir MY,Kaplan L,Marans RS,Willner D,Klein Y

    更新日期:2011-03-01 00:00:00

  • A novel infraclavicular brachial plexus block: the lateral and sagittal technique, developed by magnetic resonance imaging studies.

    abstract:UNLABELLED:A new infraclavicular brachial plexus block method has the patient supine with an adducted arm. The target is any of the three cords behind the pectoralis minor muscle. The point of needle insertion is the intersection between the clavicle and the coracoid process. The needle is advanced 0 degrees -30 degree...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Klaastad Ø,Smith HJ,Smedby O,Winther-Larssen EH,Brodal P,Breivik H,Fosse ET

    更新日期:2004-01-01 00:00:00

  • Perioperative Management of the Patient With a Left Ventricular Assist Device for Noncardiac Surgery.

    abstract::The pandemic of heart failure and the limited options for treatment of end-stage disease have resulted in an increase in the utilization of left ventricular assist devices (LVADs). Improvements in device technology and patient survival have led to an expanding population of patients requiring noncardiac surgery while ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Chung M

    更新日期:2018-06-01 00:00:00

  • Plasma concentrations of bupivacaine after lumbar sympathetic block.

    abstract::To determine the pharmacokinetics of local anesthetics after lumbar sympathetic blocks, total and free (unbound) plasma concentrations of bupivacaine in venous blood samples were measured in 12 patients using a high-performance liquid chromatography (HPLC) technique. Administration of 30 mL of plain bupivacaine 0.175%...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Wulf H,Gleim M,Schele HA

    更新日期:1994-11-01 00:00:00

  • Rapid core-to-peripheral tissue heat transfer during cutaneous cooling.

    abstract::Perioperative thermal manipulations are usually directed at the skin surface because methods of directly warming the core are invasive or ineffective. However, inadequate heat flow between peripheral and core compartments will decrease the rate at which core temperature changes. We therefore determined whether core hy...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Plattner O,Xiong J,Sessler DI,Schmied H,Christensen R,Turakhia M,Dechert M,Clough D

    更新日期:1996-05-01 00:00:00

  • The effect of graded hypothermia (36 degrees C-32 degrees C) on hemostasis in anesthetized patients without surgical trauma.

    abstract:UNLABELLED:The isolated effects of hypothermia on hemostasis have not been investigated in healthy humans. We cooled 16 anesthetized patients scheduled for elective intracranial surgery to 32 degrees C body core temperature and assessed prothrombin time (PT), activated partial thromboplastin time, thrombelastogram (TEG...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Kettner SC,Sitzwohl C,Zimpfer M,Kozek SA,Holzer A,Spiss CK,Illievich UM

    更新日期:2003-06-01 00:00:00

  • A Structured Transfer of Care Process Reduces Perioperative Complications in Cardiac Surgery Patients.

    abstract:INTRODUCTION:Serious complications are common during the intensive care of postoperative cardiac surgery patients. Some of these complications may be influenced by communication during the process of handover of care from the operating room to the intensive care unit (ICU) team. A structured transfer of care process ma...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Hall M,Robertson J,Merkel M,Aziz M,Hutchens M

    更新日期:2017-08-01 00:00:00

  • Blood use in patients undergoing coronary artery bypass surgery: impact of cardiopulmonary bypass pump, hematocrit, gender, age, and body weight.

    abstract:UNLABELLED:We investigated the impact of cardiopulmonary bypass pump (CPB), hematocrit, gender, age, and body weight on blood use in patients undergoing coronary artery bypass graft surgery at a major university hospital. Participants were 1235 consecutive patients undergoing primary coronary artery surgery over a peri...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Scott BH,Seifert FC,Glass PS,Grimson R

    更新日期:2003-10-01 00:00:00

  • The antiallodynic effect of Neurotropin is mediated via activation of descending pain inhibitory systems in rats with spinal nerve ligation.

    abstract:BACKGROUND:Neurotropin, a nonprotein extract isolated from inflamed skin of rabbits inoculated with vaccinia virus, is widely used in Japan to treat chronic pain such as neuropathic pain. Although some studies have been conducted on the mechanism of the antiallodynic action of Neurotropin, this mechanism has yet to be ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Okazaki R,Namba H,Yoshida H,Okai H,Miura T,Kawamura M

    更新日期:2008-09-01 00:00:00

  • Anesthetic Management for Percutaneous Minimally Invasive Fetoscopic Surgery of Spina Bifida Aperta: A Retrospective, Descriptive Report of Clinical Experience.

    abstract::Minimally invasive fetoscopic surgery for spina bifida aperta is a new therapeutic approach to preserve neurologic function by protecting exposed neural tissue. The anesthetic management is of paramount importance for the success of the procedure. Therefore, our protocol was developed with particular attention to safe...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Arens C,Koch C,Veit M,Greenberg RS,Lichtenstern C,Weigand MA,Khaleeva A,Schuerg R,Kohl T

    更新日期:2017-07-01 00:00:00

  • Gamma-aminobutyric acid type A receptor β3 subunit forebrain-specific knockout mice are resistant to the amnestic effect of isoflurane.

    abstract:BACKGROUND:β3 containing γ-aminobutyric acid type A receptors (GABA(A)-Rs) mediate behavioral end points of IV anesthetics such as immobility and hypnosis. A knockout mouse with targeted forebrain deletion of the β3 subunit of the GABA(A)-R shows reduced sensitivity to the hypnotic effect of etomidate, as measured by t...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Rau V,Oh I,Liao M,Bodarky C,Fanselow MS,Homanics GE,Sonner JM,Eger EI 2nd

    更新日期:2011-09-01 00:00:00

  • Resuscitation from bupivacaine-induced asystole in rats: comparison of different cardioactive drugs.

    abstract::The objective of this study was to compare the success of resuscitation attempts with different cardioactive drugs after bupivacaine-induced asystole. Saline, amrinone (1 mg/kg), dopamine (5 micrograms/kg), norepinephrine (2 micrograms/kg), epinephrine (10 micrograms/kg), or isoproterenol (1 microgram/kg) were tested....

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Heavner JE,Pitkänen MT,Shi B,Rosenberg PH

    更新日期:1995-06-01 00:00:00

  • Intravenous lecithin-coated microcrystals of dantrolene are effective in the treatment of malignant hyperthermia: an investigation in rats, dogs, and swine.

    abstract::Dantrolene effectively treats malignant hyperthermia (MH) hut the current form, Dantrium, must be dissolved to a 0.33 mg/mL, pH 9.5 solution. This study describes lecithin-coated microcrystal formulations of sodium dantrolene (MC-NaD) and neutral dantrolene (MC-D) which reconstitute to 200 mg/mL within 1 min. In rats,...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Karan SM,Lojeski EW,Haynes DH,Bina S,Wesche DL,Boedeker BH,Muldoon SM

    更新日期:1996-04-01 00:00:00

  • Time course of muscle relaxation with a combination of pancuronium and tubocurarine.

    abstract::A combination of pancuronium and d-tubocurarine is associated with potentiation of the neuromuscular blocking effects of each drug used singly. The time to onset of maximum block and the time to 25% recovery after administration of equipotent (ED95) doses of pancuronium (0.07 mg/kg) alone, d-tubocurarine (0.51 mg/kg) ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Mirakhur RK,Pandit SK,Ferres CJ,Gibson FM

    更新日期:1984-04-01 00:00:00

  • The extent of blockade following various techniques of brachial plexus block.

    abstract::The extent of sensory and motor blockades was examined in 195 patients 5 and 20 min after four different techniques of brachial plexus block using 50 ml of 0.5% bupivacaine. The interscalene technique of Winnie (N = 50) resulted in a preferential blockade of the caudad portions of the cervical plexus and the cephalad ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Lanz E,Theiss D,Jankovic D

    更新日期:1983-01-01 00:00:00

  • Inhibition of apoptotic protein p53 lowers the threshold of isoflurane-induced cardioprotection during early reperfusion in rabbits.

    abstract:INTRODUCTION:Exposure to isoflurane before and during early reperfusion protects against myocardial infarction by activating phosphatidylinositol-3-kinase (PI3K)-mediated signaling. The apoptotic protein, p53, is regulated by PI3K, and inhibition of p53 protects against ischemic injury. We tested the hypothesis that p5...

    journal_title:Anesthesia and analgesia

    pub_type: 社论


    authors: Venkatapuram S,Wang C,Krolikowski JG,Weihrauch D,Kersten JR,Warltier DC,Pratt PF Jr,Pagel PS

    更新日期:2006-12-01 00:00:00

  • Availability of anesthesia equipment in Chinese hospitals: is the safety of anesthesia patient care assured?

    abstract::Availability of physiologic monitoring equipment to ensure the safe administration of anesthesia is an expected standard in many parts of the world. Many hospitals in China may not have an adequate quantity and variety of anesthesia delivery and patient monitoring equipment to assure safe administration of anesthesia ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Juan X,Xinqiao F,Shanglong Y,Yuguang H,Buwei Y,Shiying Y,Pengqian F,Hanqing Z

    更新日期:2012-06-01 00:00:00

  • Perioperative neurotoxicity in the elderly: summary of the 4th International Workshop.

    abstract::To learn the latest developments in the various forms of postoperative cognitive dysfunction, a group of scientists and physicians met in Stockholm for a full day of presentations and interactive discussions. This article summarizes the discussion; highlighting progress, challenges, and new directions in the area of p...

    journal_title:Anesthesia and analgesia



    authors: Terrando N,Eriksson LI,Eckenhoff RG

    更新日期:2015-03-01 00:00:00

  • Abnormal Calcium Levels During Trauma Resuscitation Are Associated With Increased Mortality, Increased Blood Product Use, and Greater Hospital Resource Consumption: A Pilot Investigation.

    abstract:BACKGROUND:Admission hypocalcemia predicts both massive transfusion and mortality in severely injured patients. However, the effect of calcium derangements during resuscitation remains unexplored. We hypothesize that any hypocalcemia or hypercalcemia (either primary or from overcorrection) in the first 24 hours after s...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: MacKay EJ,Stubna MD,Holena DN,Reilly PM,Seamon MJ,Smith BP,Kaplan LJ,Cannon JW

    更新日期:2017-09-01 00:00:00