The effects of milrinone on platelets in patients undergoing cardiac surgery.

Abstract:

:Although amrinone produces thrombocytopenia, no information is available regarding the acute effects of milrinone on platelets. Therefore, we evaluated the effects of milrinone on platelet number and function in cardiac surgical patients. Twenty-seven patients were studied during cardiac surgery requiring cardiopulmonary bypass (CPB). Patients were randomized to receive no milrinone (n = 10), or milrinone (n = 17) at a loading dose of 50-75 micrograms/kg in the CPB circuit followed by 0.5-0.75 micrograms.kg-1.min-1 for 12-24 h. Bleeding times and blood samples for coagulation studies were obtained prior to induction, and at 2 and 24 h after CPB. In both groups, platelet counts decreased significantly from the baseline at 2 and 24 h after CPB, and bleeding time increased significantly from the baseline at 2 and 24 h after CPB. No significant thromboelastoplasty (TEG) changes were observed in either group, and there were no significant differences in platelet aggregation or chest tube drainage between the groups. Acute milrinone administration did not cause significant changes in platelet number or function in patients undergoing cardiac operations requiring CPB, beyond the usual adverse effects of cardiac surgery and CPB.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Kikura M,Lee MK,Safon RA,Bailey JM,Levy JH

doi

10.1097/00000539-199507000-00009

subject

Has Abstract

pub_date

1995-07-01 00:00:00

pages

44-8

issue

1

eissn

0003-2999

issn

1526-7598

journal_volume

81

pub_type

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