Transfer and uptake of alfentanil in the human placenta during in vitro perfusion.

Abstract:

:Alfentanil, a short-acting lipophilic opioid, is used for labor analgesia and cesarean section and may cause neonatal depression. However, direct placental alfentanil transfer has not been studied. We measured placental alfentanil transfer and uptake during in vitro perfusion. Placenta lobules from healthy parturients were perfused with biophase at pH 7.4, 95%:5% O2:CO2. Maternal to fetal (MTF, n = 10) and fetal to maternal (FTM, n = 10) transfer were examined during perfusion with alfentanil 10 ng/mL, antipyrine, and creatinine for 1 h. Thereafter, both MTF and FTM placentas were assayed for alfentanil content (n = 3), or perfused with biophase for 1 h to determine drug washout and then assayed for alfentanil content (n = 3). After the 1 h washout, the remaining MTF placentas (n = 4) were then perfused MTF with high-dose alfentanil 1000 ng/mL to assess saturability of placental transfer. The remaining FTM placentas (n = 4) were then perfused with alfentanil 10 ng/mL in the MTF direction to verify that the same alfentanil transfer characteristics found between placentas were valid when the direction of drug transfer was reversed in the same placenta. Alfentanil was rapidly transferred (< 5 min) across the placenta both MTF and FTM. During MTF transfer, fetal effluent reached a plateau at 2.2 ng/mL between 35 and 55 min, and was unmeasurable 30 min into washout. During FTM transfer, maternal effluent reached a plateau at 1.9 ng/mL at 25-45 min, and was absent after 20-45 min of washout.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Zakowski MI,Ham AA,Grant GJ

doi

10.1213/00000539-199412000-00011

subject

Has Abstract

pub_date

1994-12-01 00:00:00

pages

1089-93

issue

6

eissn

0003-2999

issn

1526-7598

journal_volume

79

pub_type

杂志文章
  • Pharmacodynamics and pharmacokinetics of epidural ropivacaine in humans.

    abstract::The purpose of this study was to characterize the pharmacodynamics and pharmacokinetics of three concentrations of the new long-acting amide local anesthetic, ropivacaine, given epidurally in 15 physical status ASA I or II patients for elective lower-extremity orthopedic procedures using a nonrandomized open-label des...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199001000-00004

    authors: Katz JA,Bridenbaugh PO,Knarr DC,Helton SH,Denson DD

    更新日期:1990-01-01 00:00:00

  • The detection of interatrial flow patency in awake and anesthetized patients: a comparative study using transnasal transesophageal echocardiography.

    abstract:UNLABELLED:The Valsalva maneuver in the awake patient and the ventilation maneuver in the tracheally intubated anesthetized patient are two provocation methods to detect a patent foramen ovale (PFO) by means of contrast transesophageal echocardiography. In 60 patients undergoing posterior fossa surgery, a contrast agen...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200105000-00006

    authors: Greim CA,Trautner H,Krämer K,Zimmermann P,Apfel CC,Roewer N

    更新日期:2001-05-01 00:00:00

  • An in situ technique to retrieve an entrapped j-tip guidewire from an inferior vena cava filter.

    abstract:IMPLICATIONS:Entrapment of a guidewire in the vena cava filter during central venous catheter placement is a newly recognized complication. Complex techniques have been described to free the guidewire. We describe a simple in situ technique that may free the guidewire without the application of complex techniques. ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200208000-00010

    authors: Munir MA,Chien SQ

    更新日期:2002-08-01 00:00:00

  • Whole Blood Point-of-Care Testing for Incomplete Reversal With Idarucizumab in Supratherapeutic Dabigatran.

    abstract:BACKGROUND:Incomplete reversal with a recommended 5-g dose of idarucizumab has been reported in patients with excessively high dabigatran concentrations. A timely detection of reversal failure after idarucizumab using whole blood (WB) coagulation testing is clinically useful. The aims of this study were to determine re...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000004419

    authors: Takeshita S,Tanaka KA,Sawa T,Sanda M,Mizobe T,Ogawa S

    更新日期:2020-02-01 00:00:00

  • Inhaled nitric oxide reduces pulmonary vascular resistance more than prostaglandin E(1) during heart transplantation.

    abstract:UNLABELLED:Heart transplantation in patients with increased pulmonary vascular resistance is often associated with postbypass right heart failure. We therefore compared the abilities of prostaglandin E(1) (PGE(1)) and inhaled nitric oxide to reduce pulmonary vascular resistance during heart transplantation. Patients un...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-200003000-00005

    authors: Rajek A,Pernerstorfer T,Kastner J,Mares P,Grabenwöger M,Sessler DI,Grubhofer G,Hiesmayr M

    更新日期:2000-03-01 00:00:00

  • Bacitracin irrigation: a cause of anaphylaxis in the operating room.

    abstract:IMPLICATIONS:We report a unique case of acute anaphylaxis after mediastinal irrigation with a dilute bacitracin solution. ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200010000-00049

    authors: Blas M,Briesacher KS,Lobato EB

    更新日期:2000-10-01 00:00:00

  • The effect of celiac plexus block in critically ill patients intolerant of enteral nutrition: a randomized, placebo-controlled study.

    abstract:BACKGROUND:In this study, we evaluated the efficacy of celiac plexus block for the treatment of feeding intolerance in critically ill patients. METHODS:Nineteen mechanically ventilated medical patients intolerant of enteral nutrition and receiving metoclopramide underwent bilateral celiac plexus block. The anterior pr...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验,收录出版

    doi:10.1213/ANE.0b013e3181cde870

    authors: Memis D,Inal MT,Temizoz O,Genchallac H,Ozdemir H,Sut N

    更新日期:2010-04-01 00:00:00

  • Central nervous system effects of intrathecal muscle relaxants in rats.

    abstract::When given for a sufficient time and dose intravenously, neuromuscular blocking drugs eventually can enter the cerebrospinal fluid (CSF). To study the potential pharmacologic consequences of neuromuscular blocking drugs in the CSF, a model was developed in the rat by using an intrathecal infusion of these drugs. A can...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199306000-00020

    authors: Szenohradszky J,Trevor AJ,Bickler P,Caldwell JE,Sharma ML,Rampil IJ,Miller RD

    更新日期:1993-06-01 00:00:00

  • Altered response to formalin by L5 spinal nerve ligation in rats: a behavioral and molecular study.

    abstract:BACKGROUND:The status of neuropathic pain alters the responsiveness to formalin injection in rats. However, the mechanism by which this alteration occurs is unknown. METHODS:We used immunocytochemistry to examine the expression of brain-derived neurotrophic factor (BDNF) and calcitonin gene-related peptide (CGRP) in t...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000258762.22607.15

    authors: Kaku R,Yokoyama M,Kobayashi H,Matsuoka Y,Sato T,Mizobuchi S,Itano Y,Morita K

    更新日期:2007-04-01 00:00:00

  • Hyperbaric bupivacaine for spinal anesthesia in cesarean section.

    abstract::The efficacy and safety of 0.5% hyperbaric bupivacaine (Sensorcaine, Astra) was evaluated in 22 patients undergoing elective cesarean section under spinal anesthesia. The dose varied from 7.5 to 10 mg, (depending on the patient's height) which was significantly lower than previously reported. Patients were placed in h...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Santos A,Pedersen H,Finster M,Edström H

    更新日期:1984-11-01 00:00:00

  • Plasma concentrations of lidocaine associated with cervical, thoracic, and lumbar epidural anesthesia.

    abstract::We measured arterial plasma concentrations of lidocaine by enzyme immunoassay when 10 ml of 2% lidocaine without epinephrine was injected into the cervical, thoracic, or lumbar epidural spaces in 30 patients. There was no difference in the time courses of plasma levels of lidocaine. Peak concentrations were achieved 1...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Mayumi T,Dohi S,Takahashi T

    更新日期:1983-06-01 00:00:00

  • Response time of the Narkotest anesthetic gas monitor.

    abstract::Response time (RT) of the Narkotest anesthetic gas monitor was measured for 7 inhalation anesthetics, using a 5 L/min fresh gas flow (FGF). Time to 63 percent of maximum response (RT63) and to 95 percent of maximum response (RT95) was directly related to rubber/gas and oil/gas partition coefficients. RT95 ranged from ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-197705000-00016

    authors: Velazquez JL,Feingold A,Walther P

    更新日期:1977-05-01 00:00:00

  • Transient neurologic syndrome in one thousand forty-five patients after 3% lidocaine spinal anesthesia.

    abstract:UNLABELLED:Recent reports have discussed the potential risk of transient radicular irritation (TRI) after spinal anesthesia with lidocaine. Because we have not encountered such neurologic sequelae with the high incidence reported, we prospectively examined the incidence of TRI after spinal anesthesia with lidocaine. On...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199805000-00022

    authors: Morisaki H,Masuda J,Kaneko S,Matsushima M,Takeda J

    更新日期:1998-05-01 00:00:00

  • Comparative myocardial depression of sevoflurane, isoflurane, and halothane in cultured neonatal rat ventricular myocytes.

    abstract:UNLABELLED:In this study, we compared the direct myocardial depressant effects of sevoflurane, isoflurane, and halothane and determined whether an L-type Ca2+ channel agonist, Bay K 8644, could attenuate the myocardial depression induced by these anesthetics in cultured neonatal rat ventricular myocytes. Ventricular my...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199811000-00013

    authors: Kanaya N,Kawana S,Tsuchida H,Miyamoto A,Ohshika H,Namiki A

    更新日期:1998-11-01 00:00:00

  • Early developmental exposure to volatile anesthetics causes behavioral defects in Caenorhabditis elegans.

    abstract:BACKGROUND:Mounting evidence from animal studies shows that anesthetic exposure in early life leads to apoptosis in the developing nervous system. This loss of neurons has functional consequences in adulthood. Clinical retrospective reviews have suggested that multiple anesthetic exposures in early childhood are associ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e31826d37c5

    authors: Gentry KR,Steele LM,Sedensky MM,Morgan PG

    更新日期:2013-01-01 00:00:00

  • Performance validation of a modified magnetic resonance imaging-compatible temperature probe in children.

    abstract:INTRODUCTION:During magnetic resonance imaging (MRI), children are at risk for body temperature variations. The cold MRI environment that preserves the MRI magnet can cause serious hypothermia. On the other hand, hyperthermia may also develop because of radiofrequency-induced heating of the tissues, particularly in pro...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e31824b003e

    authors: Nasr VG,Schumann R,Bonney I,Diaz L,Ahmed I

    更新日期:2012-06-01 00:00:00

  • The effect of fibrinogen substitution on reversal of dilutional coagulopathy: an in vitro model.

    abstract::Colloids and crystalloids are usually administered as treatment for hypovolemia in severely injured patients. However, dilution of clotting factors and platelets together with impaired fibrinogen polymerization are associated with fluid therapy and may aggravate hemorrhage, thus worsening final outcome of these patien...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000194359.06286.d4

    authors: Fries D,Innerhofer P,Reif C,Streif W,Klingler A,Schobersberger W,Velik-Salchner C,Friesenecker B

    更新日期:2006-02-01 00:00:00

  • Target-Controlled Infusions: Paths to Approval.

    abstract::Target-controlled infusion of IV anesthetic drugs is approved worldwide with the exception of the United States. The purpose of this special article is to review regulatory pathways that could lead to target-controlled infusion (TCI) clearance or approval in the United States. ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0000000000001018

    authors: Dryden PE

    更新日期:2016-01-01 00:00:00

  • Spine Surgery and Blood Loss: Systematic Review of Clinical Evidence.

    abstract::Spine surgery has been growing rapidly as a neurosurgical operation, with an increase of 220% over a 15-year period. Intraoperative blood transfusion is a major outcome determinant of spine procedures. Various approaches, including pharmacologic and nonpharmacologic therapies, have been tested to decrease both intraop...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0000000000001485

    authors: Willner D,Spennati V,Stohl S,Tosti G,Aloisio S,Bilotta F

    更新日期:2016-11-01 00:00:00

  • The effectiveness of a perioperative smoking cessation program: a randomized clinical trial.

    abstract:BACKGROUND:Cigarette smoking by surgical patients is associated with increased complications, particularly perioperative respiratory problems and poor wound healing. In this study, we sought to determine whether a pragmatic perioperative smoking cessation intervention designed for a busy preadmission clinic would be su...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0b013e318298a6b0

    authors: Lee SM,Landry J,Jones PM,Buhrmann O,Morley-Forster P

    更新日期:2013-09-01 00:00:00

  • An advanced specialty training program in anesthesiology: a special educational fellowship designed to return community anesthesiologists to clinical practice.

    abstract::We describe a program for community anesthesiologists designed to evaluate clinical skills and provide additional training in the latest technologies in anesthesiology. This educational program was established for previously trained anesthesiologists who require additional training for either remedial purposes or beca...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000220903.33100.15

    authors: Larson CP Jr,Steadman RH

    更新日期:2006-07-01 00:00:00

  • The effect of electroconvulsive treatment on thermal hyperalgesia and mechanical allodynia in a rat model of peripheral neuropathy.

    abstract:UNLABELLED:We tested the ability of electroconvulsive treatment (ECT) to block thermal hyperalgesia and mechanical allodynia in rats with peripheral neuropathy. Repeated ECT (six times daily) significantly reduced thermal hyperalgesia 48 h after the end of the final treatment but had no significant effects on mechanica...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199803000-00028

    authors: Shibata M,Wakisaka S,Inoue T,Shimizu T,Yoshiya I

    更新日期:1998-03-01 00:00:00

  • Reversal of combination nondepolarized neuromuscular block.

    abstract::The antagonism of a pancuronium-curare (P + C) neuromuscular block was assessed and compared to the antagonism of a pancuronium (P) block. One group of seven patients received P + C (0.024 mg/kg + 0.144 mg/kg); another similar group of seven patients received P (0.07 mg/kg). Both groups were anesthetized with nitrous ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Vitez TS,Difrancesco LV

    更新日期:1983-12-01 00:00:00

  • How to schedule elective surgical cases into specific operating rooms to maximize the efficiency of use of operating room time.

    abstract:UNLABELLED:We considered elective case scheduling at hospitals and surgical centers at which surgeons and patients choose the day of surgery, cases are not turned away, and anesthesia and nursing staffing are adjusted to maximize the efficiency of use of operating room (OR) time. We investigated scheduling a new case i...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200204000-00030

    authors: Dexter F,Traub RD

    更新日期:2002-04-01 00:00:00

  • Pressure-heart rate relationship in intact and after stepwise elimination of three major baroreflex loops in dogs.

    abstract::Systemic arterial blood pressure (BP)-heart rate (HR) relationship (the pressor test) is often used as an index of baroreflex. We evaluated this index by simultaneously comparing BP-HR, right carotid sinus pressure (CSP)-nerve action potentials (NAP), and NAP-HR relationship in dogs anesthetized with pentobarbital. BP...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199611000-00012

    authors: Behnia R,Koushanpour E,Sinclair DM

    更新日期:1996-11-01 00:00:00

  • Technical communication: new teaching model for practicing ultrasound-guided regional anesthesia techniques: no perishable food products!

    abstract:BACKGROUND:There is a pronounced learning curve for the technique of ultrasound-guided regional anesthesia. Practicing with a simulator model has been shown to speed the acquisition of these skills for various ultrasound-guided procedures. However, commercial models for ultrasound-guided regional anesthesia may be too ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e3181cc558b

    authors: Liu Y,Glass NL,Power RW

    更新日期:2010-04-01 00:00:00

  • Endobronchial high-frequency jet ventilation for endobronchial laser surgery: an alternative approach.

    abstract:IMPLICATIONS:We describe a technique of one-lung high-frequency jet ventilation surgery with continuous monitoring of airway pressures that achieves satisfactory operating conditions with less complications than other similar approaches. ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000539-200301000-00059

    authors: Unzueta MC,Casas I,Merten A,Landeira JM

    更新日期:2003-01-01 00:00:00

  • Large-dose intrathecal sufentanil prevents the hormonal stress response during major abdominal surgery: a comparison with intravenous sufentanil in a prospective randomized trial.

    abstract::We studied the effect of large-dose intrathecal sufentanil (ITS) for major abdominal surgery on the hormonal stress response. Forty patients were randomly allocated to receive either IV sufentanil (IVS) or 150 microg of ITS as part of general anesthesia. In the IVS group, adrenocorticotropic hormone (ACTH) and cortiso...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/01.ANE.0000131728.68125.4E

    authors: Borgdorff PJ,Ionescu TI,Houweling PL,Knape JT

    更新日期:2004-10-01 00:00:00

  • Improved evaluation of the location and mechanism of mitral valve regurgitation with a systematic transesophageal echocardiography examination.

    abstract:UNLABELLED:Mitral regurgitation (MR) is a major determinant of outcome in cardiac surgery. The location and mechanism of mitral lesions determine the approach to various repairs and their feasibility. Because of incomplete evaluations or change in patient condition, detailed intraoperative transesophageal echocardiogra...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000539-199906000-00004

    authors: Lambert AS,Miller JP,Merrick SH,Schiller NB,Foster E,Muhiudeen-Russell I,Cahalan MK

    更新日期:1999-06-01 00:00:00

  • Dexmedetomidine reduces propofol and remifentanil requirements during bispectral index-guided closed-loop anesthesia: a double-blind, placebo-controlled trial.

    abstract:BACKGROUND:The α2-adrenergic agonist dexmedetomidine is a sedative and can be used as an adjunct to anesthetics. Our primary goal was thus to determine the extent to which dexmedetomidine reduces the requirement for propofol and remifentanil. METHODS:This double-blinded, randomized study (NCT00921284) used an automate...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0000000000000185

    authors: Le Guen M,Liu N,Tounou F,Augé M,Tuil O,Chazot T,Dardelle D,Laloë PA,Bonnet F,Sessler DI,Fischler M

    更新日期:2014-05-01 00:00:00