Subcellular Energetics and Metabolism: Potential Therapeutic Applications.

Abstract:

:Part I of this review discussed the similarities between embryogenesis, mammalian adaptions to hypoxia (primarily driven by hypoxia-inducible factor-1 [HIF-1]), ischemia-reperfusion injury (and its relationship with reactive oxygen species), hibernation, diving animals, cancer, and sepsis, and it focused on the common characteristics that allow cells and organisms to survive in these states. Part II of this review describes techniques by which researchers gain insight into subcellular energetics and identify potential future tools for clinicians. In particular, P nuclear magnetic resonance to measure high-energy phosphates, serum lactate measurements, the use of near-infrared spectroscopy to measure the oxidation state of cytochrome aa3, and the ability of the protoporphyrin IX-triplet state lifetime technique to measure mitochondrial oxygen tension are discussed. In addition, this review discusses novel treatment strategies such as hyperbaric oxygen, preconditioning, exercise training, therapeutic gases, as well as inhibitors of HIF-1, HIF prolyl hydroxylase, and peroxisome proliferator-activated receptors.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Thiele RH

doi

10.1213/ANE.0000000000001865

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

1872-1885

issue

6

eissn

0003-2999

issn

1526-7598

journal_volume

124

pub_type

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