The effects of halothane on single human neuronal L-type calcium channels.

Abstract:

UNLABELLED:We investigated halothane's effects on the function of L-type Ca2+ channels in a human neuronal cell line, SH-SY5Y, by using the cell-attached patch voltage clamp configuration and Ba2+ as the charge carrier. In multiple-channel patches, halothane decreased the peak and persistent Ba2+ currents, accelerated the rate of inactivation, and slowed the rate of activation. Single-channel analysis showed that halothane (0.14-1.26 mM) increased the latency time for the first channel opening, increased the lifetime of nonconducting events, increased the proportion of short-lived open events, decreased the lifetime of the two open populations, and increased the percentage of current traces without channel activity. All of the observed halothane effects contribute to the halothane-induced decrease in macroscopic Ba2+ currents. The halothane concentration producing 50% reduction (IC50) of the peak Ba2+ current was 0.80 mM (approximately 1.9 hypothetical minimum alveolar anesthetic concentration [H-MAC] at 28 degrees C) and of the persistent Ba2+ current was 0.69 mM (approximately 1.7 H-MAC). The halothane effects did not always occur together, and the Hill slope of 1.6 suggested the presence of more than one interaction site or of more than one population of L-type Ca2+ channels. Halothane reduces L-type Ca2+ channel currents in human neuronal cells primarily through the stabilization of nonconducting states such as closed (before and after channel opening) and inactivated states. IMPLICATIONS:Calcium is a signaling molecule in neurons. We measured the effect of halothane on Ba2+ (a Ca2+ surrogate) movement into a human neuron-like cell electronically. Ba2+ entry through the L-type channel was depressed. Halothane decreased the likelihood of the channel opening and enhanced the rate at which the channel closed and inactivated. These actions of halothane are probably related to its anesthetic action.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Nikonorov IM,Blanck TJ,Recio-Pinto E

doi

10.1097/00000539-199804000-00038

subject

Has Abstract

pub_date

1998-04-01 00:00:00

pages

885-95

issue

4

eissn

0003-2999

issn

1526-7598

journal_volume

86

pub_type

杂志文章
  • Catheter-associated masses in patients receiving intrathecal analgesic therapy.

    abstract:UNLABELLED:A cohort of seven patients receiving intrathecal analgesic drug therapy for chronic intractable pain underwent radiocontrast myelography and computed tomography (CT) scanning to screen for catheter-associated intrathecal masses. Three of seven patients examined had intraspinal masses associated with the tip ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200301000-00039

    authors: McMillan MR,Doud T,Nugent W

    更新日期:2003-01-01 00:00:00

  • A comparison of peripheral skin blood flow and temperature during endoscopic thoracic sympathotomy.

    abstract::The assessment of sympathetic denervation to the upper extremities during surgery for hyperhidrosis is essential in predicting postoperative outcome, particularly for endoscopic thoracic chain sympathotomy, a recently described, minimally destructive technique that minimizes postoperative compensatory hyperhidrosis. T...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1213/01.ANE.0000139934.15659.7F

    authors: Eisenach JH,Pike TL,Wick DE,Dietz NM,Fealey RD,Atkinson JL,Charkoudian N

    更新日期:2005-01-01 00:00:00

  • A preplanned treatment for malignant hyperpyrexia.

    abstract::Although a rare complication of general anesthesia, unanticipated malignant hyperpyrexia requires a rapid, organized treatment plan. With the aid of a treatment protocol sheet and a compact drug and cooling package, treatment can be implemented quickly in each operating room. ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-197609000-00022

    authors: Fraser JG,Crumrine RS,Izant RJ Jr

    更新日期:1976-09-01 00:00:00

  • The diagnostic value of the anti-PF4/heparin immunoassay high-dose heparin confirmatory test in cardiac surgery patients.

    abstract::There are limited and conflicting data on how a confirmatory step using high-dose heparin can improve diagnostic specificity of the antiplatelet factor 4/heparin enzyme immunoassay for heparin-induced thrombocytopenia (HIT). We investigated sera from a recently published study on cardiac surgery patients and found tha...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e31820b5f39

    authors: Selleng S,Schreier N,Wollert HG,Greinacher A

    更新日期:2011-04-01 00:00:00

  • The effects of paracetamol and parecoxib on kidney function in elderly patients undergoing orthopedic surgery.

    abstract::The common adverse effects of traditional nonsteroidal antiinflammatory drugs on renal function include reductions in renal blood flow, glomerular filtration rate, and sodium and potassium excretion, mainly via inhibition of renal cyclooxygenase. We designed the present study to determine the effects of IV paracetamol...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/01.ane.0000244324.87947.29

    authors: Koppert W,Frötsch K,Huzurudin N,Böswald W,Griessinger N,Weisbach V,Schmieder RE,Schüttler J

    更新日期:2006-11-01 00:00:00

  • Vocalization assessed by electrolaryngography is unaffected by topical lidocaine anesthesia: a prospective, crossover, randomized, double-blind placebo-controlled study.

    abstract:BACKGROUND:Topical anesthesia of the upper airway is often recommended when difficulty in airway management is anticipated. There are published reports, however, of administration of topical anesthesia resulting in complete loss of airway control. Adverse effects are mostly attributed to interference with involuntary p...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0b013e3182455b71

    authors: Maxwell MJ,English JD,Moppett IK,McGlashan JA,Norris AM

    更新日期:2012-04-01 00:00:00

  • Isoflurane inhibits cyclic adenosine monophosphate response element-binding protein phosphorylation and calmodulin translocation to the nucleus of SH-SY5Y cells.

    abstract:BACKGROUND:Calmodulin (CaM) activation by Ca(2+), its translocation to the nucleus, and stimulation of phosphorylation of cyclic adenosine monophosphate response element-binding protein (CREB) (P-CREB) are necessary for new gene expression and have been linked to long-term potentiation, a process important in memory fo...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e3181b5a1b8

    authors: Zhang J,Sutachan JJ,Montoya-Gacharna J,Xu CF,Xu F,Neubert TA,Recio-Pinto E,Blanck TJ

    更新日期:2009-10-01 00:00:00

  • Adenosine-induced flow arrest to facilitate intracranial aneurysm clip ligation does not worsen neurologic outcome.

    abstract:BACKGROUND:When temporary arterial occlusion of the parent artery is difficult for anatomical reasons, or when inadvertent aneurysmal rupture occurs during surgical dissection, adenosine administration can be used to produce flow arrest and brief, profound systemic hypotension that can facilitate intracranial aneurysm ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e3182a6d31b

    authors: Bebawy JF,Zeeni C,Sharma S,Kim ES,DeWood MS,Hemmer LB,Ramaiah VK,Bendok BR,Koht A,Gupta DK

    更新日期:2013-11-01 00:00:00

  • Clinical uses of the Bonfils Retromolar Intubation Fiberscope: a review.

    abstract::The Bonfils Retromolar Intubation Fiberscope is a rigid, straight fiberoptic device with a 40-degree curved tip, which facilitates targeted intubation. Bonfils, using a retromolar approach to intubate tracheas of children with Pierre Robin syndrome, was first described in 1983. After an initial steep learning curve, t...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0b013e318265bae2

    authors: Thong SY,Wong TG

    更新日期:2012-10-01 00:00:00

  • Patient characteristics and anesthetic technique are additive but not synergistic predictors of successful motor evoked potential monitoring.

    abstract:BACKGROUND:Spinal cord monitoring is associated with a significantly lower rate of neurologic deficits after deformity surgery, and has been shown to have predictive value in cervical, thoracic, and lumbar surgery. Lower extremity motor evoked potentials (MEPs) are particularly sensitive to anesthetics and physiologic ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e3181e41804

    authors: Deiner SG,Kwatra SG,Lin HM,Weisz DJ

    更新日期:2010-08-01 00:00:00

  • A Methyltransferase Inhibitor (Decitabine) Alleviates Intergenerational Effects of Paternal Neonatal Exposure to Anesthesia With Sevoflurane.

    abstract:BACKGROUND:Neonatal exposure to sevoflurane induces neurobehavioral and neuroendocrine abnormalities in exposed male rats (generation F0) and neurobehavioral, but not neuroendocrine, abnormalities in their male, but not female, offspring (generation F1). These effects of sevoflurane are accompanied by a hypermethylated...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000005097

    authors: Xu N,Lei L,Lin Y,Ju LS,Morey TE,Gravenstein N,Yang J,Martynyuk AE

    更新日期:2020-10-01 00:00:00

  • World Health Organization-World Federation of Societies of Anaesthesiologists (WHO-WFSA) International Standards for a Safe Practice of Anesthesia.

    abstract::The International Standards for a Safe Practice of Anesthesia were developed on behalf of the World Federation of Societies of Anaesthesiologists (WFSA), a nonprofit organization representing anesthesiologists in 150 countries, and the World Health Organization (WHO). The recommendations have been approved by WHO and ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0000000000002927

    authors: Gelb AW,Morriss WW,Johnson W,Merry AF,Abayadeera A,Belîi N,Brull SJ,Chibana A,Evans F,Goddia C,Haylock-Loor C,Khan F,Leal S,Lin N,Merchant R,Newton MW,Rowles JS,Sanusi A,Wilson I,Velazquez Berumen A,International

    更新日期:2018-06-01 00:00:00

  • Time- and Dose-Dependent Effects of Desflurane in Sensitized Airways.

    abstract:BACKGROUND:Although the bronchodilatory actions of volatile anesthetics, such as halothane, isoflurane, and sevoflurane, have been well documented in previous studies, the properties of desflurane remain controversial. The aim of this study was to investigate the effects of desflurane at different concentrations and du...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000001754

    authors: Zhou J,Iwasaki S,Yamakage M

    更新日期:2017-02-01 00:00:00

  • A Retrospective Analysis of Clinical Research Misconduct Using FDA-Issued Warning Letters and Clinical Investigator Inspection List From 2010 to 2014.

    abstract:BACKGROUND:The US Food and Drug Administration (FDA) conducts inspections of clinical investigation sites as a component of clinical trial regulation. The FDA describes the results of these inspections in the Clinical Investigator Inspection List (CLIIL). More serious violations are followed up in FDA warning letters i...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000002694

    authors: Romano CA,Nair S,Delphin ES

    更新日期:2018-03-01 00:00:00

  • Optimal Dose of Perineural Dexamethasone to Prolong Analgesia After Brachial Plexus Blockade: A Systematic Review and Meta-analysis.

    abstract:BACKGROUND:Perineural dexamethasone has gained popularity in regional anesthesia to prolong analgesia duration. However, uncertainty remains regarding the optimal perineural dose. Clarification of this characteristic is of significant importance as the administration of dexamethasone may lead to dose-dependent complica...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,meta分析,评审

    doi:10.1213/ANE.0000000000002488

    authors: Kirkham KR,Jacot-Guillarmod A,Albrecht E

    更新日期:2018-01-01 00:00:00

  • A multicenter study of the epidemiology of hepatitis B in anesthesia residents.

    abstract::Practicing anesthesiologists are at high risk of hepatitis B infection, but the risk for anesthesia residents has not been assessed. Anesthesia residents at seven universities were surveyed to study the epidemiology of hepatitis B in these trainees. Hepatitis B virus markers in serum were measured and data from questi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Berry AJ,Isaacson IJ,Kane MA,Schatz GC,Clark BT,Beaupre P,Derrer S,Kapur P,Thompson J,Martin D

    更新日期:1985-07-01 00:00:00

  • Evolution of the French public's knowledge and attitudes regarding postoperative pain, cancer pain, and their treatments: two national surveys over a six-year period.

    abstract:UNLABELLED:Pain management has become a notable feature of public health policy and mass media communication in France over the past few years. To assess the evolution of the knowledge and attitudes of the French population with respect to pain management and morphine use, telephone surveys using similar questionnaires...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199909000-00023

    authors: Larue F,Fontaine A,Brasseur L

    更新日期:1999-09-01 00:00:00

  • Bilateral Thoracic Paravertebral Blocks Compared to Thoracic Epidural Analgesia After Midline Laparotomy: A Pragmatic Noninferiority Clinical Trial.

    abstract:BACKGROUND:Bilateral paravertebral block (PVB) is a suitable alternative to thoracic epidural analgesia (TEA) for abdominal surgeries. This randomized clinical trial aims to determine if PVB is noninferior to TEA in terms of analgesia after midline laparotomy. METHODS:Seventy American Society of Anesthesiologists (ASA...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0000000000004219

    authors: Sondekoppam RV,Uppal V,Brookes J,Ganapathy S

    更新日期:2019-09-01 00:00:00

  • Serum ammonia levels in response to glycine infusion in normal and cirrhotic rats.

    abstract::Elevated serum ammonia may play a role in central nervous system derangement after transurethral resection of the prostate. Glycine used as a surgical irrigant for prostate resection produces ammonia as a by-product after liver and renal metabolism. The presence of liver dysfunction often leads to an inability to remo...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Frink EJ Jr,DiGiovanni DA,Davis JR,Brown BR Jr

    更新日期:1989-12-01 00:00:00

  • Influence of volume on the spread of local anesthetic-methylene blue solution after injection for intercostal block.

    abstract::The purpose of this study was to evaluate the influence of the volume of methylene blue-local anesthetic on the spread of the injectate along the costal pleura. Twenty patients undergoing elective thoracotomy were studied. Twelve patients received intercostal nerve injection with 10 mL of 0.5% bupivacaine with methyle...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199209000-00013

    authors: Moorthy SS,Dierdorf SF,Yaw PB

    更新日期:1992-09-01 00:00:00

  • Total Joint Replacement Perioperative Surgical Home Program: 2-Year Follow-Up.

    abstract:BACKGROUND:Previously, our group successfully established one of the nation's first Perioperative Surgical Homes (PSHs) aimed at coordinating services to patients undergoing primary total hip arthroplasty (THA) and primary total knee arthroplasty (TKA). As we now focus on extending the PSH to other service lines within...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000001308

    authors: Cyriac J,Garson L,Schwarzkopf R,Ahn K,Rinehart J,Vakharia S,Cannesson M,Kain Z

    更新日期:2016-07-01 00:00:00

  • Forearm compartment syndrome from intravenous mannitol extravasation during general anesthesia.

    abstract:IMPLICATIONS:Complications of IV mannitol administration resulting in compartment syndrome may warrant surgical intervention. Compartment syndrome is difficult to diagnose in the anesthetized patient. Infusing mannitol in an observed IV site permits discontinuation of mannitol before complications ensue. Early recognit...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200301000-00049

    authors: Edwards JJ,Samuels D,Fu ES

    更新日期:2003-01-01 00:00:00

  • An exploration of remifentanil-propofol combinations that lead to a loss of response to esophageal instrumentation, a loss of responsiveness, and/or onset of intolerable ventilatory depression.

    abstract:BACKGROUND:Remifentanil and propofol are increasingly used for short-duration procedures in spontaneously breathing patients. In this setting, it is preferable to block the response to moderate stimuli while avoiding loss of responsiveness (LOR) and intolerable ventilatory depression (IVD). In this study, we explored s...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0b013e318210fc45

    authors: LaPierre CD,Johnson KB,Randall BR,White JL,Egan TD

    更新日期:2011-09-01 00:00:00

  • The effect of systemic zonisamide (Zonegran) on thermal hyperalgesia and mechanical allodynia in rats with an experimental mononeuropathy.

    abstract:UNLABELLED:We studied the ability of zonisamide (Zonegran) to relieve thermal hyperalgesia and/or mechanical allodynia in the chronic constriction injury model of neuropathic pain. Zonisamide (25, 50, or 100 mg/kg) or saline was administered in a blinded, randomized manner by intraperitoneal injection on postoperative ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000062652.66661.97

    authors: Hord AH,Denson DD,Chalfoun AG,Azevedo MI

    更新日期:2003-06-01 00:00:00

  • Bunegin-Albin catheter improves air retrieval and resuscitation from lethal venous air embolism in upright dogs.

    abstract::Three types of catheters, the Arrow multi-orifice catheter, the American Edwards 7 Fr Swan-Ganz catheter and the Cook Bunegin-Albin multi-orifice CVP catheter were evaluated for their ability to retrieve venous air emboli and effect on the success rate of resuscitation from venous air emboli. The catheters were insert...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Colley PS,Artru AA

    更新日期:1989-03-01 00:00:00

  • Effect of halothane on cardiac output and regional flow in the fetal lamb in utero.

    abstract::We studied the effect of halothane on the fetal cardiovascular system of six lambs in utero by measuring fetal heart rate and femoral arterial blood pressure and by injecting labeled microspheres during a control period and again after 60 and 90 min of halothane anesthesia administered to six pregnant ewes at an inspi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Biehl DR,Tweed WA,Cote J,Wade JG,Sitar D

    更新日期:1983-05-01 00:00:00

  • The vasodilator effects of clevidipine on human internal mammary artery.

    abstract:UNLABELLED:Endothelial dysfunction and platelet activation with thromboxane release may contribute to spasm or alterations in internal mammary artery (IMA) graft flow during coronary artery surgery. Clevidipine, an ultrashort-acting dihydropyridine calcium channel blocker, is undergoing clinical development, but there ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199711000-00008

    authors: Huraux C,Makita T,Szlam F,Nordlander M,Levy JH

    更新日期:1997-11-01 00:00:00

  • Vasoconstrictors in spinal anesthesia with tetracaine--a comparison of epinephrine and phenylephrine.

    abstract::A randomized double-blind study was conducted in 50 orthopedic patients to determine the effect of epinephrine and phenylephrine on the anesthetic properties of intrathecally administered tetracaine. Two doses of each vasoconstrictor agent were studied: 0.2 mg of epinephrine, 0.3 mg of epinephrine, 1 mg of phenylephri...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Concepcion M,Maddi R,Francis D,Rocco AG,Murray E,Covino BG

    更新日期:1984-02-01 00:00:00

  • Influencing Anesthesia Provider Behavior Using Anesthesia Information Management System Data for Near Real-Time Alerts and Post Hoc Reports.

    abstract::In this review article, we address issues related to using data from anesthesia information management systems (AIMS) to deliver near real-time alerts via AIMS workstation popups and/or alphanumeric pagers and post hoc reports via e-mail. We focus on reports and alerts for influencing the behavior of anesthesia provid...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0000000000000677

    authors: Epstein RH,Dexter F,Patel N

    更新日期:2015-09-01 00:00:00

  • Intramuscular versus surface electromyography of the diaphragm for determining neuromuscular blockade.

    abstract::We determined the neuromuscular blockade of 0.2 mg. kg(-1) mivacurium at the diaphragm by using two new methods of electromyographic (EMG) monitoring and compared it with acceleromyography of the orbicularis oculi (OO) and the corrugator supercilii (CS) muscle. After the induction of anesthesia in 15 patients undergoi...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000539-200101000-00021

    authors: Hemmerling TM,Schmidt J,Wolf T,Hanusa C,Siebzehnruebl E,Schmitt H

    更新日期:2001-01-01 00:00:00