Systemic mexiletine relieves chronic allodynialike symptoms in rats with ischemic spinal cord injury.

Abstract:

:We have recently reported a chronic allodynialike symptom in rats after ischemic spinal cord injury. This pain-related behavior is resistant to a number of pharmacologic treatments, including morphine, clonidine, carbamazepine, baclofen, and muscimol. In the present report, we present evidence indicating that systemic mexiletine, a local anesthetic and antiarrhythmic agent, effectively relieves the allodynia-like symptoms at doses of 15 and 30 mg/kg in these rats without inducing major side effects. It is suggested that systemically applied mexiletine may be useful in treating central pain in patients with spinal cord injury.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Xu XJ,Hao JX,Seiger A,Arnér S,Lindblom U,Wiesenfeld-Hallin Z

doi

10.1213/00000539-199205000-00005

subject

Has Abstract

pub_date

1992-05-01 00:00:00

pages

649-52

issue

5

eissn

0003-2999

issn

1526-7598

journal_volume

74

pub_type

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