Droperidol causes a dose-dependent prolongation of the QT interval.

Abstract:

:To further investigate possible prolongation of the frequency-corrected QT interval (QTc interval) after administration of droperidol (DRO), we studied 40 surgical patients who were randomly assigned to one of three groups, receiving an intravenous (IV) injection of either 0.1 mg/kg (Group 1, n = 10), 0.175 mg/kg (Group 2, n = 10), or 0.25 mg/kg (Group 3, n = 20) of DRO at induction of anesthesia. The QTc interval, heart rate, and arterial pressure were registered before and 1, 2, 3, 4, 5, 7.5, and 10 min after the respective dose injection. Significant prolongations of the median QTc interval were found in patients from all groups, ranging from 37 ms (8.0%) in Group 1, to 44 ms (10.6%) in Group 2, to 59 ms (14.9%) in Group 3, when compared with control. The heart rate showed a significant increase in all groups. Mean arterial pressure (MAP) was slightly but significantly decreased in Groups 1 and 3. Prolongation of the QTc interval is a predictable and dose-dependent side effect after injection of high-dose DRO.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Lischke V,Behne M,Doelken P,Schledt U,Probst S,Vettermann J

doi

10.1213/00000539-199411000-00028

subject

Has Abstract

pub_date

1994-11-01 00:00:00

pages

983-6

issue

5

eissn

0003-2999

issn

1526-7598

journal_volume

79

pub_type

临床试验,杂志文章,随机对照试验
  • Large-dose intrathecal sufentanil prevents the hormonal stress response during major abdominal surgery: a comparison with intravenous sufentanil in a prospective randomized trial.

    abstract::We studied the effect of large-dose intrathecal sufentanil (ITS) for major abdominal surgery on the hormonal stress response. Forty patients were randomly allocated to receive either IV sufentanil (IVS) or 150 microg of ITS as part of general anesthesia. In the IVS group, adrenocorticotropic hormone (ACTH) and cortiso...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/01.ANE.0000131728.68125.4E

    authors: Borgdorff PJ,Ionescu TI,Houweling PL,Knape JT

    更新日期:2004-10-01 00:00:00

  • Propofol inhibits ketamine-induced c-fos expression in the rat posterior cingulate cortex.

    abstract:UNLABELLED:Ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, has psychotomimetic activity. NMDA receptor antagonists cause morphological damage in the posterior cingulate cortex, which may be the brain region responsible for their psychotomimetic effects. Benzodiazepines are effective in preve...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199812000-00040

    authors: Nagata A,Nakao S,Miyamoto E,Inada T,Tooyama I,Kimura H,Shingu K

    更新日期:1998-12-01 00:00:00

  • Review articles: postoperative delirium: acute change with long-term implications.

    abstract::Delirium is an acute change in cognition and attention, which may include alterations in consciousness and disorganized thinking. Although delirium may affect any age group, it is most common in older patients, especially those with preexisting cognitive impairment. Patients with delirium after surgery recover more sl...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0b013e3182147f6d

    authors: Rudolph JL,Marcantonio ER

    更新日期:2011-05-01 00:00:00

  • Increased Perinatal Morbidity and Mortality Among Asian American and Pacific Islander Women in the United States.

    abstract:BACKGROUND:Asian American/Pacific Islanders (AAPIs) are the fastest-growing racial group in the United States. Despite a higher socioeconomic status, AAPI women experience higher rates of maternal morbidity and mortality. METHODS:Using the National Inpatient Sample, we performed a retrospective cohort analysis of wome...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000001778

    authors: Siddiqui M,Minhaj M,Mueller A,Tung A,Scavone B,Rana S,Shahul S

    更新日期:2017-03-01 00:00:00

  • Can quantitative sensory testing predict the outcome of epidural steroid injections in sciatica? A preliminary study.

    abstract::Quantitative Sensory Testing (QST) is a psycho-physiological test used to identify dysfunction of individual nerve fiber types. In the present study, we investigated whether selective nerve fiber dysfunction, as assessed by QST, correlates with the effectiveness of epidural steroid injections (ESI) in patients with lu...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1213/01.ane.0000078583.47735.69

    authors: Schiff E,Eisenberg E

    更新日期:2003-09-01 00:00:00

  • A randomized trial comparing colloid preload to coload during spinal anesthesia for elective cesarean delivery.

    abstract:BACKGROUND:Hypotension after spinal anesthesia for cesarean delivery is common. Previous studies have demonstrated that a crystalloid fluid "coload" (rapid administration of a fluid bolus starting at the time of intrathecal injection) is superior to the conventional crystalloid preload (fluid administered before the in...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ane.0b013e3181b2bd6b

    authors: Siddik-Sayyid SM,Nasr VG,Taha SK,Zbeide RA,Shehade JM,Al Alami AA,Mokadem FH,Abdallah FW,Baraka AS,Aouad MT

    更新日期:2009-10-01 00:00:00

  • Digital pressure during interscalene block is clinically ineffective in preventing anesthetic spread to the cervical plexus.

    abstract::The application of digital pressure above the injection site during interscalene block has been advocated to prevent cephalad spread of local anesthetic. In prior studies, radiographs taken immediately after interscalene injection of radiographic contrast have supported this concept. However, the clinical efficacy of ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199608000-00028

    authors: Urmey WF,Grossi P,Sharrock NE,Stanton J,Gloeggler PJ

    更新日期:1996-08-01 00:00:00

  • Fluid resuscitation with 6% hydroxyethyl starch (130/0.4) in acutely ill patients: an updated systematic review and meta-analysis.

    abstract:BACKGROUND:Recent research suggests that 6% hydroxyethyl starch (HES) 130/0.4 is one of the most frequently used resuscitation fluids worldwide. The retraction of studies evaluating its use necessitates a reevaluation of available evidence regarding its safety and efficacy. METHODS:We performed a systematic review and...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,meta分析,评审

    doi:10.1213/ANE.0b013e318236b4d6

    authors: Gattas DJ,Dan A,Myburgh J,Billot L,Lo S,Finfer S,CHEST Management Committee.

    更新日期:2012-01-01 00:00:00

  • Odds of transfusion for older adults compared to younger adults undergoing surgery.

    abstract:BACKGROUND:Recent randomized controlled trials have shown no benefit for transfusion to a hemoglobin >10 g/dL compared with lower hemoglobin thresholds in the perioperative period, even among older adults. Nevertheless, physicians may choose to transfuse older adults more liberally than younger adults. It is unclear wh...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000000033

    authors: Brown CH 4th,Savage WJ,Masear CG,Walston JD,Tian J,Colantuoni E,Hogue CW,Frank SM

    更新日期:2014-06-01 00:00:00

  • The efficacy of thoracic epidural neostigmine infusion after thoracotomy.

    abstract::Few anesthesia studies have explored perioperative continuous epidural infusion of neostigmine. We examined such a regimen in thoracotomy patients. Ninety patients were randomized to one of three groups in this double-blind trial. Before anesthesia induction, an epidural catheter was inserted in all patients at T5-8 l...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/01.ane.0000184812.94185.b3

    authors: Chia YY,Chang TH,Liu K,Chang HC,Ko NH,Wang YM

    更新日期:2006-01-01 00:00:00

  • Perioperative Management of the Patient With a Left Ventricular Assist Device for Noncardiac Surgery.

    abstract::The pandemic of heart failure and the limited options for treatment of end-stage disease have resulted in an increase in the utilization of left ventricular assist devices (LVADs). Improvements in device technology and patient survival have led to an expanding population of patients requiring noncardiac surgery while ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0000000000002669

    authors: Chung M

    更新日期:2018-06-01 00:00:00

  • A comparison of a new indicator-guided with a conventional wire-guided percutaneous cricothyroidotomy device in mannequins.

    abstract:BACKGROUND:Percutaneous cricothyroidotomy may be a life-saving procedure in cannot intubate-cannot ventilate situations. In this study we compared the insertion times of a new indicator-guided cricothyroidotomy device and a wire-guided device in mannequins. METHODS:This study was a crossover trial comparing the insert...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000266439.43797.9e

    authors: Assmann NM,Wong DT,Morales E

    更新日期:2007-07-01 00:00:00

  • Exposure to halothane and enflurane affects learning function of murine progeny.

    abstract::This study was conducted to assess the learning function of murine progeny born of mothers that had received either 1% or 2% halothane or 2% or 4% enflurane, on days 6 and 10 or days 14 and 17 or gestation. Their timed performance at the age of 6 to 7 weeks was compared in a maze with that of control mice of similar a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Chalon J,Tang CK,Ramanathan S,Eisner M,Katz R,Turndorf H

    更新日期:1981-11-01 00:00:00

  • Presenting research information to children: a tale of two methods.

    abstract:BACKGROUND:Research information for children is often presented in a manner that is difficult to understand. We designed this study, therefore, to examine the effect of improved readability and processability of written study information on children's understanding. METHODS:One-hundred-ninety children aged 7-17 yr who...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/01.ane.0000270326.44507.11

    authors: Tait AR,Voepel-Lewis T,Malviya S

    更新日期:2007-08-01 00:00:00

  • Distribution of Extreme Vital Signs and Complete Blood Count Values of Healthy Parturients: A Retrospective Database Analysis and Review of the Literature.

    abstract:BACKGROUND:The impact of physiological adjustments throughout pregnancy on maternal vital signs and laboratory values has yet to be fully defined. The present study was designed to determine the normal range of these parameters among healthy pregnant women during the peripartum period. METHODS:This is a retrospective ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0000000000003866

    authors: Gat R,Hadar E,Orbach-Zinger S,Shochat T,Kushnir S,Einav S

    更新日期:2019-12-01 00:00:00

  • The influence of endotoxemia on the electroencephalographic and antinociceptive effects of isoflurane in a swine model.

    abstract:BACKGROUND:We have previously reported that hemorrhagic shock decreases the minimum alveolar anesthetic concentration (MAC) of isoflurane but minimally alters the electroencephalographic (EEG) effect. In this study, we investigated the influence of endotoxemia on the EEG effect and the MAC of isoflurane. METHODS:Eight...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e3181c22146

    authors: Kurita T,Takata K,Morita K,Uraoka M,Sato S

    更新日期:2010-01-01 00:00:00

  • Myocardial dysfunction associated with proinflammatory cytokines after esophageal resection.

    abstract:UNLABELLED:Proinflammatory cytokines have been implicated in mediating myocardial dysfunction associated with major surgery. We investigated the profile of proinflammatory cytokines and the association of cytokine levels with myocardial function after esophagectomy. We studied 12 patients who underwent subtotal esophag...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200008000-00004

    authors: Nakanishi K,Takeda S,Terajima K,Takano T,Ogawa R

    更新日期:2000-08-01 00:00:00

  • Significance, Errors, Power, and Sample Size: The Blocking and Tackling of Statistics.

    abstract::Inferential statistics relies heavily on the central limit theorem and the related law of large numbers. According to the central limit theorem, regardless of the distribution of the source population, a sample estimate of that population will have a normal distribution, but only if the sample is large enough. The rel...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000002741

    authors: Mascha EJ,Vetter TR

    更新日期:2018-02-01 00:00:00

  • The effects of needle type, gauge, and tip bend on spinal needle deflection.

    abstract::Although the use of fine-gauge spinal needles reduces the incidence of postdural puncture headache, they are associated with increased risk of placement failure as a result of deflection and bending. This in vitro study quantifies spinal needle deflection from the axis of insertion with respect to needle type, gauge, ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199602000-00014

    authors: Sitzman BT,Uncles DR

    更新日期:1996-02-01 00:00:00

  • Renal function and proteinuria after cardiopulmonary bypass: the effects of temperature and mannitol.

    abstract::We studied three groups of patients without previous renal impairment, undergoing elective coronary artery bypass surgery. Group H (n = 7) underwent open heart surgery using moderate hypothermia (28 degrees C); Groups N and M (n = 8, each) were managed at normothermia. The extracorporeal circuit was primed with Hartma...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/00000539-199405000-00004

    authors: Ip-Yam PC,Murphy S,Baines M,Fox MA,Desmond MJ,Innes PA

    更新日期:1994-05-01 00:00:00

  • A comparison of glidescope videolaryngoscopy to direct laryngoscopy for nasotracheal intubation.

    abstract:BACKGROUND:In this study, we compared the effectiveness of direct laryngoscopy (DL) and the GlideScope videolaryngoscope (GVL) for nasotracheal intubation, as judged by the time to intubation (TTI-the primary outcome) and the ease of intubation. METHODS:Seventy patients requiring nasotracheal intubation for elective s...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ane.0b013e31816d15c9

    authors: Jones PM,Armstrong KP,Armstrong PM,Cherry RA,Harle CC,Hoogstra J,Turkstra TP

    更新日期:2008-07-01 00:00:00

  • Remifentanil dose/electroencephalogram bispectral response during combined propofol/regional anesthesia.

    abstract:UNLABELLED:The effect of opioid administration on the bispectral index (BIS) during general anesthesia is controversial. Several investigators have reported BIS to be insensitive to opioid addition, whereas others have found a hypnotic response. We designed this study to examine the effect of remifentanil on BIS during...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000539-200206000-00028

    authors: Koitabashi T,Johansen JW,Sebel PS

    更新日期:2002-06-01 00:00:00

  • Alterations in spinal, but not cerebral, cerebrospinal fluid Na+ concentrations affect the isoflurane minimum alveolar concentration in rats.

    abstract:BACKGROUND:Previous studies demonstrated that MAC (the minimum alveolar concentration of an inhaled anesthetic that produces immobility in 50% of subjects exposed to noxious stimulation) for halothane directly correlates with the central nervous system concentration of Na+. However, those studies globally altered Na+ c...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000278090.88402.26

    authors: Laster MJ,Zhang Y,Eger EI 2nd,Shnayderman D,Sonner JM

    更新日期:2007-09-01 00:00:00

  • Residual neuromuscular block: lessons unlearned. Part I: definitions, incidence, and adverse physiologic effects of residual neuromuscular block.

    abstract::In this review, we summarize the clinical implications of residual neuromuscular block. Data suggest that residual neuromuscular block is a common complication in the postanesthesia care unit, with approximately 40% of patients exhibiting a train-of-four ratio <0.9. Volunteer studies have demonstrated that small degre...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0b013e3181da832d

    authors: Murphy GS,Brull SJ

    更新日期:2010-07-01 00:00:00

  • Divergence paresis without positional headache: an unusual presentation of cerebrospinal fluid hypovolemia after spinal anesthesia.

    abstract::We report a rare complication of spinal anesthesia-divergence paresis-which is characterized by an acquired horizontal diplopia at distance without evidence for abducens palsy. A 64-yr-old man underwent prostatectomy under spinal anesthesia with 2.5 mL of dibucaine hydrochloride 0.3% injected through a 20-gauge cuttin...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000217117.77826.dd

    authors: Arai M,Matsushima S,Terada H

    更新日期:2006-06-01 00:00:00

  • Management of suspected malignant hyperpyrexia in an infant.

    abstract::A case of possible malignant hyperthermia in a 6-month-old child is presented. Malignant hyperthermia was manifested in this patient by persistent metabolic acidosis in the intraoperative and postoperative periods, by a rapid rise in temperature with concomitant unresponsiveness in the postoperative period, and by a p...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-197901000-00011

    authors: Faust DK,Gergis SD,Sokoll MD

    更新日期:1979-01-01 00:00:00

  • Peripheral flow index is a reliable and early indicator of regional block success.

    abstract::We investigated the usefulness of peripheral flow index (PFI) measurement using a standard pulse oximetry digit probe for early prediction of successful regional blocks. Sixty-six patients scheduled for limb surgery underwent either axillary or sciatic block using a nerve stimulator technique with mepivacaine 1.5%. PF...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000220947.02689.9f

    authors: Galvin EM,Niehof S,Verbrugge SJ,Maissan I,Jahn A,Klein J,van Bommel J

    更新日期:2006-07-01 00:00:00

  • Unwarranted variability in antibiotic prophylaxis for cesarean section delivery: a national survey of anesthesiologists.

    abstract:BACKGROUND:Current guidelines from the American College of Obstetricians and Gynecologists recommend antibiotic prophylaxis for cesarean delivery immediately before incision. The purpose of this study was to measure and describe correlates of adherence to these guidelines in a sample of United States anesthesiologists....

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0b013e318276cf72

    authors: Raghunathan K,Connelly NR,Friderici J,Naglieri-Prescod D,Joyce R,Prasanna P,Ponnusamy N

    更新日期:2013-03-01 00:00:00

  • Antinociceptive and neurotoxicologic screening of chronic intrathecal administration of ketorolac tromethamine in the rat.

    abstract:UNLABELLED:Many drugs are tested intrathecally to investigate alternatives to opioids. We aimed to explore the analgesic and possible neurotoxic effects of chronic intrathecally-administered ketorolac tromethamine in rats. Catheters were placed via atlantoaxial interval in 28 Wistar rats under anesthesia of intraperito...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000093226.75543.90

    authors: Korkmaz HA,Maltepe F,Erbayraktar S,Yilmaz O,Güray M,Canda MS,Günerli A,Gökmen N

    更新日期:2004-01-01 00:00:00

  • Brain edema, hemorrhagic necrosis volume, and neurological status with rapid infusion of 0.45% saline or 5% dextrose in 0.9% saline after closed head trauma in rats.

    abstract::We previously reported that in rats with closed head trauma (CHT), intravenous (IV) administration of 0.25 mL/g of 5% dextrose solution (D5W) increased blood glucose (G), decreased blood sodium (Na), caused no change in blood osmolality (Osm), increased brain edema (BE), and worsened neurological severity score (NSS) ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199703000-00016

    authors: Gurevich B,Talmor D,Artru AA,Katcko L,Geva D,Gurman G,Shapira Y

    更新日期:1997-03-01 00:00:00